@article{MTMT:34019088,
	title = {The role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex},
	url = {https://m2.mtmt.hu/api/publication/34019088},
	author = {Fabó, Dániel and Bokodi, Virág and Szabó, Johanna Petra and Tóth, Emília and Salami, Pariya and Keller, Corey J and Hajnal, Boglárka Zsófia and Thesen, Thomas and Devinsky, Orrin and Doyle, Werner and Mehta, Ashesh and Madsen, Joseph and Eskandar, Emad and Erőss, Loránd and Ulbert, István and Halgren, Eric and Cash, Sydney S},
	doi = {10.1038/s41598-022-22497-2},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {34019088},
	issn = {2045-2322},
	abstract = {Describing intracortical laminar organization of interictal epileptiform discharges (IED) and high frequency oscillations (HFOs), also known as ripples. Defining the frequency limits of slow and fast ripples. We recorded potential gradients with laminar multielectrode arrays (LME) for current source density (CSD) and multi-unit activity (MUA) analysis of interictal epileptiform discharges IEDs and HFOs in the neocortex and mesial temporal lobe of focal epilepsy patients. IEDs were observed in 20/29, while ripples only in 9/29 patients. Ripples were all detected within the seizure onset zone (SOZ). Compared to hippocampal HFOs, neocortical ripples proved to be longer, lower in frequency and amplitude, and presented non-uniform cycles. A subset of ripples (≈ 50%) co-occurred with IEDs, while IEDs were shown to contain variable high-frequency activity, even below HFO detection threshold. The limit between slow and fast ripples was defined at 150 Hz, while IEDs' high frequency components form clusters separated at 185 Hz. CSD analysis of IEDs and ripples revealed an alternating sink-source pair in the supragranular cortical layers, although fast ripple CSD appeared lower and engaged a wider cortical domain than slow ripples MUA analysis suggested a possible role of infragranularly located neural populations in ripple and IED generation. Laminar distribution of peak frequencies derived from HFOs and IEDs, respectively, showed that supragranular layers were dominated by slower (< 150 Hz) components. Our findings suggest that cortical slow ripples are generated primarily in upper layers while fast ripples and associated MUA in deeper layers. The dissociation of macro- and microdomains suggests that microelectrode recordings may be more selective for SOZ-linked ripples. We found a complex interplay between neural activity in the neocortical laminae during ripple and IED formation. We observed a potential leading role of cortical neurons in deeper layers, suggesting a refined utilization of LMEs in SOZ localization.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Fabó, Dániel/0000-0001-5141-5351; Szabó, Johanna Petra/0000-0001-7690-9171; Erőss, Loránd/0000-0002-5796-5546; Ulbert, István/0000-0001-9941-9159}
}

@article{MTMT:32785453,
	title = {Bursting of excitatory cells is linked to interictal epileptic discharge generation in humans.},
	url = {https://m2.mtmt.hu/api/publication/32785453},
	author = {Hofer, Katharina and Kandrács, Ágnes and Tóth, Kinga and Hajnal, Boglárka Zsófia and Bokodi, Virág and Tóth, Estilla Zsófia and Erőss, Loránd and Entz, László and Bagó, Attila György and Fabó, Dániel and Ulbert, István and Wittner, Lucia},
	doi = {10.1038/s41598-022-10319-4},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {12},
	unique-id = {32785453},
	issn = {2045-2322},
	abstract = {Knowledge about the activity of single neurons is essential in understanding the mechanisms of synchrony generation, and particularly interesting if related to pathological conditions. The generation of interictal spikes-the hypersynchronous events between seizures-is linked to hyperexcitability and to bursting behaviour of neurons in animal models. To explore its cellular mechanisms in humans we investigated the activity of clustered single neurons in a human in vitro model generating both physiological and epileptiform synchronous events. We show that non-epileptic synchronous events resulted from the finely balanced firing of excitatory and inhibitory cells, which was shifted towards an enhanced excitability in epileptic tissue. In contrast, interictal-like spikes were characterised by an asymmetric overall neuronal discharge initiated by excitatory neurons with the presumptive leading role of bursting pyramidal cells, and possibly terminated by inhibitory interneurons. We found that the overall burstiness of human neocortical neurons is not necessarily related to epilepsy, but the bursting behaviour of excitatory cells comprising both intrinsic and synaptically driven bursting is clearly linked to the generation of epileptiform synchrony.},
	year = {2022},
	eissn = {2045-2322},
	orcid-numbers = {Kandrács, Ágnes/0000-0002-6408-2397; Tóth, Kinga/0000-0002-8751-8499; Erőss, Loránd/0000-0002-5796-5546; Fabó, Dániel/0000-0001-5141-5351; Ulbert, István/0000-0001-9941-9159; Wittner, Lucia/0000-0001-6800-0953}
}

