@article{MTMT:35445641, title = {Risk factors of early death in heat stroke and the challenges of emergency care in Hungary - a case series study}, url = {https://m2.mtmt.hu/api/publication/35445641}, author = {Ádám, Kornél and Berényi, Tamás and Melicher, Dóra and Fenyves, Bánk and Gaál, Szabolcs and Varga, Csaba}, doi = {10.1186/s12245-024-00743-w}, journal-iso = {INT J EMERG MED}, journal = {INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE}, volume = {17}, unique-id = {35445641}, issn = {1865-1372}, year = {2024}, eissn = {1865-1380}, orcid-numbers = {Melicher, Dóra/0000-0003-4848-1424; Fenyves, Bánk/0000-0003-2374-7513} } @article{MTMT:35077323, title = {A rare cause of abdominal pain in pregnancy - mesenteric artery thrombosis and miscarriage in a 34-year-old patient}, url = {https://m2.mtmt.hu/api/publication/35077323}, author = {Melicher, Dóra and Gaál, Szabolcs and Berényi, Tamás and Fenyves, Bánk and Nagy, Norbert and Hegedűs, Péter and Fülöp, András and Szijártó, Attila and Varga, Csaba}, doi = {10.1186/s12245-024-00661-x}, journal-iso = {INT J EMERG MED}, journal = {INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE}, volume = {17}, unique-id = {35077323}, issn = {1865-1372}, year = {2024}, eissn = {1865-1380}, orcid-numbers = {Melicher, Dóra/0000-0003-4848-1424; Fenyves, Bánk/0000-0003-2374-7513} } @article{MTMT:34868573, title = {The Population-Based Hungarian Twin Registry. An Update.}, url = {https://m2.mtmt.hu/api/publication/34868573}, author = {Tárnoki, Dávid László and Piroska, Márton and Forgó, Bianka and Szabó, Helga and Zöldi, Luca and Melicher, Dóra and Metneki, Julia and Littvay, Levente and Tárnoki, Ádám Domonkos}, doi = {10.1017/thg.2024.15}, journal-iso = {TWIN RES HUM GENET}, journal = {TWIN RESEARCH AND HUMAN GENETICS}, volume = {27}, unique-id = {34868573}, issn = {1832-4274}, abstract = {Between 2006 and 2021, the Hungarian Twin Registry (HTR) operated a volunteer twin registry of all age groups (50% monozygotic [MZ], 50% dizygotic [DZ], 70% female, average age 34 ± 22 years), including 1044 twin pairs, 24 triplets and one quadruplet set. In 2021, the HTR transformed from a volunteer registry into a population-based one, and it was established in the Medical Imaging Centre of Semmelweis University in Budapest. Semmelweis University's innovation fund supported the development of information technology, a phone bank and voicemail infrastructure, administrative materials, and a new website was established where twins and their relatives (parent, foster parent or caregiver) can register. The HTR's biobank was also established: 157,751 individuals with a likely twin-sibling living in Hungary (77,042 twins, 1194 triplets, 20 quadruplets, and one quintuplet) were contacted between February and March of 2021 via sealed letters. Until November 20, 2022, 12,001 twin individuals and their parents or guardians (6724 adult twins, 3009 parents/guardians and 5277 minor twins) registered, mostly online. Based on simple self-reports, 37.6% of the registered adults were MZ twins and 56.8% were DZ; 1.12% were triplets and 4.5% were unidentified. Of the registered children, 22.3% were MZ, 72.7% were DZ, 1.93% were triplets, and 3.05% were unidentified. Of the registered twins, 59.9% were female (including both the adult and minor twins). The registration questionnaire consists of eight parts, including socio-demographic and anthropometric data, smoking habits and medical questions (diseases, operations, therapies). Hungary's twin registry has become the sole and largest population-based twin registry in Central Eastern Europe. This new resource will facilitate performing world-class modern genetic research.