@article{MTMT:34551425,
	title = {Screening for chemical components, antioxidant and anti-enzymatic abilites activities of three Astragalus species from Turkey},
	url = {https://m2.mtmt.hu/api/publication/34551425},
	author = {Zengin, Gokhan and Yagi, Sakina and Ibrahime, Sinan and Yildiztugay, Evren and Jekő, József and Cziáky, Zoltán and Aktumsek, Abdurrahman},
	doi = {10.23812/j.biol.regul.homeost.agents.20243802.78},
	journal-iso = {J BIOL REG HOMEOS AG},
	journal = {JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS},
	volume = {38},
	unique-id = {34551425},
	issn = {0393-974X},
	abstract = {Background: In Turkey, Astragalus species are highly appreciated for their traditional therapeutic values. This research was devised to investigate the chemical composition, antioxidant, and enzyme inhibition activities of the aerial components of Astragalus (A.) angustifolius subsp. pungens, A. prusianus, and A. zederbaueri.
		
		Methods: Four extracts namely; ethyl acetate (EtOAc), methanol (MeOH), 70% MeOH, and aqueous extracts, were meticulously prepared. The chemical composition was examined utilizing spectrophotometric and High performance liquid chromatography-mass spectrometry (HPLC-MS)/MS techniques. The antioxidant activity was assessed by investigating the extracts' capability to scavenge radicals, reduce ions, and chelate ferrous ions. The enzyme inhibition properties were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase (Tyr), α-glucosidase, and α-amylase enzymes.
		
		Results: The findings revealed that the greatest total phenolic (28.33 mg gallic acid equivalent/g) and flavonoid (66.59 mg rutin equivalent/g) contents were achieved with the MeOH extract of A. angustifolius. The chemical profiles of the three species were marked by the presence of flavonol glycosides containing kaempferol, rhamnetin, isorhamnetin, and quercetin structural motifs. MeOH extract of A. angustifolius exerted the highest 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (48.73 mg trolox equivalent (TE)/g), Cu++ (150.10 mg TE/g) and Fe+++ (84.78 mg TE/g) reducing capacity. The three polar extracts (67.18–69.64 mg TE/g) of this species in addition to the aqueous extract (69.46 mg TE/g) of A. zederbaueri displayed the best 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity. 70% MeOH extract of A. prusianus had the highest metal chelating power (25.61 mg ethylenediaminetetraacetate equivalent (EDTAE)/g). MeOH extracts (2.37–2.50 mg galatamine equivalent (GALAE)/g) of the three species revealed the highest AChE inhibition activity while EtOAc extract (2.01 mg GALAE/g) of A. zederbaueri had the highest BChE inhibition activity. The highest anti-Tyr (50.40 mg kojic acid equivalent/g) activity was recorded from the EtOAc extract of A. zederbaueri.
		
		Conclusion: Thus, the three species of the studied Astragalus may represent a promising natural source of pyhtopharmaceutical agents for various pharmaceutical and nutritional uses.},
	year = {2024},
	eissn = {1724-6083},
	pages = {973-987}
}

@article{MTMT:34543379,
	title = {Establishment and elicitation of liquid adventitious root cultures of Inula crithmoides L. for increased caffeoylquinic acids production and hepatoprotective properties},
	url = {https://m2.mtmt.hu/api/publication/34543379},
	author = {Custódio, L. and Cziáky, Zoltán and Castañeda-Loaiza, V. and Rodrigues, M.J.},
	doi = {10.1007/s11240-024-02690-z},
	journal-iso = {PLANT CELL TISS ORG},
	journal = {PLANT CELL TISSUE AND ORGAN CULTURE},
	volume = {156},
	unique-id = {34543379},
	issn = {0167-6857},
	year = {2024},
	eissn = {1573-5044}
}

