TY - JOUR AU - Lugosi, Katalin AU - Engh, Marie Anne AU - Huszár, Zsolt AU - Hegyi, Péter AU - Mátrai, Péter AU - Csukly, Gábor AU - Molnár, Zsolt AU - Horváth, Klaudia AU - Mátis, Dóra AU - Mezei, Zsolt TI - Domain-specific cognitive impairment in multiple sclerosis : A systematic review and meta-analysis JF - ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY J2 - ANN CLIN TRANSL NEUROL VL - 11 PY - 2024 IS - 3 SP - 564 EP - 576 PG - 13 SN - 2328-9503 DO - 10.1002/acn3.51976 UR - https://m2.mtmt.hu/api/publication/34501793 ID - 34501793 N1 - Meta-Analysis; Systematic Review; Journal Article AB - Methods of cognitive measurements in multiple sclerosis (MS) are not standardized. We aimed to identify the prevalence of cognitive domain-specific impairment (DSI) in MS by using subtests of the Brief Repeatable Battery of Neuropsychological Tests (BRB-N) with analyzing different cutoff values.The systematic review and meta-analysis were registered on PROSPERO (ID: CRD42021287004). The systematic literature search was performed via PubMed, Embase, and CENTRAL on 24 October 2021. Inclusion criteria were adults of different MS subtypes (CIS, RRMS, PPMS, and SPMS) with the condition of distinct DSI measured by BRB-N. Pediatric MS, computerized versions of BRB-N, and patients receiving steroids were excluded. Primary outcome was pooled prevalence rates of impaired patients within each cutoff and MS subtype, with 95% confidence interval, I-squared statistics for heterogeneity, and chi-squared test for subgroup differences. Risk of bias was assessed using the "JBI Quality Assessment Tool for Prevalence Studies."In 48 eligible observational studies (n = 3431 patients), the three most prevalent thresholds were the 2.0 SD and 1.5 SD below the mean of normative values, and the score below the fifth percentile of the normative values. A progressively increasing worsening of the overall DSI was observed from CIS, moving toward RRMS, PPMS, and SPMS.Cognitive impairment is observed in all MS phenotypes, with varying degrees. Due to several potential influencing factors, our comprehensive literature review has not revealed consistent findings, and we, therefore, recommend considering a more sophisticated, "individual referencing" approach, acknowledging the diverse clinical and sociodemographic characteristics among populations and disparities in cognitive testing. LA - English DB - MTMT ER - TY - JOUR AU - Eitmann, Szimonetta AU - Mátrai, Péter AU - Hegyi, Péter AU - Balaskó, Márta AU - Erőss, Bálint Mihály AU - Dorogi, Kira AU - Pétervári, Erika TI - Obesity paradox in older sarcopenic adults - a delay in aging : A systematic review and meta-analysis JF - AGEING RESEARCH REVIEWS J2 - AGEING RES REV VL - 93 PY - 2024 PG - 20 SN - 1568-1637 DO - 10.1016/j.arr.2023.102164 UR - https://m2.mtmt.hu/api/publication/34453597 ID - 34453597 AB - The prognostic significance of obesity in sarcopenic adults is controversial. This systematic review and meta-analysis aimed to investigate the effect of additional obesity on health outcomes in sarcopenia. MEDLINE, EMBASE, Scopus and CENTRAL were systematically searched for studies to compare health outcomes of adults with sarcopenic obesity (SO) to those of sarcopenic non-obese (SNO) adults. We also considered the methods of assessing obesity. Of 15060 records screened, 65 papers were included (100612 participants). Older community-dwelling SO adults had 15% lower mortality risk than the SNO group (hazard ratio, HR: 0.85, 95% confidence interval 0.76, 0.94) even when obesity was assessed by measurement of body composition. Additionally, meta-regression analysis revealed a significant negative linear correlation between the age and the HR of all-cause mortality in SO vs. SNO community-dwelling adults, but not in severely ill patients. Compared with SNO, SO patients presented lower physical performance, higher risk for metabolic syndrome, but similar cognitive function, risk of falls and cardiovascular diseases. Age-related obesity, SO and later fat loss leading to SNO represent consecutive phases of biological aging. Additional obesity could worsen the health state in