TY - JOUR AU - Ádám, Kornél AU - Berényi, Tamás AU - Melicher, Dóra AU - Fenyves, Bánk AU - Gaál, Szabolcs AU - Varga, Csaba TI - Risk factors of early death in heat stroke and the challenges of emergency care in Hungary - a case series study JF - INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE J2 - INT J EMERG MED VL - 17 PY - 2024 IS - 1 PG - 7 SN - 1865-1372 DO - 10.1186/s12245-024-00743-w UR - https://m2.mtmt.hu/api/publication/35445641 ID - 35445641 LA - English DB - MTMT ER - TY - JOUR AU - Melicher, Dóra AU - Gaál, Szabolcs AU - Berényi, Tamás AU - Fenyves, Bánk AU - Nagy, Norbert AU - Hegedűs, Péter AU - Fülöp, András AU - Szijártó, Attila AU - Varga, Csaba TI - A rare cause of abdominal pain in pregnancy - mesenteric artery thrombosis and miscarriage in a 34-year-old patient JF - INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE J2 - INT J EMERG MED VL - 17 PY - 2024 IS - 1 PG - 6 SN - 1865-1372 DO - 10.1186/s12245-024-00661-x UR - https://m2.mtmt.hu/api/publication/35077323 ID - 35077323 LA - English DB - MTMT ER - TY - JOUR AU - Tárnoki, Dávid László AU - Piroska, Márton AU - Forgó, Bianka AU - Szabó, Helga AU - Zöldi, Luca AU - Melicher, Dóra AU - Metneki, Julia AU - Littvay, Levente AU - Tárnoki, Ádám Domonkos TI - The Population-Based Hungarian Twin Registry. An Update. TS - An Update. JF - TWIN RESEARCH AND HUMAN GENETICS J2 - TWIN RES HUM GENET VL - 27 PY - 2024 IS - 2 SP - 115 EP - 119 PG - 5 SN - 1832-4274 DO - 10.1017/thg.2024.15 UR - https://m2.mtmt.hu/api/publication/34868573 ID - 34868573 AB - Between 2006 and 2021, the Hungarian Twin Registry (HTR) operated a volunteer twin registry of all age groups (50% monozygotic [MZ], 50% dizygotic [DZ], 70% female, average age 34 ± 22 years), including 1044 twin pairs, 24 triplets and one quadruplet set. In 2021, the HTR transformed from a volunteer registry into a population-based one, and it was established in the Medical Imaging Centre of Semmelweis University in Budapest. Semmelweis University's innovation fund supported the development of information technology, a phone bank and voicemail infrastructure, administrative materials, and a new website was established where twins and their relatives (parent, foster parent or caregiver) can register. The HTR's biobank was also established: 157,751 individuals with a likely twin-sibling living in Hungary (77,042 twins, 1194 triplets, 20 quadruplets, and one quintuplet) were contacted between February and March of 2021 via sealed letters. Until November 20, 2022, 12,001 twin individuals and their parents or guardians (6724 adult twins, 3009 parents/guardians and 5277 minor twins) registered, mostly online. Based on simple self-reports, 37.6% of the registered adults were MZ twins and 56.8% were DZ; 1.12% were triplets and 4.5% were unidentified. Of the registered children, 22.3% were MZ, 72.7% were DZ, 1.93% were triplets, and 3.05% were unidentified. Of the registered twins, 59.9% were female (including both the adult and minor twins). The registration questionnaire consists of eight parts, including socio-demographic and anthropometric data, smoking habits and medical questions (diseases, operations, therapies). Hungary's twin registry has become the sole and largest population-based twin registry in Central Eastern Europe. This new resource will facilitate performing world-class modern genetic research. LA - English DB - MTMT ER - TY - JOUR AU - Melicher, Dóra AU - Gaál, Szabolcs AU - Berényi, Tamás AU - Fenyves, Bánk AU - Novák, Pál Kaposi AU - Tóth, Ambrus AU - Szegedi, László AU - Varga, Csaba TI - Acute hydrocephalus caused by a colloid cyst — a case report JF - INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE J2 - INT J EMERG MED VL - 16 PY - 2023 IS - 1 PG - 5 SN - 1865-1372 DO - 10.1186/s12245-023-00500-5 UR - https://m2.mtmt.hu/api/publication/33770864 ID - 33770864 LA - English DB - MTMT ER - TY - JOUR AU - Melicher, Dóra AU - Illés, Anett AU - Littvay, Levente AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László AU - Bikov, András AU - Kunos, László AU - Csabán, Dóra AU - Buzás, Edit Irén AU - Molnár, Mária Judit AU - Falus, András TI - Positive association and future perspectives of mitochondrial DNA copy number and telomere length – a pilot twin study JF - ARCHIVES OF MEDICAL SCIENCE J2 - ARCH MED SCI VL - 17 PY - 2021 IS - 5 SP - 1191 EP - 1199 PG - 9 SN - 1734-1922 DO - 10.5114/aoms.2019.83173 UR - https://m2.mtmt.hu/api/publication/30636506 ID - 30636506 N1 - Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary MTA-SE Immunproteogenomics Extracellular Vesicle Research Group Hungarian Twin Registry, Budapest, Hungary Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, Hungary Central European University, Budapest, Hungary Department of Radiology, Semmelweis University, Budapest, Hungary Department of Pulmonology, Semmelweis University, Budapest, Hungary Cited By :3 Export Date: 23 January 2024 Correspondence Address: Falus, A.; Department of Genetics, Nagyvárad tér 4, Hungary; email: falus.andras@med.semmelweis-univ.hu LA - English DB - MTMT ER - TY - JOUR AU - Jokkel, Zsofia AU - Melicher, Dóra AU - Illes, Anett AU - Piroska, Marton AU - Bikov, Andras AU - Szabo, Helga AU - Hernyes, Anita AU - Molnar, Maria Judit AU - Buzás, Edit Irén AU - Falus, András AU - Meszaros, Szilvia AU - Horvath, Csaba AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - Genetic versus Environmental Background on the Relationship of Telomere Length and Bone Mineral Density JF - ORVOSKÉPZÉS J2 - ORVOSKÉPZÉS VL - 95 PY - 2020 IS - 1 SP - 64 EP - 64 PG - 1 SN - 0030-6037 UR - https://m2.mtmt.hu/api/publication/31799888 ID - 31799888 LA - English DB - MTMT ER - TY - JOUR AU - Simon, Botond AU - Lipták, Laura Mária AU - Lipták, Klaudia Margit AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László AU - Melicher, Dóra AU - Vág, János TI - Application of intraoral scanner to identify monozygotic twins JF - BMC ORAL HEALTH J2 - BMC ORAL HEALTH VL - 20 PY - 2020 IS - 1 PG - 8 SN - 1472-6831 DO - 10.1186/s12903-020-01261-w UR - https://m2.mtmt.hu/api/publication/31617754 ID - 31617754 AB - DNA base identification is a proper and high specificity method. However, identification could be challenged in a situation where there is no database or the DNA sequence is almost identical, as in the case of monozygotic (MZ) twins. The aim of this study was to introduce a novel forensic method for distinguishing between almost identical MZ twins by means of an intraoral scanner using the 3D digital pattern of the human palate. LA - English DB - MTMT ER - TY - BOOK ED - Tárnoki, Ádám Domonkos ED - Tárnoki, Dávid László ED - Littvay, Levente ED - Métneki, J ED - Melicher, Dóra ED - Pári, András TI - Ikerkutatás és epigenetika. Egyetemi tankönyv TS - Egyetemi tankönyv ET - 0 PB - Medicina Könyvkiadó CY - Budapest PY - 2020 SP - 200 SN - 9789632267517 UR - https://m2.mtmt.hu/api/publication/3113852 ID - 3113852 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László AU - Forgó, Bianka AU - Szabó, Helga AU - Melicher, Dóra AU - Metneki, Julia AU - Littvay, Levente TI - The Hungarian Twin Registry Update: Turning From a Voluntary to a Population-Based Registry JF - TWIN RESEARCH AND HUMAN GENETICS J2 - TWIN RES HUM GENET VL - 22 PY - 2019 IS - 6 SP - 561 EP - 566 PG - 6 SN - 1832-4274 DO - 10.1017/thg.2019.100 UR - https://m2.mtmt.hu/api/publication/31122140 ID - 31122140 LA - English DB - MTMT ER - TY - JOUR AU - Melicher, Dóra AU - Illés, Anett AU - Pállinger, Éva AU - Kovács, Árpád Ferenc AU - Littvay, Levente AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László AU - Bikov, András AU - Molnár, Mária Judit AU - Buzás, Edit Irén AU - Falus, András TI - Tight co-twin similarity of monozygotic twins for hTERT protein level of T cell subsets, for telomere length and mitochondrial DNA copy number, but not for telomerase activity. JF - CELLULAR AND MOLECULAR LIFE SCIENCES J2 - CELL MOL LIFE SCI VL - 75 PY - 2018 IS - 13 SP - 2447 EP - 2456 PG - 10 SN - 1420-682X DO - 10.1007/s00018-017-2738-z UR - https://m2.mtmt.hu/api/publication/3318282 ID - 3318282 N1 - Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary Hungarian Twin Registry, Budapest, Hungary MTA-SE Immunproteogenomics Extracellular Vesicle Research Group, Budapest, Hungary Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, Hungary Central European University, Budapest, Hungary Department of Radiology, Semmelweis University, Budapest, Hungary Department of Pulmonology, Semmelweis University, Budapest, Hungary Cited By :2 Export Date: 18 August 2020 CODEN: CMLSF Correspondence Address: Falus, A.; Department of Genetics, Cell- and Immunobiology, Semmelweis UniversityHungary; email: afalus@gmail.com AB - Our study analyzed lymphocyte subpopulations of 32 monozygotic twins and compared the level of the catalytic reverse transcriptase protein subunit (hTERT) in T lymphocytes (Tly), helper- (Th), cytotoxic- (Tc) and regulatory T cell (Treg) subgroups. Four variables related to telomere and mitochondrial biology were simultaneously assessed, applying multi-parametric flow cytometry, TRAP-ELISA assay and qPCR standard curve method on peripheral blood mononuclear cell (PBMC) samples of genetically matched individuals. Twin data of telomerase activity (TA), hTERT protein level, telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) were analyzed for co-twin similarity. The present study has provided novel information by demonstrating very high intraclass correlation (ICC) of hTERT protein level in T lymphocytes (0.891) and in both Th (0.896), Treg (0.885) and Tc (0.798) cell subgroups. When comparing results measured from PBMCs, intraclass correlation was also high for telomere length (0.815) and considerable for mtDNA copy number (0.524), and again exceptionally high for the rate-limiting telomerase subunit, hTERT protein level (0.946). In contrast, telomerase activity showed no co-twin similarity (ICC 0). By comparing relative amounts of hTERT protein levels in different lymphocyte subgroups of twin subjects, in Treg cells significantly higher level could be detected compared to Tly, Th or Tc cell subgroups. This is the first study that simultaneously analyzed co-twin similarity in MZ twins for the above four variables and alongside assessed their relationship, whereby positive association was found between TL and mtDNAcn. LA - English DB - MTMT ER -