@article{MTMT:34779723,
	title = {Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine},
	url = {https://m2.mtmt.hu/api/publication/34779723},
	author = {Eszlári, Nóra and Hullám, Gábor István and Gál, Zsófia and Török, Dóra and Nagy, Tamás and Millinghoffer, András Dániel and Baksa, Dániel and Gonda, Xénia and Antal, Péter and Bagdy, György and Juhász, Gabriella},
	doi = {10.1038/s41398-024-02867-2},
	journal-iso = {TRANSL PSYCHIAT},
	journal = {TRANSLATIONAL PSYCHIATRY},
	volume = {14},
	unique-id = {34779723},
	issn = {2158-3188},
	abstract = {Most current approaches to establish subgroups of depressed patients for precision medicine aim to rely on biomarkers that require highly specialized assessment. Our present aim was to stratify participants of the UK Biobank cohort based on three readily measurable common independent risk factors, and to investigate depression genomics in each group to discover common and separate biological etiology. Two-step cluster analysis was run separately in males ( n  = 149,879) and females ( n  = 174,572), with neuroticism (a tendency to experience negative emotions), body fat percentage, and years spent in education as input variables. Genome-wide association analyses were implemented within each of the resulting clusters, for the lifetime occurrence of either a depressive episode or recurrent depressive disorder as the outcome. Variant-based, gene-based, gene set-based, and tissue-specific gene expression test were applied. Phenotypically distinct clusters with high genetic intercorrelations in depression genomics were found. A two-cluster solution was the best model in each sex with some differences including the less important role of neuroticism in males. In females, in case of a protective pattern of low neuroticism, low body fat percentage, and high level of education, depression was associated with pathways related to olfactory function. While also in females but in a risk pattern of high neuroticism, high body fat percentage, and less years spent in education, depression showed association with complement system genes. Our results, on one hand, indicate that alteration of olfactory pathways, that can be paralleled to the well-known rodent depression models of olfactory bulbectomy, might be a novel target towards precision psychiatry in females with less other risk factors for depression. On the other hand, our results in multi-risk females may provide a special case of immunometabolic depression.},
	year = {2024},
	eissn = {2158-3188},
	orcid-numbers = {Eszlári, Nóra/0000-0003-4913-028X; Hullám, Gábor István/0000-0002-4765-2351; Gál, Zsófia/0000-0002-9441-1497; Török, Dóra/0000-0001-9213-4345; Nagy, Tamás/0000-0002-0137-4341; Baksa, Dániel/0000-0002-7826-9179; Gonda, Xénia/0000-0001-9015-4203; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267}
}

@article{MTMT:34496842,
	title = {Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk},
	url = {https://m2.mtmt.hu/api/publication/34496842},
	author = {Kristóf, Zsüliet and Gál, Zsófia and Török, Dóra and Eszlári, Nóra and Sutori, Sara and Sperlágh, Beáta and Anderson, Ian M. and Deakin, Bill and Bagdy, György and Juhász, Gabriella and Gonda, Xénia},
	doi = {10.3390/ijms25020865},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34496842},
	issn = {1661-6596},
	abstract = {Both early childhood traumatic experiences and current stress increase the risk of suicidal behaviour, in which immune activation might play a role. Previous research suggests an association between mood disorders and P2RX7 gene encoding P2X7 receptors, which stimulate neuroinflammation. We investigated the effect of P2RX7 variation in interaction with early childhood adversities and traumas and recent stressors on lifetime suicide attempts and current suicide risk markers. Overall, 1644 participants completed questionnaires assessing childhood adversities, recent negative life events, and provided information about previous suicide attempts and current suicide risk-related markers, including thoughts of ending their life, death, and hopelessness. Subjects were genotyped for 681 SNPs in the P2RX7 gene, 335 of which passed quality control and were entered into logistic and linear regression models, followed by a clumping procedure to identify clumps of SNPs with a significant main and interaction effect. We identified two significant clumps with a main effect on current suicidal ideation with top SNPs rs641940 and rs1653613. In interaction with childhood trauma, we identified a clump with top SNP psy_rs11615992 and another clump on hopelessness containing rs78473339 as index SNP. Our results suggest that P2RX7 variation may mediate the effect of early childhood adversities and traumas on later emergence of suicide risk.},
	keywords = {STRESS; neuroinflammation; suicide; P2rx7; GxE interaction; childhood adversities; recent life events},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Kristóf, Zsüliet/0000-0001-5041-0444; Gál, Zsófia/0000-0002-9441-1497; Török, Dóra/0000-0001-9213-4345; Eszlári, Nóra/0000-0003-4913-028X; Sutori, Sara/0000-0003-3468-0780; Deakin, Bill/0000-0002-2750-962X; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267; Gonda, Xénia/0000-0001-9015-4203}
}

