TY - JOUR AU - Horváth-Szalai, Zoltán AU - Jakabfi-Csepregi, Rita AU - Szirmay, Balázs AU - Ragán, Dániel AU - Simon, Gerda AU - Kovács-Ábrahám, Zoltán AU - Szabó, Péter AU - Sipos, Dávid AU - Péterfalvi, Ágnes AU - Miseta, Attila János AU - Csontos, Csaba AU - Kőszegi, Tamás AU - Némethné Tóth, Ildikó TI - Serum Total Antioxidant Capacity (TAC) and TAC/Lymphocyte Ratio as Promising Predictive Markers in COVID-19 JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 16 PG - 14 SN - 1661-6596 DO - 10.3390/ijms241612935 UR - https://m2.mtmt.hu/api/publication/34113082 ID - 34113082 N1 - ISSN:1422-0067 AB - SARS-CoV-2 infection might cause a critical disease, and patients' follow-up is based on multiple parameters. Oxidative stress is one of the key factors in the pathogenesis of COVID-19 suggesting that its level could be a prognostic marker. Therefore, we elucidated the predictive value of the serum non-enzymatic total antioxidant capacity (TAC) and that of the newly introduced TAC/lymphocyte ratio in COVID-19. We included 61 COVID-19 (n = 27 ward, n = 34 intensive care unit, ICU) patients and 29 controls in our study. Serum TAC on admission was measured by an enhanced chemiluminescence (ECL) microplate assay previously validated by our research group. TAC levels were higher (p < 0.01) in ICU (median: 407.88 µmol/L) than in ward patients (315.44 µmol/L) and controls (296.60 µmol/L). Besides the classical parameters, both the TAC/lymphocyte ratio and TAC had significant predictive values regarding the severity (AUC-ROC for the TAC/lymphocyte ratio: 0.811; for TAC: 0.728) and acute kidney injury (AUC-ROC for the TAC/lymphocyte ratio: 0.747; for TAC: 0.733) in COVID-19. Moreover, the TAC/lymphocyte ratio had significant predictive value regarding mortality (AUC-ROC: 0.752). Serum TAC and the TAC/lymphocyte ratio might offer valuable information regarding the severity of COVID-19. TAC measured by our ECL microplate assay serves as a promising marker for the prediction of systemic inflammatory diseases. LA - English DB - MTMT ER - TY - JOUR AU - Kappéter, Ágnes AU - Sipos, Dávid AU - Varga, Adorján AU - Vigvári, Szabolcs József AU - Halda-Kiss, Bernadett AU - Péterfi, Zoltán TI - Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation JF - MICROORGANISMS J2 - MICROORGANISMS VL - 11 PY - 2023 IS - 8 PG - 14 SN - 2076-2607 DO - 10.3390/microorganisms11082083 UR - https://m2.mtmt.hu/api/publication/34095174 ID - 34095174 N1 - ISSN:2076-2607 AB - Migraine is a painful neurological condition characterized by severe pain on one or both sides of the head. It may be linked to changes in the gut microbiota, which are influenced by antibiotic use and other factors. Dysbiosis, which develops and persists as a result of earlier antibiotic therapy, changes the composition of the intestinal flora, and can lead to the development of various diseases such as metabolic disorders, obesity, hematological malignancies, neurological or behavioral disorders, and migraine. Metabolites produced by the gut microbiome have been shown to influence the gut–brain axis. The use of probiotics as a dietary supplement may reduce the number and severity of migraine episodes. Dietary strategies can affect the course of migraines and are a valuable tool for improving migraine management. With fecal microbiota transplantation, gut microbial restoration is more effective and more durable. Changes after fecal microbiota transplantation were studied in detail, and many data help us to interpret the successful interventions. The microbiological alteration of the gut microflora can lead to normalization of the inflammatory mediators, the serotonin pathway, and influence the frequency and intensity of migraine pain. LA - English DB - MTMT ER - TY - JOUR AU - Péterfi, Zoltán AU - Varga, Adorján AU - Vigvári, Szabolcs József AU - Sipos, Dávid TI - A széklettranszplantáció aktuális hazai