TY - JOUR AU - Bocskai, Gábor AU - Pótári, Adrián AU - Gombos, Ferenc AU - Kovács, Ilona TI - The adolescent pattern of sleep spindle development revealed by HD‐EEG JF - JOURNAL OF SLEEP RESEARCH J2 - J SLEEP RES VL - 32 PY - 2023 IS - 2 SN - 0962-1105 DO - 10.1111/jsr.13618 UR - https://m2.mtmt.hu/api/publication/32791005 ID - 32791005 AB - Sleep spindles are developmentally relevant cortical oscillatory patterns; however, they have mostly been studied by considering the entire spindle frequency range (11–15 Hz) without a distinction between the functionally and topographically different slow and fast spindles, using relatively few electrodes and analysing wide age ranges. Here, we employ high-density night sleep electroencephalography in three age-groups between 12 and 20 years of age (30 females and 30 males) and analyse the adolescent developmental pattern of the four major parameters of slow and fast sleep spindles. Most of our findings corroborate those very few previous studies that also make a distinction between slow and fast spindles in their developmental analysis. We find spindle frequency increasing with age. A spindle density change is not obvious in our study. We confirm the declining tendencies for amplitude and duration, although within narrower, more specific age-windows than previously determined. Spindle frequency seems to be higher in females in the oldest age-group. Based on the pattern of our findings, we suggest that high-density electroencephalography, specifically targeting slow and fast spindle ranges and relatively narrow age-ranges would advance the understanding of both adolescent cortical maturation and development and the functional relevance of sleep spindles in general. LA - English DB - MTMT ER - TY - JOUR AU - Gombos, Ferenc AU - Bódizs, Róbert AU - Pótári, Adrián AU - Bocskai, Gábor AU - Berencsi, Andrea AU - Szakács, Hanna AU - Kovács, Ilona TI - Topographical relocation of adolescent sleep spindles reveals a new maturational pattern in the human brain JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 10 SN - 2045-2322 DO - 10.1038/s41598-022-11098-8 UR - https://m2.mtmt.hu/api/publication/32800032 ID - 32800032 AB - Current theories of human neural development emphasize the posterior-to-anterior pattern of brain maturation. However, this scenario leaves out significant brain areas not directly involved with sensory input and behavioral control. Suggesting the relevance of cortical activity unrelated to sensory stimulation, such as sleep, we investigated adolescent transformations in the topography of sleep spindles. Sleep spindles are known to be involved in neural plasticity and in adults have a bimodal topography: slow spindles are frontally dominant, while fast spindles have a parietal/precuneal origin. The late functional segregation of the precuneus from the frontoparietal network during adolescence suggests that spindle topography might approach the adult state relatively late in development, and it may not be a result of the posterior-to-anterior maturational pattern. We analyzed the topographical distribution of spindle parameters in HD-EEG polysomnographic sleep recordings of adolescents and found that slow spindle duration maxima traveled from central to anterior brain regions, while fast spindle density, amplitude and frequency peaks traveled from central to more posterior brain regions. These results provide evidence for the gradual posteriorization of the anatomical localization of fast sleep spindles during adolescence and indicate the existence of an anterior-to-posterior pattern of human brain maturation. LA - English DB - MTMT ER - TY - GEN AU - Bocskai, Gábor AU - Pótári, Adrián AU - Gombos, Ferenc AU - Kovács, Ilona TI - The adolescent pattern of sleep spindle development revealed by HD-EEG polysomnography PY - 2021 SP - 1 EP - 9 PG - 9 UR - https://m2.mtmt.hu/api/publication/32548487 ID - 32548487 AB - Sleep spindles are developmentally relevant cortical oscillatory patterns; however, they have mostly been studied by considering the entire spindle frequency range (11 to 15 Hz) without a distinction between the functionally and topographically different