@misc{MTMT:34175067,
	title = {Hogyan járul hozzá a genetika az endogén és reaktív típusú depresszióhoz? - SNP-alapú öröklődés és genetikai összefüggések bizonyítékai több GWAS-vizsgálat alapján},
	url = {https://m2.mtmt.hu/api/publication/34175067},
	author = {Erdélyi-Hamza, Berta and Török, Dóra and Gál, Zsófia and Győrik, Dorka and Eszlári, Nóra and Bagdy, György and Juhász, Gabriella and Gonda, Xénia},
	unique-id = {34175067},
	year = {2023},
	orcid-numbers = {Erdélyi-Hamza, Berta/0000-0002-1669-6722; Török, Dóra/0000-0001-9213-4345; Gál, Zsófia/0000-0002-9441-1497; Eszlári, Nóra/0000-0003-4913-028X; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267; Gonda, Xénia/0000-0001-9015-4203}
}

@misc{MTMT:34091555,
	title = {Pharmacological Characterization of Multimorbidity-Based Clusters in Depression},
	url = {https://m2.mtmt.hu/api/publication/34091555},
	author = {Nagy, Tamás and Gezsi, Andras and Hullam, Gabor and Eszlári, Nóra and Antal, Péter and Juhász, Gabriella},
	unique-id = {34091555},
	year = {2023},
	orcid-numbers = {Nagy, Tamás/0000-0002-0137-4341; Eszlári, Nóra/0000-0003-4913-028X; Juhász, Gabriella/0000-0002-5975-4267}
}

@misc{MTMT:34091468,
	title = {Olfactory Receptors as a Potential Pathomechanism for Depression When No Classic Risk Factors Are Present in Women? Genomic Results from the UK Biobank Cohort},
	url = {https://m2.mtmt.hu/api/publication/34091468},
	author = {Eszlári, Nóra and Hullam, Gabor and Gál, Zsófia and Török, Dóra and Nagy, Tamás and Millinghoffer, Andras and Baksa, Dániel and Antal, Péter and Bagdy, György and Juhász, Gabriella},
	unique-id = {34091468},
	year = {2023},
	orcid-numbers = {Eszlári, Nóra/0000-0003-4913-028X; Gál, Zsófia/0000-0002-9441-1497; Török, Dóra/0000-0001-9213-4345; Nagy, Tamás/0000-0002-0137-4341; Baksa, Dániel/0000-0002-7826-9179; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267}
}

@misc{MTMT:34091453,
	title = {CLOCK gene plays role in the genetic background of depression after stressful life events – a GWAS study},
	url = {https://m2.mtmt.hu/api/publication/34091453},
	author = {Erdelyi-Hamza, Berta and Török, Dóra and Gál, Zsófia and Gyorik, Dorka and Eszlári, Nóra and Bagdy, György and Juhász, Gabriella and Gonda, Xénia},
	unique-id = {34091453},
	year = {2023},
	orcid-numbers = {Török, Dóra/0000-0001-9213-4345; Gál, Zsófia/0000-0002-9441-1497; Eszlári, Nóra/0000-0003-4913-028X; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267; Gonda, Xénia/0000-0001-9015-4203}
}

@misc{MTMT:34091418,
	title = {Chronotype Affects Physical and Mental Health Status of Migraineurs},
	url = {https://m2.mtmt.hu/api/publication/34091418},
	author = {Baksa, Dániel and Eszlári, Nóra and Török, Dóra and Juhász, Gabriella},
	unique-id = {34091418},
	year = {2023},
	orcid-numbers = {Baksa, Dániel/0000-0002-7826-9179; Eszlári, Nóra/0000-0003-4913-028X; Török, Dóra/0000-0001-9213-4345; Juhász, Gabriella/0000-0002-5975-4267}
}

