TY - JOUR AU - Vámos, Orsolya AU - Komora, Péter AU - Gede, Noémi AU - Hegyi, Péter AU - Kelemen, Kata AU - Varga, Gábor AU - Mikulás, Krisztina Ágnes AU - Kerémi, Beáta AU - Kispélyi, Ida Barbara TI - The effect of nicotine-containing products on peri-implant tissues : A systematic review and network meta-analysis JF - NICOTINE AND TOBACCO RESEARCH J2 - NICOTINE TOB RES PY - 2024 SN - 1462-2203 DO - 10.1093/ntr/ntae085 UR - https://m2.mtmt.hu/api/publication/34801787 ID - 34801787 AB - Smokers have a higher chance of developing peri-implant diseases and are therefore considered an at-risk population. Our aim was to compare peri-implant characteristics in users of electronic cigarettes (EC), waterpipes (WP), cigarettes (CS), smokeless tobacco (ST), and non-smokers (non-users of any nicotine and tobacco product; NS).A systematic search of four electronic databases (PubMed, EMBASE, Web of Science, CENTRAL) was performed until April 2023, restricted to English language. Thirty-nine observational studies were included in the qualitative synthesis, of which 32 studies were included in a Bayesian network meta-analysis. Using a predesigned form, two researchers independently collected data about marginal bone loss (MBL), probing pocket depth (PPD), plaque index (PI), bleeding on probing (BOP), modified plaque index (mPI), probing pocket depth > 4mm (PPD>4), gingival index (GI), peri-implant sulcular fluid (PISF) volume, and TNF-α and IL-1β levels. QUIPS and CINeMA were used to evaluate the risk of bias and certainty of evidence.NS had the smallest MBL. Most nicotine-containing product users had significantly higher MBL (CS, MD:1.34 CrI: 0.85, 1.79; WP, MD:1.58 CrI: 0.84, 2.35; ST, MD:2.53, CrI: 1.20, 3.87) than NS. EC did not show significant difference compared to NS (MD:0.52 CrI: -0.33, 1.36). In secondary outcomes NS were ranked in first place. Subset analysis based on smoking habit, implant duration, and maintenance control revealed no differences in ranking probability.Most nicotine-containing product users presented worse peri-implant parameters compared to non-smokers, while EC users did not show significant differences to NS in many outcomes.Alternative nicotine-containing products are gaining popularity and are often considered less harmful by the general public compared to traditional cigarettes. This is the first network meta-analysis comparing users of four nicotine-containing products and non-smokers. This study shows that CS, WP and ST have a detrimental effect on the overall health of peri-implant tissues. EC users also presented inferior parameters compared to NS, however, the difference was not significant in many outcomes. It is essential to educate patients who are using nicotine-containing products, and to provide proper maintenance and appropriate cessation support. Well-designed multi-armed studies are needed for direct comparison of different products, including heated tobacco products. Greater transparency of confounding factors is needed regarding smoking habit and oral hygiene. LA - English DB - MTMT ER - TY - JOUR AU - Juhász, Anna Evelin AU - Stubnya, Márton Péter AU - Teutsch, Brigitta AU - Gede, Noémi AU - Hegyi, Péter AU - Nyirády, Péter AU - Bánhidy, Ferenc AU - Ács, Nándor AU - Juhász, Réka TI - Ranking the dietary interventions by their effectiveness in the management of polycystic ovary syndrome : a systematic review and network meta-analysis JF - REPRODUCTIVE HEALTH J2 - REPROD HEALTH VL - 21 PY - 2024 IS - 1 PG - 12 SN - 1742-4755 DO - 10.1186/s12978-024-01758-5 UR - https://m2.mtmt.hu/api/publication/34680511 ID - 34680511 N1 - Funding Agency and Grant Number: Semmelweis University; New National Excellence Program of the Ministry for Innovation and Technology [BT-UNKP-22-3-I-PTE-169] Funding text: Open access funding provided by Semmelweis