TY - JOUR AU - Lendvai-Emmert, Dominika AU - Magyar-Sümegi, Zsófia Dina AU - Hegedüs, Emőke AU - Szarka, Nikolett AU - Fazekas, Bálint AU - Amrein, Krisztina AU - Czeiter, Endre AU - Büki, András AU - Ungvári, Zoltán István AU - Tóth, Péter József TI - Mild traumatic brain injury-induced persistent blood–brain barrier disruption is prevented by cyclosporine A treatment in hypertension JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 14 PY - 2023 PG - 9 SN - 1664-2295 DO - 10.3389/fneur.2023.1252796 UR - https://m2.mtmt.hu/api/publication/34392087 ID - 34392087 N1 - This work was supported by grants from the National Research, Development and Innovation Office (OTKA K-134555 and OTKA FK-123798 to PT), the Hungarian Academy of Sciences Bolyai Research Scholarship (to PT), National Clinical Neuroscience Laboratory (RRF-2.3.1-21-2022-00011), the Thematic Excellence Program 2021 Health sub-program of the Ministry for Innovation and Technology in Hungary, within the framework of the EGA-16 project of the University of Pecs (to PT), the National Institute on Aging (RF1AG072295, R01AG055395, R01AG068295, and K01-AG073614), the National Institute of Neurological Disorders and Stroke (R01NS100782), the National Cancer Institute (R01CA255840). LA - English DB - MTMT ER - TY - JOUR AU - Koller, Ákos AU - Szénási, Annamária AU - Amrein, Krisztina AU - Czeiter, Endre AU - Szarka, Nikolett AU - Tóth, Péter József TI - Impaired mechanotransduction of small cerebral arteries after traumatic brain injury. Role of arachidonic acid pathway dysfunction. JF - FASEB JOURNAL J2 - FASEB J VL - 36 PY - 2022 IS - S1 PG - 1 SN - 0892-6638 DO - 10.1096/fasebj.2022.36.S1.0R725 UR - https://m2.mtmt.hu/api/publication/32830059 ID - 32830059 AB - Healthy functioning of the brain requires a precise autoregulation of cerebral blood flow, which in part is achieved by the pressure and flow sensitive vasomotor mechanisms. Traumatic brain injury (TBI) frequently occurs worldwide, resulting in brain diseases with high morbidity and mortality. Here, we hypothesized that TBI impairs the autoregulatory mechanisms, namely the pressure- and flow-induced constrictions of isolated rat middle cerebral arteries (MCAs).TBI was induced in anaesthetized rats by weight drop model, and then MCAs were isolated and transferred into a pressure-flow chamber. Changes in internal diameter in response to hemodynamic forces and vasoactive drugs were measured by a video-microscopy.In MCAs from intact rats, increases in pressure-, flow- and pressure + flow elicited constrictions (max.: -26 ± 1.7; -26 ± 1.9; and -52 ± 2.8 µm, p < 0.05). Flow-induced constrictions were significantly reduced by HET0016, an inhibitor of cytochrome P450 4A (CYP450 4A) or in the presence of thromboxane-prostanoid (TP receptor) antagonist SQ 29,548. Both responses were significantly reduced after TBI. Arachidonic acid, (AA, 10-7 M), and CYP450 4A metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) elicited constrictions of intact MCA (-26 ± 2.3% and -31 ± 3.6%), which were significantly reduced after TBI (to -11 ± 1.3% and -16 ±2.5%). The TP receptor agonist U46619 (10-7 M) elicited substantial constrictions of MCA from intact rats (-21 ± 3.3%), which were also significantly reduced, after TBI (to -16 ± 2.4%).Both pressure and flow-induced constrictions of MCA were impaired by traumatic brain injury, likely due to the reduced ability of cytochrome P450 4A to convert arachidonic acid to constrictor prostaglandins (cPGs) and the mitigated sensitivity of thromboxane-prostanoid receptors to cPGs. We propose that the impairment of autoregulatory vasomotor mechanisms contribute to the TBI-induced human brain diseases, such as headache, disruption of blood brain barrier, brain edema, Alzheimer-type diseases and vascular dementia. LA - English