TY - THES AU - Fási, Laura TI - Preparation of bioactive oxidized hydroxycinnamic acid derivatives [Bioaktív oxidált hidroxifahéjsav-származékok előállítása] PB - Szegedi Tudományegyetem PY - 2022 SP - 55 DO - 10.14232/phd.10852 UR - https://m2.mtmt.hu/api/publication/34115677 ID - 34115677 LA - English DB - MTMT ER - TY - JOUR AU - Fási, Laura AU - Latif, Ahmed Dhahir AU - Zupkó, István AU - Sándor, Lévai AU - Dékány, Miklós AU - Béni, Zoltán AU - Árpád, Könczöl AU - Balogh, György Tibor AU - Hunyadi, Attila TI - AAPH or Peroxynitrite-Induced Biorelevant Oxidation of Methyl Caffeate Yields a Potent Antitumor Metabolite JF - BIOMOLECULES J2 - BIOMOLECULES VL - 10 PY - 2020 IS - 11 PG - 13 SN - 2218-273X DO - 10.3390/biom10111537 UR - https://m2.mtmt.hu/api/publication/31657056 ID - 31657056 LA - English DB - MTMT ER - TY - CONF AU - Fási, Laura AU - Vágvölgyi, Máté AU - Latif, Ahmed Dhahir AU - Issaadi, Halima Meriem AU - Zoofishan, Zoofishan AU - Zupkó, István AU - Spengler, Gabriella AU - Martins, Ana AU - Hunyadi, Attila TI - Natural product inspired chemical approaches against MDR cancer T2 - New Diagnostic and Therapeutic Tools against Multidrug-Resistant Tumours PY - 2019 SP - 12 EP - 13 PG - 2 UR - https://m2.mtmt.hu/api/publication/31192702 ID - 31192702 LA - English DB - MTMT ER - TY - JOUR AU - Fási, Laura AU - Di Meo, Florent AU - Kuo, Ching-Ying AU - Stojkovic Buric, Sonja AU - Martins, Ana AU - Kúsz, Norbert AU - Béni, Zoltán AU - Dékány, Miklós AU - Balogh, György Tibor AU - Pesic, Milica AU - Wang, Hui-Chun AU - Trouillas, Patrick AU - Hunyadi, Attila TI - Antioxidant-inspired drug discovery: antitumor metabolite is formed in situ from a hydroxycinnamic acid derivative upon free radical scavenging JF - JOURNAL OF MEDICINAL CHEMISTRY J2 - J MED CHEM VL - 62 PY - 2019 IS - 3 SP - 1657 EP - 1668 PG - 12 SN - 0022-2623 DO - 10.1021/acs.jmedchem.8b01994 UR - https://m2.mtmt.hu/api/publication/30380633 ID - 30380633 AB - Cancer cells generally possess higher levels of reactive oxygen species than normal cells, and this can serve as a possible therapeutic target. In this proof-of-concept study, an antioxidant-inspired drug discovery strategy was evaluated using a hydroxycinnamic acid derivative. The processing of oxidized mixtures of p-coumaric acid methyl ester (pcm) revealed a new antitumor lead, graviquinone. Graviquinone bypassed ABCB1-mediated resistance, induced DNA damage in lung carcinoma cells but exerted DNA protective activity in normal keratinocytes, and modulated DNA damage response in MCF-7 cells. The cytotoxic effect of pcm in MCF-7 cells was potentiated under H2O2-induced oxidative stress, and the formation of graviquinone was confirmed by Fenton's reaction on pcm. In silico density functional theory calculations suggested graviquinone as a kinetic product of pcm-scavenging (OH)-O-center dot radicals. Our results demonstrate the pharmacological value of an in situ-formed, oxidative stress-related metabolite of an antioxidant. This might be of particular importance for designing new strategies for antioxidant-based drug discovery. LA - English DB - MTMT ER - TY - CONF AU - Fási, Laura AU - Gyovai, András AU - Zupkó, István AU - Nové, Márta AU - Spengler, Gabriella AU - Fang-Rong, Chang AU - Hunyadi, Attila TI - Semi-synthetic preparation of antitumor p-coumaric acid derivatives T2 - GA2018: The 