TY - JOUR AU - Wirth, Roland AU - Maróti, Gergely AU - Lipták, Lídia AU - Mester, Mónika Klára AU - Al Ayoubi, Alaa AU - Pap, Bernadett AU - Madléna, Melinda AU - Minárovits, János AU - Kovács, Kornél Lajos TI - Microbiomes in supragingival biofilms and saliva of adolescents with gingivitis and gingival health JF - ORAL DISEASES J2 - ORAL DIS VL - 28 PY - 2022 IS - 7 SP - 2000 EP - 2014 PG - 15 SN - 1354-523X DO - 10.1111/odi.13883 UR - https://m2.mtmt.hu/api/publication/32020395 ID - 32020395 N1 - Department of Biotechnology, University of Szeged, Szeged, Hungary Institute of Plant Biology, Biological Research Centre, Szeged, Hungary Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, University of Szeged, Szeged, Hungary Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, Szeged, Hungary Export Date: 20 October 2021 CODEN: ORDIF Correspondence Address: Kovács, K.L.; Department of Biotechnology, Hungary; email: kovacs.kornel@bio.u-szeged.hu Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Regional Development Fund, ERDF, FK123899, GINOP‐2.3.2‐15‐2016‐00011, PD132145 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH Funding details: National Research, Development and Innovation Office Funding text 1: This research was funded by the European Regional Development Fund to a project led by JM grant GINOP‐2.3.2‐15‐2016‐00011. Additional projects GINOP‐2.2.1‐15‐2017‐00081, GINOP‐2.2.1‐15‐2017‐00033, and EFOP‐3.6.2‐16‐2017‐00010 also contributed to this work. RW (PD132145) and GM (FK123899) received support from the National Research, Development and Innovation Office (NKFIH), Hungary. This work was also supported by the János Bolyai Research Scholarship (for GM) of the Hungarian Academy of Sciences. The authors thank the funding agencies for their support. We are indebted to Dr. Márió Gajdács and the unknown Reviewers for critical reading of the manuscript. AB - Background Important alterations exist in the microbiomes of supragingival biofilm and saliva samples from adolescent patients developing induced or spontaneous gingivitis relative to healthy controls. These and the relationships to dental health are not fully understood yet. Subjects and Methods Supragingival biofilm samples (n = 36) were collected from the teeth of 9 adolescents with gingivitis induced by orthodontic appliances, as well as dental plaques (n = 40) from 10 adolescents with spontaneous gingivitis, in addition to similar samples (n = 36) from 9 healthy controls. The bacterial metagenomes were analyzed by 16S rRNA gene amplicon sequencing. Salivary microbiomes of the same persons were characterized by shotgun metagenome sequencing. The data sets were examined using advanced bioinformatics workflows and two reference databases. Results The composition and diversity of bacterial communities did not differ extensively among the three study groups. Nevertheless, the relative abundances of the genera Fusobacterium, Akkermansia, Treponema, and Campylobacter were prominently higher in gingivitis patients versus controls. In contrast, the genera Lautropia, Kingella, Neisseria, Actinomyces, and Rothia were significantly more abundant in controls than in either of the two gingivitis groups. Conclusions The abundance pattern of certain taxa rather than individual strains shows characteristic features of potential diagnostic value. Stringent bioinformatics treatment of the sequencing data is mandatory to avoid unintentional misinterpretations. LA - English DB - MTMT ER - TY - CHAP AU - Madléna, Melinda AU - Lipták, Lídia AU - Gyulai-Gaál, Szabolcs ED - Radnai, Márta ED - Fazekas, András TI - A fogak sérülései T2 - Fogászat PB - Medicina Könyvkiadó CY - Budapest SN - 9789632267357 PY - 2019 SP - 49 EP - 54 PG - 6 UR - https://m2.mtmt.hu/api/publication/30805913 ID - 