}, keywords = {Central Eastern Europe; genetic research; twin registry}, year = {2024}, eissn = {1839-2628}, pages = {115-119}, orcid-numbers = {Tárnoki, Dávid László/0000-0002-7001-7647; Piroska, Márton/0000-0002-6000-5044; Zöldi, Luca/0000-0003-4187-1673; Melicher, Dóra/0000-0003-4848-1424; Littvay, Levente/0000-0003-2022-6886; Tárnoki, Ádám Domonkos/0000-0001-5909-3780} } @article{MTMT:33770864, title = {Acute hydrocephalus caused by a colloid cyst — a case report}, url = {https://m2.mtmt.hu/api/publication/33770864}, author = {Melicher, Dóra and Gaál, Szabolcs and Berényi, Tamás and Fenyves, Bánk and Novák, Pál Kaposi and Tóth, Ambrus and Szegedi, László and Varga, Csaba}, doi = {10.1186/s12245-023-00500-5}, journal-iso = {INT J EMERG MED}, journal = {INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE}, volume = {16}, unique-id = {33770864}, issn = {1865-1372}, year = {2023}, eissn = {1865-1380}, orcid-numbers = {Melicher, Dóra/0000-0003-4848-1424; Fenyves, Bánk/0000-0003-2374-7513} } @article{MTMT:30636506, title = {Positive association and future perspectives of mitochondrial DNA copy number and telomere length – a pilot twin study}, url = {https://m2.mtmt.hu/api/publication/30636506}, author = {Melicher, Dóra and Illés, Anett and Littvay, Levente and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László and Bikov, András and Kunos, László and Csabán, Dóra and Buzás, Edit Irén and Molnár, Mária Judit and Falus, András}, doi = {10.5114/aoms.2019.83173}, journal-iso = {ARCH MED SCI}, journal = {ARCHIVES OF MEDICAL SCIENCE}, volume = {17}, unique-id = {30636506}, issn = {1734-1922}, year = {2021}, eissn = {1896-9151}, pages = {1191-1199}, orcid-numbers = {Melicher, Dóra/0000-0003-4848-1424; Illés, Anett/0000-0001-5351-9015; Littvay, Levente/0000-0003-2022-6886; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647; Bikov, András/0000-0002-8983-740X; Csabán, Dóra/0000-0003-4602-6639; Buzás, Edit Irén/0000-0002-3744-206X; Molnár, Mária Judit/0000-0001-9350-1864; Falus, András/0000-0002-6843-6789} } @article{MTMT:31799888, title = {Genetic versus Environmental Background on the Relationship of Telomere Length and Bone Mineral Density}, url = {https://m2.mtmt.hu/api/publication/31799888}, author = {Jokkel, Zsofia and Melicher, Dóra and Illes, Anett and Piroska, Marton and Bikov, Andras and Szabo, Helga and Hernyes, Anita and Molnar, Maria Judit and Buzás, Edit Irén and Falus, András and Meszaros, Szilvia and Horvath, Csaba and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László}, journal-iso = {ORVOSKÉPZÉS}, journal = {ORVOSKÉPZÉS}, volume = {95}, unique-id = {31799888}, issn = {0030-6037}, year = {2020}, pages = {64-64}, orcid-numbers = {Melicher, Dóra/0000-0003-4848-1424; Hernyes, Anita/0000-0001-5875-4006; Buzás, Edit Irén/0000-0002-3744-206X; Falus, András/0000-0002-6843-6789; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647} } @article{MTMT:31617754, title = {Application of intraoral scanner to identify monozygotic twins}, url = {https://m2.mtmt.hu/api/publication/31617754}, author = {Simon, Botond and Lipták, Laura Mária and Lipták, Klaudia Margit and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László and Melicher, Dóra and Vág, János}, doi = {10.1186/s12903-020-01261-w}, journal-iso = {BMC ORAL HEALTH}, journal = {BMC ORAL HEALTH}, volume = {20}, unique-id = {31617754}, issn = {1472-6831}, abstract = {DNA base identification is a proper and high specificity method. However, identification could be challenged in a situation where there is no database or the DNA sequence is almost identical, as in the case of monozygotic (MZ) twins. The aim of this study was to introduce a novel forensic method for distinguishing between almost identical MZ twins by means of an intraoral scanner using the 3D digital pattern of the human palate.}, year = {2020}, eissn = {1472-6831}, orcid-numbers = {Simon, Botond/0000-0003-1851-1688; Lipták, Laura Mária/0009-0009-5470-3469; Lipták, Klaudia Margit/0009-0003-5177-1390; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647; Melicher, Dóra/0000-0003-4848-1424; Vág, János/0000-0002-6183-7598} } @book{MTMT:3113852, title = {Ikerkutatás és epigenetika. Egyetemi tankönyv}, url = {https://m2.mtmt.hu/api/publication/3113852}, isbn = {9789632267517}, editor = {Tárnoki, Ádám Domonkos and Tárnoki, Dávid László and Littvay, Levente and Métneki, J and Melicher, Dóra and Pári, András}, publisher = {Medicina Kiadó Zrt.