sarcopenia, but above 65 years SO represents a biologically earlier phase with longer life expectancy than SNO. LA - English DB - MTMT ER - TY - JOUR AU - Tajti, Péter AU - Sólyom, Eleonóra AU - Váncsa, Szilárd AU - Mátrai, Péter AU - Hegyi, Péter AU - Varga, Gábor AU - Hermann, Péter AU - Borbély, Judit AU - Sculean, Anton AU - Mikulás, Krisztina Ágnes TI - Less marginal bone loss around bone-level implants restored with long abutments : A systematic review and meta-analysis JF - PERIODONTOLOGY 2000 J2 - PERIODONTOL 2000 PY - 2024 SN - 0906-6713 DO - 10.1111/prd.12534 UR - https://m2.mtmt.hu/api/publication/34165693 ID - 34165693 N1 - Funding Agency and Grant Number: This study was supported by the Centre for Translational Medicine, Semmelweis University.; Centre for Translational Medicine, Semmelweis University Funding text: This study was supported by the Centre for Translational Medicine, Semmelweis University. AB - The aim of this study was to investigate the biological outcomes of bone-level implants restored with long vs. short abutments, with regard to the 'one abutment at one time' protocol. The systematic search was performed in five databases: MEDLINE (PubMed), EMBASE, Web of Science, Scopus, and CENTRAL for randomized controlled trials up to January 14, 2023. Data were collected for marginal bone loss, bleeding on probing, and probing pocket depth by two reviewers. As effect size measure, mean difference (MD), and risk ratio (RR) were used for continuous and categorical outcomes, R-statistics software was used for conducting statistical analyses. For quality and certainty assessment, Risk of Bias Tool 2, ROBINS-I, and GRADE approach were used. The search resulted in 4055 records without any duplicates. After title, abstract, and full-text analysis, eight articles were found eligible for inclusion. Bone-level and platform-switched implants presented less marginal bone loss after 6 months and 1 year as well, when long abutments were used (MD 0.63, 95% CI: [-0.16; 1.42]) and (MD 0.26, 95% CI: [-0.02; 0.53]). However, subgroup analysis revealed no difference in marginal bone loss when applying 'one abutment at one time' protocol (p = 0.973). Bleeding on probing and probing pocket depth presented similarly good results in both groups without almost any differences (RR 0.97, 95% CI: [0.76; 1.23]) and (MD -0.05, 95% CI: [-1.11; 1.01]). Longer abutments on bone-level implants seem to be a favorable choice for decreasing early marginal bone loss, irrespective of connection timing. LA - English DB - MTMT ER - TY - JOUR AU - Sindler, Dóra Lili AU - Mátrai, Péter AU - Szakó, Lajos AU - Berki, Dávid AU - Berke, Gergő AU - Csontos, Armand AU - Papp, Csenge AU - Hegyi, Péter AU - Papp, András TI - Faster recovery and bowel movement after early oral feeding compared to late oral feeding after upper GI tumor resections: a meta-analysis JF - FRONTIERS IN SURGERY J2 - FRONT SURG VL - 10 PY - 2023 PG - 11 SN - 2296-875X DO - 10.3389/fsurg.2023.1092303 UR - https://m2.mtmt.hu/api/publication/34011864 ID - 34011864 LA - English DB - MTMT ER - TY - JOUR AU - Ocskay, Klementina AU - Mátrai, Péter AU - Hegyi, Péter AU - Párniczky, Andrea TI - Lactated Ringer's Solution Reduces Severity, Mortality, Systemic and Local Complications in Acute Pancreatitis : A Systematic Review and Meta-Analysis JF - BIOMEDICINES J2 - BIOMEDICINES VL - 11 PY - 2023 IS - 2 PG - 11 SN - 2227-9059 DO - 10.3390/biomedicines11020321 UR - https://m2.mtmt.hu/api/publication/33667132 ID - 33667132 N1 - Heim Pál National Pediatric Institute, Budapest, 1089, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pécs, 7623, Hungary Centre for Translational Medicine, Semmelweis University, Budapest, 1085, Hungary Institute of Pancreatic Diseases, Semmelweis University, Budapest, 1083, Hungary Translational Pancreatology Research Group, Interdisciplinary Centre of Excellence for Research Development and Innovation, University of Szeged, Szeged, 6725, Hungary Export Date: 11 September 2023 Correspondence Address: Párniczky, A.; Heim Pál National Pediatric InstituteHungary; email: andrea.parniczky@gmail.com AB - Fluid therapy is the cornerstone