slow and fast spindles, using relatively few electrodes and analysing wide age-ranges. Here, we employ HD-EEG polysomnography in three age-groups between 12 to 20 years of age, with an equal distribution between the two genders, and analyse the adolescent developmental pattern of the four major parameters of slow and fast sleep spindles. Most of our findings corroborate those very few previous studies that also make a distinction between slow and fast spindles in their developmental analysis. We find spindle frequency increasing with age, although spindle density change is not obvious in our study. We confirm the declining tendencies for amplitude and duration, although within narrower, more specific age-windows than previously. Spindle frequency seems to be higher in females in the oldest age-group. Based on the pattern of our findings, we suggest that HD-EEG, specifically targeting slow and fast spindle ranges and relatively narrow age-ranges would advance the understanding of both adolescent development and the functional relevance of sleep spindles in general. LA - English DB - MTMT ER - TY - GEN AU - Gombos, Ferenc AU - Bódizs, Róbert AU - Pótári, Adrián AU - Bocskai, Gábor AU - Berencsi, Andrea AU - Szakács, Hanna AU - Kovács, Ilona TI - Topographical relocation of adolescent sleep spindles reveals a new maturational pattern of the human brain PY - 2021 PG - 19 UR - https://m2.mtmt.hu/api/publication/32037889 ID - 32037889 AB - Current theories of human neural development and brain maturation emphasize the posterior-to-anterior or back-to-front pattern as an unequivocal ontogenetic feature that is largely due to the late maturing frontal lobes. The back-to-front pattern has received substantial support from both anatomical and electrophysiological studies, the latter looking at the age-related changes in the topography of sleep slow waves. However, the above scenario of a unidirectional developmental and anatomical route disregards the major hub of the so-called default-mode network, which is a human-specific and late maturing neural structure of the brain, undergoing significant differentiation during adolescence: the precuneus. In order to understand how the late maturation of the precuneus might modify the presently accepted large-scale maturational pattern of the human brain, here we focus on sleep spindles that are known to be involved in neural plasticity with major sources in the precuneus in adults. We provide evidence for the posteriorization in the prevailing anatomical localization of fast sleep spindles. The predominantly central maxima in density and amplitude of fast spindles at the age of 12 years becomes gradually shifted to the parietal regions until the age of 20. Similar changes, albeit at a smaller anatomical distance take place in terms of fast sleep spindle frequency. These findings indicate a front-to-back pattern of brain maturation and correspond with reports on an increased differentiation of the precuneus during adolescence. LA - English DB - MTMT ER - TY - JOUR AU - Bódizs, Róbert AU - Szalárdy, Orsolya AU - G. Horváth, Csenge AU - Ujma, Przemyslaw Péter AU - Gombos, Ferenc AU - Simor, Péter Dániel AU - Pótári, Adrián AU - Zeising, Marcel AU - Steiger, Axel AU - Dresler, Martin TI - A set of composite, non-redundant EEG measures of NREM sleep based on the power law scaling of the Fourier spectrum JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 11 PY - 2021 IS - 1 PG - 18 SN - 2045-2322 DO - 10.1038/s41598-021-81230-7 UR - https://m2.mtmt.hu/api/publication/31825420 ID - 31825420 LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Ilona AU - Pótári, Adrián AU - Milanovich, Dominika TI - Kell-e különórára járnia, ha nem akar? JF - MINDENNAPI PSZICHOLÓGIA J2 - MINDENNAPI PSZICHOLÓGIA VL - 6 PY - 2019 IS - december-január SP - 26 EP - 31 PG - 6 SN - 2060-2626 UR - https://m2.mtmt.hu/api/publication/31155556 ID - 31155556 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ujma, Przemyslaw Péter AU - Konrad, Boris N AU - Gombos, Ferenc AU - Simor, Péter Dániel AU - Pótári, Adrián AU - Genzel, Lisa AU - Pawlowski, Marcel AU - Steiger, Axel AU - Bódizs, Róbert AU - Dresler, Martin