TY - JOUR AU - Komáromy, Hedvig AU - He, Mingchen AU - Perlaki, Gábor AU - Orsi, Gergely AU - Nagy, Szilvia Anett AU - Bosnyák, Edit AU - Kamson Olayinka, Dávid AU - John, Flóra AU - Trauninger, Anita AU - Pfund, Zoltán TI - Influence of hemispheric white matter lesions and migraine characteristics on cortical thickness and volume JF - JOURNAL OF HEADACHE AND PAIN J2 - J HEADACHE PAIN VL - 20 ET - 0 PY - 2019 IS - 1 PG - 8 SN - 1129-2369 DO - 10.1186/s10194-019-0959-2 UR - https://m2.mtmt.hu/api/publication/30390795 ID - 30390795 AB - Migraine-related intracerebral white matter lesions (WMLs) are likely to be microvascular in nature and can be found in all hemispheric lobes. The aim of this study was to investigate migraine patients with or without WMLs to see the effects of these tissue damages on cortical thickness and volume. The role of migraine characteristics (duration of headache, attack frequency, estimated lifetime attack number, aura) was also tested.As study participants, 161 female migraine patients (63 with aura; 52 with WMLs) and 40 age-matched healthy female subjects were enrolled in the study. None of the included migraine patients' headache or aura (where present) was unilaterally side-locked. Patients and controls were all right handed. Except for migraine, patients were free of any medical comorbidity. Cortical reconstruction and segmentation were performed on the 3D T1-weighted images using Freesurfer 5.3 image analysis suite. The automatic cortical parcellation was based on Freesurfer's Desikan-Killiany-Tourville atlas, which has 31 cortical regions per hemisphere. The segmented regions were divided into five lobes (frontal, parietal, temporal, occipital, insula). Since the left and right differences in lobar and insular volumes/thicknesses were not different among our groups, volume and cortical thickness were calculated for corresponding bilateral lobes.There was no significant difference in age between the whole migraine and the control groups. Migraineurs with WMLs (L+ patients) were significantly older than lesion-free (L-) patients (P = 0.0003) and controls (P = 0.018). Disease duration (P = 0.003), the total number of migraine attacks (P = 0.022) and the rate of aura (P = 0.0003) were significantly higher in L+ patients than in L- patients. Cortical thickness and volume measurements of lobes were not statistically different between the three groups (L+, L-, control). Age showed a significant negative association with both thickness and volume in each examined lobe (P < 0.001). Intracranial volume (ICV) showed a significant positive association with all regional volumes (P < 0.001). There were no significant group*age, group*ICV, or age*ICV interactions. None of the migraine characteristics were selected by stepwise linear regression as significant predictors of cortical thickness or volume. Only age (for both thickness and volume) and ICV (for volume) were identified as significant predictors (P < 0.001). When the L + group was divided into two subgroups by median split of total and lobar lesion number and volume, the cortical measures did not show any significant difference between the groups with low vs. high lesion number/volume by stepwise linear regression.In a female migraine group, we found that the WMLs and clinical migraine characteristics have no effect on cortical thickness and volume of bilateral lobes. Lobar cortical thicknesses were equivalent within the range of ±0.1 mm. Only age and ICV proved to be significant predictors; the former for both cortical thickness and volume, while the latter for cortical volume. LA - English DB - MTMT ER - TY - JOUR AU - Erdélyi-Bótor, Szilvia AU - Komáromy, Hedvig AU - Kamson Olayinka, Dávid AU - Kovács, Norbert AU - Perlaki, Gábor AU - Orsi, Gergely AU - Molnár, Tihamér AU - Illés, Zsolt László AU - Nagy, Lajos AU - Kéki, Sándor AU - Deli, Gabriella AU - Bosnyák, Edit AU - Trauninger, Anita AU - Pfund, Zoltán TI - Serum L-arginine and Dimethylarginine Levels in Migraine Patients with Brain White Matter Lesions JF - CEPHALALGIA J2 - CEPHALALGIA VL - 37 PY - 2017 IS - 6 SP - 571 EP - 580 PG - 10 SN - 0333-1024 DO - 10.1177/0333102416651454 UR - https://m2.mtmt.hu/api/publication/3055175 ID - 3055175 LA - English DB - MTMT ER - TY - JOUR AU - Erdélyi-Bótor, Szilvia AU - Aradi, Mihály AU - Kamson Olayinka, Dávid AU - Kovács, Norbert AU - Perlaki, Gábor AU - Orsi, Gergely AU - Nagy, Szilvia Anett AU - Schwarcz, Attila AU - Dóczi, Tamás Péter AU - Komoly, Sámuel AU - Deli, Gabriella AU - Trauninger, Anita AU - Pfund, Zoltán TI - Changes of Migraine-Related White Matter Hyperintensities After 3 Years: A Longitudinal MRI Study. JF - HEADACHE J2 - HEADACHE VL - 55 PY - 2015 IS - 1 SP - 55 EP - 70 PG - 16 SN - 0017-8748 DO - 10.1111/head.12459 UR - https://m2.mtmt.hu/api/publication/2758889 ID - 2758889 AB - OBJECTIVE/BACKGROUND: The aim of this longitudinal study was to investigate changes of migraine-related brain white matter hyperintensities 3 years after an initial study. Baseline quantitative magnetic resonance imaging (MRI) studies of migraine patients with hemispheric white matter hyperintensities performed in 2009 demonstrated signs of tissue damage within the hyperintensities. The hyperintensities appeared most frequently in the deep white matter of the frontal lobe with a similar average hyperintensity size in all hemispheric lobes. Since in this patient group the repeated migraine attacks were the only known risk factors for the development of white matter hyperintensities, the remeasurements of migraineurs after a 3-year long follow-up may show changes in the status of these structural abnormalities as the effects of the repeated headaches. METHODS: The same patient group was reinvestigated in 2012 using the same MRI scanner and acquisition protocol. MR measurements were performed on a 3.0-Tesla clinical MRI scanner. Beyond the routine T1-, T2-weighted, and fluid-attenuated inversion recovery imaging, diffusion and perfusion-weighted imaging, proton magnetic resonance spectroscopy, and T1 and T2 relaxation time measurements were also performed. Findings of the baseline and follow-up studies were compared with each other. RESULTS: The follow-up proton magnetic resonance spectroscopy studies of white matter hyperintensities showed significantly decreased N-acetyl-aspartate (median values 8.133 vs 7.153 mmol/L, P = .009) and creatine/phosphocreatine (median values 4.970 vs 4.641 mmol/L, P = .015) concentrations compared to the baseline, indicating a more severe axonal loss and glial hypocellularity with decreased intracellular energy production. The diffusion values, the T1 and T2 relaxation times, and the cerebral blood flow and volume measurements presented only mild changes between the studies. The number (median values 21 vs 25, P < .001) and volume (median values 0.896 vs 1.140 mL, P < .001) of hyperintensities were significantly higher in the follow-up study. No changes were found in the hemispheric and lobar distribution of hyperintensities. An increase in the hyperintensity size of preexisting lesions was much more common than a decrease (median values 14 vs 5, P = .004). A higher number of newly developed hyperintensities were detected than disappeared ones (130 vs 22), and most of them were small (<.034 mL). Small white matter hyperintensities in patients with a low migraine attack frequency had a higher chance to disappear than large white matter hyperintensities or white matter hyperintensities in patients with a high attack frequency (coefficient: -0.517, P = .034). CONCLUSIONS: This longitudinal MRI study found clinically silent brain white matter hyperintensities to be predominantly progressive in nature. The absence of a control group precludes definitive conclusions about the nature of these changes or if their degree is beyond normal aging. LA - English DB - MTMT ER - TY - THES AU - Kamson Olayinka, Dávid TI - Multimodality neuroimaging in migraine and brain tumors PY - 2014 SP - 50 UR - https://m2.mtmt.hu/api/publication/2712846 ID - 2712846 LA - English DB - MTMT ER - TY - GEN AU - Kamson Olayinka, Dávid AU - Juhász, C AU - Robinette, NL AU - Muzik, O AU - Chakraborty, PK AU - Barger, GR AU - Mittal, S TI - Low tryptophan uptake in contrast-enhancing lesions predicts long-term survival in patients with a previously treated glioblastoma: A PET study PY - 2014 UR - https://m2.mtmt.hu/api/publication/2581817 ID - 2581817 N1 - Poster Presentation LA - English DB - MTMT ER - TY - JOUR AU - Juhász, Csaba AU - Dwivedi, S AU - Kamson Olayinka, Dávid AU - Michelhaugh, S AU - Mittal, S TI - Comparison of Amino Acid Positron Emission Tomographic Radiotracers for Molecular Imaging of Primary and Metastatic Brain Tumors JF - MOLECULAR IMAGING J2 - MOL IMAGING VL - 13 PY - 2014 IS - 6 PG - 16 SN - 1535-3508 DO - 10.2310/7290.2014.00015 UR - https://m2.mtmt.hu/api/publication/2581393 ID - 2581393 N1 - Export Date: 27 January 2024 LA - English DB - MTMT ER - TY - JOUR AU - Christensen, Michael AU - Kamson Olayinka, Dávid AU - Snyder, Michael AU - Kim, Harold AU - Robinette, Natasha L AU - Mittal, Sandeep AU - Juhász, Csaba TI - Tryptophan PET-defined gross tumor volume offers better coverage of initial progression than standard MRI-based planning in glioblastoma patients JF - JOURNAL OF RADIATION ONCOLOGY J2 - J RADIAT ONCOL VL - 3 PY - 2014 IS - 2 SP - 131 EP - 138 PG - 8 SN - 1948-7894 DO - 10.1007/s13566-013-0132-5 UR - https://m2.mtmt.hu/api/publication/2581380 ID - 2581380 N1 - Funding Agency and Grant Number: National Cancer Institute [R01 CA123451] Funding text: The study was partially supported by a grant from the National Cancer Institute (R01 CA123451 to