@article{MTMT:34392087,
	title = {Mild traumatic brain injury-induced persistent blood–brain barrier disruption is prevented by cyclosporine A treatment in hypertension},
	url = {https://m2.mtmt.hu/api/publication/34392087},
	author = {Lendvai-Emmert, Dominika and Magyar-Sümegi, Zsófia Dina and Hegedüs, Emőke and Szarka, Nikolett and Fazekas, Bálint and Amrein, Krisztina and Czeiter, Endre and Büki, András and Ungvári, Zoltán István and Tóth, Péter József},
	doi = {10.3389/fneur.2023.1252796},
	journal-iso = {FRONT NEUR},
	journal = {FRONTIERS IN NEUROLOGY},
	volume = {14},
	unique-id = {34392087},
	issn = {1664-2295},
	year = {2023},
	eissn = {1664-2295},
	orcid-numbers = {Fazekas, Bálint/0000-0002-8445-4100; Czeiter, Endre/0000-0002-9578-6944; Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:32830059,
	title = {Impaired mechanotransduction of small cerebral arteries after traumatic brain injury. Role of arachidonic acid pathway dysfunction.},
	url = {https://m2.mtmt.hu/api/publication/32830059},
	author = {Koller, Ákos and Szénási, Annamária and Amrein, Krisztina and Czeiter, Endre and Szarka, Nikolett and Tóth, Péter József},
	doi = {10.1096/fasebj.2022.36.S1.0R725},
	journal-iso = {FASEB J},
	journal = {FASEB JOURNAL},
	volume = {36},
	unique-id = {32830059},
	issn = {0892-6638},
	abstract = {Healthy functioning of the brain requires a precise autoregulation of cerebral blood flow, which in part is achieved by the pressure and flow sensitive vasomotor mechanisms. Traumatic brain injury (TBI) frequently occurs worldwide, resulting in brain diseases with high morbidity and mortality. Here, we hypothesized that TBI impairs the autoregulatory mechanisms, namely the pressure- and flow-induced constrictions of isolated rat middle cerebral arteries (MCAs).TBI was induced in anaesthetized rats by weight drop model, and then MCAs were isolated and transferred into a pressure-flow chamber. Changes in internal diameter in response to hemodynamic forces and vasoactive drugs were measured by a video-microscopy.In MCAs from intact rats, increases in pressure-, flow- and pressure + flow elicited constrictions (max.: -26 ± 1.7; -26 ± 1.9; and -52 ± 2.8 µm, p < 0.05). Flow-induced constrictions were significantly reduced by HET0016, an inhibitor of cytochrome P450 4A (CYP450 4A) or in the presence of thromboxane-prostanoid (TP receptor) antagonist SQ 29,548. Both responses were significantly reduced after TBI. Arachidonic acid, (AA, 10-7 M), and CYP450 4A metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) elicited constrictions of intact MCA (-26 ± 2.3% and -31 ± 3.6%), which were significantly reduced after TBI (to -11 ± 1.3% and -16 ±2.5%). The TP receptor agonist U46619 (10-7 M) elicited substantial constrictions of MCA from intact rats (-21 ± 3.3%), which were also significantly reduced, after TBI (to -16 ± 2.4%).Both pressure and flow-induced constrictions of MCA were impaired by traumatic brain injury, likely due to the reduced ability of cytochrome P450 4A to convert arachidonic acid to constrictor prostaglandins (cPGs) and the mitigated sensitivity of thromboxane-prostanoid receptors to cPGs. We propose that the impairment of autoregulatory vasomotor mechanisms contribute to the TBI-induced human brain diseases, such as headache, disruption of blood brain barrier, brain edema, Alzheimer-type diseases and vascular dementia.},
	year = {2022},
	eissn = {1530-6860},
	orcid-numbers = {Koller, Ákos/0000-0003-3256-8701; Szénási, Annamária/0000-0002-2422-1081; Czeiter, Endre/0000-0002-9578-6944}
}