University. Funding was provided by the UNKP-22-3 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (to BT-UNKP-22-3-I-PTE-1693). The funding provider had no role in study design, data collection, data analysis, data interpretation, or the writing of the report. AB - Polycystic ovary syndrome (PCOS) is a common condition in women, characterised by reproductive and metabolic dysfunction. While dietary approaches have been evaluated as a first-line treatment for patients with PCOS, there is limited evidence to support preference for a specific dietary composition. This systematic review and network meta-analysis was performed with the objective of comparing different dietary interventions in terms of positive impact. Metformin, the currently preferred treatment, was also compared.The latest systematic search was performed on the 20th of March, 2023. Eligible randomised controlled trials (RCTs) included patients with PCOS and compared the dietary approach with another intervention or a standard diet. Outcomes were expressed via anthropometric measurements and hormonal, glycemic, and lipid levels. The Bayesian method was used to perform a network meta-analysis and to calculate the surface under the cumulative ranking curve (SUCRA) values in order to rank the dietary interventions. The overall quality of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation system.19 RCTs were identified, comprising data from 727 patients who were variously treated with 10 types of dietary interventions and metformin. The Dietary Approaches to Stop Hypertension (DASH) diet was the most effective in reducing Homeostatic Model Assessment of Insulin Resistance (SUCRA 92.33%), fasting blood glucose (SUCRA 85.92%), fasting insulin level (SUCRA 79.73%) and triglyceride level (SUCRA 82.07%). For body mass index (BMI), the most effective intervention was the low-calorie diet (SUCRA 84.59%). For weight loss, the low-calorie diet with metformin (SUCRA 74.38%) was the most effective intervention. Metformin produced the greatest reductions in low-density lipoprotein cholesterol (SUCRA 78.08%) and total testosterone levels (SUCRA 71.28%). The low-carb diet was the most effective intervention for reducing cholesterol levels (SUCRA 69.68%), while the normal diet (SUCRA 65.69%) ranked first for increasing high-density lipoprotein cholesterol levels.Dietary interventions vary in their effects on metabolic parameters in women with PCOS. Based on our results, the DASH diet is the most effective dietary intervention for treating PCOS. Registration PROSPERO ID CRD42021282984. LA - English DB - MTMT ER - TY - JOUR AU - Berke, Gergő AU - Beer, Sebastian AU - Gede, Noémi AU - Takáts, Amanda AU - Szentesi, Andrea Ildikó AU - Hegyi, Péter AU - Rosendahl, Jonas AU - Sahin-Tóth, Miklós AU - Németh, Balázs AU - Hegyi, Eszter TI - Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: Case-control studies and meta-analysis JF - PANCREATOLOGY J2 - PANCREATOLOGY VL - 23 PY - 2023 IS - 5 SP - 481 EP - 490 PG - 10 SN - 1424-3903 DO - 10.1016/j.pan.2023.05.013 UR - https://m2.mtmt.hu/api/publication/34011872 ID - 34011872 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Juhász, Anna Evelin AU - Greff, Dorina AU - Teutsch, Brigitta AU - Gede, Noémi AU - Hegyi, Péter AU - Horvath, Eszter Mária AU - Deák, Pál Ákos AU - Nyirády, Péter AU - Ács, Nándor AU - Juhász, Réka TI - Galactomannans are the most effective soluble dietary fibers in type 2 diabetes: a systematic review and network meta-analysis JF - AMERICAN JOURNAL OF CLINICAL NUTRITION J2 - AM J CLIN NUTR VL - 117 PY - 2023 IS - 2 SP - 266 EP - 277 PG - 12 SN - 0002-9165 DO - 10.1016/j.ajcnut.2022.12.015 UR - https://m2.mtmt.hu/api/publication/33588657 ID - 33588657 AB - Background Soluble dietary fibers are known to reduce the levels of blood glucose and lipids in patients