TY - JOUR AU - Kiss, Péter AU - Bánki, Eszter Márta AU - Gaszner, Balázs AU - Nagy, Daniel AU - Helyes, Zsuzsanna AU - Pál, Endre AU - Rémán, Gyöngyvér Éva AU - Tóth, Gábor AU - Tamás, Andrea AU - Reglődi, Dóra TI - Protective effects of PACAP in a rat model of diabetic neuropathy JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 19 PG - 18 SN - 1661-6596 DO - 10.3390/ijms221910691 UR - https://m2.mtmt.hu/api/publication/32242113 ID - 32242113 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Fund [FK129190, K135457, K119759]; National Brain Research Program [NAP2017-1.2.1-NKP-2017-00002, MTA-TKI-14016, GINOP-2.3.2-15-2016-00050, EFOP-3.6.300009, EFOP-3.6.1-16-2016-00004, EFOP-3.6.2-16-2017-00008]; Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary [20765/3/2018/FEKUTSTRAT, 2020-4.1.1-TKP2020-FIKP III] Funding text: This research was funded by the National Research, Development and Innovation Fund FK129190, K135457, K119759; National Brain Research Program NAP2017-1.2.1-NKP-2017-00002; MTA-TKI-14016; GINOP-2.3.2-15-2016-00050 "PEPSYS"; EFOP-3.6.2-16-2017-00008; EFOP-3.6.300009; EFOP-3.6.1-16-2016-00004; Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary: 20765/3/2018/FEKUTSTRAT, 2020-4.1.1-TKP2020-FIKP III. LA - English DB - MTMT ER - TY - JOUR AU - Horváth-Opper, Gabriella AU - Reglődi, Dóra AU - Czétány, Péter AU - Illés, Anita AU - Rémán, Gyöngyvér Éva AU - Fekete, Andrea AU - Tóth, Gábor AU - László, Eszter AU - Opper, Balázs TI - Effects of Pituitary Adenylate Cyclase Activating Polypeptide in Human Proximal Tubule Cells Against Gentamicin Toxicity JF - INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS J2 - INT J PEPT RES THER VL - 25 PY - 2019 IS - 1 SP - 257 EP - 264 PG - 8 SN - 1573-3149 DO - 10.1007/s10989-017-9666-5 UR - https://m2.mtmt.hu/api/publication/3320609 ID - 3320609 N1 - Funding Agency and Grant Number: Comprehensive Development for Implementing Smart Specialization Strategies at the University of Pecs/Centre for neuroscience [EFOP-3.6.1.-16-2016-00004]; PTE AOK Research Grant [KA-2016-03, KA-2017-17]; OTKA (NKFIH) [115874, 119759, 2017-1.2.1-NKP-2017-00002]; Bolyai Scholarship [GINOP-2.3.2-15-2016-00050 "PEPSYS", LP2011-08/2011, MTA-TKI 14016]; [EFOP-3.6.2-16-2017-00008] Funding text: EFOP-3.6.1.-16-2016-00004, Comprehensive Development for Implementing Smart Specialization Strategies at the University of Pecs/Centre for neuroscience, EFOP-3.6.2-16-2017-00008, "The role of neuro-inflammation in neurodegeneration: from molecules to clinics", PTE AOK Research Grant KA-2016-03, KA-2017-17, OTKA (NKFIH) 115874 and 119759, 2017-1.2.1-NKP-2017-00002, Bolyai Scholarship, GINOP-2.3.2-15-2016-00050 "PEPSYS", LP2011-08/2011, MTA-TKI 14016. LA - English DB - MTMT ER - TY - JOUR AU - Varjú-Solymár, Margit AU - Ivic, Ivan AU - Balaskó, Márta AU - Fülöp, Balázs Dániel AU - Tóth, Gábor AU - Tamás, Andrea AU - Rémán, Gyöngyvér Éva AU - Koller, Ákos AU - Reglődi, Dóra TI - Pituitary adenylate cyclase-activating polypeptide ameliorates vascular dysfunction induced by hyperglycaemia JF - DIABETES & VASCULAR DISEASE RESEARCH J2 - DIABETES VASC DIS RES VL - 15 PY - 2018 IS - 4 SP - 277 EP - 285 PG - 9 SN - 1479-1641 DO - 10.1177/1479164118757922 UR - https://m2.mtmt.hu/api/publication/3339992 ID - 3339992 AB - BACKGROUND: Short-lasting hyperglycaemia occurs frequently in prediabetes and poorly controlled diabetes mellitus leading to vascular damage. Pituitary adenylate cyclase-activating polypeptide (PACAP) has been shown to play a protective role in vascular complications of diabetes; moreover, antioxidant effects of PACAP were also described. Therefore, we hypothesized that PACAP exerts protective effects in short-term hyperglycaemia-induced vascular dysfunctions. METHODS: After short-term hyperglycaemia, acetylcholine-induced and sodium nitroprusside-induced vascular relaxation of mouse carotid arteries were tested with a myograph with or without the presence of PACAP or superoxide dismutase. Potential direct antioxidant superoxide-scavenging action of pituitary adenylate cyclase-activating peptide was tested with pyrogallol autoxidation assay; furthermore, the effect of pituitary adenylate cyclase-activating peptide or superoxide dismutase was investigated on hyperglycaemia-associated vascular markers. RESULTS: PACAP administration resulted in reduced endothelial dysfunction after a 1-h hyperglycaemic episode. PACAP was able to restore acetylcholine-induced relaxation of the vessels and improved sodium nitroprusside-induced relaxation. This effect was comparable to the protective effect of superoxide dismutase, but PACAP was unable to directly scavenge superoxide produced by autoxidation of pyrogallol. Endothelial dysfunction was associated with elevated levels of fibroblast growth factor basic, matrix metalloproteinase 9 and nephroblastoma overexpressed gene proteins. Their release was reduced by PACAP administration. CONCLUSION: These results suggest a strong protective role of PACAP in the vascular complications of diabetes. LA - English DB - MTMT ER - TY - JOUR AU - Tamás, Andrea AU - Jávorházy, András AU - Csanaky, Katalin AU - Ragnhildstveit, E AU - Vikjord, SA AU - Sarlos, PD AU - Sárszegi, Zsolt AU - Zapf, I AU - Szántó, Z AU - Faludi, B AU - Molnár, T AU - Németh, J AU - Bánki, E AU - Lelesz, B AU - Rémán, Gyöngyvér Éva AU - Reglődi, Dóra TI - Examination of PACAP-like immunoreactivity in different pathological clinical samples JF - JOURNAL OF MOLECULAR NEUROSCIENCE J2 - J MOL NEUROSCI VL - 51 PY - 2013 IS - suppl.1 SP - 207 EP - 208 PG - 2 SN - 0895-8696 UR - https://m2.mtmt.hu/api/publication/2523801 ID - 2523801 LA - English DB - MTMT ER -