@article{MTMT:33688118,
	title = {Role of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia},
	url = {https://m2.mtmt.hu/api/publication/33688118},
	author = {Barabási, Beáta and Barna, Lilla and Santa Maria, Anaraquel and Harazin, András and Molnár, Réka and Kincses, András and Vigh, Judit Piroska and Dukay, Brigitta and Sántha, Miklós and Tóth, Erzsébet Melinda and Walter, Fruzsina and Deli, Mária Anna and Hoyk, Zsófia},
	doi = {10.1186/s12987-023-00418-3},
	journal-iso = {FLUIDS BARRIERS CNS},
	journal = {FLUIDS AND BARRIERS OF THE CNS},
	volume = {20},
	unique-id = {33688118},
	issn = {2045-8118},
	year = {2023},
	eissn = {2045-8118},
	orcid-numbers = {Santa Maria, Anaraquel/0000-0003-3505-5477; Harazin, András/0000-0002-0904-5606; Molnár, Réka/0000-0002-3128-825X; Walter, Fruzsina/0000-0001-8145-2823; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:32843432,
	title = {Islet damage and regeneration in a mouse model of chronic pancreatititis},
	url = {https://m2.mtmt.hu/api/publication/32843432},
	author = {Ébert, Attila and Gajdos, Tamás and Erdélyi, Miklós and Molnár, Réka and Kelemen, D and Hegyi, Péter and Venglovecz, Viktória},
	journal-iso = {CENT EUR J GASTRO HEPATOL},
	journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE},
	volume = {8},
	unique-id = {32843432},
	year = {2022},
	eissn = {2415-9107},
	pages = {73-73},
	orcid-numbers = {Gajdos, Tamás/0000-0002-5288-4659; Erdélyi, Miklós/0000-0002-9501-5752; Molnár, Réka/0000-0002-3128-825X; Hegyi, Péter/0000-0003-0399-7259; Venglovecz, Viktória/0000-0002-2316-7247}
}

@article{MTMT:32487977,
	title = {Analysis of Ionizing Radiation Induced DNA Damage by Superresolution dSTORM Microscopy},
	url = {https://m2.mtmt.hu/api/publication/32487977},
	author = {Brunner, Szilvia and Varga, Dániel and Bozó, Renáta and Polanek, Róbert and Tőkés, Tünde and Szabó, Emilia Rita and Molnár, Réka and Gémes, Nikolett and Szebeni, Gábor and Puskás, László and Erdélyi, Miklós and Hideghéty, Katalin},
	doi = {10.3389/pore.2021.1609971},
	journal-iso = {PATHOL ONCOL RES},
	journal = {PATHOLOGY AND ONCOLOGY RESEARCH},
	volume = {27},
	unique-id = {32487977},
	issn = {1219-4956},
	year = {2021},
	eissn = {1532-2807},
	orcid-numbers = {Varga, Dániel/0000-0003-0391-5057; Bozó, Renáta/0000-0003-4242-2474; Polanek, Róbert/0000-0003-3645-8331; Tőkés, Tünde/0000-0002-0587-7886; Szabó, Emilia Rita/0000-0003-3611-2066; Molnár, Réka/0000-0002-3128-825X; Szebeni, Gábor/0000-0002-6998-5632; Erdélyi, Miklós/0000-0002-9501-5752; Hideghéty, Katalin/0000-0001-7080-2365}
}

@mastersthesis{MTMT:32475841,
	title = {The investigation of HCO3- secretion in pancreatic ductal organoid cultures [A hasnyálmirigy duktális epitél sejtek HCO3- szekréciójának vizsgálata organoid sejtkultúrában]},
	url = {https://m2.mtmt.hu/api/publication/32475841},
	author = {Molnár, Réka},
	doi = {10.14232/phd.10685},
	publisher = {SZTE},
	unique-id = {32475841},
	year = {2021},
	orcid-numbers = {Molnár, Réka/0000-0002-3128-825X}
}

@{MTMT:31683899,
	title = {Investigation of the pancreatic ductal ion secretion in pancreatic ductal organoid cultures},
	url = {https://m2.mtmt.hu/api/publication/31683899},
	author = {Molnár, Réka and Fanczal, Júlia and Madácsy, Tamara and Hegyi, Péter and Maléth, József},
	booktitle = {Proceedings of the EFOP-3.6.2-16-2017-00006 (LIVE LONGER) project},
	unique-id = {31683899},
	year = {2020},
	pages = {18-18},
	orcid-numbers = {Molnár, Réka/0000-0002-3128-825X; Fanczal, Júlia/0000-0001-7356-3857; Madácsy, Tamara/0000-0001-5598-9723; Hegyi, Péter/0000-0003-0399-7259; Maléth, József/0000-0001-5768-3090}
}