@article{MTMT:31794996,
	title = {Laminar distribution of electrically evoked hippocampal short latency ripple activity highlights the importance of the subiculum in vivo in human epilepsy, an intraoperative study},
	url = {https://m2.mtmt.hu/api/publication/31794996},
	author = {Tóth, Emília and Bokodi, Virág and Somogyvári, Zoltán and Maglóczky, Zsófia and Wittner, Lucia and Ulbert, István and Erőss, Loránd and Fabó, Dániel},
	doi = {10.1016/j.eplepsyres.2020.106509},
	journal-iso = {EPILEPSY RES},
	journal = {EPILEPSY RESEARCH},
	volume = {169},
	unique-id = {31794996},
	issn = {0920-1211},
	year = {2021},
	eissn = {1872-6844},
	orcid-numbers = {Wittner, Lucia/0000-0001-6800-0953; Ulbert, István/0000-0001-9941-9159; Erőss, Loránd/0000-0002-5796-5546; Fabó, Dániel/0000-0001-5141-5351}
}

@article{MTMT:30868010,
	title = {Reorganization of Large-Scale Functional Networks during Low-Frequency Electrical Stimulation of the Cortical Surface},
	url = {https://m2.mtmt.hu/api/publication/30868010},
	author = {File, Bálint and Nánási, Tibor and Tóth, E. and Bokodi, Virág and Tóth, Brigitta and Hajnal, Boglárka Zsófia and Balogh-Kardos, Zsófia Klára and Entz, László and Erőss, Loránd and Ulbert, István and Fabó, Dániel},
	doi = {10.1142/S0129065719500229},
	journal-iso = {INT J NEURAL SYST},
	journal = {INTERNATIONAL JOURNAL OF NEURAL SYSTEMS},
	volume = {30},
	unique-id = {30868010},
	issn = {0129-0657},
	year = {2020},
	eissn = {1793-6462},
	orcid-numbers = {Erőss, Loránd/0000-0002-5796-5546; Ulbert, István/0000-0001-9941-9159; Fabó, Dániel/0000-0001-5141-5351}
}

@article{MTMT:3193263,
	title = {Short latency electrically evoked high frequency activity in the human hippocampus in vivo},
	url = {https://m2.mtmt.hu/api/publication/3193263},
	author = {Bokodi, Virág},
	journal-iso = {PHD PROC PPKE IT},
	journal = {PHD PROCEEDINGS ANNUAL ISSUES OF THE DOCTORAL SCHOOL FACULTY OF INFORMATION TECHNOLOGY AND BIONICS},
	volume = {11},
	unique-id = {3193263},
	issn = {2064-7271},
	year = {2016},
	pages = {21-24}
}

@CONFERENCE{MTMT:3015752,
	title = {High frequency oscillations in the human hippocampal formation using single pulse cortical electrical stimulation [poster]},
	url = {https://m2.mtmt.hu/api/publication/3015752},
	author = {Bokodi, Virág and Tóth, Emília and Somogyvári, Zoltán and Maglóczky, Zsófia and Erőss, Loránd and Ulbert, István and Fabó, Dániel},
	booktitle = {IBRO Workshop 2016},
	unique-id = {3015752},
	year = {2016},
	orcid-numbers = {Erőss, Loránd/0000-0002-5796-5546; Ulbert, István/0000-0001-9941-9159; Fabó, Dániel/0000-0001-5141-5351}
}

@article{MTMT:3192399,
	title = {Evoked high frequency oscillations in human hippocampus},
	url = {https://m2.mtmt.hu/api/publication/3192399},
	author = {Bokodi, Virág},
	journal-iso = {PHD PROC PPKE IT},
	journal = {PHD PROCEEDINGS ANNUAL ISSUES OF THE DOCTORAL SCHOOL FACULTY OF INFORMATION TECHNOLOGY AND BIONICS},
	volume = {10},
	unique-id = {3192399},
	issn = {2064-7271},
	year = {2015},
	pages = {17-20}
}

@misc{MTMT:3028097,
	title = {Evoked high frequency oscillations in the human hippocampal formation [lecture]},
	url = {https://m2.mtmt.hu/api/publication/3028097},
	author = {Bokodi, Virág and Emília, Tóth and Zsófia, Maglóczky and Entz, László and Erőss, Loránd and István, Ulbert and Fabó, Dániel},
	unique-id = {3028097},
	year = {2015},
	orcid-numbers = {Erőss, Loránd/0000-0002-5796-5546; Fabó, Dániel/0000-0001-5141-5351}
}