@article{MTMT:33688118,
	title = {Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia},
	url = {https://m2.mtmt.hu/api/publication/33688118},
	author = {Barabási, Beáta and Barna, Lilla and Santa Maria, Anaraquel and Harazin, András and Molnár, Réka and Kincses, András and Vigh, Judit Piroska and Dukay, Brigitta and Sántha, Miklós and Tóth, Erzsébet Melinda and Walter, Fruzsina and Deli, Mária Anna and Hoyk, Zsófia},
	doi = {10.1186/s12987-023-00418-3},
	journal-iso = {FLUIDS BARRIERS CNS},
	journal = {FLUIDS AND BARRIERS OF THE CNS},
	volume = {20},
	unique-id = {33688118},
	issn = {2045-8118},
	year = {2023},
	eissn = {2045-8118},
	orcid-numbers = {Santa Maria, Anaraquel/0000-0003-3505-5477; Harazin, András/0000-0002-0904-5606; Molnár, Réka/0000-0002-3128-825X; Walter, Fruzsina/0000-0001-8145-2823; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:33064300,
	title = {Cellular Therapy Using Epitope-Imprinted Composite Nanoparticles to Remove α-Synuclein from an In Vitro Model},
	url = {https://m2.mtmt.hu/api/publication/33064300},
	author = {Lee, Mei-Hwa and Jan, Jeng-Shiung and Thomas, James L. and Shih, Yuan-Pin and Li, Jin-An and Lin, Chien-Yu and Ooya, Tooru and Barna, Lilla and Mészáros, Mária and Harazin, András and Porkoláb, Gergő and Veszelka, Szilvia and Deli, Mária Anna and Lin, Hung-Yin},
	doi = {10.3390/cells11162584},
	journal-iso = {CELLS-BASEL},
	journal = {CELLS},
	volume = {11},
	unique-id = {33064300},
	abstract = {Several degenerative disorders of the central nervous system, including Parkinson’s disease (PD), are related to the pathological aggregation of proteins. Antibodies against toxic disease proteins, such as α-synuclein (SNCA), are therefore being developed as possible therapeutics. In this work, one peptide (YVGSKTKEGVVHGVA) from SNCA was used as the epitope to construct magnetic molecularly imprinted composite nanoparticles (MMIPs). These composite nanoparticles were characterized by dynamic light scattering (DLS), high-performance liquid chromatography (HPLC), isothermal titration calorimetry (ITC), Brunauer–Emmett–Teller (BET) analysis, and superconducting quantum interference device (SQUID) analysis. Finally, the viability of brain endothelial cells that were treated with MMIPs was measured, and the extraction of SNCA from CRISPR/dCas9a-activated HEK293T cells from the in vitro model system was demonstrated for the therapeutic application of MMIPs.},
	year = {2022},
	eissn = {2073-4409},
	orcid-numbers = {Jan, Jeng-Shiung/0000-0002-8379-404X; Ooya, Tooru/0000-0001-7766-5455; Harazin, András/0000-0002-0904-5606; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:32779076,
	title = {Novel cyclic C5-curcuminoids penetrating the blood-brain barrier: design, synthesis and antiproliferative activity against astrocytoma and neuroblastoma cells},
	url = {https://m2.mtmt.hu/api/publication/32779076},
	author = {Huber, Imre and Pandur, Edina and Sipos, Katalin and Barna, Lilla and Harazin, András and Deli, Mária Anna and Tyukodi, Levente and Gulyás, Gergely and Kulcsár, Győző and Rozmer, Zsuzsanna},
	doi = {10.1016/j.ejps.2022.106184},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {173},
	unique-id = {32779076},
	issn = {0928-0987},
