@article{MTMT:34113082, title = {Serum Total Antioxidant Capacity (TAC) and TAC/Lymphocyte Ratio as Promising Predictive Markers in COVID-19}, url = {https://m2.mtmt.hu/api/publication/34113082}, author = {Horváth-Szalai, Zoltán and Jakabfi-Csepregi, Rita and Szirmay, Balázs and Ragán, Dániel and Simon, Gerda and Kovács-Ábrahám, Zoltán and Szabó, Péter and Sipos, Dávid and Péterfalvi, Ágnes and Miseta, Attila János and Csontos, Csaba and Kőszegi, Tamás and Némethné Tóth, Ildikó}, doi = {10.3390/ijms241612935}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34113082}, issn = {1661-6596}, abstract = {SARS-CoV-2 infection might cause a critical disease, and patients' follow-up is based on multiple parameters. Oxidative stress is one of the key factors in the pathogenesis of COVID-19 suggesting that its level could be a prognostic marker. Therefore, we elucidated the predictive value of the serum non-enzymatic total antioxidant capacity (TAC) and that of the newly introduced TAC/lymphocyte ratio in COVID-19. We included 61 COVID-19 (n = 27 ward, n = 34 intensive care unit, ICU) patients and 29 controls in our study. Serum TAC on admission was measured by an enhanced chemiluminescence (ECL) microplate assay previously validated by our research group. TAC levels were higher (p < 0.01) in ICU (median: 407.88 µmol/L) than in ward patients (315.44 µmol/L) and controls (296.60 µmol/L). Besides the classical parameters, both the TAC/lymphocyte ratio and TAC had significant predictive values regarding the severity (AUC-ROC for the TAC/lymphocyte ratio: 0.811; for TAC: 0.728) and acute kidney injury (AUC-ROC for the TAC/lymphocyte ratio: 0.747; for TAC: 0.733) in COVID-19. Moreover, the TAC/lymphocyte ratio had significant predictive value regarding mortality (AUC-ROC: 0.752). Serum TAC and the TAC/lymphocyte ratio might offer valuable information regarding the severity of COVID-19. TAC measured by our ECL microplate assay serves as a promising marker for the prediction of systemic inflammatory diseases.}, keywords = {PREDICTIVE VALUE; enhanced chemiluminescence; COVID-19; TAC/lymphocyte ratio; serum total antioxidant capacity (TAC)}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Kovács-Ábrahám, Zoltán/0009-0005-2516-8349; Miseta, Attila János/0000-0002-7984-3347} } @article{MTMT:34095174, title = {Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation}, url = {https://m2.mtmt.hu/api/publication/34095174}, author = {Kappéter, Ágnes and Sipos, Dávid and Varga, Adorján and Vigvári, Szabolcs József and Halda-Kiss, Bernadett and Péterfi, Zoltán}, doi = {10.3390/microorganisms11082083}, journal-iso = {MICROORGANISMS}, journal = {MICROORGANISMS}, volume = {11}, unique-id = {34095174}, issn = {2076-2607}, abstract = {Migraine is a painful neurological condition characterized by severe pain on one or both sides of the head. It may be linked to changes in the gut microbiota, which are influenced by antibiotic use and other factors. Dysbiosis, which develops and persists as a result of earlier antibiotic therapy, changes the composition of the intestinal flora, and can lead to the development of various diseases such as metabolic disorders, obesity, hematological malignancies, neurological or behavioral disorders, and migraine. Metabolites produced by the gut microbiome have been shown to influence the gut–brain axis. The use of probiotics as a dietary supplement may reduce the number and severity of migraine episodes. Dietary strategies can affect the course of migraines and are a valuable tool for improving migraine management. With fecal microbiota transplantation, gut microbial restoration is more effective and more durable. Changes after fecal microbiota transplantation were studied in detail, and many data help us to interpret the successful interventions. The microbiological alteration of the gut microflora can lead to normalization of the inflammatory mediators, the serotonin pathway, and influence the frequency and intensity of migraine pain.