of early supportive therapy in acute pancreatitis (AP). Regrettably, the type of fluid is still debated among clinicians, despite recent evidence from randomized controlled trials (RCTs). We aimed to incorporate all evidence from RCTs comparing lactated Ringer's solution (LR) with normal saline (NS) in adult and pediatric AP patients, with particular emphasis on clinically relevant outcomes. We evaluated RCTs comparing intravenous fluid resuscitation with LR to NS in adult or pediatric AP patients according to a prospectively registered protocol (CRD42021224542). Moderate-to-severe AP (MSAP), mortality, length of hospitalization (LoH), need for intensive care, the incidence of systemic (organ failure, OF) and local complications (in total), necrosis and pseudocyst formation were analyzed separately. Risk ratio (RR) and median difference (MD) were calculated with 95% confidence intervals (CI) using a random effect model. Risk of bias and quality of evidence were assessed. Altogether, 8 eligible RCTs were found, including 557 patients (LR: 278; NS: 279). LR reduced the risk of MSAP by 31% (RR: 0.59, 95% CI: 0.36-0.97, high quality) and the risk of death by 62% (RR: 0.48; 95% CI: 0.24-0.98, very low quality). LR was associated with a significantly lower risk of need for intensive care (RR: 0.50, 95% CI: 0.33-0.77), OF (RR: 0.78, 95% CI: 0.61-0.99) and local complications (RR: 0.64, 95% CI: 0.46-0.89). No significant risk reduction was observed for LoH (MD: -0.57 days, CI: -1.33-0.19), necrosis, pseudocyst and inflammatory parameters by LR compared to NS. LR reduces severity, mortality, need of intensive care and systemic and local complications in AP. LA - English DB - MTMT ER - TY - JOUR AU - Kreska, Zita AU - Mátrai, Péter AU - Németh, Balázs AU - Ajtay, Bella Eszter AU - Kiss, István AU - Hejjel, László AU - Ajtay, Zénó TI - Physical Vascular Therapy (BEMER) Affects Heart Rate Asymmetry in Patients With Coronary Heart Disease. JF - IN VIVO J2 - IN VIVO VL - 36 PY - 2022 IS - 3 SP - 1408 EP - 1415 PG - 8 SN - 0258-851X DO - 10.21873/invivo.12845 UR - https://m2.mtmt.hu/api/publication/32800048 ID - 32800048 AB - The aim of this study was to assess the acute effects of physical vascular therapy (PVT) on the autonomous nervous system by heart rate variability (HRV) and heart rate asymmetry (HRA) analysis. The low-frequency, pulsed electromagnetic field (<35 μTesla) with a patented BEMER pattern can improve vasomotion and microcirculation. A non-invasive confirmation of the instant effects of PVT may provide an opportunity to give an immediate feedback to the patient and therapist.Altogether 48 patients on inward rehabilitation with coronary heart disease (CHD) were involved, their treatment included PVT with B.Box Professional and B.Body Pro applicator (BEMER International AG, Triesen, Lichtenstein). After 15 min of postural adaptation, 6-min electrocardiograms (ECG) were taken immediately before, in the first and in the last 6 min of the 20-min PVT, and one hour after the treatment. Of the 48 patients, the last twenty patients received sham PVT with the same protocol. Off-line analysis was blinded. We used linear mixed statistical model to compare HRV and HRA parameters.The time domain parameters did not show any statistically significant differences between the changes in the real PVT and sham groups but, in the first stage of the treatment, Porta and Guzik indices significantly rose everywhere except in the sham group.PVT significantly increases the Guzik and Porta indices in chronic ischemic heart disease patients reflecting a delicate autonomic response. HRA as a measure of autonomic regulation seems to be more sensitive than time domain parameters. LA - English DB - MTMT ER - TY - JOUR AU - Ruzsics, István AU - Mátrai, Péter AU - Hegyi, Péter AU - Németh, Dávid AU - Tenk, Judit AU - Csenkey, Alexandra AU - Erőss, Bálint Mihály AU - Varga, Gábor AU - Balaskó, Márta AU - Pétervári, Erika AU - Veres, Gábor AU - Sepp, Róbert AU - Rakonczay, Zoltán AU - Vincze, Áron AU - Garami, András AU - Rumbus, Zoltán TI - Noninvasive ventilation improves the outcome in patients with pneumonia-associated