TY - JOUR AU - Vollár, Martin AU - Gyovai, András AU - Szűcs, Péter AU - Zupkó, István AU - Marschall, Marianna AU - Csupor-Löffler, Boglárka AU - Bérdi, Péter AU - Vecsernyés, A AU - Csorba, Attila AU - Liktor-Busa, Erika AU - Zsoldiné Urbán, Edit AU - Csupor, Dezső TI - Antiproliferative and Antimicrobial Activities of Selected Bryophytes JF - MOLECULES J2 - MOLECULES VL - 23 PY - 2018 IS - 7 PG - 15 SN - 1420-3049 DO - 10.3390/molecules23071520 UR - https://m2.mtmt.hu/api/publication/3399728 ID - 3399728 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Tivadar AU - Cank, Kristóf Bence AU - Orbán-Gyapai, Orsolya AU - Liktor-Busa, Erika AU - Zomborszki, Zoltán Péter AU - Santa, Rutkovska AU - Irēna, Pučka AU - Anikó, Németh AU - Csupor, Dezső TI - Phytochemical and pharmacological investigation of Spiraea chamaedryfolia: a contribution to the chemotaxonomy of Spiraea genus JF - BMC RESEARCH NOTES J2 - BMC RES NOTES VL - 10 PY - 2017 PG - 6 SN - 1756-0500 DO - 10.1186/s13104-017-3013-y UR - https://m2.mtmt.hu/api/publication/3307270 ID - 3307270 LA - English DB - MTMT ER - TY - JOUR AU - Ványolós, Attila AU - Kovács, Bernadett AU - Béni, Zoltán AU - Dékány, M AU - Krámos, B AU - Liktor-Busa, Erika AU - Zomborszki, Zoltán Péter AU - Zupkó, István AU - Hohmann, Judit TI - Hungarian mushrooms as untapped source of natural products: from screening studies to biologically active metabolites JF - PLANTA MEDICA INTERNATIONAL OPEN J2 - PLANTA MEDICA INT OPEN VL - 4 PY - 2017 IS - S 01 SN - 2509-6656 DO - 10.1055/s-0037-1608106 UR - https://m2.mtmt.hu/api/publication/3287856 ID - 3287856 N1 - [Poszter] LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Bernadett AU - Zomborszki, Zoltán Péter AU - Orbán-Gyapai, Orsolya AU - Csupor-Löffler, Boglárka AU - Liktor-Busa, Erika AU - Lázár, Andrea AU - Papp, Viktor AU - Zsoldiné Urbán, Edit AU - Hohmann, Judit AU - Ványolós, Attila TI - Investigation of Antimicrobial, Antioxidant, and Xanthine Oxidase−Inhibitory Activities of Phellinus (Agaricomycetes) Mushroom Species Native to Central Europe JF - INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS J2 - INT J MED MUSHROOM VL - 19 PY - 2017 IS - 5 SP - 387 EP - 394 PG - 8 SN - 1521-9437 DO - 10.1615/IntJMedMushrooms.v19.i5.10 UR - https://m2.mtmt.hu/api/publication/3247431 ID - 3247431 LA - English DB - MTMT ER - TY - CHAP AU - Cank, Kristóf Bence AU - Kiss, Tivadar AU - Orbán-Gyapai, Orsolya AU - Liktor-Busa, Erika AU - Santa, Rutkovska AU - Irēna, Pučka AU - Csupor, Dezső ED - Céline, Rivière TI - Phytochemical and pharmacological investigation of Spiraea chamaedryfolia T2 - Trends in Natural Product Research - PSE Young Scientists’ Meeting Lille 2017. Natural Products in Health, Agro-food and Cosmetics: Abstracts of the Phytochemical Society of Europe PB - Phytochemical Society of Europe CY - Leicester SN - 9780956547262 PY - 2017 SP - 123 EP - 123 PG - 1 UR - https://m2.mtmt.hu/api/publication/3245171 ID - 3245171 AB - Diterpene alkaloids are characteristic compounds for the Ranunculaceae family and for some other very few plant taxa. The high biological activity of these compounds depends on the skeleton type and the substitution pattern1. Poorly examined diterpene alkaloid-containing taxa might be promising sources of new compounds with pharmacological activities. The genus Spiraea is one of the unique and very few taxa that contain diterpene alkaloids2. The aim of our present work was the identification of a new diterpene alkaloid-containing Spiraea species. Methanolic, acidic and alkaline extracts were prepared from seven Spiraea species (S. crenata, S. media, S. salicifolia, S. nipponica, S. vanhouttei, S. billardii and S. chamaedryfolia) and their diterpene alkaloid content was examined by means of TLC by applying highly selective alkaloid