helyzete JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 9 PY - 2023 IS - 2 SP - 59 EP - 62 PG - 4 SN - 2415-9107 DO - 10.33570/CEUJGH.9.2.59 UR - https://m2.mtmt.hu/api/publication/34025825 ID - 34025825 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Varga, Adorján AU - Makszin, Lilla AU - Bufa, Anita AU - Sipos, Dávid AU - Kása, Péter AU - Pál, Szilárd AU - Rosenstiel, Philip AU - Sommer, Felix AU - Kocsis, Béla AU - Péterfi, Zoltán TI - Efficacy of lyophilised bacteria-rich faecal sediment and supernatant with reduced bacterial count for treating patients with Clostridioides difficile Infection – A novel method for capsule faecal microbiota transfer JF - FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY J2 - FRONT CELL INFECT MI VL - 13 PY - 2023 PG - 15 SN - 2235-2988 DO - 10.3389/fcimb.2023.1041384 UR - https://m2.mtmt.hu/api/publication/33588242 ID - 33588242 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Molnár, Tihamér AU - Várnai, Réka AU - Schranz, Dániel AU - Závori, László AU - Péterfi, Zoltán AU - Sipos, Dávid AU - Tőkés-Füzesi, Margit AU - Illés, Zsolt László AU - Büki, András AU - Csécsei, Péter TI - Severe Fatigue and Memory Impairment Are Associated with Lower Serum Level of Anti-SARS-CoV-2 Antibodies in Patients with Post-COVID Symptoms JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 10 PY - 2021 IS - 19 PG - 14 SN - 2077-0383 DO - 10.3390/jcm10194337 UR - https://m2.mtmt.hu/api/publication/32237455 ID - 32237455 LA - English DB - MTMT ER - TY - JOUR AU - Varga, Adorján AU - Kocsis, Béla AU - Sipos, Dávid AU - Kása, Péter AU - Vigvári, Szabolcs József AU - Pál, Szilárd AU - Dembrovszky, Fanni AU - Borbásné Farkas, Kornélia AU - Péterfi, Zoltán TI - How to Apply FMT More Effectively, Conveniently and Flexible – A Comparison of FMT Methods JF - FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY J2 - FRONT CELL INFECT MI VL - 11 PY - 2021 PG - 11 SN - 2235-2988 DO - 10.3389/fcimb.2021.657320 UR - https://m2.mtmt.hu/api/publication/32056248 ID - 32056248 N1 - Department of Medical Microbiology and Immunology, University of Pécs Clinical Centre, Pécs, Hungary Department of Internal Medicine – Department of Infectology, University of Pécs Clinical Centre, Pécs, Hungary Institute of Pharmaceutical Technology and Biopharmacy, University of Pécs, Faculty of Pharmacy, Pécs, Hungary Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary Institute of Bioanalysis, University of Pécs Medical School, Pécs, Hungary Cited By :17 Export Date: 23 April 2024 Correspondence Address: Varga, A.; Department of Medical Microbiology and Immunology, Hungary LA - English DB - MTMT ER - TY - JOUR AU - Sipos, Dávid AU - Nyul, Adrienn AU - Kovács, Krisztina AU - Alizadeh, Hussain AU - Péterfi, Zoltán TI - Kórokozóspektrum egy hematológiai osztályon JF - HEMATOLÓGIA-TRANSZFUZIOLÓGIA J2 - HEMATOLÓGIA-TRANSZFUZIOLÓGIA VL - 52 PY - 2019 IS - 1 SP - 57 EP - 61 PG - 5 SN - 1786-5913 DO - 10.1556/2068.2019.52.1.11 UR - https://m2.mtmt.hu/api/publication/30637910 ID - 30637910 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Vigvári, Szabolcs József AU - Vincze, Áron AU - Solt, Jenő AU - Sipos, Dávid AU - Feiszt, Zsófia AU - Kovács, Beáta AU - Kappéter, Ágnes AU - Péterfi, Zoltán TI - Experiences with fecal microbiota transplantation in Clostridium difficile infections via upper gastrointestinal tract JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 66 ET - 0 PY - 2019 IS - 2 SP - 179 EP - 188 PG - 10 SN - 1217-8950 DO - 10.1556/030.65.2018.051 UR - https://m2.mtmt.hu/api/publication/30362752 ID - 30362752 AB - Dramatic changes in the epidemiology of Clostridium difficile infections have been reported from the western world in the past decade. The proportion of severe cases is significantly elevating and clinicians now have to contend with the problem of additional and more frequent episodes of recurrences