@article{MTMT:34502575,
	title = {Metabolomics‐based pharmaceutical evaluation of different parts of Swertia chirayita (Roxb.) Buch.‐Ham. ex C.B. Clarke from the western Himalayas},
	url = {https://m2.mtmt.hu/api/publication/34502575},
	author = {Tewari, Devesh and Bawari, Sweta and Mishra, Saurabh T and Gupta, Pawan and M, Aryalaxmi and Cziáky, Zoltán and Jekő, József and Lazarova, Irina and Zengin, Gökhan},
	doi = {10.1002/jssc.202300795},
	journal-iso = {J SEP SCI},
	journal = {JOURNAL OF SEPARATION SCIENCE},
	volume = {47},
	unique-id = {34502575},
	issn = {1615-9306},
	abstract = {Swertia species are common ingredients in numerous herbal remedies. It is also used to treat a wide range of illnesses and possess diverse therapeutic activities. The aim of the study is to elucidate the comprehensive metabolomics profile of Swertia chirayita and the role of various extraction methods in the phytochemical compositions of the extracts of S. chirayita , and their antioxidant and enzyme inhibitory activities. Extraction of the stems, leaves, and flowering tops of S. chirayita was performed by maceration, infusion, and soxhlation using methanol and water as solvent. Extracts were subjected to phytochemical profiling by a liquid‐chromatographic system. Antioxidant and enzyme inhibitory activity was carried out. The metabolomics profiling showed that a diverse range of specialized metabolites were present in the stems and leaves & flowering tops of the plant. All the extracts showed substantial antioxidant and enzyme inhibitory activities further confirmed by molecular docking studies. This study appraised the use of S. chirayita aerial parts as a potential antioxidant and its therapeutic application in various chronic illnesses including Alzheimer's disease, diabetes, and other skin‐related disorders.},
	year = {2024},
	eissn = {1615-9314},
	orcid-numbers = {Tewari, Devesh/0000-0002-5125-3791; Zengin, Gökhan/0000-0001-6548-7823}
}

@article{MTMT:34442108,
	title = {LC–MS/MS phytochemical profiling, antioxidant activity, and enzyme inhibitory of Potentilla reptans L. root: Computational studies and experimental validation},
	url = {https://m2.mtmt.hu/api/publication/34442108},
	author = {Mirzaei, Hasan and Jekő, József and Cziáky, Zoltán and Jahanshahi, Mehrdad and Zengin, Gokhan and Enayati, Aysheh},
	doi = {10.1016/j.procbio.2023.12.013},
	journal-iso = {PROCESS BIOCHEM},
	journal = {PROCESS BIOCHEMISTRY},
	volume = {137},
	unique-id = {34442108},
	issn = {1359-5113},
	year = {2024},
	eissn = {1873-3298},
	pages = {30-40}
}

@article{MTMT:34157617,
	title = {Harnessing the Bioactive Potential of Limonium spathulatum (Desf.) Kuntze: Insights into Enzyme Inhibition and Phytochemical Profile},
	url = {https://m2.mtmt.hu/api/publication/34157617},
	author = {Youssef, Seria and Custódio, Luisa and Rodrigues, Maria João and Pereira, Catarina G. and Calhelha, Ricardo C. and Jekő, József and Cziáky, Zoltán and Ben Hamed, Karim},
	doi = {10.3390/plants12193391},
	journal-iso = {PLANTS-BASEL},
	journal = {PLANTS-BASEL},
	volume = {12},
	unique-id = {34157617},
	abstract = {This study assessed the halophyte species Limonium spathulatum (Desf.) as a possible source of natural ingredients with the capacity to inhibit enzymes related to relevant human health disorders and food browning. Extracts using food-grade solvents such as water and ethanol were prepared by maceration from dried L. spathulatum leaves. They were evaluated for in vitro inhibition activity of enzymes such as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), α-glucosidase, tyrosinase and lipase, related to Alzheimer’s disease, type-2-diabetes mellitus, skin hyperpigmentation, and obesity, respectively. These extracts were also appraised for in vitro acute toxicity on tumoral and non-tumoral cell lines and their chemical composition by high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC-ESI-MS/MS). The extracts were more effective towards BChE than AChE. The best results were obtained with the hydroethanolic and water extracts, with IC50 values of 0.03 mg/mL and 0.06 mg/mL, respectively. The hydroethanolic extract had the highest capacity to inhibit α-glucosidase (IC50: 0.04 mg/mL), higher than the positive control used (acarbose, IC50 = 3.14 mg/mL). The ethanol extract displayed the best inhibitory activity against tyrosinase (IC50 = 0.34 mg/mL). The tested samples did not inhibit lipase and exhibited low to moderate cytotoxic activity against the tested cell lines. The hydroethanolic extract had a higher diversity of compounds, followed by the ethanol and water samples. Similar molecules were identified in all the extracts and were mainly hydroxybenzoic acids, hydroxycinnamic acids, and flavonoids. Taken together, these results suggest that L. spathulatum should be further explored as a source of bioactive ingredients for the food, cosmetic, and pharmaceutical industries.},
	year = {2023},
	eissn = {2223-7747},
	orcid-numbers = {Custódio, Luisa/0000-0003-4338-7703; Rodrigues, Maria João/0000-0001-8732-710X; Pereira, Catarina G./0000-0002-1131-8773; Calhelha, Ricardo C./0000-0002-6801-4578}
}