@mastersthesis{MTMT:32873810,
	title = {CEREBROVASCULAR DYSFUNCTION FOLLOWING TRAUMATIC BRAIN INJURY},
	url = {https://m2.mtmt.hu/api/publication/32873810},
	author = {Szarka, Nikolett},
	doi = {10.14753/SE.2021.2514},
	unique-id = {32873810},
	year = {2021}
}

@article{MTMT:32172268,
	title = {The effect of mild traumatic brain injury on cerebral microbleeds in aging},
	url = {https://m2.mtmt.hu/api/publication/32172268},
	author = {Tóth, Luca and Czigler, András and Horváth, Péter and Szarka, Nikolett and Környei, Bálint Soma and Tóth, Arnold and Schwarcz, Attila and Ungvári, Zoltán István and Büki, András and Tóth, Péter József},
	doi = {10.3389/fnagi.2021.717391},
	journal-iso = {FRONT AGING NEUROSCI},
	journal = {FRONTIERS IN AGING NEUROSCIENCE},
	volume = {13},
	unique-id = {32172268},
	issn = {1663-4365},
	abstract = {A traumatic brain injury (TBI) induces the formation of cerebral microbleeds (CMBs), which are associated with cognitive impairments, psychiatric disorders, and gait dysfunctions in patients. Elderly people frequently suffer TBIs, especially mild brain trauma (mTBI). Interestingly, aging is also an independent risk factor for the development of CMBs. However, how TBI and aging may interact to promote the development of CMBs is not well established. In order to test the hypothesis that an mTBI exacerbates the development of CMBs in the elderly, we compared the number and cerebral distribution of CMBs and assessed them by analysing susceptibility weighted (SW) MRI in young (25 ± 10 years old, n = 18) and elder (72 ± 7 years old, n = 17) patients after an mTBI and in age-matched healthy subjects (young: 25 ± 6 years old, n = 20; aged: 68 ± 5 years old, n = 23). We found significantly more CMBs in elder patients after an mTBI compared with young patients; however, we did not observe a significant difference in the number of cerebral microhemorrhages between aged and aged patients with mTBI. The majority of CMBs were found supratentorially (lobar and basal ganglion). The lobar distribution of supratentorial CMBs showed that aging enhances the formation of parietal and occipital CMBs after mTBIs. This suggests that aging and mTBIs do not synergize in the induction of the development of CMBs, and that the different distribution of mTBI-induced CMBs in aged patients may lead to specific age-related clinical characteristics of mTBIs.},
	year = {2021},
	eissn = {1663-4365},
	orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039}
}

@{MTMT:32131009,
	title = {Evaluation of neurovascular coupling by transcranial doppler ultrasound system},
	url = {https://m2.mtmt.hu/api/publication/32131009},
	author = {Tóth, Luca and Czigler, András and Viktoria, Kovacs and Szarka, Nikolett and Tóth, Péter József},
	booktitle = {Medical Conference for PhD Students and Experts of Clinical Sciences 2021},
	unique-id = {32131009},
	year = {2021},
	pages = {92-92}
}

@article{MTMT:32077922,
	title = {Molecular Pathomechanisms of Impaired Flow-Induced Constriction of Cerebral Arteries Following Traumatic Brain Injury: A Potential Impact on Cerebral Autoregulation},
	url = {https://m2.mtmt.hu/api/publication/32077922},
	author = {Szénási, Annamária and Amrein, Krisztina and Czeiter, Endre and Szarka, Nikolett and Tóth, Péter József and Koller, Ákos},
	doi = {10.3390/ijms22126624},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {22},
	unique-id = {32077922},
	issn = {1661-6596},
	year = {2021},
	eissn = {1422-0067},
	orcid-numbers = {Szénási, Annamária/0000-0002-2422-1081; Czeiter, Endre/0000-0002-9578-6944; Koller, Ákos/0000-0003-3256-8701}
}