DB - MTMT ER - TY - THES AU - Szarka, Nikolett TI - CEREBROVASCULAR DYSFUNCTION FOLLOWING TRAUMATIC BRAIN INJURY PY - 2021 DO - 10.14753/SE.2021.2514 UR - https://m2.mtmt.hu/api/publication/32873810 ID - 32873810 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Luca AU - Czigler, András AU - Horváth, Péter AU - Szarka, Nikolett AU - Környei, Bálint Soma AU - Tóth, Arnold AU - Schwarcz, Attila AU - Ungvári, Zoltán István AU - Büki, András AU - Tóth, Péter József TI - The effect of mild traumatic brain injury on cerebral microbleeds in aging JF - FRONTIERS IN AGING NEUROSCIENCE J2 - FRONT AGING NEUROSCI VL - 13 PY - 2021 PG - 7 SN - 1663-4365 DO - 10.3389/fnagi.2021.717391 UR - https://m2.mtmt.hu/api/publication/32172268 ID - 32172268 AB - A traumatic brain injury (TBI) induces the formation of cerebral microbleeds (CMBs), which are associated with cognitive impairments, psychiatric disorders, and gait dysfunctions in patients. Elderly people frequently suffer TBIs, especially mild brain trauma (mTBI). Interestingly, aging is also an independent risk factor for the development of CMBs. However, how TBI and aging may interact to promote the development of CMBs is not well established. In order to test the hypothesis that an mTBI exacerbates the development of CMBs in the elderly, we compared the number and cerebral distribution of CMBs and assessed them by analysing susceptibility weighted (SW) MRI in young (25 ± 10 years old, n = 18) and elder (72 ± 7 years old, n = 17) patients after an mTBI and in age-matched healthy subjects (young: 25 ± 6 years old, n = 20; aged: 68 ± 5 years old, n = 23). We found significantly more CMBs in elder patients after an mTBI compared with young patients; however, we did not observe a significant difference in the number of cerebral microhemorrhages between aged and aged patients with mTBI. The majority of CMBs were found supratentorially (lobar and basal ganglion). The lobar distribution of supratentorial CMBs showed that aging enhances the formation of parietal and occipital CMBs after mTBIs. This suggests that aging and mTBIs do not synergize in the induction of the development of CMBs, and that the different distribution of mTBI-induced CMBs in aged patients may lead to specific age-related clinical characteristics of mTBIs. LA - English DB - MTMT ER - TY - CHAP AU - Tóth, Luca AU - Czigler, András AU - Viktoria, Kovacs AU - Szarka, Nikolett AU - Tóth, Péter József ED - Csiszár, Beáta ED - Hankó, Csilla ED - Kajos, Luca Fanni ED - Mező, Emerencia TI - Evaluation of neurovascular coupling by transcranial doppler ultrasound system T2 - Medical Conference for PhD Students and Experts of Clinical Sciences 2021 PB - University of Pécs, Doctoral Student Association CY - Pécs SN - 9789634296539 PY - 2021 SP - 92 EP - 92 PG - 1 UR - https://m2.mtmt.hu/api/publication/32131009 ID - 32131009 LA - English DB - MTMT ER - TY - JOUR AU - Szénási, Annamária AU - Amrein, Krisztina AU - Czeiter, Endre AU - Szarka, Nikolett AU - Tóth, Péter József AU - Koller, Ákos TI - Molecular Pathomechanisms of Impaired Flow-Induced Constriction of Cerebral Arteries Following Traumatic Brain Injury: A Potential Impact on Cerebral Autoregulation JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 12 PG - 12 SN - 1661-6596 DO - 10.3390/ijms22126624 UR - https://m2.mtmt.hu/api/publication/32077922 ID - 32077922 LA - English DB - MTMT ER - TY - JOUR AU - Szarka, Nikolett AU - Szellar, Dora AU - Kiss, Szabolcs AU - Borbásné Farkas, Kornélia AU - Szakács, Zsolt AU - Czigler, András AU - Ungvári, Zoltán István AU - Hegyi, Péter AU - Büki, András AU - Tóth, Péter József TI - Effect of Growth Hormone on Neuropsychological Outcomes and Quality of Life of Patients with Traumatic Brain Injury: A Systematic Review JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 38 PY - 2021 IS - 11 SP - 1467 EP - 1483 PG - 17 SN - 0897-7151 DO - 10.1089/neu.2020.7265 UR - https://m2.mtmt.hu/api/publication/31905619 ID - 31905619 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office [NKFI-FK123798, K-134555]; Hungarian Academy of Sciences Bolyai Research Scholarship [EFOP-3.6.2.