with type 2 diabetes mellitus (type 2 diabetes). Although several different dietary fiber supplements are utilized, to our knowledge, no previous study has ranked their efficacy yet. Objectives We performed this systematic review and network meta-analysis to rank the effects of different types of soluble dietary fibers. Methods We performed our last systematic search on November 20, 2022. Eligible randomized controlled trials (RCTs) included adult patients with type 2 diabetes and compared the intake of soluble dietary fibers with that of another type of dietary fiber or no fiber. The outcomes were related to glycemic and lipid levels. The Bayesian method was used to perform a network meta-analysis and calculate the surface under the cumulative ranking (SUCRA) curve values to rank the interventions. The Grading of Recommendations Assessment, Development, and Evaluation system was applied to evaluate the overall quality of the evidence. Results We identified 46 RCTs, including data from 2685 patients who received 16 types of dietary fibers as intervention. Galactomannans had the highest effect on reducing the levels of HbA1c (SUCRA: 92.33%) and fasting blood glucose (SUCRA: 85.92%). With regard to fasting insulin level, HOMA-IR, β-glucans (SUCRA: 73.45%), and psyllium (SUCRA: 96.67%) were the most effective interventions. Galactomannans were ranked first in reducing the levels of triglycerides (SUCRA: 82.77%) and LDL cholesterol (SUCRA: 86.56%). With regard to cholesterol and HDL cholesterol levels, xylo-oligosaccharides (SUCRA: 84.59%) and gum arabic (SUCRA: 89.06%) were the most effective fibers. Most comparisons had a low or moderate certainty of evidence. Conclusions Galactomannans were the most effective dietary fiber for reducing the levels of HbA1c, fasting blood glucose, triglycerides, and LDL cholesterol in patients with type 2 diabetes. This study was registered at PROSPERO as ID CRD42021282984. LA - English DB - MTMT ER - TY - JOUR AU - Dudás, Csaba AU - Czumbel, László Márk AU - Kiss, Szabolcs AU - Gede, Noémi AU - Hegyi, Péter AU - Mártha, Krisztina AU - Varga, Gábor TI - Clinical bracket failure rates between different bonding techniques: a systematic review and meta-analysis JF - EUROPEAN JOURNAL OF ORTHODONTICS J2 - EUR J ORTHODONT VL - 45 PY - 2023 IS - 2 SP - 175 EP - 185 PG - 11 SN - 0141-5387 DO - 10.1093/ejo/cjac050 UR - https://m2.mtmt.hu/api/publication/33146777 ID - 33146777 N1 - * Megosztott szerzőség AB - Bracket failure increases the treatment time of orthodontic therapy and burdens patients with unnecessary costs, increased chair time, and possible new appointments.To compare the bond failures of different orthodontic materials based on the results of available clinical studies.A systematic search of clinical trials was performed in the Cochrane, Embase, and Pubmed databases with no limitations. The list of investigated techniques contained conventional acid-etch primer (CM-AEP), self-etch primer (SEP), self-cure resin (SCR), and simple or resin-modified glass ionomer (RM-GIC) materials and procedures.Clinical studies reporting the failure rate of bonded brackets after using direct adhesive techniques on buccal sites of healthy teeth were included.Bracket failure rates from eligible studies were extracted by two authors independently. Risk ratios (RRs) were pooled using the random-effects model with DerSimonian-Laird estimation.Thirty-four publications, involving 1221 patients, were included. Our meta-analysis revealed no significant difference in the risk of bracket failures between SEP and CM-AEP. After 6, 12, and 18 months of bonding, the values of RR were 1.04 [95% confidence interval (CI), 0.67-1.61], 1.37 (95% CI, 0.98-1.92), and 0.93 (95% CI, 0.72-1.20), respectively. At 18 months, bracket failure was 4.9 and 5.2% for SEP and CM-AEP, respectively. Heterogeneity