TY - JOUR AU - Földi, Mihály AU - Bencze, Szilvia AU - Hertelendy, Péter AU - Veszter, Sara AU - Kovacs, Tina AU - Drexler, Dóra TI - Farmer involvement in agro-ecological research: organic on-farm wheat variety trials in Hungary and the Slovakian upland JF - ORGANIC AGRICULTURE J2 - ORGANIC AGRICULTURE VL - 12 PY - 2022 IS - 3 SP - 293 EP - 305 PG - 13 SN - 1879-4238 DO - 10.1007/s13165-020-00335-x UR - https://m2.mtmt.hu/api/publication/34796626 ID - 34796626 AB - The acreage of organic farming is constantly increasing in Hungary. The cultivation of cereals-and within it-the production of winter wheat is of main importance in organic field crop production. Besides the challenges of global climate change, various difficulties are known, such as the inadequate variety assortment, lack of knowledge on the performance of varieties under organic conditions and often low quality of the seeds sown. As official post-registration variety trials only exist under conventional farming conditions in Hungary, the Hungarian Research Institute of Organic Agriculture (oMKi) started participatory organic on-farm variety tests in 2012, with the involvement of volunteer farmers all over the country. Over the past 7 years, nearly 60 wheat varieties and more than 20 farms have been included in the tests. The aim of the study was to find the most suitable varieties for high-quality organic wheat production and exclude inappropriate varieties for respective production regions. Results demonstrated that there is great potential in choosing varieties best suited to regional environmental conditions and that it is possible to achieve both high yield and excellent quality also in organic farming when adopting the appropriate varieties. The use of varieties, which were proven to be disease tolerant or resistant, can significantly contribute to safer organic production. The comparisons between the performance of varieties indicated that organic breeding has a great role in all of the above matters. LA - English DB - MTMT ER - TY - THES AU - Hertelendy, Péter TI - The impact of age on the elicitation of spreading depolarization and the implication of prostanoids in the associated cerebral blood flow response Hertelendy Péter PB - Szegedi Tudományegyetem (SZTE) PY - 2019 SP - 102 DO - 10.14232/phd.10277 UR - https://m2.mtmt.hu/api/publication/31267847 ID - 31267847 LA - English DB - MTMT ER - TY - JOUR AU - Tarantini, Stefano AU - Valcarcel-Ares, Marta Noa AU - Tóth, Péter József AU - Yabluchanskiy, Andriy AU - Tucsek, Zsuzsanna AU - Kiss, Tamás AU - Hertelendy, Péter AU - Kinter, Michael AU - Ballabh, Praveen AU - Süle, Zoltán AU - Farkas, Eszter AU - Baur, Joseph A AU - Sinclair, David A AU - Csiszar, Anna AU - Ungvári, Zoltán István TI - Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice JF - REDOX BIOLOGY J2 - REDOX BIOL VL - 24 PY - 2019 PG - 14 SN - 2213-2317 DO - 10.1016/j.redox.2019.101192 UR - https://m2.mtmt.hu/api/publication/30646506 ID - 30646506 AB - Adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling (NVC) has an essential role in maintenance of healthy cognitive function. In aging increased oxidative stress and cerebromicrovascular endothelial dysfunction impair NVC, contributing to cognitive decline. There is increasing evidence showing that a decrease in NAD+ availability with age plays a critical role in a range of age-related cellular impairments but its role in impaired NVC responses remains unexplored. The present study was designed to test the hypothesis that restoring NAD+ concentration may exert beneficial effects on NVC responses in aging. To test this hypothesis 24-month-old C57BL/6 mice were treated with nicotinamide mononucleotide (NMN), a key NAD+ intermediate, for 2 weeks. NVC was assessed by measuring CBF responses (laser Doppler flowmetry) evoked by contralateral whisker stimulation. We found that NVC responses were significantly impaired in aged mice. NMN supplementation rescued NVC responses by increasing endothelial NO-mediated vasodilation, which was associated with significantly improved spatial working memory and gait coordination. These findings are paralleled by