including an upward trend in the mortality rate. This situation led us to investigate the possibility of the fecal microbiota transplantation (FMT). An amount of 100 ml of fecal microbiota solution was instilled into a nasojejunal (NJ) tube in 16 cases and into a nasogastric (NG) tube in 44 cases. In all of the cases, where the solution was instilled via nasojejunal tubes, the symptoms resolved within 24 h. We did not note any recurrences in this group. When the material was flushed in through nasogastric tubes, the symptoms resolved in 39 (88.64%) cases within 24 h. In this group, we have experienced a recurrent episode of C. difficile infection in five (11.36%) cases. Three of them were cured with a second transplantation. We have found that in our practice the upper gastrointestinal tract methods had the primary cure rate of 91.67%, whereas the secondary cure rate is 96.67%. When we compared the NJ and NG methods, we have found that the differences in the outcomes are not significant statistically (p = 0.3113 using Fisher's exact probability test). In conclusion, FMT proved to be very effective, particularly in recurrent infections and in cases where conventional treatment had failed. LA - English DB - MTMT ER - TY - JOUR AU - Vigvári, Szabolcs József AU - Sipos, Dávid AU - Solt, Jenő AU - Vincze, Áron AU - Kocsis, Béla AU - Nemes, Zsuzsanna AU - Kappéter, Ágnes AU - Feiszt, Zsófia AU - Kovács, Beáta AU - Péterfi, Zoltán TI - Faecal microbiota transplantation for Clostridium difficile infection using a lyophilized inoculum from non-related donors: A case series involving 19 patients JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 66 PY - 2019 IS - 1 SP - 69 EP - 78 PG - 10 SN - 1217-8950 DO - 10.1556/030.64.2017.042 UR - https://m2.mtmt.hu/api/publication/3304835 ID - 3304835 N1 - Department of Infectious Diseases, 1st Department of Internal Medicine, University of Pécs, Pécs, Hungary Department of Gastroenterology, 1st Department of Internal Medicine, University of Pécs, Pécs, Hungary Department of Medical Microbiology and Immunology, University of Pécs, Pécs, Hungary Cited By :10 Export Date: 23 April 2024 Correspondence Address: Vigvári, S.; Department of Infectious Diseases, Hungary; email: szabolcs.vigvari@gmail.com AB - Faecal microbiota transplantation (FMT) has been reported to be effective in treating relapsing of refractory Clostridium difficile infections, although some practical barriers are limiting its widespread use. In this study, our objective was to evaluate the rate of resolution of diarrhea following administration of lyophilized and resolved FMT via a nasogastric (NG) tube. We recruited 19 patients suffered from laboratory-confirmed C. difficile infection. Each of them was treated by lyophilized and resolved inoculum through a NG tube. One participant succumbed following the procedure due to unrelated diseases. Out of 18 cases, 15 patients reportedly experienced a resolution of the symptoms. One patient was treated with another course of antibiotics, and two of the non-responders were successfully retreated with another course of FMT utilizing a lyophilized inoculum. Notably, no significant adverse activities were observed. In accordance to our clinical experiences, a patient will likely benefit from FMT treatment including lyophilized inoculum. LA - English DB - MTMT ER - TY - JOUR AU - Varga, Adorján AU - Kocsis, Béla AU - Sipos, Dávid AU - Vigvári, Szabolcs József AU - Kása, Péter AU - Pál, Szilárd AU - Mikó, Éva AU - Szereday, László AU - Bechtolsheim, F. AU - Péterfi, Zoltán TI - Treatment options of Clostridium difficile infection: our latest experiences with fecal microbiota transplant JF - CLINICAL CHEMISTRY AND LABORATORY MEDICINE J2 - CLIN CHEM LAB MED VL - 56 PY - 2018 IS - 9 SP - eA133 EP - eA133 SN - 1434-6621 UR - https://m2.mtmt.hu/api/publication/30600970 ID - 30600970 LA - English DB - MTMT ER -