66th Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA); S-TCM 2018 : The 11th Shanghai International Conference on Traditional Chinese Medicine and Natural Medicine PY - 2018 UR - https://m2.mtmt.hu/api/publication/3426792 ID - 3426792 N1 - [poszter] LA - English DB - MTMT ER - TY - JOUR AU - Háznagyné Radnai, Erzsébet AU - Fási, Laura AU - Wéber, Edit AU - Pinke, Gyula AU - Király, Botond Gergely AU - Sztojkov-Ivanov, Anita AU - Gáspár, Róbert AU - Hohmann, Judit TI - Anti-inflammatory Activity of Melampyrum barbatum and Isolation of Iridoid and Flavonoid Compounds JF - NATURAL PRODUCT COMMUNICATIONS J2 - NAT PROD COMMUN VL - 13 PY - 2018 IS - 3 SP - 235 EP - 236 PG - 2 SN - 1934-578X DO - 10.1177/1934578x1801300301 UR - https://m2.mtmt.hu/api/publication/3347203 ID - 3347203 AB - Melampyrum barbatum Waldst. & Kit. ex Willd. (Scrophulariaceae) has been used in traditional medicine for the treatment of rheumatic complaints and different skin diseases. In the course of our study the anti-inflammatory activity of the aerial parts of M barbatum was evaluated. A MeOH extract was prepared and consecutively partitioned with CHCl3, EtOAc and n-BuOH. The fractions were assayed in in vivo carrageenan-induced rat paw oedema model. The intraperitoneally administered n-BuOH phase exerted marked inhibitory effect (33.6 %, p < 0.01). Multistep chromatographic separation afforded mussaenoside and aucubine from n-BuOH fraction. Moreover, 8-epiloganin, loganic acid and mussaenoside were obtained from EtOAc fraction and apigenin, luteolin, benzoic acid and galactitol from CHCl3 fraction. These data validate the ethnomedicinal use of M barbatum for the treatment of inflammatory diseases and reveal that iridoids and flavonoids could be responsible for the anti-inflammatory effect of this species. LA - English DB - MTMT ER - TY - GEN AU - Fási, Laura TI - Az emésztés, valamint a bél- és májműködés támogatása PY - 2016 SP - 16 EP - 17 PG - 2 UR - https://m2.mtmt.hu/api/publication/3141373 ID - 3141373 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Fási, Laura AU - Hunyadi, Attila TI - Cephalotaxus harringtonia − homoharringtonin JF - GYÓGYSZERÉSZET J2 - GYÓGYSZERÉSZET VL - 60 PY - 2016 IS - 8 SP - 469 EP - 471 PG - 3 SN - 0017-6036 UR - https://m2.mtmt.hu/api/publication/3133476 ID - 3133476 LA - Hungarian DB - MTMT ER - TY - CONF AU - Fási, Laura AU - Martins, Ana AU - Kúsz, Norbert AU - Fődi, Tamás AU - Ignácz, Gergő AU - Béni, Zoltán AU - Balogh, György Tibor AU - Hunyadi, Attila ED - Csupor, Dezső ED - Rédei, Dóra ED - Kiss, Tivadar TI - A p-kumársav-metilészter antitumor hatású oxidált származékainak előállítása T2 - Fiatal Gyógynövénykutatók Fóruma: a Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztályának tudományos konferenciája PB - Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztálya C1 - Szeged PY - 2016 SP - 10 EP - 10 PG - 1 UR - https://m2.mtmt.hu/api/publication/3082840 ID - 3082840 LA - Hungarian DB - MTMT ER - TY - CONF AU - Hunyadi, Attila AU - Dankó, Balázs Ödön AU - Csábi, József AU - Vágvölgyi, Máté AU - Issaadi, Halima Meriem AU - Fási, Laura AU - Zoofishan, Zoofishan TI - What we can provide for collaboration: an overview of our available compound library T2 - 2nd meeting of COST Action CM1407 PY - 2016 SP - 37 PG - 1 UR - https://m2.mtmt.hu/api/publication/3054546 ID - 3054546 LA - English DB - MTMT ER -