respiratory failure: Systematic review and meta-analysis JF - JOURNAL OF INFECTION AND PUBLIC HEALTH J2 - J INFECT PUBLIC HEALTH VL - 15 PY - 2022 IS - 3 SP - 349 EP - 359 PG - 11 SN - 1876-0341 DO - 10.1016/j.jiph.2022.02.004 UR - https://m2.mtmt.hu/api/publication/32692193 ID - 32692193 AB - Background Noninvasive ventilation (NIV) is beneficial in exacerbations of chronic obstructive pulmonary disease (COPD), but its effectiveness in pneumonia-associated respiratory failure is still controversial. In the current meta-analysis, we aimed to investigate whether the use of NIV before intubation in pneumonia improves the mortality and intubation rates of respiratory failure as compared to no use of NIV in adults. Methods We searched three databases from inception to December 2019. We included studies, in which pneumonia patients were randomized initially into either NIV-treated or non-NIV-treated groups. Five full-text publications, including 121 patients, reported eligible data for statistical analysis. Results With NIV the overall hospital mortality rate seemed lower in patients with pneumonia-associated respiratory failure, but this was not significant [odds ratio (OR) = 0.39; 95% confidence interval (CI): 0.13–1.14; P = 0.085]. In the intensive care unit, the mortality was significantly lower when NIV was applied compared to no NIV treatment (OR = 0.22; 95% CI: 0.07–0.75; P = 0.015). NIV also decreased mortality compared to no NIV in patient groups, which did not exclude patients with COPD (OR = 0.25; 95% CI: 0.08–0.74; P = 0.013). The need for intubation was significantly reduced in NIV-treated patients (OR = 0.22; 95% CI: 0.09–0.53; P = 0.001), which effect was more prominent in pneumonia patient groups not excluding patients with pre-existing COPD (OR = 0.13; 95% CI: 0.03–0.46; P = 0.002). Conclusion NIV markedly decreases the death rate in the intensive care unit and reduces the need for intubation in patients with pneumonia-associated respiratory failure. The beneficial effects of NIV seem more pronounced in populations that include patients with COPD. Our findings suggest that NIV should be considered in the therapeutic guidelines of pneumonia, given that future clinical trials confirm the results of our meta-analysis. Availability of data and materials All data and materials generated during the current study are available from the corresponding author on reasonable request. LA - English DB - MTMT ER - TY - JOUR AU - Szentesi, Andrea Ildikó AU - Borbásné Farkas, Kornélia AU - Sipos, Zoltán AU - Mátrai, Péter AU - Vincze, Áron AU - Izbéki, Ferenc AU - Párniczky, Andrea AU - Hegyi, Péter ED - Erőss, Bálint / Collaborator ED - Hegyi, Péter Jenő / Collaborator ED - Váncsa, Szilárd / Collaborator ED - Nagy, Rita / Collaborator ED - Márta, Katalin / Collaborator ED - Ocskay, Klementina / Collaborator ED - Juhász, Márk Félix / Collaborator ED - Imrei, Marcell / Collaborator ED - Földi, Mária / Collaborator ED - Kiss, Szabolcs / Collaborator ED - Németh, Balázs / Collaborator ED - Takács, Tamás / Collaborator ED - Czakó, László / Collaborator ED - Gódi, Szilárd / Collaborator ED - Bajor, Judit / Collaborator ED - Sarlós, Patrícia / Collaborator ED - Gajdán, László / Collaborator ED - Papp, Mária / Collaborator ED - Hamvas, József / Collaborator ED - Varga, Márta / Collaborator ED - Macarie, Melania / Collaborator ED - Török, Imola / Collaborator ED - Novák, János / Collaborator ED - Mickevicius, Artautas / Collaborator ED - Maldonado, Elena Ramirez / Collaborator ED - Galeev, Shamil / Collaborator ED - Sallinen, Ville / Collaborator ED - Bod, Barnabás / Collaborator ED - Ince, Ali Tüzün / Collaborator ED - Nagy, Tamás / Collaborator ED - Faluhelyi, Nándor / Collaborator ED - Gede, Noémi / Collaborator ED - Bunduc, Stefania / Collaborator ED - Hussein, Tamás / Collaborator ED - Lipp, Mónika Bernadett / Collaborator ED - Németh, Anna / Collaborator ED - Urbán, Orsolya / Collaborator ED - Tarján, Dorottya / Collaborator ED - Tóth, Simon / Collaborator ED - Pécsi, Dániel / Collaborator ED - Varjú, Péter / Collaborator ED - Zádori, Noémi / Collaborator TI - Alcohol consumption and smoking