TI - The sleep EEG spectrum is a sexually dimorphic marker of general intelligence JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 7 PY - 2017 IS - 1 PG - 10 SN - 2045-2322 DO - 10.1038/s41598-017-18124-0 UR - https://m2.mtmt.hu/api/publication/3307361 ID - 3307361 AB - The shape of the EEG spectrum in sleep relies on genetic and anatomical factors and forms an individual “EEG fingerprint”. Spectral components of EEG were shown to be connected to mental ability both in sleep and wakefulness. EEG sleep spindle correlates of intelligence, however, exhibit a sexual dimorphism, with a more pronounced association to intelligence in females than males. In a sample of 151 healthy individuals, we investigated how intelligence is related to spectral components of full-night sleep EEG, while controlling for the effects of age. A positive linear association between intelligence and REM anterior beta power was found in females but not males. Transient, spindle-like “REM beta tufts” are described in the EEG of healthy subjects, which may reflect the functioning of a recently described cingular-prefrontal emotion and motor regulation network. REM sleep frontal high delta power was a negative correlate of intelligence. NREM alpha and sigma spectral power correlations with intelligence did not unequivocally remain significant after multiple comparisons correction, but exhibited a similar sexual dimorphism. These results suggest that the neural oscillatory correlates of intelligence in sleep are sexually dimorphic, and they are not restricted to either sleep spindles or NREM sleep. LA - English DB - MTMT ER - TY - JOUR AU - Bódizs, Róbert AU - Gombos, Ferenc AU - Ujma, Przemyslaw Péter AU - Szakadát, Sára AU - Sándor, Piroska AU - Simor, Péter Dániel AU - Pótári, Adrián AU - Konrad, BN AU - Genzel, L AU - Steiger, A AU - Dresler, M AU - Kovács, Ilona TI - The hemispheric lateralization of sleep spindles in humans JF - SLEEP SPINDLES & CORTICAL UP STATES J2 - SLEEP SPINDLES CORTICAL UP STATES VL - 1 PY - 2017 IS - 1 SP - 42 EP - 54 PG - 13 SN - 2559-9070 DO - 10.1556/2053.01.2017.002 UR - https://m2.mtmt.hu/api/publication/3198876 ID - 3198876 LA - English DB - MTMT ER - TY - JOUR AU - Pótári, Adrián AU - Ujma, Przemyslaw Péter AU - Konrad, Boris N AU - Genzel, Lisa AU - Simor, Péter Dániel AU - Körmendi, János AU - Gombos, Ferenc AU - Steiger, Axel AU - Dresler, Martin AU - Bódizs, Róbert TI - Age-related changes in sleep EEG are attenuated in highly intelligent individuals JF - NEUROIMAGE J2 - NEUROIMAGE VL - 146 PY - 2017 SP - 554 EP - 560 PG - 7 SN - 1053-8119 DO - 10.1016/j.neuroimage.2016.09.039 UR - https://m2.mtmt.hu/api/publication/3117265 ID - 3117265 AB - Abstract Impaired sleep is a frequent complaint in ageing and a risk factor for many diseases. Non-rapid eye movement (NREM) sleep EEG delta power reflects neural plasticity and, in line with age-related cognitive decline, decreases with age. Individuals with higher general intelligence are less affected by age-related cognitive decline or other disorders and have longer lifespans. We investigated the correlation between age and EEG power in 159 healthy human subjects (age range: 17-69 years), and compared an average (IQ<120; N=87) with a high (IQ≥120; N=72) intelligence subgroup. We found less age-related decrease in all-night relative NREM sleep EEG delta power in the high intelligence subgroup. Our results suggest that highly intelligent individuals are less affected by the sleep-related effects of biological ageing, and therefore potentially less at risk for age-related cognitive deficits and other diseases. LA - English DB - MTMT ER - TY - JOUR AU - Bódizs, Róbert AU - Dresler, M AU - Ujma, Przemyslaw Péter AU - Gombos, Ferenc AU - Szakadát, Sára AU - Sándor, Piroska AU - Simor, Péter Dániel AU - Pótári, Adrián AU - Konrad, BN AU - Genzel, L AU - Steiger, A AU - Kovács, Ilona TI - Sex differences in the hemispheric lateralization of sleep spindles in humans JF - JOURNAL OF SLEEP RESEARCH J2 - J SLEEP RES VL - 25 PY - 2016 IS - Suppl. 1 SP - 293 EP - 293 PG - 1 SN - 0962-1105 UR - https://m2.mtmt.hu/api/publication/3113987 ID - 3113987 LA - English DB - MTMT ER -