@article{MTMT:34129813,
	title = {Phytoconstituent Profiles Associated with Relevant Antioxidant Potential and Variable Nutritive Effects of the Olive, Sweet Almond, and Black Mulberry Gemmotherapy Extracts},
	url = {https://m2.mtmt.hu/api/publication/34129813},
	author = {Alaya, Amina and Mihok, Emőke and Pecsenye, Bence and Jolji, Maria and Kertész, Attila and Bársony, Péter and Vigh, Szabolcs and Cziáky, Zoltán and Máthé , Anna  and Burtescu, Ramona Flavia and Oláh, Neli-Kinga and Neamțu, Andreea-Adriana and Turcuș, Violeta and Máthé, Endre},
	doi = {10.3390/antiox12091717},
	journal-iso = {ANTIOXIDANTS-BASEL},
	journal = {ANTIOXIDANTS},
	volume = {12},
	unique-id = {34129813},
	abstract = {The extracts of whole plants or specific organs from different plant species are gaining increasing attention for their phytotherapy applications. Accordingly, we prepared standardized gemmotherapy extracts (GTEs) from young shoots/buds of olive (Olea europaea), sweet almond (Prunus amygdalus), and black mulberry (Morus nigra), and analyzed the corresponding phytonutrient profiles. We identified 42, 103, and 109 phytonutrients in the olive, almond, and black mulberry GTEs, respectively, containing amino acids, vitamins, polyphenols, flavonoids, coumarins, alkaloids, iridoids, carboxylic acids, lignans, terpenoids, and others. In order to assess the physiological effects generated by the GTEs, we developed a translational nutrition model based on Drosophila melanogaster and Cyprinus carpio. The results indicate that GTEs could influence, to a variable extent, viability and ATP synthesis, even though both are dependent on the specific carbohydrate load of the applied diet and the amino acid and polyphenol pools provided by the GTEs. It seems, therefore, likely that the complex chemical composition of the GTEs offers nutritional properties that cannot be separated from the health-promoting mechanisms that ultimately increase viability and survival. Such an approach sets the paves the way for the nutritional genomic descriptions regarding GTE-associated health-promoting effects.},
	year = {2023},
	eissn = {2076-3921},
	orcid-numbers = {Neamțu, Andreea-Adriana/0000-0002-5219-5466}
}

@article{MTMT:34112875,
	title = {Elucidation of chemical compounds in different extracts of two Lavandula taxa and their biological potentials: Walking with versatile agents on the road from nature to functional applications},
	url = {https://m2.mtmt.hu/api/publication/34112875},
	author = {Zengin, Gokhan and Yagi, Sakina and Selvi, Selami and Cziáky, Zoltán and Jekő, József and Sinan, Kouadio Ibrahime and Topcu, Asena Ayyüce and Erci, Fatih and Boczkaj, Grzegorz},
	doi = {10.1016/j.indcrop.2023.117366},
	journal-iso = {IND CROP PROD},
	journal = {INDUSTRIAL CROPS AND PRODUCTS},
	volume = {204},
	unique-id = {34112875},
	issn = {0926-6690},
	year = {2023},
	eissn = {1872-633X},
	orcid-numbers = {Boczkaj, Grzegorz/0000-0002-5874-7591}
}