	abstract = {Novel series of cyclic C5-curcuminoids 17a-j and 19-22 were prepared as cytotoxic agents and evaluated against human neuroblastoma (SH-SY5Y) or human grade IV astrocytoma (CCF-STTG1) cell lines in low (∼0.1 nM - 10 nM) concentrations. Among the tested 21 derivatives, 16 displayed potent antiproliferative activity with IC50 values in the low nanomolar to picomolar range (IC50 = 7.483-0.139 nM). Highly active compounds like N-monocarboxylic derivative 19b with IC50 = 0.139 nM value against neuroblastoma and N-alkyl substituted 11 with IC50 = 0.257 nM against astrocytoma proved some degree of selectivity toward non-cancerous astrocytes and kidney cells. This potent anticancer activity did not show a strong correlation with experimental logPTLC values, but the most potent antiproliferative molecules 11-13 and 19-22 are belonging to discrete subgroups of the cyclic C5-curcuminoids. Compounds 12, 17c and 19b were subjected to blood-brain barrier (BBB) penetration studies, too. The BBB was revealed to be permeable for all of them but, as the apparent permeability coefficient (Papp) values mirrored, in different ratios. Lower toxicity of 12, 17c and 19b was observed toward primary rat brain endothelial cells of the BBB model, which means they remained undamaged under 10 µM concentrations. Penetration depends, at least in part, on albumin binding of 12, 17c and 19b and the presence of monocarboxylic acid transporters in the case of 19b. Permeation through the BBB and albumin binding, we described here, is the first example of cyclic C5-curcuminoids as to our knowledge.},
	year = {2022},
	eissn = {1879-0720},
	orcid-numbers = {Huber, Imre/0000-0003-0217-0188; Pandur, Edina/0000-0001-5012-3242; Sipos, Katalin/0000-0002-6706-2682; Harazin, András/0000-0002-0904-5606; Deli, Mária Anna/0000-0001-6084-6524; Tyukodi, Levente/0000-0002-8983-1876; Kulcsár, Győző/0000-0002-4098-1072}
}

@article{MTMT:32667372,
	title = {Blood–brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells},
	url = {https://m2.mtmt.hu/api/publication/32667372},
	author = {Walter, Fruzsina and Harazin, András and Tóth, Andrea and Veszelka, Szilvia and Santa Maria, Anaraquel and Barna, Lilla and Kincses, András and Biczo, G and Balla, Zsolt and Kui, Balázs and Maléth, József and Cervenak, László and Tubak, Vilmos and Kittel, Ágnes and Rakonczay, Zoltán and Deli, Mária Anna},
	doi = {10.1186/s12987-022-00308-0},
	journal-iso = {FLUIDS BARRIERS CNS},
	journal = {FLUIDS AND BARRIERS OF THE CNS},
	volume = {19},
	unique-id = {32667372},
	issn = {2045-8118},
	year = {2022},
	eissn = {2045-8118},
	orcid-numbers = {Walter, Fruzsina/0000-0001-8145-2823; Harazin, András/0000-0002-0904-5606; Santa Maria, Anaraquel/0000-0003-3505-5477; Maléth, József/0000-0001-5768-3090; Cervenak, László/0000-0003-0166-8697; Tubak, Vilmos/0000-0002-6141-3920; Rakonczay, Zoltán/0000-0002-1499-3416; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:32491017,
	title = {S1R agonist modulates rat platelet eicosanoid synthesis and aggregation},
	url = {https://m2.mtmt.hu/api/publication/32491017},
	author = {Váczi, Sándor and Barna, Lilla and Harazin, András and Mészáros, Mária and Porkoláb, Gergő and Zvara, Ágnes and Ónody, Rita and Földesi, Imre and Veszelka, Szilvia and Penke, Botond and Fülöp, Lívia and Deli, Mária Anna and Mezei, Zsófia},
	doi = {10.1080/09537104.2021.1981843},
	journal-iso = {PLATELETS},
	journal = {PLATELETS},
	volume = {33},
	unique-id = {32491017},
	issn = {0953-7104},
