@article{MTMT:35201814,
	title = {Ball-Milling Enhanced UV Protection Performance of Ca2Fe-Sulisobenzone Layered Double Hydroxide Organic Clay},
	url = {https://m2.mtmt.hu/api/publication/35201814},
	author = {Szabados, Márton and Mészáros, Rebeka Ildikó and Dobó, Dorina Gabriella and Kónya, Zoltán and Kukovecz, Ákos and Sipos, Pál Miklós},
	doi = {10.3390/nano14171436},
	journal-iso = {NANOMATERIALS-BASEL},
	journal = {NANOMATERIALS},
	volume = {14},
	unique-id = {35201814},
	abstract = {Using a co-precipitation technique, the anionic form of sulisobenzone (benzophenone-4) sunscreen ingredient was incorporated into the interlayer space of CaFe-hydrocalumite for the first time. Using detailed post-synthetic millings of the photoprotective nanocomposite obtained, we aimed to study the mechanochemical effects on complex, hybridized layered double hydroxides (LDHs). Various physicochemical properties of the ground and the intact LDHs were compared by powder X-ray diffractometry, N2 adsorption-desorption, UV–Vis diffuse reflectance, infrared and Raman spectroscopy, scanning electron microscopy and thermogravimetric measurements. The data showed significant structural and morphological deformations, surface and textural changes and multifarious thermal behavior. The most interesting development was the change in the optical properties of organic LDHs; the milling significantly improved the UV light blocking ability, especially around 320 nm. Spectroscopic results verified that this could be explained by a modification in interaction between the LDH layers and the sulisobenzone anions, through modulated π–π conjugation and light absorption of benzene rings. In addition to the vibrating mill often used in the laboratory, the photoprotection reinforcement can also be induced by the drum mill grinding system commonly applied in industry.},
	year = {2024},
	eissn = {2079-4991},
	orcid-numbers = {Szabados, Márton/0000-0002-7588-335X; Mészáros, Rebeka Ildikó/0000-0002-2860-3431; Kónya, Zoltán/0000-0002-9406-8596; Kukovecz, Ákos/0000-0003-0716-9557; Sipos, Pál Miklós/0000-0003-1407-0950}
}

@article{MTMT:35069127,
	title = {Investigation of the Electrokinetic Potential of Granules and Optimization of the Pelletization Method Using the Quality by Design Approach},
	url = {https://m2.mtmt.hu/api/publication/35069127},
	author = {Mahmoud, Azza and Hassan, Alharith Abdulraheem Abdulmajeed and Dobó, Dorina Gabriella and Ludasi, Krisztina and Janovák, László and Regdon, Géza (ifj.) and Pannonhalminé Csóka, Ildikó and Kristó, Katalin},
	doi = {10.3390/pharmaceutics16070848},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {16},
	unique-id = {35069127},
	issn = {1999-4923},
	abstract = {The preparation of pellets using a high-shear granulator in a rapid single-step is considered a good economic alternative to the extrusion spheronization process. As process parameters and material attributes greatly affect pellet qualities, successful process optimization plays a vital role in producing pellet dosage forms with the required critical quality attributes. This study was aimed at the development and optimization of the pelletization technique with the Pro-CepT granulator. According to the quality by design (QbD) and screening design results, chopper speed, the volume of the granulating liquid, binder amount, and impeller speed were selected as the highest risk variables for a two-level full factorial design and central composite design, which were applied to the formula of microcrystalline cellulose, mannitol, and with a binding aqueous polyvinylpyrrolidone solution. The design space was estimated based on physical response results, including the total yield of the required size, hardness, and aspect ratio. The optimized point was tested with two different types of active ingredients. Amlodipine and hydrochlorothiazide were selected as model drugs and were loaded into an optimized formulation. The kinetics of the release of the active agent was examined and found that the results show a correlation with the electrokinetic potential because amlodipine besylate can be adsorbed on the surface of the MCC, while hydrochlorothiazide less so; therefore, in this case, the release of the active agent increases. The research results revealed no significant differences between plain and model drug pellets, except for hydrochlorothiazide yield percent, in addition to acceptable content uniformity and dissolution enhancement.},
	year = {2024},
	eissn = {1999-4923},
	orcid-numbers = {Janovák, László/0000-0002-2066-319X; Regdon, Géza (ifj.)/0000-0002-6921-3069; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@misc{MTMT:34411568,
	title = {Liposzómás gyógyszerkészítmények gyártástechnológiai fejlesztése},
	url = {https://m2.mtmt.hu/api/publication/34411568},
	author = {Dobó, Dorina Gabriella and Csóka, Ildikó},
	unique-id = {34411568},
	year = {2023},
	orcid-numbers = {Csóka, Ildikó/0000-0003-0807-2781}
}