@article{MTMT:31097108,
	title = {TRPM2-mediated extracellular Ca2+ entry promotes acinar cell necrosis in biliary acute pancreatitis},
	url = {https://m2.mtmt.hu/api/publication/31097108},
	author = {Fanczal, Júlia and Pallagi, Petra and Görög, Marietta and Diszházi, Gyula and Almássy, János and Madácsy, Tamara and Varga, Árpád and Csernay-Biró, Péter and Katona, Xénia and Tóth, Emese and Molnár, Réka and Rakonczay, Zoltán and Hegyi, Péter and Maléth, József},
	doi = {10.1113/JP279047},
	journal-iso = {J PHYSIOL-LONDON},
	journal = {JOURNAL OF PHYSIOLOGY-LONDON},
	volume = {598},
	unique-id = {31097108},
	issn = {0022-3751},
	abstract = {Acute biliary pancreatitis is a significant clinical challenge as currently no specific pharmaceutical treatment exists. Intracellular Ca2+ overload, increased reactive oxygen species (ROS) production, mitochondrial damage and intra-acinar digestive enzyme activation caused by bile acids are hallmarks of acute biliary pancreatitis. Transient Receptor Potential Melastatin 2 (TRPM2) is a non-selective cation channel that has recently emerged as an important contributor to oxidative-stress-induced cellular Ca2+ overload across different diseases. We demonstrated that TRPM2 is expressed in the plasma membrane of mouse pancreatic acinar and ductal cells, which can be activated by increased oxidative stress induced by H2 O2 treatment and contributed to bile acid-induced extracellular Ca2+ influx in acinar cells, which promoted acinar cell necrosis in vitro and in vivo. These results suggest that the inhibition of TRPM2 may be a potential treatment option for biliary pancreatitis.Acute biliary pancreatitis poses a significant clinical challenge as currently no specific pharmaceutical treatment exists. Disturbed intracellular Ca2+ signalling caused by bile acids is a hallmark of the disease, which induces increased reactive oxygen species (ROS) production, mitochondrial damage, intra-acinar digestive enzyme activation and cell death. Because of this mechanism of action, prevention of toxic cellular Ca2+ overload is a promising therapeutic target. Transient Receptor Potential Melastatin 2 (TRPM2) is a non-selective cation channel that has recently emerged as an important contributor to oxidative-stress-induced cellular Ca2+ overload across different diseases. However, the expression and possible functions of TRPM2 in the exocrine pancreas remain unknown. Here we found that TRPM2 is expressed in the plasma membrane of mouse pancreatic acinar and ductal cells, which can be activated by increased oxidative stress induced by H2 O2 treatment. TRPM2 activity was found to contribute to bile acid-induced extracellular Ca2+ influx in acinar cells, but did not have the same effect in ductal cells. The generation of intracellular ROS in response to bile acids was remarkably higher in pancreatic acinar cells compared to isolated ducts, which can explain the difference between acinar and ductal cells. This activity promoted acinar cell necrosis in vitro independently from mitochondrial damage or mitochondrial fragmentation. In addition, bile-acid-induced experimental pancreatitis was less severe in TRPM2 knockout mice, whereas the lack of TRPM2 had no protective effect in cerulein induced acute pancreatitis. Our results suggest that the inhibition of TRPM2 may be a potential treatment option for biliary pancreatitis. This article is protected by copyright. All rights reserved.},
	keywords = {Acute pancreatitis; bile acid; Ca2+ signalling; TRPM2 channel; epithelial ion transport; acinar cell necrosis},
	year = {2020},
	eissn = {1469-7793},
	pages = {1253-1270},
	orcid-numbers = {Fanczal, Júlia/0000-0001-7356-3857; Pallagi, Petra/0000-0001-8906-0840; Görög, Marietta/0000-0003-3615-3140; Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Katona, Xénia/0000-0002-6053-9097; Molnár, Réka/0000-0002-3128-825X; Rakonczay, Zoltán/0000-0002-1499-3416; Hegyi, Péter/0000-0003-0399-7259; Maléth, József/0000-0001-5768-3090}
}