}, year = {2023}, eissn = {2076-2607}, orcid-numbers = {Péterfi, Zoltán/0000-0001-9658-153X} } @article{MTMT:34025825, title = {A széklettranszplantáció aktuális hazai helyzete}, url = {https://m2.mtmt.hu/api/publication/34025825}, author = {Péterfi, Zoltán and Varga, Adorján and Vigvári, Szabolcs József and Sipos, Dávid}, doi = {10.33570/CEUJGH.9.2.59}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {9}, unique-id = {34025825}, year = {2023}, eissn = {2415-9107}, pages = {59-62}, orcid-numbers = {Péterfi, Zoltán/0000-0001-9658-153X} } @article{MTMT:33588242, title = {Efficacy of lyophilised bacteria-rich faecal sediment and supernatant with reduced bacterial count for treating patients with Clostridioides difficile Infection – A novel method for capsule faecal microbiota transfer}, url = {https://m2.mtmt.hu/api/publication/33588242}, author = {Varga, Adorján and Makszin, Lilla and Bufa, Anita and Sipos, Dávid and Kása, Péter and Pál, Szilárd and Rosenstiel, Philip and Sommer, Felix and Kocsis, Béla and Péterfi, Zoltán}, doi = {10.3389/fcimb.2023.1041384}, journal-iso = {FRONT CELL INFECT MI}, journal = {FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY}, volume = {13}, unique-id = {33588242}, issn = {2235-2988}, year = {2023}, eissn = {2235-2988}, orcid-numbers = {Makszin, Lilla/0000-0002-9764-4763; Kása, Péter/0000-0002-6134-0928; Péterfi, Zoltán/0000-0001-9658-153X} } @article{MTMT:32237455, title = {Severe Fatigue and Memory Impairment Are Associated with Lower Serum Level of Anti-SARS-CoV-2 Antibodies in Patients with Post-COVID Symptoms}, url = {https://m2.mtmt.hu/api/publication/32237455}, author = {Molnár, Tihamér and Várnai, Réka and Schranz, Dániel and Závori, László and Péterfi, Zoltán and Sipos, Dávid and Tőkés-Füzesi, Margit and Illés, Zsolt László and Büki, András and Csécsei, Péter}, doi = {10.3390/jcm10194337}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {10}, unique-id = {32237455}, year = {2021}, eissn = {2077-0383}, orcid-numbers = {Závori, László/0000-0002-1715-4167; Péterfi, Zoltán/0000-0001-9658-153X; Illés, Zsolt László/0000-0001-9655-0450} } @article{MTMT:32056248, title = {How to Apply FMT More Effectively, Conveniently and Flexible – A Comparison of FMT Methods}, url = {https://m2.mtmt.hu/api/publication/32056248}, author = {Varga, Adorján and Kocsis, Béla and Sipos, Dávid and Kása, Péter and Vigvári, Szabolcs József and Pál, Szilárd and Dembrovszky, Fanni and Borbásné Farkas, Kornélia and Péterfi, Zoltán}, doi = {10.3389/fcimb.2021.657320}, journal-iso = {FRONT CELL INFECT MI}, journal = {FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY}, volume = {11}, unique-id = {32056248}, issn = {2235-2988}, year = {2021}, eissn = {2235-2988}, orcid-numbers = {Kása, Péter/0000-0002-6134-0928; Dembrovszky, Fanni/0000-0001-6953-3591; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Péterfi, Zoltán/0000-0001-9658-153X} } @article{MTMT:30637910, title = {Kórokozóspektrum egy hematológiai osztályon}, url = {https://m2.mtmt.hu/api/publication/30637910}, author = {Sipos, Dávid and Nyul, Adrienn and Kovács, Krisztina and Alizadeh, Hussain and Péterfi, Zoltán}, doi = {10.1556/2068.2019.52.1.11}, journal-iso = {HEMATOLÓGIA-TRANSZFUZIOLÓGIA}, journal = {HEMATOLÓGIA-TRANSZFUZIOLÓGIA}, volume = {52}, unique-id = {30637910}, issn = {1786-5913}, year = {2019}, pages = {57-61}, orcid-numbers = {Péterfi, Zoltán/0000-0001-9658-153X} } @article{MTMT:30362752, title = {Experiences with fecal microbiota transplantation in Clostridium difficile infections via upper gastrointestinal tract}, url = {https://m2.mtmt.hu/api/publication/30362752}, author = {Vigvári, Szabolcs József and Vincze, Áron and Solt, Jenő and Sipos, Dávid and Feiszt, Zsófia and Kovács, Beáta and Kappéter, Ágnes and Péterfi, Zoltán}, doi = {10.1556/030.65.2018.051}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {66}, unique-id = {30362752}, issn = {1217-8950}, abstract = {Dramatic changes in the epidemiology of Clostridium difficile infections have been reported from the western world in the past decade. The proportion of severe cases is significantly elevating