was good or moderate (I2 < 42.2%). The results of RM-GIC at 12 months indicated a 57% lower risk of bracket failure using SCR as compared with RM-GIC (RR: 0.38; 95% CI, 0.24-0.61). At 18 months, bracket failures for SCR and RM-GIC were 15.8 and 36.6%, respectively (RR: 0.44; 95% CI, 0.37-0.52, I2 = 78.9%), demonstrating three to six times higher failure rate than in the case of etching primer applications.A major limitation of the present work is that the included clinical trials, with no exceptions, showed variable levels of risk of bias. Another possible problem affecting the outcome is the difference between the clustering effects of the split mouth and the parallel group bracket allocation methods.The results revealed no significant difference between SEP and CM-AEP up to 18 months after application. RM-GIC had much worse failure rates than acid-etching methods; additionally, the superiority of SCR over RM-GIC was evident, indicating strong clinical relevance.Prospero with CRD42020163362. LA - English DB - MTMT ER - TY - JOUR AU - Berke, Gergő AU - Gede, Noémi AU - Szadai, Leticia AU - Ocskay, Klementina AU - Hegyi, Péter AU - Sahin-Tóth, Miklós AU - Hegyi, Eszter TI - Bicarbonate defective CFTR variants increase risk for chronic pancreatitis: A meta-analysis JF - PLOS ONE J2 - PLOS ONE VL - 17 PY - 2022 IS - 10 PG - 11 SN - 1932-6203 DO - 10.1371/journal.pone.0276397 UR - https://m2.mtmt.hu/api/publication/33193011 ID - 33193011 N1 - * Megosztott szerzőség AB - Cystic fibrosis transmembrane conductance regulator (CFTR) plays a central role in pancreatic ductal fluid secretion by mediating Cl- and HCO3- ion transport across the apical membrane. Severe CFTR mutations that diminish chloride conductance cause cystic fibrosis (CF) if both alleles are affected, whereas heterozygous carrier status increases risk for chronic pancreatitis (CP). It has been proposed that a subset of CFTR variants characterized by a selective bicarbonate conductance defect (CFTRBD) may be associated with CP but not CF. However, a rigorous genetic analysis of the presumed association has been lacking.To investigate the role of heterozygous CFTRBD variants in CP by meta-analysis of published case-control studies.A systematic search was conducted in the MEDLINE, Embase, Scopus, and CENTRAL databases for published studies that reported the CFTRBD variants p.R74Q, p.R75Q, p.R117H, p.R170H, p.L967S, p.L997F, p.D1152H, p.S1235R, and p.D1270N in CP patients and controls.Twenty-two studies were eligible for quantitative synthesis. Combined analysis of the 9 CFTRBD variants indicated enrichment in CP patients versus controls (OR = 2.31, 95% CI = 1.17-4.56). Individual analysis of CFTRBD variants revealed no association of p.R75Q with CP (OR = 1.12, 95% CI = 0.89-1.40), whereas variants p.R117H and p.L967S were significantly overrepresented in cases relative to controls (OR = 3.16, 95% CI = 1.94-5.14, and OR = 3.88, 95% CI = 1.32-11.47, respectively). The remaining 6 low-frequency variants gave inconclusive results when analyzed individually, however, their pooled analysis indicated association with CP (OR = 2.08, 95% CI = 1.38-3.13).Heterozygous CFTRBD variants, with the exception of p.R75Q, increase CP risk about 2-4-fold. LA - English DB - MTMT ER - TY - JOUR AU - Dezso, Flóra AU - Birkás, Béla AU - Vizin, Gabriella AU - Váncsa, Szilárd AU - Szőcs, Henrietta AU - Erőss, Attila AU - Lex, Dániel AU - Gede, Noémi AU - Molnár, Zsolt AU - Hegyi, Péter AU - Csathó, Árpád TI - Examining the mental health adversity among healthcare providers during the two waves of the COVID-19 pandemic: results from a cross-sectional, survey-based study JF - BMJ OPEN J2 - BMJ OPEN VL - 12 PY - 2022 IS - 8 PG - 9 SN - 2044-6055 DO - 10.1136/bmjopen-2021-059493 UR - https://m2.mtmt.hu/api/publication/33064761 ID - 