	abstract = {Sigma-1 receptor (S1R) is detected in different cell types and can regulate intracellular signaling pathways. S1R plays a role in the pathomechanism of diseases and the regulation of neurotransmitters. Fluvoxamine can bind to S1R and reduce the serotonin uptake of neurons and platelets. We therefore hypothesized that platelets express S1R, which can modify platelet function. The expression of the SIGMAR1 gene in rat platelets was examined with a reverse transcription polymerase chain reaction and a quantitative polymerase chain reaction. The receptor was also visualized by immunostaining and confocal laser scanning microscopy. The effect of S1R agonist PRE-084 on the eicosanoid synthesis of isolated rat platelets and ADP- and AA-induced platelet aggregation was examined. S1R was detected in rat platelets both at gene and protein levels. Pretreatment with PRE-084 of resting platelets induced elevation of eicosanoid synthesis. The rate of elevation in thromboxane B2 and prostaglandin D2 synthesis was similar, but the production of prostaglandin E2 was higher. The concentration-response curve showed a sigmoidal form. The most effective concentration of the agonist was 2 µM. PRE-084 increased the quantity of cyclooxygenase-1 as detected by ELISA. PRE-084 also elevated the ADP- and AA-induced platelet aggregation. S1R of platelets might regulate physiological or pathological functions. © 2021 Taylor & Francis Group, LLC.},
	keywords = {AGGREGATION; PLATELETS; Sigma-1 receptor; Eicosanoid; PRE-084},
	year = {2022},
	eissn = {1369-1635},
	pages = {709-718},
	orcid-numbers = {Váczi, Sándor/0000-0002-9642-7126; Harazin, András/0000-0002-0904-5606; Földesi, Imre/0000-0002-3329-8136; Penke, Botond/0000-0003-0938-0567; Fülöp, Lívia/0000-0002-8010-0129; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:32258744,
	title = {Kynurenic acid and its analogue SZR-72 ameliorate the severity of experimental acute necrotizing pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/32258744},
	author = {Balla, Zsolt and Kormányos, Eszter Sára and Kui, Balázs and Bálint, Emese Réka and Fűr, Gabriella and Orján, Erik Márk and Iványi, Béla and Vécsei, László and Fülöp, Ferenc and Varga, Gabriella and Harazin, András and Tubak, Vilmos and Deli, Mária Anna and Papp, Csaba Gergő and Gácser, Attila and Madácsy, Tamara and Venglovecz, Viktória and Maléth, József and Hegyi, Péter and Kiss, Lóránd and Rakonczay, Zoltán},
	doi = {10.3389/fimmu.2021.702764},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {12},
	unique-id = {32258744},
	issn = {1664-3224},
	year = {2021},
	eissn = {1664-3224},
	orcid-numbers = {Orján, Erik Márk/0000-0003-4176-0834; Vécsei, László/0000-0001-8037-3672; Fülöp, Ferenc/0000-0003-1066-5287; Varga, Gabriella/0000-0003-1888-8629; Harazin, András/0000-0002-0904-5606; Tubak, Vilmos/0000-0002-6141-3920; Deli, Mária Anna/0000-0001-6084-6524; Papp, Csaba Gergő/0000-0003-4450-0667; Madácsy, Tamara/0000-0001-5598-9723; Venglovecz, Viktória/0000-0002-2316-7247; Maléth, József/0000-0001-5768-3090; Hegyi, Péter/0000-0003-0399-7259; Rakonczay, Zoltán/0000-0002-1499-3416}
}

@article{MTMT:32166650,
	title = {Identification of Reference Genes for Circadian Studies on Brain Microvessels and Choroid Plexus Samples Isolated from Rats},
	url = {https://m2.mtmt.hu/api/publication/32166650},