@misc{MTMT:33692135,
	title = {Hatóanyag-tartalmú liposzómák előállítása és jellemzése},
	url = {https://m2.mtmt.hu/api/publication/33692135},
	author = {Dobó, Dorina Gabriella and Németh, Zsófia and Reza, Semnani and Pannonhalminé Csóka, Ildikó},
	unique-id = {33692135},
	year = {2022},
	orcid-numbers = {Németh, Zsófia/0000-0003-3953-9831; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@CONFERENCE{MTMT:33199232,
	title = {Liposzómás készítmények gyártástechnológiai fejlesztése},
	url = {https://m2.mtmt.hu/api/publication/33199232},
	author = {Dobó, Dorina Gabriella and Németh, Zsófia and Sipos, Bence and Reza, Semnani Jazani and Pannonhalminé Csóka, Ildikó},
	booktitle = {Gyógyszertechnológiai és Ipari Gyógyszerészeti Konferencia 2022: A Magyar Gyógyszerésztudományi Társaság Gyógyszeripari Szervezetének és Gyógyszertechnológiai Szakosztályának Konferenciája},
	unique-id = {33199232},
	year = {2022},
	pages = {50-50},
	orcid-numbers = {Németh, Zsófia/0000-0003-3953-9831; Sipos, Bence/0000-0002-0131-4728; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@article{MTMT:33070907,
	title = {Quality by Design-Driven Zeta Potential Optimisation Study of Liposomes with Charge Imparting Membrane Additives},
	url = {https://m2.mtmt.hu/api/publication/33070907},
	author = {Németh, Zsófia and Pannonhalminé Csóka, Ildikó and Semnani Jazani, Reza and Sipos, Bence and Haspel, Henrik and Kozma, Gábor and Kónya, Zoltán and Dobó, Dorina Gabriella},
	doi = {10.3390/pharmaceutics14091798},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {14},
	unique-id = {33070907},
	issn = {1999-4923},
	abstract = {Liposomal formulations, as versatile nanocarrier systems suitable for targeted delivery, have a highly focused role in the therapy development of unmet clinical needs and diagnostic imaging techniques. Formulating nanomedicine with suitable zeta potential is an essential but challenging task. Formulations with a minimum ±30 mV zeta potential are considered stable. The charge of the phospholipid bilayer can be adjusted with membrane additives. The present Quality by Design-derived study aimed to optimise liposomal formulations prepared via the thin-film hydration technique by applying stearylamine (SA) or dicetyl phosphate (DCP) as charge imparting agents. This 32 fractional factorial design-based study determined phosphatidylcholine, cholesterol, and SA/DCP molar ratios for liposomes with characteristics meeting the formulation requirements. The polynomials describing the effects on the zeta potential were calculated. The optimal molar ratios of the lipids were given as 12.0:5.0:5.0 for the SA-PBS pH 5.6 (optimised sample containing stearylamine) and 8.5:4.5:6.5 for the DCP-PBS pH 5.6 (optimised sample containing dicetyl phosphate) particles hydrated with phosphate-buffered saline pH 5.6. The SA-PBS pH 5.6 liposomes had a vesicle size of 108 ± 15 nm, 0.20 ± 0.04 polydispersity index, and +30.1 ± 1.2 mV zeta potential, while these values were given as 88 ± 14 nm, 0.21 ± 0.02, and −36.7 ± 3.3 mV for the DCP-PBS pH 5.6 vesicles. The prepared liposomes acquired the requirements of the zeta potential for stable formulations.},
	year = {2022},
	eissn = {1999-4923},
	orcid-numbers = {Németh, Zsófia/0000-0003-3953-9831; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781; Sipos, Bence/0000-0002-0131-4728; Haspel, Henrik/0000-0002-1362-2752; Kozma, Gábor/0000-0003-2033-0720; Kónya, Zoltán/0000-0002-9406-8596; Dobó, Dorina Gabriella/0000-0001-9528-9983}
}

@article{MTMT:32707423,
	title = {Pharmaceutical Development and Design of Thermosensitive Liposomes Based on the QbD Approach},
	url = {https://m2.mtmt.hu/api/publication/32707423},
	author = {Dobó, Dorina Gabriella and Németh, Zsófia and Sipos, Bence and Cseh, Martin and Pallagi, Edina and Berkesi, Dániel Simon and Kozma, Gábor and Kónya, Zoltán and Pannonhalminé Csóka, Ildikó},
	doi = {10.3390/molecules27051536},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {27},
	unique-id = {32707423},
	issn = {1420-3049},
	year = {2022},
	eissn = {1420-3049},
	orcid-numbers = {Németh, Zsófia/0000-0003-3953-9831; Sipos, Bence/0000-0002-0131-4728; Kozma, Gábor/0000-0003-2033-0720; Kónya, Zoltán/0000-0002-9406-8596; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@{MTMT:32613069,
	title = {Pharmaceutical study of essential oil-loaded liposomal formulations},
	url = {https://m2.mtmt.hu/api/publication/32613069},
	author = {Reza, Semnani Jazani and Németh, Zsófia and Dobó, Dorina Gabriella and Pannonhalminé Csóka, Ildikó},
	booktitle = {IV. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science : book of abstracts},
	doi = {10.14232/syrptbrs.2022.59},
	unique-id = {32613069},
	year = {2022},
	pages = {59-59},
	orcid-numbers = {Németh, Zsófia/0000-0003-3953-9831; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@{MTMT:32612795,
	title = {Risk-based optimization of liposome-based nano-carrier systems},
	url = {https://m2.mtmt.hu/api/publication/32612795},
	author = {Németh, Zsófia and Reza, Semnani Jazani and Sipos, Bence and Dobó, Dorina Gabriella and Pallagi, Edina and Pannonhalminé Csóka, Ildikó},
	booktitle = {IV. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science : book of abstracts},
	doi = {10.14232/syrptbrs.2022.44},
	unique-id = {32612795},
	year = {2022},
	pages = {44-44},
	orcid-numbers = {Németh, Zsófia/0000-0003-3953-9831; Sipos, Bence/0000-0002-0131-4728; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@misc{MTMT:32748244,
	title = {Essential oils and liposomes – Potentials in their pharmaceutical use},
	url = {https://m2.mtmt.hu/api/publication/32748244},
	author = {Reza, Semnani Jazani and Németh, Zsófia and Dobó, Dorina Gabriella and Pannonhalminé Csóka, Ildikó},
	unique-id = {32748244},
	year = {2021},
	orcid-numbers = {Németh, Zsófia/0000-0003-3953-9831; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}