33064761 N1 - * Megosztott szerzőség AB - The current global health crisis of the COVID-19 pandemic has drastically affected the whole population, but healthcare workers are particularly exposed to high levels of physical and mental stress. This enormous burden requires both the continuous monitoring of their health conditions and research into various protective factors.Cross-sectional surveys.Self-administered questionnaires were constructed assessing COVID-19-related worries of health workers in Hungary. The surveys were conducted during two consecutive waves of the COVID-19 pandemic (N-first wave=376, N-second wave=406), between 17 July 2020 and 31 December 2020.COVID-19-related worry, well-being and distress levels of healthcare workers. We also tested whether psychological resilience mediates the association of worry with well-being and distress. Multiple linear regression analyses were performed.The results indicated that healthcare workers had high levels of worry and distress in both pandemic waves. When comparing the two waves, enhanced levels of worry (Wald's χ2=4.36, p=0.04) and distress (Wald's χ2=25.18, p<0.001), as well as compromised well-being (Wald's χ2=58.64, p<0.001), were found in the second wave. However, not all types of worries worsened to the same extent across the waves drawing attention to some specific COVID-19-sensitive concerns. Finally, the protective role of psychological resilience was shown by a mediator analysis suggesting the importance of increasing resilience as a key factor in maintaining the mental health of healthcare workers in the burden of the COVID-19 pandemic.Our results render the need for regular psychological surveillance in healthcare workers.Hungarian Scientific and Research Ethics Committee of the Medical Research Council (IV/5079-2/2020/EKU). LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Barbara AU - Jávorházy, András AU - Nyirády, Péter AU - Csupor-Löffler, Boglárka AU - Birinyi, Péter AU - Zhanel, George AU - Naber, Kurt AU - Länger, Reinhard AU - Vörhendi, Nóra AU - Gede, Noémi AU - Váncsa, Szilárd AU - Hegyi, Péter AU - Csupor, Dezső TI - Bearberry in the treatment of acute uncomplicated cystitis (BRUMI) : protocol of a multicentre, randomised double-blind clinical trial JF - BMJ OPEN J2 - BMJ OPEN VL - 12 PY - 2022 IS - 6 PG - 7 SN - 2044-6055 DO - 10.1136/bmjopen-2021-057982 UR - https://m2.mtmt.hu/api/publication/32911943 ID - 32911943 AB - Bearberry (Arctostaphylos uva-ursi) leaf is available as a treatment of uncomplicated cystitis in several European countries. The antimicrobial activity of its extracts and some of its individual constituents has been observed in vitro; however, the efficacy of bearberry compared with standard antimicrobial therapy has not been assessed yet.The objective of the study is to assess the safety and non-inferiority of bearberry as an alternative therapy in the treatment of acute uncomplicated cystitis in comparison with standard antibiotic therapy (fosfomycin).This is a randomised controlled double-blinded multicentre trial. Eligible patients will be premenopausal women with a sum score of ≥6 for the typical acute uncomplicated cystitis symptoms (frequency, urgency, painful urination, incomplete emptying, suprapubic pain and visible haematuria) reported on the Acute Cystitis Symptom Score (ACSS) typical domain and pyuria. Patients will be randomly assigned to receive 3 g single dose of fosfomycin powder and two placebo tablets three times a day for 7 days or B a single dose of placebo powder and two tablets containing a dry extract of Uvae ursi folium. At least 504 patients (allocated as 1:1) will need to be enrolled to access non-inferiority with a non-inferiority limit of 14% for the primary endpoint.Improvement of symptoms of uncomplicated cystitis (based on the ACSS score) at