@article{MTMT:32085404, title = {Comparison of Modern In Vitro Permeability Methods with the Aim of Investigation Nasal Dosage Forms}, url = {https://m2.mtmt.hu/api/publication/32085404}, author = {Bartos, Csilla and Révész, Piroska and Horváth, Tamás and Varga, Patrícia Orsolya and Ambrus, Rita}, doi = {10.3390/pharmaceutics13060846}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {13}, unique-id = {32085404}, issn = {1999-4923}, year = {2021}, eissn = {1999-4923}, orcid-numbers = {Révész, Piroska/0000-0002-5336-6052; Ambrus, Rita/0000-0001-5496-1710} } @article{MTMT:3076538, title = {Effect of solubility enhancement on nasal absorption of meloxicam}, url = {https://m2.mtmt.hu/api/publication/3076538}, author = {Horváth, Tamás and Ambrus, Rita and Völgyi, Gergely and Budai-Szűcs, Mária and Márki, Árpád and Sipos, Péter and Bartos, Csilla and Seres, Adrienn and Sztojkov-Ivanov, Anita and Takácsné Novák, Krisztina and Csányi, Erzsébet and Gáspár, Róbert and Révész, Piroska}, doi = {10.1016/j.ejps.2016.05.031}, journal-iso = {EUR J PHARM SCI}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES}, volume = {95}, unique-id = {3076538}, issn = {0928-0987}, abstract = {Besides the opioids the standard management of the World Health Organization suggests NSAIDs (non-steroidal anti-inflammatory drugs) alone or in combination to enhance analgesia in malignant and non-malignant pain therapy. The applicability of NSAIDs in a nasal formulation is a new approach in pharmaceutical technology. In order to enhance the nasal absorption of meloxicam (MX) as an NSAID, its salt form, meloxicam potassium monohydrate (MXP), registered by Egis Plc., was investigated in comparison with MX. The physico-chemical properties of the drugs (structural analysis, solubility and dissolution rate) and the mucoadhesivity of nasal formulations were controlled. In vitro and in vivo studies were carried out to determine the nasal applicability of MXP as a drug candidate in pain therapy. It can be concluded that MX and MXP demonstrated the same equilibrium solubility at the pH5.60 of the nasal mucosa (0.017mg/ml); nonetheless, MXP indicated faster dissolution and a higher permeability through the synthetic membrane. The animal studies justified the short Tmax value (15min) and the high AUC of MXP, which is important in acute pain therapy. It can be assumed that the low mucoadhesivity of MXP spray did not increase the residence time in the nasal cavity, and the elimination from the nasal mucosa was therefore faster than in the case of MX. Further experiments are necessary to prove the therapeutic relevance of this MXP-containing innovative intranasal formulation.}, keywords = {PHARMACOKINETICS; IN-VITRO; DELIVERY; NANOPARTICLES; Solubility; meloxicam; mucoadhesion; Meloxicam potassium monohydrate; Nasal formulation; Side-Bi-Side (TM) model; SODIUM HYALURONATE}, year = {2016}, eissn = {1879-0720}, pages = {96-102}, orcid-numbers = {Völgyi, Gergely/0000-0001-8990-3916; Budai-Szűcs, Mária/0000-0001-5187-5702; Márki, Árpád/0000-0002-6056-8891; Takácsné Novák, Krisztina/0000-0002-4467-1143; Csányi, Erzsébet/0000-0002-3010-1959; Gáspár, Róbert/0000-0002-1571-7579; Révész, Piroska/0000-0002-5336-6052} } @article{MTMT:3066564, title = {Cytotoxicity of different excipients on RPMI 2650 human nasal epithelial cells}, url = {https://m2.mtmt.hu/api/publication/3066564}, author = {Horváth, Tamás and Bartos, Csilla and Bocsik, Alexandra and Kiss, Lóránd and Veszelka, Szilvia and Deli, Mária Anna and Újhelyi, G and Révész, Piroska and Ambrus, Rita}, doi = {10.3390/molecules21050658}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {21}, unique-id = {3066564}, issn = {1420-3049}, year = {2016}, eissn = {1420-3049}, orcid-numbers = {Deli, Mária Anna/0000-0001-6084-6524; Révész, Piroska/0000-0002-5336-6052} } @article{MTMT:2920571, title = {Nazális gyógyszerformák permeabilitási vizsgálata Side-Bi-Side™ horizontális cella alkalmazásával}, url = {https://m2.mtmt.hu/api/publication/2920571}, author = {Horváth, Tamás and Ambrus, Rita and Révész, Piroska}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {85}, unique-id = {2920571}, issn = {0001-6659}, year = {2015}, eissn = {1587-1495}, pages = {19-28}, orcid-numbers = {Révész, Piroska/0000-0002-5336-6052} } @article{MTMT:2917042, title = {Study of sodium hyaluronate-based intranasal formulations containing micro- or nanosized meloxicam particles}, url = {https://m2.mtmt.hu/api/publication/2917042}, author = {Bartos, Csilla and Ambrus, Rita and Sipos, Péter and Budai-Szűcs, Mária and Csányi, Erzsébet and Gáspár, Róbert and Márki, Árpád and Seres, Adrienn and Sztojkov-Ivanov, Anita and Horváth, Tamás and Révész, Piroska}, doi = {10.1016/j.ijpharm.2015.06.046}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {491}, unique-id = {2917042}, issn = {0378-5173}, year = {2015}, eissn = {1873-3476}, pages = {198-207}, orcid-numbers = {Budai-Szűcs, Mária/0000-0001-5187-5702; Csányi, Erzsébet/0000-0002-3010-1959; Gáspár, Róbert/0000-0002-1571-7579; Márki, Árpád/0000-0002-6056-8891; Révész, Piroska/0000-0002-5336-6052} } @CONFERENCE{MTMT:3083603, title = {Application of acoustic cavitation in order to prepare nasal formulation}, url = {https://m2.mtmt.hu/api/publication/3083603}, author = {Bartos, Csilla and Révész, Piroska and Horváth, Tamás and Ambrus, Rita}, booktitle = {10th Central European Symposium on Pharmaceutical Technology}, unique-id = {3083603}, year = {2014}, pages = {75-76}, orcid-numbers = {Révész, Piroska/0000-0002-5336-6052} } @article{MTMT:2597098, title = {Nazális gyógyszerformák hatóanyagának permeabilitás vizsgálata módosított horizontális cella alkalmazásával}, url = {https://m2.mtmt.hu/api/publication/2597098}, author = {Horváth, Tamás and Bartos, Csilla and Révész, Piroska and Ambrus, Rita}, journal-iso = {GYÓGYSZERÉSZET}, journal = {GYÓGYSZERÉSZET}, volume = {58}, unique-id = {2597098}, issn = {0017-6036}, year = {2014}, pages = {S109-S109}, orcid-numbers = {Révész, Piroska/0000-0002-5336-6052} }