the sirtuin-dependent protective effects of NMN on mitochondrial production of reactive oxygen species and mitochondrial bioenergetics in cultured cerebromicrovascular endothelial cells derived from aged animals. Thus, a decrease in NAD+ availability contributes to age-related cerebromicrovascular dysfunction, exacerbating cognitive decline. The cerebromicrovascular protective effects of NMN highlight the preventive and therapeutic potential of NAD+ intermediates as effective interventions in patients at risk for vascular cognitive impairment (VCI). LA - English DB - MTMT ER - TY - JOUR AU - Hertelendy, Péter AU - Varga, Dániel Péter AU - Menyhárt, Ákos AU - Bari, Ferenc AU - Farkas, Eszter TI - Susceptibility of the cerebral cortex to spreading depolarization in neurological disease states: The impact of aging JF - NEUROCHEMISTRY INTERNATIONAL J2 - NEUROCHEM INT VL - 127 ET - 0 PY - 2019 SP - 125 EP - 136 PG - 12 SN - 0197-0186 DO - 10.1016/j.neuint.2018.10.010 UR - https://m2.mtmt.hu/api/publication/30345331 ID - 30345331 N1 - Department of Medical Physics and Informatics, Faculty of Medicine and Faculty of Science and Informatics, University of Szeged, Korányis Fasor 9, Szeged, H-6720, Hungary Department of Neurology Faculty of Medicine, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Export Date: 22 December 2018 Article in Press CODEN: NEUID Correspondence Address: Farkas, E.; Department of Medical Physics and Informatics, Faculty of Medicine and Faculty of Science and Informatics, University of Szeged, Korányis Fasor 9, Hungary; email: farkas.eszter.1@med.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Hertelendy, Péter AU - Toldi, József AU - Fülöp, Ferenc AU - Vécsei, László TI - Ischemic Stroke and Kynurenines: Medicinal Chemistry Aspects JF - CURRENT MEDICINAL CHEMISTRY J2 - CURR MED CHEM VL - 25 PY - 2018 IS - 42 SP - 5945 EP - 5957 PG - 13 SN - 0929-8673 DO - 10.2174/0929867325666180313113411 UR - https://m2.mtmt.hu/api/publication/30461805 ID - 30461805 N1 - Cited By :9 Export Date: 11 September 2023 CODEN: CMCHE Correspondence Address: Vécsei, L.; Department of Neurology, Semmelweis u. 6, Hungary; email: vecsei.laszlo@med.u-szeged.hu Chemicals/CAS: 3 hydroxykynurenine, 484-78-6; kynurenic acid, 492-27-3; kynurenine, 16055-80-4, 343-65-7; quinolinic acid, 89-00-9; tryptophan, 6912-86-3, 73-22-3; 3-hydroxykynurenine; Excitatory Amino Acid Antagonists; Kynurenic Acid; Kynurenine; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Tryptophan Funding details: 2.3.2-15-2016-00048 Funding text 1: We express our gratitude to Dr. Dániel Varga for his kind help regarding the figures and the general concept of the review. This work was supported by the by GINOP 2.3.2-15-2016-00048 (STAY ALIVE). AB - Ischemic stroke is one of the leading causes of mortality and permanent disability in developed countries, Stroke induces massive glutamate release, which in turn causes N-Methyl-D-aspartate (NMDA) receptor over-excitation and thus, calcium overload in neurons leading to cell death via apoptotic cascades, The kynurenine pathway is a complex enzymatic cascade of tryptophan catabolism, generating various neuroactive metabolites. One metabolite, kynurenic acid (KYNA), is a potent endogenous NMDA glutamate receptor antagonist, making it a possible therapeutic tool to decrease excitotoxicity and neuroinflammation. Recently, clinical investigations have shown that during the acute phase of ischemic stroke, kynurenine pathway is activated and peripheral levels of metabolites correlated with worse outcome. In this review, we set out to summarize the current literature on the connection of the kynurenine pathway and ischemic stroke and set a course for future investigations and potential drug development. LA - English DB - MTMT ER - TY - JOUR AU - Tarantini, Stefano AU - Yabluchanskiy, Andriy AU - Fülöp, Gábor Áron AU - Hertelendy, Péter AU - Valcarcel-Ares, M. Noa AU - Kiss, Tamás AU - Bagwell, Jonathan M. AU - O'Connor, Daniel AU - Farkas, Eszter AU - Sorond, Farzaneh AU - Csiszar, Anna AU - Ungvári, Zoltán István TI - Corretion to: Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 40 