@article{MTMT:33708483, title = {Prolonged activity of the transposase helper may raise safety concerns during DNA transposon-based gene therapy}, url = {https://m2.mtmt.hu/api/publication/33708483}, author = {Imre, Gergely and Takács, Bertalan Vilmos and Czipa, Erik and Drubi, Andrea and Jaksa, Gábor and Latinovics, Dóra and Nagy, Andrea and Karkas, Réka and Hudoba, Liza and Vásárhelyi, Bálint Márk and Pankotai-Bodó, Gabriella and Blastyák, András and Hegedűs, Zoltán and Germán, Péter and Bálint, Balázs and Abdullah, Khaldoon Sadiq Ahmed and Kopasz, Anna Georgina and Kovács, Anita Kármen and Nagy, László and Sükösd, Farkas and Pintér, Lajos and Rülicke, Thomas and Barta, Endre and Nagy, István and Haracska, Lajos and Mátés, Lajos}, doi = {10.1016/j.omtm.2023.03.003}, journal-iso = {MOL THER-METH CLIN D}, journal = {MOLECULAR THERAPY-METHODS AND CLINICAL DEVELOPMENT}, volume = {29}, unique-id = {33708483}, year = {2023}, eissn = {2329-0501}, pages = {145-159}, orcid-numbers = {Vásárhelyi, Bálint Márk/0000-0003-1782-8691; Kovács, Anita Kármen/0000-0001-9805-1647; Barta, Endre/0000-0002-6753-0714} } @article{MTMT:32773206, title = {A versatile transposon-based technology to generate loss- and gain-of-function phenotypes in the mouse liver}, url = {https://m2.mtmt.hu/api/publication/32773206}, author = {Kopasz, Anna Georgina and Pusztai, Dávid and Karkas, Réka and Hudoba, Liza and Abdullah, Khaldoon Sadiq Ahmed and Imre, Gergely and Pankotai-Bodó, Gabriella and Migh, Ede and Nagy, Andrea and Kriston, András and Germán, Péter and Drubi, Andrea and Molnár, Anna and Fekete, Ildikó and Dani, Virág Éva and Ocsovszki, Imre and Puskás, László and Horváth, Péter and Sükösd, Farkas and Mátés, Lajos}, doi = {10.1186/s12915-022-01262-x}, journal-iso = {BMC BIOL}, journal = {BMC BIOLOGY}, volume = {20}, unique-id = {32773206}, issn = {1741-7007}, year = {2022}, eissn = {1741-7007}, orcid-numbers = {Abdullah, Khaldoon Sadiq Ahmed/0000-0001-9980-3724; Dani, Virág Éva/0000-0001-9715-2569; Ocsovszki, Imre/0000-0003-1290-996X} } @misc{MTMT:32528660, title = {Comparison of the DNA transposon-based approaches in the gene therapy of the Mouse Model of Tyrosinemia Type I}, url = {https://m2.mtmt.hu/api/publication/32528660}, author = {Karkas, R and Blastyák, A and Hudoba, L and Bakné, Drubi A and Imre, Gergely and Mátés, L}, unique-id = {32528660}, year = {2021} } @misc{MTMT:31614585, title = {Somatic-transgenic mouse model to introduce random genome-wide deletions}, url = {https://m2.mtmt.hu/api/publication/31614585}, author = {Imre, Gergely and Hudoba, L and Nagy, A and Balazs, B and Nagy, I and Rülicke, T and Mates, L}, unique-id = {31614585}, year = {2016} } @misc{MTMT:31614602, title = {A novel transgenic organ model to screen for the genetic drivers of tumorgenesis}, url = {https://m2.mtmt.hu/api/publication/31614602}, author = {Nagy, A and Hudoba, L and Imre, Gergely and Hegedus, K and Fekete, I and Rulicke, T and Mates, L}, unique-id = {31614602}, year = {2015} } @article{MTMT:2998018, title = {Transposon-based gene delivery vectors for gene therapy}, url = {https://m2.mtmt.hu/api/publication/2998018}, author = {Nagy, Andrea and Imre, Gergely and Mátés, Lajos}, journal-iso = {ACTA BIOL SZEGED}, journal = {ACTA BIOLOGICA SZEGEDIENSIS}, volume = {59}, unique-id = {2998018}, issn = {1588-385X}, abstract = {The first gene therapy clinical trials were initiated more than two decades ago thanks to the previous development of viral vectors that allow high efficiency gene transfer into mammalian cells. Since then the application of viral gene transfer has been a successful treatment option for a variety of