30805913 LA - Hungarian DB - MTMT ER - TY - THES AU - Lipták, Lídia TI - Fogászati lakkok orális egészségre gyakorolt hatásának vizsgálata PY - 2019 DO - 10.14753/SE.2019.2249 UR - https://m2.mtmt.hu/api/publication/30741236 ID - 30741236 LA - Hungarian DB - MTMT ER - TY - GEN AU - Lipták, Lídia TI - Fogászati lakkok orális egészségre gyakorolt hatásának vizsgálata PY - 2018 UR - https://m2.mtmt.hu/api/publication/30676459 ID - 30676459 LA - Hungarian DB - MTMT ER - TY - CONF AU - Lipták, Lídia AU - Twetman, S. AU - Márton, Sándor József AU - Bársony, Nóra AU - Madléna, Melinda TI - Fogászati lakkok orális egészségre gyakorolt hatásának vizsgálata T2 - Translational interactive hands-on training and conference on epithelial ion transport including two symposia: "Antibacterial and mucolytic therapy in cystic fibrosis" and "Research in oral cavity – from basic science to clinical use" PY - 2018 SP - 73 UR - https://m2.mtmt.hu/api/publication/30421489 ID - 30421489 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Lipták, Lídia AU - Twetman, Svante AU - Márton, Sándor József AU - Bársony, Nóra AU - Madléna, Melinda ED - Seres, László TI - Fogászati lakkok orális egészségre gyakorolt hatásának vizsgálata T2 - Magyar Arc-, Állcsont- és Szájsebészeti Társaság XXII. Kongresszusa és Szegedi Fogorvos Találkozó PB - Szegedi Tudományegyetem, Arc-, Állcsont- és Szájsebészeti Klinika CY - Szeged SN - 9789633066072 PY - 2018 SP - 69 EP - 69 PG - 1 UR - https://m2.mtmt.hu/api/publication/3419126 ID - 3419126 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Lipták, Lídia AU - Szabó, Krisztina AU - Nagy, Gábor AU - Márton, Sándor József AU - Madléna, Melinda TI - Microbiological Changes and Caries-Preventive Effect of an Innovative Varnish Containing Chlorhexidine in Orthodontic Patients JF - CARIES RESEARCH J2 - CARIES RES VL - 52 PY - 2018 IS - 4 SP - 272 EP - 278 PG - 7 SN - 0008-6568 DO - 10.1159/000486140 UR - https://m2.mtmt.hu/api/publication/3333996 ID - 3333996 N1 - Department of Paedodontics and Orthodontics, Faculty of Dentistry, Semmelweis University, Budapest, Hungary Department of Community Dentistry, Faculty of Dentistry, Semmelweis University, Budapest, Hungary Department of Sociology and Social Policy, Faculty of Arts, University of Debrecen, Debrecen, Hungary Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, University of Szeged, Tisza L. krt. 64-66, Szeged, HU-6720, Hungary Cited By :9 Export Date: 15 June 2023 CODEN: CAREB Chemicals/CAS: chlorhexidine, 3697-42-5, 55-56-1; thymol, 89-83-8; Anti-Infective Agents, Local; Cariostatic Agents; Chlorhexidine; chlorhexidine, thymol drug combination; Drug Combinations; Thymol AB - The aim of this study was to investigate the effects of Cervitec Plus(R) on the level of mutans streptococcus (SM) and lactobacillus (LB) colonies and the development of white spot lesions (WSLs) in patients with fixed orthodontic appliances. Informed consent was obtained from 32 volunteers (age 16.5 +/- 2.75 years). At baseline, levels of the bacterial colonies were determined in saliva and plaque using a chairside test (CRT Bacteria, Ivoclar-Vivadent, Schaan, Liechtenstein), and the number of WSLs was registered. After placing the fixed appliance, Cervitec Plus(R) or placebo varnishes (Ivoclar-Vivadent, Schaan, Liechtenstein) were applied monthly around the brackets and tubes, randomly in the right or left (test and placebo) quadrants of the same dental arch. SM and LB colonies in saliva and the SM colonies in plaque were determined on 11-21, 13-23, 15-25, and 16-26 teeth monthly over a 6-month period. At the sixth month, the number of new WSLs was determined. By the end of the study, compared with baseline, the ratio of saliva samples belonging to the low-risk category was significantly higher (p