day 7 is defined as the primary endpoint, whereas several secondary endpoints such as the number and ratio of patients with bacteriuria at day 7, frequency and severity of side effects; recurrence of urinary tract infection, concurrent use of other over the counter (OTC) medications and food supplements will be determined to elucidate more detailed differences between the groups. The number of recurrences and medications taken for treatment will be monitored for a follow-up period of 90 days (80-100 days).This study has been approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (IV/4225-1/2021/EKU). The results will be disseminated by publication of peer-reviewed manuscripts.NCT05055544. LA - English DB - MTMT ER - TY - JOUR AU - Kui, Balázs AU - Pintér, József AU - Molontay, Roland AU - Nagy, Marcell AU - Borbásné Farkas, Kornélia AU - Gede, Noémi AU - Vincze, Áron AU - Bajor, Judit AU - Gódi, Szilárd AU - Czimmer, József AU - Szabó, Imre AU - Illés, Anita AU - Sarlós, Patrícia AU - Hágendorn, Roland AU - Pár, Gabriella AU - Papp, Mária AU - Vitális, Zsuzsanna AU - Kovács, György AU - Fehér, Eszter AU - Földi, Ildikó AU - Izbéki, Ferenc AU - Gajdán, László AU - Fejes, Roland AU - Németh, Balázs AU - Török, Imola AU - Farkas, Hunor AU - Mickevicius, Artautas AU - Sallinen, Ville AU - Galeev, Shamil AU - Ramírez-Maldonado, Elena AU - Párniczky, Andrea AU - Erőss, Bálint Mihály AU - Hegyi, Péter Jenő AU - Márta, Katalin AU - Váncsa, Szilárd AU - Sutton, Robert AU - Szatmary, Peter AU - Latawiec, Diane AU - Halloran, Chris AU - de-Madaria, Enrique AU - Pando, Elizabeth AU - Alberti, Piero AU - Gómez-Jurado, Maria José AU - Tantau, Alina AU - Szentesi, Andrea Ildikó AU - Hegyi, Péter TI - EASY-APP: An artificial intelligence model and application for early and easy prediction of severity in acute pancreatitis JF - CLINICAL AND TRANSLATIONAL MEDICINE J2 - CLIN TRANSL MED VL - 12 PY - 2022 IS - 6 PG - 13 SN - 2001-1326 DO - 10.1002/ctm2.842 UR - https://m2.mtmt.hu/api/publication/32865751 ID - 32865751 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office Research Fund [K131996, FK131864, K128222, FK124632]; University of Pecs Medical School Research Fund [300909] Funding text: The research was supported by National Research, Development and Innovation Office Research Fund (project grants K131996 to Peter Hegyi, FK131864 to Artautas Mickevicius, K128222 to Laszlo Gajdan, FK124632 to Balazs Csaba Nemeth), and by funding from the University of Pecs Medical School Research Fund (300909) to Andrea Szentesi. The funders had no effect on the concept, data collection, analysis and writing of the manuscript. We wish to thank all further contributing members of the Hungarian Pancreatic Study Group, full names together with affiliations are listed in the Supplementary material. AB - Acute pancreatitis (AP) is a potentially severe or even fatal inflammation of the pancreas. Early identification of patients at high risk for developing a severe course of the disease is crucial for preventing organ failure and death. Most of the former predictive scores require many parameters or at least 24 h to predict the severity; therefore, the early therapeutic window is often missed.The early achievable severity index (EASY) is a multicentre, multinational, prospective and observational study (ISRCTN10525246). The predictions were made using machine learning models. We used the scikit-learn, xgboost and catboost Python packages for modelling. We evaluated our models using fourfold cross-validation, and the receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), and accuracy metrics were calculated on the union of the test sets of the cross-validation. The most critical factors and their contribution to the prediction were identified using a modern tool of explainable artificial intelligence