@article{MTMT:34106557,
	title = {Monitoring physiological processes of fast-growing broilers during the whole life cycle: Changes of redox-homeostasis effected to trassulfuration pathway predicting the development of non-alcoholic fatty liver disease},
	url = {https://m2.mtmt.hu/api/publication/34106557},
	author = {Pesti-Asbóth, Georgina and Szilágyi, Endre and Bíróné Molnár, Piroska and Oláh, János and Babinszky, László and Czeglédi, Levente and Cziáky, Zoltán and Paholcsek, Melinda and Stündl, László and Gálné Remenyik, Judit},
	doi = {10.1371/journal.pone.0290310},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {18},
	unique-id = {34106557},
	issn = {1932-6203},
	abstract = {In the broiler industry, the average daily gain and feed conversion ratio are extremely favorable, but the birds are beginning to approach the maximum of their genetic capacity. However, as a consequence of strong genetic selection, the occurrence of certain metabolic diseases, such as myopathies, ascites, sudden cardiac death and tibial dyschondroplasia, is increasing. These metabolic diseases can greatly affect the health status and welfare of birds, as well as the quality of meat. The main goal of this study was to investigate the changes in the main parameters of redox homeostasis during the rearing (1–42 days of age) of broilers with high genetic capacity, such as the concentrations of malondialdehyde, vitamin C, vitamin E, and reduced glutathione, the activities of glutathione peroxidase and glutathione reductase, and the inhibition rate of superoxide dismutase. Damage to the transsulfuration pathway during growth and the reason for changes in the level of homocysteine were investigated. Further, the parameters that can characterize the biochemical changes occurring in the birds were examined. Our study is the first characterize plasma albumin saturation. A method was developed to measure the levels of other small molecule thiol components of plasma. Changes in redox homeostasis induce increases in the concentrations of tumor necrosis factor alpha and inflammatory interleukins interleukin 2, interleukin 6 and interleukin 8 in broilers reared according to current large-scale husbandry technology and feeding protocols. A significant difference in all parameters tested was observed on the 21st day. The concentrations of cytokines and homocysteine increased, while the concentrations of glutathione and cysteine in the plasma decreased. Our findings suggest that observed changes in the abovementioned biochemical indices have a negative effect on poultry health.},
	year = {2023},
	eissn = {1932-6203}
}

@inbook{MTMT:34058054,
	title = {A liofilizált gyömbérkondenzvíz szárazanyagtartalom- és HPLC-MS-vizsgálata},
	url = {https://m2.mtmt.hu/api/publication/34058054},
	author = {Antal, Tamás and Cziáky, Zoltán},
	booktitle = {Ezerarcú tudomány a régió szolgálatában},
	unique-id = {34058054},
	year = {2023},
	pages = {9-17},
	orcid-numbers = {Antal, Tamás/0000-0002-9505-7100}
}

@article{MTMT:33785479,
	title = {Phytochemical profiling, antioxidant activities, enzymatic activities and insecticidal potential of aqueous extracts of four plants on the larvae of Helicoverpa armigera (Lepidoptera: Noctuidae), the main pest of cotton plant in Ivory Coast},
	url = {https://m2.mtmt.hu/api/publication/33785479},
	author = {Bini, Kouadio Kra Norbert and Kobenan, Koffi Christophe and Kouakou, Malanno and Kouadio, Ibrahime Sinan and Zengin, Gokhan and Jekő, József and Cziáky, Zoltán and Danho, Mathias and Ochou, Ochou Germain},
	doi = {10.1002/arch.22017},
	journal-iso = {ARCH INSECT BIOCHEM},
	journal = {ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY},
	volume = {1133},
	unique-id = {33785479},
	issn = {0739-4462},
	year = {2023},
	eissn = {1520-6327}
}