CJ). The authors are thankful to Geoffrey Barger, MDwho performed the clinical follow-up of the patients after postsurgical chemoradiation. Also, the authors are also thankful to Janet Barger, RN; Melissa Burkett, CNMT; Jane Cornett, RN; Anna DeBoard, RN; Kelly Forcucci, RN; Cathie Germain, MA; Carole Klapko, CNMT; Mei-li Lee, MS; Xin Lu, MS; Marcia Lodej, RN; AndrewMosqueda, CNMT; Karen Nichols, NP; Galina Rabkin, CNMT; and Angela Wigeluk, CNMT for their assistance in patient recruitment, scheduling, and preparation, as well as for their technical assistance in performing the PET studies. Finally, the authors are grateful to Pulak Chakraborty, PhD and Hancheng Cai, PhD for the reliable radiosynthesis of the PET radiotracer. LA - English DB - MTMT ER - TY - JOUR AU - Kamson Olayinka, Dávid AU - Juhász, Csaba AU - Shin, J AU - Behen, ME AU - Guy, WC AU - Chugani, HT AU - Jeong, JW TI - Patterns of structural reorganization of the corticospinal tract in children with Sturge-Weber syndrome. JF - PEDIATRIC NEUROLOGY J2 - PEDIATR NEUROL VL - 50 PY - 2014 IS - 4 SP - 337 EP - 342 PG - 6 SN - 0887-8994 DO - 10.1016/j.pediatrneurol.2013.12.012 UR - https://m2.mtmt.hu/api/publication/2581365 ID - 2581365 N1 - Export Date: 27 January 2024; CODEN: PNEUE AB - BACKGROUND: Reorganization of the corticospinal tract after early damage can limit motor deficit. In this study, we explored patterns of structural corticospinal tract reorganization in children with Sturge-Weber syndrome. METHODS: Five children (age 1.5-7 years) with motor deficit resulting from unilateral Sturge-Weber syndrome were studied prospectively and longitudinally (1-2 years follow-up). Corticospinal tract segments belonging to hand and leg movements were separated and their volume was measured by diffusion tensor imaging tractography using a recently validated method. Corticospinal tract segmental volumes were normalized and compared between the Sturge-Weber syndrome children and age-matched healthy controls. Volume changes during follow-up were also compared with clinical motor symptoms. RESULTS: In the Sturge-Weber syndrome children, hand-related (but not leg-related) corticospinal tract volumes were consistently decreased in the affected cerebral hemisphere at baseline. At follow-up, two distinct patterns of hand corticospinal tract volume changes emerged. (1) Two children with extensive frontal lobe damage showed a corticospinal tract volume decrease in the lesional hemisphere and a concomitant increase in the nonlesional (contralateral) hemisphere. These children developed good hand grasp but no fine motor skills. (2) The three other children, with relative sparing of the frontal lobe, showed an interval increase of the normalized hand corticospinal tract volume in the affected hemisphere; these children showed no gross motor deficit at follow-up. CONCLUSIONS: Diffusion tensor imaging tractography can detect differential abnormalities in the hand corticospinal tract segment both ipsi- and contralateral to the lesion. Interval increase in the corticospinal tract hand segment suggests structural reorganization, whose pattern may determine clinical motor outcome and could guide strategies for early motor intervention. LA - English DB - MTMT ER - TY - JOUR AU - Kamson Olayinka, Dávid AU - Mittal, S AU - Robinette, NL AU - Muzik, O AU - Kupsky, WJ AU - Barger, GR AU - Juhász, Csaba TI - Increased tryptophan uptake on PET has strong independent prognostic value in patients with a previously treated high-grade glioma. JF - NEURO-ONCOLOGY J2 - NEURO-ONCOLOGY VL - 16 PY - 2014 IS - 10 SP - 1373 EP - 1383 PG - 11 SN - 1522-8517 DO - 10.1093/neuonc/nou042 UR - https://m2.mtmt.hu/api/publication/2581364 ID - 2581364 N1 - Export Date: 27 January 2024; CODEN: NEURJ AB - BACKGROUND: Previously, we demonstrated the high accuracy of alpha-[11C]methyl-L-tryptophan (AMT) PET for differentiating recurrent gliomas from radiation injury. The present study evaluated the prognostic value of increased AMT uptake in patients with previously treated high-grade glioma. METHODS: AMT-PET was performed in 39 patients with suspected recurrence of World Health Organization grades III-IV glioma following surgical resection, radiation, and chemotherapy. Mean and maximum standardized uptake values (SUVs) and unidirectional AMT uptake (K) were measured in brain regions suspicious for tumor and compared with the contralateral cortex (ie, background). Optimal cutoff thresholds for 1-year survival prediction were determined for each AMT parameter and used for calculating the prognostic value of high (above threshold) versus low (below threshold) values for post-PET overall survival (OS). RESULTS: In univariate analyses, 1-year survival was strongly associated with 3 AMT parameters (SUVmax, SUVmean, and tumor-to-background K-ratio; odds ratios: 21.3-25.6; P