@article{MTMT:30766190,
	title = {Mouse pancreatic ductal organoid culture as a relevant model to study exocrine pancreatic ion secretion},
	url = {https://m2.mtmt.hu/api/publication/30766190},
	author = {Molnár, Réka and Madácsy, Tamara and Varga, Árpád and Németh, Margit and Katona, Xénia and Görög, Marietta and Molnár, Brigitta and Fanczal, Júlia and Rakonczay, Zoltán and Hegyi, Péter and Pallagi, Petra and Maléth, József},
	doi = {10.1038/s41374-019-0300-3},
	journal-iso = {LAB INVEST},
	journal = {LABORATORY INVESTIGATION},
	volume = {100},
	unique-id = {30766190},
	issn = {0023-6837},
	abstract = {Pancreatic exocrine secretory processes are challenging to investigate on primary epithelial cells. Pancreatic organoid cultures may help to overcome shortcomings of the current models, however the ion secretory processes in pancreatic organoids-and therefore their physiological relevance or their utility in disease modeling-are not known. To answer these questions, we provide side-by-side comparison of gene expression, morphology, and function of epithelial cells in primary isolated pancreatic ducts and organoids. We used mouse pancreatic ductal fragments for experiments or were grown in Matrigel to obtain organoid cultures. Using PCR analysis we showed that gene expression of ion channels and transporters remarkably overlap in primary ductal cells and organoids. Morphological analysis with scanning electron microscopy revealed that pancreatic organoids form polarized monolayers with brush border on the apical membrane. Whereas the expression and localization of key proteins involved in ductal secretion (cystic fibrosis transmembrane conductance regulator, Na+/H+ exchanger 1 and electrogenic Na+/HCO3- cotransporter 1) are equivalent to the primary ductal fragments. Measurements of intracellular pH and Cl- levels revealed no significant difference in the activities of the apical Cl-/HCO3- exchange, or in the basolateral Na+ dependent HCO3- uptake. In summary we found that ion transport activities in the mouse pancreatic organoids are remarkably similar to those observed in freshly isolated primary ductal fragments. These results suggest that organoids can be suitable and robust model to study pancreatic ductal epithelial ion transport in health and diseases and facilitate drug development for secretory pancreatic disorders like cystic fibrosis, or chronic pancreatitis.},
	year = {2020},
	eissn = {1530-0307},
	pages = {84-97},
	orcid-numbers = {Molnár, Réka/0000-0002-3128-825X; Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Katona, Xénia/0000-0002-6053-9097; Görög, Marietta/0000-0003-3615-3140; Fanczal, Júlia/0000-0001-7356-3857; Rakonczay, Zoltán/0000-0002-1499-3416; Hegyi, Péter/0000-0003-0399-7259; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090}
}

@article{MTMT:31398797,
	title = {Pancreatic ductal organoid cultures are a suitable model to studypancreatic ductal ion secretion},
	url = {https://m2.mtmt.hu/api/publication/31398797},
	author = {Molnár, Réka and Görög, Marietta and Fanczal, Júlia and Madácsy, Tamara and Németh, Margit and Varga, Árpád and Katona, Xénia and Rakonczay, Zoltán and Hegyi, Péter and Pallagi, Petra and Maléth, József},
	doi = {10.1016/j.pan.2019.05.039},
	journal-iso = {PANCREATOLOGY},
	journal = {PANCREATOLOGY},
	volume = {19},
	unique-id = {31398797},
	issn = {1424-3903},
	year = {2019},
	eissn = {1424-3911},
	pages = {S18-S18},
	orcid-numbers = {Molnár, Réka/0000-0002-3128-825X; Görög, Marietta/0000-0003-3615-3140; Fanczal, Júlia/0000-0001-7356-3857; Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Katona, Xénia/0000-0002-6053-9097; Rakonczay, Zoltán/0000-0002-1499-3416; Hegyi, Péter/0000-0002-3128-825X; Pallagi, Petra/0000-0001-8906-0840; Maléth, József/0000-0001-5768-3090}
}

@article{MTMT:30735558,
	title = {Development and Validation of an UV-Spectrophotometric Method for the Assay of Strontium Ranelate and HPLC Stability Testing from Bulk and Pharmaceutical Dosage Form},
	url = {https://m2.mtmt.hu/api/publication/30735558},
	author = {Kovács, Béla and Molnár, Réka and Nagy, Előd Ernő and Kelemen, Éva Katalin and Székely-Szentmiklósi, Blanka and Székely-Szentmiklósi, István and Kovács-Deák, Boglárka and Gyéresi, Árpád},
	doi = {10.2478/amma-2019-0014},
	journal-iso = {ACTA MED MARISIENSIS},
	journal = {ACTA MEDICA MARISIENSIS},
	volume = {65},
	unique-id = {30735558},
	issn = {2068-3324},
	year = {2019},
	eissn = {2247-6113},
	pages = {55-59},
	orcid-numbers = {Molnár, Réka/0000-0002-3128-825X}
}

@article{MTMT:3394435,
	title = {Human pancreatic ductal organoids as a new model in pancreas physiology},
	url = {https://m2.mtmt.hu/api/publication/3394435},
	author = {Németh, M and Katona, X and Varga, Árpád and Madácsy, Tamara and Molnár, Réka and Takács, Tamás and Farkas, Gyula Jr. and Maléth, József},
	journal-iso = {CENT EUR J GASTRO HEPATOL},
	journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE},
	volume = {4},
	unique-id = {3394435},
	year = {2018},
	eissn = {2415-9107},
	pages = {123-124},
	orcid-numbers = {Varga, Árpád/0000-0002-2379-139X; Madácsy, Tamara/0000-0001-5598-9723; Molnár, Réka/0000-0002-3128-825X; Maléth, József/0000-0001-5768-3090}
}