called SHapley Additive exPlanations (SHAP).The prediction model was based on an international cohort of 1184 patients and a validation cohort of 3543 patients. The best performing model was an XGBoost classifier with an average AUC score of 0.81 ± 0.033 and an accuracy of 89.1%, and the model improved with experience. The six most influential features were the respiratory rate, body temperature, abdominal muscular reflex, gender, age and glucose level. Using the XGBoost machine learning algorithm for prediction, the SHAP values for the explanation and the bootstrapping method to estimate confidence, we developed a free and easy-to-use web application in the Streamlit Python-based framework (http://easy-app.org/).The EASY prediction score is a practical tool for identifying patients at high risk for severe AP within hours of hospital admission. The web application is available for clinicians and contributes to the improvement of the model. LA - English DB - MTMT ER - TY - JOUR AU - Virág, M. AU - Rottler, Máté AU - Gede, Noémi AU - Ocskay, Klementina AU - Leiner, Tamás AU - Tuba, Máté AU - Ábrahám, Szabolcs AU - Borbásné Farkas, Kornélia AU - Hegyi, Péter AU - Molnár, Zsolt TI - Goal-Directed Fluid Therapy Enhances Gastrointestinal Recovery after Laparoscopic Surgery: A Systematic Review and Meta-Analysis JF - JOURNAL OF PERSONALIZED MEDICINE J2 - J PERS MED VL - 12 PY - 2022 IS - 5 PG - 17 SN - 2075-4426 DO - 10.3390/jpm12050734 UR - https://m2.mtmt.hu/api/publication/32837327 ID - 32837327 N1 - Szentágothai Research Centre, Institute for Translational Medicine, Medical School, University of Pécs, Pécs, 7624, Hungary Department of Anesthesiology and Intensive Therapy, Szent György University Teaching Hospital of Fejér County, Székesfehérvár, 8000, Hungary Doctoral School of Clinical Medicine, University of Szeged, Szeged, 6720, Hungary Centre for Translational Medicine, Semmelweis University, Budapest, 1085, Hungary Anaesthetic Department, Hinchingbrooke Hospital, North West Anglia NHS Foundation Trust, Huntingdon, PE29 6NT, United Kingdom Division for Pancreatic Disorders, Heart and Vascular Center, Semmelweis University, Budapest, 1122, Hungary Department of Anaesthesiology and Intensive Therapy, Poznan University of Medical Sciences, Poznan, 61-701, Poland Department of Anaesthesiology and Intensive Therapy, Semmelweis University, Budapest, 1082, Hungary Cited By :3 Export Date: 17 January 2024 Correspondence Address: Molnár, Z.; Szentágothai Research Centre, Hungary; email: zsoltmolna@gmail.com AB - (1) Background: Whether goal-directed fluid therapy (GDFT) provides any outcome benefit as compared to non-goal-directed fluid therapy (N-GDFT) in elective abdominal laparoscopic surgery has not been determined yet. (2) Methods: A systematic literature search was conducted in MEDLINE, Embase, CENTRAL, Web of Science, and Scopus. The main outcomes were length of hospital stay (LOHS), time to first flatus and stool, intraoperative fluid and vasopressor requirements, serum lactate levels, and urinary output. Pooled risks ratios (RRs) with 95% confidence intervals (CI) were calculated for dichotomous outcomes and weighted mean difference (WMD) with 95% CI for continuous outcomes. (3) Results: Eleven studies were included in the quantitative, and fifteen in the qualitative synthesis. LOHS (WMD: -1.18 days, 95% CI: -1.84 to -0.53) and time to first stool (WMD: -9.8 h; CI -12.7 to -7.0) were significantly shorter in the GDFT group. GDFT resulted in significantly less intraoperative fluid administration (WMD: -441 mL, 95% CI: -790 to -92) and lower lactate levels at the end of the operation: WMD: -0.25 mmol L-1; 95% CI: -0.36 to -0.14. (4) Conclusions: GDFT resulted in enhanced recovery of the gastrointestinal function and shorter LOHS as compared to N-GDFT. LA - English DB - MTMT ER -