@CONFERENCE{MTMT:34577105, title = {Exploring the gut-brain connection: How does microbiome composition relate to cognitive behavior in Wisket model rats?}, url = {https://m2.mtmt.hu/api/publication/34577105}, author = {Plesz, Szonja Bianka and Adlan, Leatitia Gabriella and Büki, Alexandra and Horváth, Gyöngyi and Ligeti, Balázs and Zádori, Zoltán Sándor and Kékesi, Gabriella}, booktitle = {7th Hungarian Neuroscience Doctoral Conference for Undergraduate Students, Graduate Students and Junior Post-Docs (HUNDOC) Booklet}, unique-id = {34577105}, year = {2024}, pages = {86}, orcid-numbers = {Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577; Zádori, Zoltán Sándor/0000-0001-7312-618X; Kékesi, Gabriella/0000-0002-0185-2155} } @CONFERENCE{MTMT:34577022, title = {The Firmicutes/Bacteroidetes ratio in the triple-hit Wisket model rats of schizophrenia}, url = {https://m2.mtmt.hu/api/publication/34577022}, author = {Adlan, Leatitia Gabriella and Plesz, Szonja Bianka and Büki, Alexandra and Horváth, Gyöngyi and Ligeti, Balázs and Zádori, Zoltán Sándor and Kékesi, Gabriella}, booktitle = {International Neuroscience Conference, Pécs 2024}, unique-id = {34577022}, year = {2024}, pages = {74}, orcid-numbers = {Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577; Zádori, Zoltán Sándor/0000-0001-7312-618X; Kékesi, Gabriella/0000-0002-0185-2155} } @CONFERENCE{MTMT:34576951, title = {Is gut dysbiosis associated with the motivational deficit observed in Wisket animals?}, url = {https://m2.mtmt.hu/api/publication/34576951}, author = {Plesz, Szonja Bianka and Adlan, Leatitia Gabriella and Büki, Alexandra and Ligeti, Balázs and Zádori, Zoltán Sándor and Kékesi, Gabriella}, booktitle = {International Neuroscience Conference, Pécs 2024}, unique-id = {34576951}, year = {2024}, pages = {73}, orcid-numbers = {Büki, Alexandra/0000-0003-2078-5231; Zádori, Zoltán Sándor/0000-0001-7312-618X; Kékesi, Gabriella/0000-0002-0185-2155} } @CONFERENCE{MTMT:34577063, title = {A Lactobacillaceae baktériumok előfordulása a szkizofrénia Wisket állatmodelljének mikrobiomjában}, url = {https://m2.mtmt.hu/api/publication/34577063}, author = {Plesz, Szonja Bianka and Adlan, Leatitia Gabriella and Büki, Alexandra and Ligeti, Balázs and Zádori, Zoltán Sándor and Horváth, Gyöngyi and Kékesi, Gabriella}, booktitle = {A XI. Eötvözet Konferencián elhangzó előadások rövid összefoglalója}, unique-id = {34577063}, year = {2023}, pages = {24-24}, orcid-numbers = {Büki, Alexandra/0000-0003-2078-5231; Zádori, Zoltán Sándor/0000-0001-7312-618X; Horváth, Gyöngyi/0000-0002-6025-4577; Kékesi, Gabriella/0000-0002-0185-2155} } @article{MTMT:34407638, title = {DECREASED LACTOBACILLACEAE ABUNDANCE IN THE GUT MICROBIOTA OF A ‘THREE-HIT’ SCHIZOPHRENIA RAT MODEL (WISKET)}, url = {https://m2.mtmt.hu/api/publication/34407638}, author = {Plesz, Szonja Bianka and Adlan, Leatitia Gabriella and Büki, Alexandra and Horváth, Gyöngyi and Ligeti, Balázs and Zádori, Zoltán and Kékesi, Gabriella}, doi = {10.1016/j.ibneur.2023.08.1256}, journal-iso = {IBRO NEUROSCI REP}, journal = {IBRO NEUROSCIENCE REPORTS}, volume = {15}, unique-id = {34407638}, year = {2023}, eissn = {2667-2421}, pages = {S630}, orcid-numbers = {Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577; Kékesi, Gabriella/0000-0002-0185-2155} } @article{MTMT:34407636, title = {PERSONALIZED BEHAVIORAL ANALYSIS OF RODENTS IN HOME-CAGE CONDITION}, url = {https://m2.mtmt.hu/api/publication/34407636}, author = {Hernadi, Zsófia and Adlan, Leatitia Gabriella and Kékesi, Gabriella and Büki, Alexandra and Tuboly, Gabor and Horváth, Gyöngyi}, doi = {10.1016/j.ibneur.2023.08.1146}, journal-iso = {IBRO NEUROSCI REP}, journal = {IBRO NEUROSCIENCE REPORTS}, volume = {15}, unique-id = {34407636}, year = {2023}, eissn = {2667-2421}, pages = {S579}, orcid-numbers = {Kékesi, Gabriella/0000-0002-0185-2155; Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577} } @article{MTMT:34407635, title = {GUT MICROBIAL ABUNDANCE IN THE SCHIZOPHRENIA-LIKE WISKET RAT MODEL}, url = {https://m2.mtmt.hu/api/publication/34407635}, author = {Adlan, Leatitia Gabriella and Plesz, Szonja Bianka and Büki, Alexandra and Horváth, Gyöngyi and Ligeti, Balázs and Zádori, Zoltán and Kékesi, Gabriella}, doi = {10.1016/j.ibneur.2023.08.1027}, journal-iso = {IBRO NEUROSCI REP}, journal = {IBRO NEUROSCIENCE REPORTS}, volume = {15}, unique-id = {34407635}, year = {2023}, eissn = {2667-2421}, pages = {S522}, orcid-numbers = {Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577; Kékesi, Gabriella/0000-0002-0185-2155} } @article{MTMT:34178429, title = {Neurobehavioral impairments in ciprofloxacin-treated osteoarthritic adult rats}, url = {https://m2.mtmt.hu/api/publication/34178429}, author = {Kékesi, Gabriella and Ducza, Eszter and Gálity, Hristifor and Büki, Alexandra and Tóth, Kálmán and Tuboly, Gábor and Horváth, Gyöngyi}, doi = {10.18071/isz.76.0327}, journal-iso = {IDEGGYOGY SZEMLE}, journal = {IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE}, volume = {76}, unique-id = {34178429}, issn = {0019-1442}, abstract = {Background and purpose – Ciprofloxacin (CIP) is a broad-spectrum antibiotic widely used in clinical practice to treat musculoskeletal infections. Fluoroquinoloneinduced neurotoxic adverse events have been reported in a few case reports, all the preclinical studies on its neuropsychiatric side effects involved only healthy animals. This study firstly investigated the behavioral effects of CIP in an osteoarthritis rat model with joint destruction and pain, which can simulate inflammation-associated musculoskeletal pain. Furthermore, effects of CIP on regional brain-derived neurotrophic factor (BDNF) expression were examined given its major contributions to the neuromodulation and plasticity underlying behavior and cognition. Methods – Fourteen days after induction of chronic osteoarthritis, animals were administered vehicle, 33 mg/kg or 100 mg/kg CIP for five days intraperitoneally. Motor activity, behavioral motivation, and psychomotor learning were examined in a reward-based behavioral test (Ambitus) on Day 4 and sensorimotor gating by the prepulse inhibition test on Day 5. Thereafter, the prolonged BDNF mRNA and protein expression levels were measured in the hippocampus and the prefrontal cortex. Results – CIP dose-dependently reduced both locomotion and reward-motivated exploratory activity, accompanied with impaired learning ability. In contrast, there were no significant differences in startle reflex and sensory gating among treatment groups; however, CIP treatment reduced motor activity of the animals in this test, too. These alterations were associated with reduced BDNF mRNA and protein expression levels in the hippocampus but not the prefrontal cortex. Conclusion – This study revealed the detrimental effects of CIP treatment on locomotor activity and motivation/learning ability during osteoarthritic condition, which might be due to, at least partially, deficient hippocampal BDNF expression and ensuing impairments in neural and synaptic plasticity.}, year = {2023}, eissn = {2498-6208}, pages = {327-337}, orcid-numbers = {Kékesi, Gabriella/0000-0002-0185-2155; Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577} } @CONFERENCE{MTMT:33853465, title = {Gut-microbiome analysis in a ‘three-hit’ schizophrenia rat model (Wisket)}, url = {https://m2.mtmt.hu/api/publication/33853465}, author = {Adlan, Leatitia Gabriella and Plesz, Szonja Bianka and Büki, Alexandra and Horváth, Gyöngyi and Ligeti, Balázs and Zádori, Zoltán Sándor and Kékesi, Gabriella}, booktitle = {Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA)}, unique-id = {33853465}, year = {2023}, pages = {130-130}, orcid-numbers = {Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577; Zádori, Zoltán Sándor/0000-0001-7312-618X; Kékesi, Gabriella/0000-0002-0185-2155} } @CONFERENCE{MTMT:33843815, title = {Decreased Lactobacillaceae abundance in the gut microbiota of the ‘three-hit’ schizophrenia rat model (Wisket)}, url = {https://m2.mtmt.hu/api/publication/33843815}, author = {Plesz, Szonja Bianka and Adlan, Leatitia Gabriella and Büki, Alexandra and Horváth, Gyöngyi and Ligeti, Balázs and Zádori S., Zoltán and Kékesi, Gabriella}, booktitle = {6th Hungarian Neuroscience Doctoral Conference for Undergraduate Students, Graduate Students and Junior Postdoc}, unique-id = {33843815}, year = {2023}, pages = {43}, orcid-numbers = {Büki, Alexandra/0000-0003-2078-5231; Horváth, Gyöngyi/0000-0002-6025-4577; Kékesi, Gabriella/0000-0002-0185-2155} }