PY - 2018 IS - 2 SP - 219 EP - 219 PG - 1 SN - 2509-2715 DO - 10.1007/s11357-018-0012-4 UR - https://m2.mtmt.hu/api/publication/30452343 ID - 30452343 LA - English DB - MTMT ER - TY - JOUR AU - Tarantini, Stefano AU - Yabluchanskiy, Andriy AU - Fulop, Gabor Aaron AU - Hertelendy, Péter AU - Valcarcel-Ares, Marta Noa AU - Kiss, Tamás AU - Bagwell, Jonathan M. AU - O'Connor, Daniel AU - Farkas, Eszter AU - Sorond, Farzaneh AU - Csiszar, Anna AU - Ungvári, Zoltán István TI - Pharmacologically-induced impairment of neurovascular coupling responses alters gait coordination in mice JF - FASEB JOURNAL J2 - FASEB J VL - 32 PY - 2018 IS - S1 SP - 711.9 EP - 711.9 PG - 2 SN - 0892-6638 UR - https://m2.mtmt.hu/api/publication/30452341 ID - 30452341 LA - English DB - MTMT ER - TY - JOUR AU - Tarantini, Stefano AU - Valcarcel-Ares, MN AU - Yabluchanskiy, A AU - Tucsek, Z AU - Hertelendy, Péter AU - Kiss, Tamás AU - Gautam, T AU - Zhang, XA AU - Sonntag, WE AU - de Cabo, R AU - Farkas, Eszter AU - Elliott, MH AU - Kinter, MT AU - Deak, F AU - Ungvári, Zoltán István AU - Csiszar, Anna TI - Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype JF - JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES J2 - J GERONTOL A-BIOL MED SCI VL - 73 ET - 0 PY - 2018 IS - 7 SP - 853 EP - 863 PG - 10 SN - 1079-5006 DO - 10.1093/gerona/glx177 UR - https://m2.mtmt.hu/api/publication/3413924 ID - 3413924 N1 - Export Date: 3 April 2024 CODEN: JGASF AB - Obesity has deleterious effects on cognitive function in the elderly adults. In mice, aging exacerbates obesity-induced oxidative stress, microvascular dysfunction, blood-brain barrier (BBB) disruption, and neuroinflammation, which compromise cognitive health. However, the specific mechanisms through which aging and obesity interact to remain elusive. Previously, we have shown that Nrf2 signaling plays a critical role in microvascular resilience to obesity and that aging is associated with progressive Nrf2 dysfunction, promoting microvascular impairment. To test the hypothesis that Nrf2 deficiency exacerbates cerebromicrovascular dysfunction induced by obesity Nrf2(+/+) and Nrf2(-/-), mice were fed an adipogenic high-fat diet (HFD). Nrf2 deficiency significantly exacerbated HFD-induced oxidative stress and cellular senescence, impairment of neurovascular coupling responses, BBB disruption, and microglia activation, mimicking the aging phenotype. Obesity in Nrf2(-/-) mice elicited complex alterations in the amyloidogenic gene expression profile, including upregulation of amyloid precursor protein. Nrf2 deficiency and obesity additively reduced long-term potentiation in the CAI area of the hippocampus. Collectively, Nrf2 dysfunction exacerbates the deleterious effects of obesity, compromising cerebromicrovascular and brain health by impairing neurovascular coupling mechanisms, BBB integrity and synaptic function and promoting neuroinflammation. These results support a possible role for age-related Nrf2 dysfunction in the pathogenesis of vascular cognitive impairment and Alzheimer's disease. LA - English DB - MTMT ER - TY - JOUR AU - Tarantini, Stefano AU - Valcarcel-Ares, NM AU - Yabluchanskiy, A AU - Fülöp, Gábor Áron AU - Hertelendy, Péter AU - Gautam, T AU - Farkas, Eszter AU - Perz, A AU - Rabinovitch, PS AU - Sonntag, WE AU - Csiszar, Anna AU - Ungvári, Zoltán István TI - Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice JF - AGING CELL J2 - AGING CELL VL - 17 ET - 0 PY - 2018 IS - 2 PG - 12 SN - 1474-9718 DO - 10.1111/acel.12731 UR - https://m2.mtmt.hu/api/publication/3367042 ID - 3367042 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Yabluchanskiy, Andriy AU - Tarantini, Stefano AU - Hertelendy, Péter AU - Valcarcel-Ares, Marta Noa AU - Gautam, Tripti AU - Farkas, Eszter AU - Sonntag, William E. AU - Csiszar, Anna AU - Ungvári, Zoltán István TI - Neurovascular uncoupling predicts cognitive decline and gait abnormalities in a clinically relevant mouse model of whole brain irradiation JF - FASEB JOURNAL J2 - FASEB J VL - 31 PY - 2017 IS - S1 PG - 1 SN - 0892-6638 UR - https://m2.mtmt.hu/api/publication/30452358 ID - 30452358 LA - English DB - MTMT ER -