}, unique-id = {3113852}, year = {2020}, orcid-numbers = {Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647; Littvay, Levente/0000-0003-2022-6886; Melicher, Dóra/0000-0003-4848-1424; Pári, András/0000-0002-3098-9863} } @article{MTMT:31122140, title = {The Hungarian Twin Registry Update: Turning From a Voluntary to a Population-Based Registry}, url = {https://m2.mtmt.hu/api/publication/31122140}, author = {Tárnoki, Ádám Domonkos and Tárnoki, Dávid László and Forgó, Bianka and Szabó, Helga and Melicher, Dóra and Metneki, Julia and Littvay, Levente}, doi = {10.1017/thg.2019.100}, journal-iso = {TWIN RES HUM GENET}, journal = {TWIN RESEARCH AND HUMAN GENETICS}, volume = {22}, unique-id = {31122140}, issn = {1832-4274}, year = {2019}, eissn = {1839-2628}, pages = {561-566}, orcid-numbers = {Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647; Melicher, Dóra/0000-0003-4848-1424; Littvay, Levente/0000-0003-2022-6886} } @article{MTMT:3318282, title = {Tight co-twin similarity of monozygotic twins for hTERT protein level of T cell subsets, for telomere length and mitochondrial DNA copy number, but not for telomerase activity.}, url = {https://m2.mtmt.hu/api/publication/3318282}, author = {Melicher, Dóra and Illés, Anett and Pállinger, Éva and Kovács, Árpád Ferenc and Littvay, Levente and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László and Bikov, András and Molnár, Mária Judit and Buzás, Edit Irén and Falus, András}, doi = {10.1007/s00018-017-2738-z}, journal-iso = {CELL MOL LIFE SCI}, journal = {CELLULAR AND MOLECULAR LIFE SCIENCES}, volume = {75}, unique-id = {3318282}, issn = {1420-682X}, abstract = {Our study analyzed lymphocyte subpopulations of 32 monozygotic twins and compared the level of the catalytic reverse transcriptase protein subunit (hTERT) in T lymphocytes (Tly), helper- (Th), cytotoxic- (Tc) and regulatory T cell (Treg) subgroups. Four variables related to telomere and mitochondrial biology were simultaneously assessed, applying multi-parametric flow cytometry, TRAP-ELISA assay and qPCR standard curve method on peripheral blood mononuclear cell (PBMC) samples of genetically matched individuals. Twin data of telomerase activity (TA), hTERT protein level, telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) were analyzed for co-twin similarity. The present study has provided novel information by demonstrating very high intraclass correlation (ICC) of hTERT protein level in T lymphocytes (0.891) and in both Th (0.896), Treg (0.885) and Tc (0.798) cell subgroups. When comparing results measured from PBMCs, intraclass correlation was also high for telomere length (0.815) and considerable for mtDNA copy number (0.524), and again exceptionally high for the rate-limiting telomerase subunit, hTERT protein level (0.946). In contrast, telomerase activity showed no co-twin similarity (ICC 0). By comparing relative amounts of hTERT protein levels in different lymphocyte subgroups of twin subjects, in Treg cells significantly higher level could be detected compared to Tly, Th or Tc cell subgroups. This is the first study that simultaneously analyzed co-twin similarity in MZ twins for the above four variables and alongside assessed their relationship, whereby positive association was found between TL and mtDNAcn.}, year = {2018}, eissn = {1420-9071}, pages = {2447-2456}, orcid-numbers = {Melicher, Dóra/0000-0003-4848-1424; Illés, Anett/0000-0001-5351-9015; Pállinger, Éva/0000-0002-5789-0951; Kovács, Árpád Ferenc/0000-0002-7742-160X; Littvay, Levente/0000-0003-2022-6886; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647; Bikov, András/0000-0002-8983-740X; Molnár, Mária Judit/0000-0001-9350-1864; Buzás, Edit Irén/0000-0002-3744-206X; Falus, András/0000-0002-6843-6789} }