@article{MTMT:31905619,
	title = {Effect of Growth Hormone on Neuropsychological Outcomes and Quality of Life of Patients with Traumatic Brain Injury: A Systematic Review},
	url = {https://m2.mtmt.hu/api/publication/31905619},
	author = {Szarka, Nikolett and Szellar, Dora and Kiss, Szabolcs and Borbásné Farkas, Kornélia and Szakács, Zsolt and Czigler, András and Ungvári, Zoltán István and Hegyi, Péter and Büki, András and Tóth, Péter József},
	doi = {10.1089/neu.2020.7265},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	volume = {38},
	unique-id = {31905619},
	issn = {0897-7151},
	year = {2021},
	eissn = {1557-9042},
	pages = {1467-1483},
	orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Szakács, Zsolt/0000-0002-7035-941X; Ungvári, Zoltán István/0000-0002-6035-6039; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:31620181,
	title = {Traumatic brain injury-induced cerebral microbleeds in the elderly},
	url = {https://m2.mtmt.hu/api/publication/31620181},
	author = {Tóth, Luca and Czigler, András and Horváth, Péter and Környei, Bálint Soma and Szarka, Nikolett and Schwarcz, Attila and Ungvári, Zoltán István and Büki, András and Tóth, Péter József},
	doi = {10.1007/s11357-020-00280-3},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {43},
	unique-id = {31620181},
	issn = {2509-2715},
	abstract = {Traumatic brain injury (TBI) was shown to lead to the development of cerebral microbleeds (CMBs), which are associated with long term cognitive decline and gait disturbances in patients. The elderly is one of the most vulnerable parts of the population to suffer TBI. Importantly, ageing is known to exacerbate microvascular fragility and to promote the formation of CMBs. In this overview, the effect of ageing is discussed on the development and characteristics of TBI-related CMBs, with special emphasis on CMBs associated with mild TBI. Four cases of TBI-related CMBs are described to illustrate the concept that ageing exacerbates the deleterious microvascular effects of TBI and that similar brain trauma may induce more CMBs in old patients than in young ones. Recommendations are made for future prospective studies to establish the mechanistic effects of ageing on the formation of CMBs after TBI, and to determine long-term consequences of CMBs on clinically relevant outcome measures including cognitive performance, gait and balance function.},
	keywords = {Mild traumatic brain injury; Ageing; Brain trauma; Microbleed; Vascular changes; Cerebral microhaemorrhage},
	year = {2021},
	eissn = {2509-2723},
	pages = {125-136},
	orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:31629993,
	title = {Traumatic Brain Injury Impairs Flow-Dependent Constrictions of Isolated Rat Middle Cerebral Arteries, Primarily by Interfering with the Flow Sensing Mechanisms},
	url = {https://m2.mtmt.hu/api/publication/31629993},
	author = {Koller, Ákos and Szénási, Annamária and Szarka, Nikolett and Büki, András and Toth, Peter},
	doi = {10.1096/fasebj.2020.34.s1.02767},
	journal-iso = {FASEB J},
	journal = {FASEB JOURNAL},
	volume = {34},
	unique-id = {31629993},
	issn = {0892-6638},
	keywords = {Biology; Biochemistry & Molecular Biology},
	year = {2020},
	eissn = {1530-6860},
	orcid-numbers = {Koller, Ákos/0000-0003-3256-8701; Szénási, Annamária/0000-0002-2422-1081}
}

@article{MTMT:31355922,
	title = {The role of transient receptor potential channels in cerebral myogenic autoregulation in hypertension and aging},
	url = {https://m2.mtmt.hu/api/publication/31355922},
	author = {Tóth, Luca and Czigler, András and Szarka, Nikolett and Tóth, Péter József},
	doi = {10.1152/ajpheart.00403.2020},
	journal-iso = {AM J PHYSIOL HEART C},
	journal = {AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY},
	volume = {319},
	unique-id = {31355922},
	issn = {0363-6135},
	keywords = {HYPERTENSION; Aging; MYOGENIC RESPONSE; cognitive decline},
	year = {2020},
	eissn = {1522-1539},
	pages = {H159-H161}
}