and clinicians now have to contend with the problem of additional and more frequent episodes of recurrences including an upward trend in the mortality rate. This situation led us to investigate the possibility of the fecal microbiota transplantation (FMT). An amount of 100 ml of fecal microbiota solution was instilled into a nasojejunal (NJ) tube in 16 cases and into a nasogastric (NG) tube in 44 cases. In all of the cases, where the solution was instilled via nasojejunal tubes, the symptoms resolved within 24 h. We did not note any recurrences in this group. When the material was flushed in through nasogastric tubes, the symptoms resolved in 39 (88.64%) cases within 24 h. In this group, we have experienced a recurrent episode of C. difficile infection in five (11.36%) cases. Three of them were cured with a second transplantation. We have found that in our practice the upper gastrointestinal tract methods had the primary cure rate of 91.67%, whereas the secondary cure rate is 96.67%. When we compared the NJ and NG methods, we have found that the differences in the outcomes are not significant statistically (p = 0.3113 using Fisher's exact probability test). In conclusion, FMT proved to be very effective, particularly in recurrent infections and in cases where conventional treatment had failed.}, keywords = {nasojejunal tube; FECAL MICROBIOTA TRANSPLANTATION; nasogastric tube}, year = {2019}, eissn = {1588-2640}, pages = {179-188}, orcid-numbers = {Vincze, Áron/0000-0003-2217-7686; Péterfi, Zoltán/0000-0001-9658-153X} } @article{MTMT:3304835, title = {Faecal microbiota transplantation for Clostridium difficile infection using a lyophilized inoculum from non-related donors: A case series involving 19 patients}, url = {https://m2.mtmt.hu/api/publication/3304835}, author = {Vigvári, Szabolcs József and Sipos, Dávid and Solt, Jenő and Vincze, Áron and Kocsis, Béla and Nemes, Zsuzsanna and Kappéter, Ágnes and Feiszt, Zsófia and Kovács, Beáta and Péterfi, Zoltán}, doi = {10.1556/030.64.2017.042}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {66}, unique-id = {3304835}, issn = {1217-8950}, abstract = {Faecal microbiota transplantation (FMT) has been reported to be effective in treating relapsing of refractory Clostridium difficile infections, although some practical barriers are limiting its widespread use. In this study, our objective was to evaluate the rate of resolution of diarrhea following administration of lyophilized and resolved FMT via a nasogastric (NG) tube. We recruited 19 patients suffered from laboratory-confirmed C. difficile infection. Each of them was treated by lyophilized and resolved inoculum through a NG tube. One participant succumbed following the procedure due to unrelated diseases. Out of 18 cases, 15 patients reportedly experienced a resolution of the symptoms. One patient was treated with another course of antibiotics, and two of the non-responders were successfully retreated with another course of FMT utilizing a lyophilized inoculum. Notably, no significant adverse activities were observed. In accordance to our clinical experiences, a patient will likely benefit from FMT treatment including lyophilized inoculum.}, year = {2019}, eissn = {1588-2640}, pages = {69-78}, orcid-numbers = {Vincze, Áron/0000-0003-2217-7686; Péterfi, Zoltán/0000-0001-9658-153X} } @article{MTMT:30600970, title = {Treatment options of Clostridium difficile infection: our latest experiences with fecal microbiota transplant}, url = {https://m2.mtmt.hu/api/publication/30600970}, author = {Varga, Adorján and Kocsis, Béla and Sipos, Dávid and Vigvári, Szabolcs József and Kása, Péter and Pál, Szilárd and Mikó, Éva and Szereday, László and Bechtolsheim, F. and Péterfi, Zoltán}, journal-iso = {CLIN CHEM LAB MED}, journal = {CLINICAL CHEMISTRY AND LABORATORY MEDICINE}, volume = {56}, unique-id = {30600970}, issn = {1434-6621}, year = {2018}, eissn = {1437-4331}, pages = {eA133-eA133}, orcid-numbers = {Kása, Péter/0000-0002-6134-0928; Szereday, László/0000-0002-1208-2969; Péterfi, Zoltán/0000-0001-9658-153X} }