-16-2017-00008, GINOP-2.3.2-152016-00048, GINOP-2.2.1-15-2017-00067]; Hungarian Brain Research Program 2.0 Grant [2017-1.2.1-NKP-2017-00002]; National Institute of Health [R01-AG055395, R01NS100782, R01-AT006526]; Higher Education Institutional Excellence Programme of the Ministry of Human Capacities -FIKP III Funding text: This work was supported by grants from the National Research, Development and Innovation Office to P.T. (NKFI-FK123798) and A.B. (K-134555), the Hungarian Academy of Sciences Bolyai Research Scholarship to P.T. EFOP-3.6.2.-16-2017-00008, GINOP-2.3.2-152016-00048, GINOP-2.2.1-15-2017-00067 to P.T. and A.B., Hungarian Brain Research Program 2.0 Grant No. 2017-1.2.1-NKP-2017-00002 to A.B., the Higher Education Institutional Excellence Programme of the Ministry of Human Capacities -FIKP III to P.T. and A.B., and the National Institute of Health R01-AG055395, R01NS100782, R01-AT006526 to Z.U. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Luca AU - Czigler, András AU - Horváth, Péter AU - Környei, Bálint Soma AU - Szarka, Nikolett AU - Schwarcz, Attila AU - Ungvári, Zoltán István AU - Büki, András AU - Tóth, Péter József TI - Traumatic brain injury-induced cerebral microbleeds in the elderly JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 43 PY - 2021 IS - 1 SP - 125 EP - 136 PG - 12 SN - 2509-2715 DO - 10.1007/s11357-020-00280-3 UR - https://m2.mtmt.hu/api/publication/31620181 ID - 31620181 AB - Traumatic brain injury (TBI) was shown to lead to the development of cerebral microbleeds (CMBs), which are associated with long term cognitive decline and gait disturbances in patients. The elderly is one of the most vulnerable parts of the population to suffer TBI. Importantly, ageing is known to exacerbate microvascular fragility and to promote the formation of CMBs. In this overview, the effect of ageing is discussed on the development and characteristics of TBI-related CMBs, with special emphasis on CMBs associated with mild TBI. Four cases of TBI-related CMBs are described to illustrate the concept that ageing exacerbates the deleterious microvascular effects of TBI and that similar brain trauma may induce more CMBs in old patients than in young ones. Recommendations are made for future prospective studies to establish the mechanistic effects of ageing on the formation of CMBs after TBI, and to determine long-term consequences of CMBs on clinically relevant outcome measures including cognitive performance, gait and balance function. LA - English DB - MTMT ER - TY - JOUR AU - Koller, Ákos AU - Szénási, Annamária AU - Szarka, Nikolett AU - Büki, András AU - Toth, Peter TI - Traumatic Brain Injury Impairs Flow-Dependent Constrictions of Isolated Rat Middle Cerebral Arteries, Primarily by Interfering with the Flow Sensing Mechanisms JF - FASEB JOURNAL J2 - FASEB J VL - 34 PY - 2020 IS - S1 PG - 2 SN - 0892-6638 DO - 10.1096/fasebj.2020.34.s1.02767 UR - https://m2.mtmt.hu/api/publication/31629993 ID - 31629993 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Luca AU - Czigler, András AU - Szarka, Nikolett AU - Tóth, Péter József TI - The role of transient receptor potential channels in cerebral myogenic autoregulation in hypertension and aging JF - AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY J2 - AM J PHYSIOL HEART C VL - 319 PY - 2020 IS - 1 SP - H159 EP - H161 PG - 3 SN - 0363-6135 DO - 10.1152/ajpheart.00403.2020 UR - https://m2.mtmt.hu/api/publication/31355922 ID - 31355922 LA - English DB - MTMT ER -