dose-dependently and synergistically worsen local pancreas damage JF - GUT J2 - GUT VL - 71 PY - 2022 IS - 12 SP - 2601 EP - 2602 PG - 2 SN - 0017-5749 DO - 10.1136/gutjnl-2021-326853 UR - https://m2.mtmt.hu/api/publication/32607518 ID - 32607518 N1 - Letter LA - English DB - MTMT ER - TY - JOUR AU - Eitmann, Szimonetta AU - Mátrai, Péter AU - Németh, Dávid AU - Hegyi, Péter AU - Lukács, Anita AU - Bérczi, Bálint AU - Czumbel, László Márk AU - Kiss, István AU - Gyöngyi, Zoltán AU - Varga, Gábor AU - Balaskó, Márta AU - Pétervári, Erika TI - Maternal overnutrition elevates offspring's blood pressure-A systematic review and meta-analysis JF - PAEDIATRIC AND PERINATAL EPIDEMIOLOGY J2 - PAEDIATR PERINAT EP VL - 36 PY - 2022 IS - 2 SP - 276 EP - 287 PG - 12 SN - 0269-5022 DO - 10.1111/ppe.12859 UR - https://m2.mtmt.hu/api/publication/32604750 ID - 32604750 N1 - Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary Szentágothai Research Centre, Medical School, University of Pécs, Pécs, Hungary Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Department of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary Department of Oral Biology, Faculty of Dentistry, Semmelweis University, Budapest, Hungary Cited By :8 Export Date: 10 October 2023 CODEN: PPEPE Correspondence Address: Pétervári, E.; Institute for Translational Medicine, Hungary; email: erika.petervari@aok.pte.hu AB - Maternal overnutrition during pregnancy predisposes the offspring to cardiometabolic diseases.This systematic review and meta-analysis aimed to investigate the association between maternal overnutrition and offspring's blood pressure (BP) and the effect of offspring's obesity on this association.PubMed, EMBASE, Clinicaltrials.gov, CENTRAL.Human studies published in English before October 2021 were identified that presented quantitative estimates of association between maternal overnutrition just before or during pregnancy and the offspring's BP.Random-effect model with the DerSimonian and Laird weighting method was used to analyse regression coefficients or mean differences.After selection, 17 observational studies (140,517 mother-offspring pairs) were included. Prepregnancy body mass index (ppBMI) showed positive correlation with BP in offspring (regression coefficient for systolic: 0.38 mmHg per kg/m2 , 95% confidence interval (CI) 0.17, 0.58; diastolic: 0.10 mmHg per kg/m2 , 95% CI 0.05, 0.14). These indicate 1.9 mmHg increase in systolic and 0.5 mmHg increase in diastolic BP of offspring with every 5 kg/m2 gain in maternal ppBMI. Results on coefficients adjusted for offspring's BMI also showed association (systolic: 0.08 mmHg per kg/m2 , 95% CI 0.04, 0.11; diastolic: 0.03 mmHg per kg/m2 , 95% CI 0.01, 0.04). Independent from ppBMI, gestational weight gain (GWG) showed positive correlation with systolic BP (systolic BP: 0.05 mmHg per kg, 95% CI 0.01, 0.09), but not after adjustment for offspring's BMI. Mean systolic BP was higher in children of mothers with excessive GWG than in those of mothers with optimal GWG (difference: 0.65 mmHg, 95% CI 0.25, 1.05).Independent from offspring's BMI, higher prepregnancy BMI may increase the risk for hypertension in offspring. The positive association between GWG and offspring's systolic BP is indirect via offspring's obesity. Reduction in maternal obesity and treatment of obesity in children of obese mothers are needed to prevent hypertension. LA - English DB - MTMT ER - TY - JOUR AU - Thanyaporn, Sang-ngoen AU - Czumbel, László Márk AU - Wuttapon, Sadaeng AU - Mikó, Alexandra AU - Németh, Dávid AU - Mátrai, Péter AU - Hegyi, Péter AU - Tóth, Barbara AU - Csupor, Dezső AU - Kiss, István AU - Szabó, Andrea AU - Gerber, Gábor AU - Varga, Gábor AU - Kerémi, Beáta TI - Orally Administered Probiotics Decrease Aggregatibacter actinomycetemcomitans but Not Other Periodontal Pathogenic Bacteria Counts in the Oral Cavity: A Systematic Review and Meta-Analysis JF - FRONTIERS IN PHARMACOLOGY J2 - FRONT PHARMACOL VL - 12 PY - 2021 PG - 14 SN - 1663-9812 DO - 10.3389/fphar.2021.682656 UR - https://m2.mtmt.hu/api/publication/32094723 ID - 32094723 N1 - * Megosztott szerzőség LA - English DB - MTMT ER -