detection. The multistep extraction of diterpene alkaloids was performed and the extracts were subjected to in vitro antibacterial and xanthine oxidase inhibitory activity.Our research group detected the presence of diterpene alkaloids in S. chamaedryfolia for the first time. For alkaloid extraction, a multistep method was developed. The neutral, acidic and alkaline extracts of the roots exerted noteworthy xanthine oxidase inhibitory activity (>70%). The extracts exhibited antibacterial activity in vitro against Staphylococcus aureus, Bacillus subtilis, Moraxella catarrhalis, Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). Based on these results the continuation of the phytochemical work seems promising with the aim of isolation of pure compounds and the characterization of the compounds responsible for the antibacterial and xanthine oxidase inhibitory activity. LA - English DB - MTMT ER - TY - JOUR AU - Orbán-Gyapai, Orsolya AU - Liktor-Busa, Erika AU - Kúsz, Norbert AU - Stefkó, Dóra AU - Zsoldiné Urbán, Edit AU - Hohmann, Judit AU - Vasas, Andrea TI - Antibacterial screening of Rumex species native to the Carpathian Basin and bioactivity-guided isolation of compounds from Rumex aquaticus JF - FITOTERAPIA J2 - FITOTERAPIA VL - 118 PY - 2017 SP - 101 EP - 106 PG - 6 SN - 0367-326X DO - 10.1016/j.fitote.2017.03.009 UR - https://m2.mtmt.hu/api/publication/3201412 ID - 3201412 AB - Abstract Plants belonging to the genus Rumex (family Polygonaceae) are used worldwide in traditional medicine for the treatment of various diseases caused by different microorganisms (e.g. bacteria-related dermatologic conditions, dysentery and enteritis). The present study focused on the antibacterial screening of Rumex species native to the Carpathian Basin, and isolation of compounds from one of the most efficient species, Rumex aquaticus. The antibacterial effects of n-hexane, chloroform and aqueous fractions of methanol extracts prepared from different parts of 14 Rumex species (R. acetosella, R. acetosa, R. alpinus, R. aquaticus, R. conglomeratus, R. crispus, R. hydrolapathum, R. obtusifolius subsp. obtusifolius, R. obtusifolius subsp. subalpinus, R. patientia, R. pulcher, R. scutatus, R. stenophyllus and R. thyrsiflorus) were investigated against Staphylococcus epidermidis, S. aureus, MRSA, Bacillus subtilis, Moraxella catarrhalis, Streptococcus pyogenes, S. pneumoniae, S. agalactiae, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae using the disc diffusion method. Mainly the n-hexane and chloroform extracts prepared from the roots of the plants displayed high antibacterial activity (inhibition zones > 15 mm) against one or more bacterial strains. The highly active extracts of the aerial part and root of R. aquaticus were subjected to a multistep separation procedure. 19 Compounds, among them naphthalenes (musizin, and its glucoside, torachrysone-glucoside, 2-methoxystypandrone), anthraquinones (emodin, chrysophanol, physcion, citreorosein, chrysophanol-8-O-glucoside), flavonoids (quercetin, quercetin-3,3′-dimethylether, isokaempferide, quercetin 3-O-arabinoside, quercetin 3-O-galactoside, catechin), stilbenes (resveratrol, piceid), and 1-stearoylglycerol were isolated from the plant. The antibacterial activities of isolated compounds were determined, and it was observed that especially naphthalenes exerted remarkable antibacterial effects against several bacterial strains. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Barbara AU - Liktor-Busa, Erika AU - Kúsz, Norbert AU - Szappanos, Ádám AU - Mándi, Attila AU - Kurtán, Tibor AU - Zsoldiné Urbán, Edit AU - Hohmann, Judit AU - Fang-Rong, Chang AU - Vasas, Andrea TI - Phenanthrenes from Juncus inflexus with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus JF - JOURNAL OF NATURAL PRODUCTS J2 - J NAT PROD VL - 79 PY - 2016 IS - 11 SP - 2814 EP - 2823 PG - 10 SN - 0163-3864 DO - 10.1021/acs.jnatprod.6b00581 UR - https://m2.mtmt.hu/api/publication/3143290 ID - 3143290 AB - The present study has focused on an investigation of the antibacterial effects of Juncus inflexus and the isolation and identification of its active compounds. Eleven phenanthrenes were isolated from a methanolic extract of the roots. Four compounds (jinflexins A−D, 1−4) are new natural products, while seven phenanthrenes [juncuenins A (5), B (6), and D (8), juncusol (7), dehydrojuncuenins A (9) and B (11), and dehydrojuncusol (10)] were isolated for the first time from the plant. Jinflexin D (4) is a dimer with an unprecedented heptacyclic ring system. The absolute configurations of the new compounds were determined by TDDFT-ECD calculations, and their enantiomeric purity was checked by chiral HPLC analysis. Extracts of different polarity (n-hexane, dichloromethane, and ethyl acetate) were evaluated for their antimicrobial effects against methicillin-resistant Staphylococcus aureus, extended-spectrum β-lactamase (ESBL)-producing Citrobacter freundii, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, multiresistant Acinetobacter baumannii, and Pseudomonas aeruginosa. The MIC values of the isolated compounds were determined by a microdilution method. Jinflexin B (2), juncusol (7), juncuenin D (8), and dehydrojuncuenin B (11) showed significant activity (MIC value range 12.5−100 μg/mL) against MRSA strains. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Barbara AU - Liktor-Busa, Erika AU - Zsoldiné Urbán, Edit AU - Csorba, Attila AU - Jakab, Gusztáv AU - Hohmann, Judit AU - Vasas, Andrea TI - Antibacterial screening of Juncaceae species native to the Carpathian Basin against resistant strains and LC-MS investigation of phenanthrenes responsible for the effect JF - FITOTERAPIA J2 - FITOTERAPIA VL - 115 PY - 2016 SP - 69 EP - 73 PG - 5 SN - 0367-326X DO - 10.1016/j.fitote.2016.09.024 UR - https://m2.mtmt.hu/api/publication/3121418 ID - 3121418 N1 - Department of Pharmacognosy, University of Szeged, Szeged, 6720, Hungary Institute of Clinical Microbiology, University of Szeged, Szeged, 6725, Hungary Institute of Environmental Sciences, Faculty of Water and Environmental Management, Szent István University, Szarvas, 5540, Hungary Interdisciplinary Centre of Natural Products, University of Szeged, Szeged, 6720, Hungary Cited By :6 Export Date: 7 September 2023 CODEN: FTRPA Correspondence Address: Vasas, A.; Department of Pharmacognosy, Hungary; email: vasasa@pharmacognosy.hu LA - English DB - MTMT ER - TY - CONF AU - Tóth, Barbara AU - Kúsz, Norbert AU - Liktor-Busa, Erika AU - Zsoldiné Urbán, Edit AU - Hunyadi, Attila AU - Chang, Fang-Rong AU - Kurtán, Tibor AU - Hohmann, Judit AU - Vasas, Andrea ED - Csupor, Dezső ED - Rédei, Dóra ED - Kiss, Tivadar TI - Juncaceae fajok biológiailag aktív vegyületeinek izolálása és szerkezet-meghatározása T2 - Fiatal Gyógynövénykutatók Fóruma: a Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztályának tudományos konferenciája PB - Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztálya C1 - Szeged PY - 2016 SP - 6 EP - 6 PG - 1 UR - https://m2.mtmt.hu/api/publication/3082834 ID - 3082834 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Liktor-Busa, Erika AU - Kovács, Bernadett AU - Zsoldiné Urbán, Edit AU - Hohmann, Judit AU - Ványolós, Attila TI - Investigation of Hungarian mushrooms for antibacterial activity and synergistic effects with standard antibiotics against resistant bacterial strains JF - LETTERS IN APPLIED MICROBIOLOGY J2 - LETT APPL MICROBIOL VL - 62 PY - 2016 IS - 6 SP - 437 EP - 443 PG - 7 SN - 0266-8254 DO - 10.1111/lam.12576 UR - https://m2.mtmt.hu/api/publication/3058452 ID - 3058452 LA - English DB - MTMT ER -