diseases. Hematopoietic stem cells (HSCs) represent the most frequently targeted cell population for the treatment of severe monogenic diseases as their gene therapeutic correction is a valid alternative to conventional HSC transplantation when a compatible donor is not available. Indeed, viral gene transfer was successfully applied in HSC-based ex vivo gene therapy of the blood and immune systems, albeit several studies have exposed serious adverse effects that were caused by the therapeutic vector induced inappropriate activation of proto-oncogenes. After these failures, researchers have developed new types of randomly integrating vectors that have proven safer in preclinical studies, which is consistent with interim reports of clinical trials also foreshadowing that they potentially have an improved safety profile. This review focuses on new and clinically relevant DNA transposon-based gene delivery vectors, and compares their properties with those of the old and new generation viral vectors.}, keywords = {Gene Therapy; piggyback; TRANSPOSABLE ELEMENTS; Non-viral vectors; Sleeping beauty}, year = {2015}, eissn = {1588-4082}, pages = {247-260} } @{MTMT:1945980, title = {Characterization of HMG-CoA reductase genes of the carotenoid producing Mucor circinelloides}, url = {https://m2.mtmt.hu/api/publication/1945980}, author = {Nagy, Gábor and Csernetics, Árpád and Imre, Gergely and Farkas, Anita and Vágvölgyi, Csaba and Papp, Tamás}, booktitle = {2nd CEFSER (Center of Excellence in Food Safety and Emerging Risks) Workshop Persistant Organic Pollutants in Food and the Environment [and] 26th Symposium on Recent Developments in Dairy Technology [and] BIOXEN seminar Novel Approaches for Environmental Protection}, unique-id = {1945980}, year = {2011}, pages = {54}, orcid-numbers = {Nagy, Gábor/0000-0002-7871-6098; Vágvölgyi, Csaba/0000-0003-0009-7773; Papp, Tamás/0000-0001-8211-5431} } @article{MTMT:1945835, title = {HMG-CoA reductase genes of the carotenoid producing Mucor circinelloides}, url = {https://m2.mtmt.hu/api/publication/1945835}, author = {Nagy, Gábor and Farkas, Anita and Imre, Gergely and Csernetics, Árpád and Vágvölgyi, Csaba and Papp, Tamás}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {58}, unique-id = {1945835}, issn = {1217-8950}, year = {2011}, eissn = {1588-2640}, pages = {190}, orcid-numbers = {Nagy, Gábor/0000-0002-7871-6098; Vágvölgyi, Csaba/0000-0003-0009-7773; Papp, Tamás/0000-0001-8211-5431} } @article{MTMT:1939772, title = {A prenyl pyrophosphate synthase gene from the zygomycete fungus, Gilbertella persicaria}, url = {https://m2.mtmt.hu/api/publication/1939772}, author = {Nagy, Gábor and Imre, Gergely and Csernetics, Árpád and Petkovits, Tamás and Nagy, László and Szekeres, András and Vágvölgyi, Csaba and Papp, Tamás}, journal-iso = {ACTA BIOL SZEGED}, journal = {ACTA BIOLOGICA SZEGEDIENSIS}, volume = {55}, unique-id = {1939772}, issn = {1588-385X}, year = {2011}, eissn = {1588-4082}, pages = {7-12}, orcid-numbers = {Nagy, Gábor/0000-0002-7871-6098; Szekeres, András/0000-0003-1651-4623; Vágvölgyi, Csaba/0000-0003-0009-7773; Papp, Tamás/0000-0001-8211-5431} } @{MTMT:1968802, title = {Characterization of HMG-CoA reductase genes in Mucor circinelloides}, url = {https://m2.mtmt.hu/api/publication/1968802}, author = {Nagy, Gábor and Csernetics, Árpád and Imre, Gergely and Vágvölgyi, Csaba and Papp, Tamás}, booktitle = {ISIRR 2010 - 11th International Symposium "Interdisciplinary Regional Research"}, unique-id = {1968802}, year = {2010}, orcid-numbers = {Nagy, Gábor/0000-0002-7871-6098; Vágvölgyi, Csaba/0000-0003-0009-7773; Papp, Tamás/0000-0001-8211-5431} }