@misc{MTMT:34001410,
	title = {Investigating the association between polygenic risk score of depression and functional connectivity of the Nucleus Accumbens in healthy individuals: distinct role of SIRT1},
	url = {https://m2.mtmt.hu/api/publication/34001410},
	author = {Török, Dóra and Gecse, Kinga and Hammer, Angela and Nemeth, Anna and Eszlári, Nóra and Gonda, Xénia and Bagdy, György and Petschner, Péter and Juhász, Gabriella},
	unique-id = {34001410},
	year = {2023},
	orcid-numbers = {Török, Dóra/0000-0001-9213-4345; Gecse, Kinga/0000-0002-3512-2572; Eszlári, Nóra/0000-0003-4913-028X; Gonda, Xénia/0000-0001-9015-4203; Bagdy, György/0000-0001-8141-3410; Petschner, Péter/0000-0002-3198-858X; Juhász, Gabriella/0000-0002-5975-4267}
}

@misc{MTMT:34001390,
	title = {LncRNA or actin cytoskeleton-related genes in depression, depending on the joint pattern of sex, neuroticism, body fat, education, and stress},
	url = {https://m2.mtmt.hu/api/publication/34001390},
	author = {Eszlári, Nóra and Hullám, Gábor István and Gál, Zsófia and Török, Dóra and Nagy, Tamas and Millinghoffer, András Dániel and Baksa, Dániel and Gonda, Xénia and Antal, Péter and Bagdy, György and Juhász, Gabriella},
	unique-id = {34001390},
	year = {2023},
	orcid-numbers = {Eszlári, Nóra/0000-0003-4913-028X; Hullám, Gábor István/0000-0002-4765-2351; Gál, Zsófia/0000-0002-9441-1497; Török, Dóra/0000-0001-9213-4345; Baksa, Dániel/0000-0002-7826-9179; Gonda, Xénia/0000-0001-9015-4203; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267}
}

@article{MTMT:33841048,
	title = {Variation along P2RX7 interacts with early traumas on severity of anxiety suggesting a role for neuroinflammation},
	url = {https://m2.mtmt.hu/api/publication/33841048},
	author = {Kristóf, Zsüliet and Gál, Zsófia and Török, Dóra and Eszlári, Nóra and Sütöri, Sára and Erdélyi-Hamza, Berta and Petschner, Péter and Sperlágh, Beáta and Anderson, Ian M and Deakin, John Francis William and Bagdy, György and Juhász, Gabriella and Gonda, Xénia},
	doi = {10.1038/s41598-023-34781-w},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {33841048},
	issn = {2045-2322},
	abstract = {Emotional stress is a leading risk factor in the development of neuropsychiatric disorders possibly via immune activation. P2X7 receptors promote neuroinflammation, and research suggests a relationship between chromosome region 12q2431, in which the P2X7R gene is located, and development of mood disorders, however, few studies concentrate on its association with anxiety. Our aim was to investigate the effects of P2RX7 variation in interaction with early childhood traumas and recent stressors on anxiety. 1752 participants completed questionnaires assessing childhood adversities and recent negative life events, provided data on anxiety using the Brief Symptom Inventory, and were genotyped for 681 SNPs in the P2RX7 gene, 335 of which passed quality control and were entered into linear regression models followed by a linkage disequilibrium-based clumping procedure to identify clumps of SNPs with a significant main or interaction effect. We identified a significant clump with top SNP rs67881993 and containing a set of 29SNPs that are in high LD, which significantly interacted with early childhood traumas but not with recent stress conveying a protective effect against increased anxiety in those exposed to early adversities. Our study demonstrated that P2RX7 variants interact with distal and more etiological stressors in influencing the severity of anxiety symptoms, supporting previous scarce results and demonstrating its role in moderating the effects of stress.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Gál, Zsófia/0000-0002-9441-1497; Török, Dóra/0000-0001-9213-4345; Eszlári, Nóra/0000-0003-4913-028X; Erdélyi-Hamza, Berta/0000-0002-1669-6722; Petschner, Péter/0000-0002-3198-858X; Bagdy, György/0000-0001-8141-3410; Juhász, Gabriella/0000-0002-5975-4267; Gonda, Xénia/0000-0001-9015-4203}
}