	author = {Szczepkowska, Aleksandra and Harazin, András and Barna, Lilla and Deli, Mária Anna and Skipor, Janina},
	doi = {10.3390/biom11081227},
	journal-iso = {BIOMOLECULES},
	journal = {BIOMOLECULES},
	volume = {11},
	unique-id = {32166650},
	issn = {2218-273X},
	year = {2021},
	eissn = {2218-273X},
	orcid-numbers = {Szczepkowska, Aleksandra/0000-0001-5578-3063; Harazin, András/0000-0002-0904-5606; Deli, Mária Anna/0000-0001-6084-6524; Skipor, Janina/0000-0001-5900-6472}
}

@article{MTMT:31385933,
	title = {Development and Characterization of Potential Ocular Mucoadhesive Nano Lipid Carriers Using Full Factorial Design},
	url = {https://m2.mtmt.hu/api/publication/31385933},
	author = {L. Kiss, Eszter and Berkó, Szilvia and Gácsi, Attila and Kovács, Anita and Katona, Gábor and Soós, Judit and Csányi, Erzsébet and Gróf, Ilona and Harazin, András and Deli, Mária Anna and Balogh, György Tibor and Budai-Szűcs, Mária},
	doi = {10.3390/pharmaceutics12070682},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {12},
	unique-id = {31385933},
	issn = {1999-4923},
	year = {2020},
	eissn = {1999-4923},
	orcid-numbers = {Berkó, Szilvia/0000-0002-3842-8876; Kovács, Anita/0000-0001-5593-1329; Katona, Gábor/0000-0003-1564-4813; Csányi, Erzsébet/0000-0002-3010-1959; Harazin, András/0000-0002-0904-5606; Deli, Mária Anna/0000-0001-6084-6524; Balogh, György Tibor/0000-0003-3347-1880; Budai-Szűcs, Mária/0000-0001-5187-5702}
}

@article{MTMT:31377384,
	title = {Combination of Alanine and Glutathione as Targeting Ligands of Nanoparticles Enhances Cargo Delivery into the Cells of the Neurovascular Unit},
	url = {https://m2.mtmt.hu/api/publication/31377384},
	author = {Porkoláb, Gergő and Mészáros, Mária and Tóth, András and Szecskó, Anikó and Harazin, András and Szegletes, Zsolt and Ferenc, Györgyi and Blastyák, András and Mátés, Lajos and Rákhely, Gábor and Deli, Mária Anna and Veszelka, Szilvia},
	doi = {10.3390/pharmaceutics12070635},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {12},
	unique-id = {31377384},
	issn = {1999-4923},
	year = {2020},
	eissn = {1999-4923},
	orcid-numbers = {Harazin, András/0000-0002-0904-5606; Szegletes, Zsolt/0000-0003-2202-6933; Ferenc, Györgyi/0000-0002-3456-319X; Rákhely, Gábor/0000-0003-2557-3641; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:31335512,
	title = {The Effect of Sodium Bicarbonate, a Beneficial Adjuvant Molecule in Cystic Fibrosis, on Bronchial Epithelial Cells Expressing a Wild-Type or Mutant CFTR Channel},
	url = {https://m2.mtmt.hu/api/publication/31335512},
	author = {Gróf, Ilona and Bocsik, Alexandra and Harazin, András and Santa Maria, Anaraquel and Vizsnyiczai, Gaszton and Barna, Lilla and Kiss, Lóránd and Fűr, Gabriella and Rakonczay, Zoltán and Ambrus, Rita and Révész, Piroska and Gosselet, Fabien and Pongsiri, Jaikumpun and Szabó, Hajnalka and Zsembery, Ákos and Deli, Mária Anna},
	doi = {10.3390/ijms21114024},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {21},
	unique-id = {31335512},
	issn = {1661-6596},
	year = {2020},
	eissn = {1422-0067},
	orcid-numbers = {Harazin, András/0000-0002-0904-5606; Santa Maria, Anaraquel/0000-0003-3505-5477; Vizsnyiczai, Gaszton/0000-0003-3245-3736; Rakonczay, Zoltán/0000-0002-1499-3416; Révész, Piroska/0000-0002-5336-6052; Pongsiri, Jaikumpun/0000-0001-9160-2645; Zsembery, Ákos/0000-0003-0253-9379; Deli, Mária Anna/0000-0001-6084-6524}
}