TY - JOUR AU - Joó, József Gábor AU - Csatlós, Éva AU - Börzsönyi, Balázs AU - Demendi, Csaba AU - Kornya, László TI - Az oxidatív stressz etiológiai szerepe a főbb szülészeti kórállapotok hátterében JF - MAGYAR NŐORVOSOK LAPJA J2 - MAGYAR NŐORVOSOK LAPJA VL - 86 PY - 2023 IS - 6 SP - 314 EP - 320 PG - 7 SN - 0025-021X UR - https://m2.mtmt.hu/api/publication/34432072 ID - 34432072 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Joó, József Gábor AU - Sulyok, Endre AU - Bódis, József AU - Kornya, László TI - Disrupted Balance of the Oxidant–Antioxidant System in the Pathophysiology of Female Reproduction: Oxidative Stress and Adverse Pregnancy Outcomes JF - CURRENT ISSUES IN MOLECULAR BIOLOGY J2 - CURR ISSUES MOL BIOL VL - 45 PY - 2023 IS - 10 SP - 8091 EP - 8111 PG - 21 SN - 1467-3037 DO - 10.3390/cimb45100511 UR - https://m2.mtmt.hu/api/publication/34196772 ID - 34196772 N1 - ISSN:1467-3045 AB - The significance of oxidative stress in the pathophysiology of male reproductive processes has been closely studied in the last two decades. Recently, it has become clear that oxidative stress can lead to numerous pathological conditions during female reproductive processes as well, contributing to the development of endometriosis, polycystic ovary syndrome and various forms of infertility. During pregnancy, physiological generation of reactive oxygen species (ROS) occurs in association with several developmental processes including oocyte maturation and implantation. An overproduction of ROS can lead to disturbances in fetal development and increases the risk for missed abortion, intrauterine growth restriction, pre-eclampsia, premature delivery and gestational diabetes. Our review focuses on the etiological role of the disrupted oxidant–antioxidant system during human gestation as it relates to adverse pregnancy outcomes. LA - English DB - MTMT ER - TY - JOUR AU - Joó, József Gábor AU - Csatlós, Éva AU - Börzsönyi, Balázs AU - Demendi, Csaba AU - Kornya, László TI - Az oxidatív stressz szerepe a női reprodukcióban JF - MAGYAR NŐORVOSOK LAPJA J2 - MAGYAR NŐORVOSOK LAPJA VL - 86 PY - 2023 IS - 4 SP - 207 EP - 213 PG - 7 SN - 0025-021X UR - https://m2.mtmt.hu/api/publication/34141637 ID - 34141637 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gyimesi, Máté AU - Rauscher, Anna Á. AU - Suthar, Sharad Kumar AU - Hamow, Kamirán Áron AU - Oravecz, Kinga AU - Lőrincz, István AU - Borhegyi, Zsolt AU - Déri, Máté Tamás AU - Kiss, Ádám F. AU - Monostory, Katalin AU - Szabó, Pál Tamás AU - Nag, Suman AU - Tomasic, Ivan AU - Krans, Jacob AU - Tierney, Patrick J. AU - Kovács, Mihály AU - Kornya, László AU - Málnási Csizmadia, András TI - Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) Properties of Blebbistatin Derivatives Indicate That Blebbistatin Scaffold Is Ideal for drug Development Targeting Myosin-2 JF - JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS J2 - J PHARMACOL EXP THER VL - 376 PY - 2021 IS - 3 SP - 358 EP - 373 PG - 16 SN - 0022-3565 DO - 10.1124/jpet.120.000167 UR - https://m2.mtmt.hu/api/publication/31822988 ID - 31822988 N1 - Funding Agency and Grant Number: Hungarian National Research, Development and Innovation Office [NVKP 16-1-2016-0051]; Hungarian Ministry of Finance [GINOP-2.1.7-15-2016-02580] Funding text: This study has been supported by the Hungarian National Research, Development and Innovation Office [NVKP 16-1-2016-0051 to M.G., and A.M.-C.] and the Hungarian Ministry of Finance [GINOP-2.1.7-15-2016-02580 to M.G.]. LA - English DB - MTMT ER - TY - JOUR AU - Kemenesi, Gábor AU - Zeghbib, Safia AU - Somogyi, Balázs Antal AU - Tóth, Gábor Endre AU - Bányai, Krisztián AU - Solymosi, Norbert AU - Szabo, Peter M AU - Szabó, István AU - Bálint, Ádám AU - Urbán, Péter AU - Herczeg, Róbert AU - Gyenesei, Attila AU - Nagy, Ágnes AU - Pereszlényi, Csaba István AU - Babinszky, Gergely Csaba AU - Dudás, Gábor AU - Terhes, Gabriella AU - Zöldi, Viktor AU - Lovas, Róbert AU - Tenczer, Szabolcs AU - Kornya, László AU - Jakab, Ferenc TI - Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix JF - VIRUSES J2 - VIRUSES-BASEL VL - 12 PY - 2020 IS - 12 PG - 10 SN - 1999-4915 DO - 10.3390/v12121401 UR - https://m2.mtmt.hu/api/publication/31733407 ID - 31733407 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Kemenesi, Gábor AU - Kornya, László AU - Tóth, Gábor Endre AU - Kurucz, Kornélia AU - Zeghbib, Safia AU - Somogyi, Balázs Antal AU - Zoldi, Viktor AU - Urbán, Péter AU - Herczeg, Róbert AU - Jakab, Ferenc TI - Nursing homes and the elderly regarding the COVID-19 pandemic: situation report from Hungary JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 42 PY - 2020 IS - 4 SP - 1093 EP - 1099 PG - 7 SN - 2509-2715 DO - 10.1007/s11357-020-00195-z UR - https://m2.mtmt.hu/api/publication/31331388 ID - 31331388 AB - The global impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is significant in terms of public health effects and its long-term socio-economic implications. Among all social groups, the elderly is by far the most affected age group regarding morbidity and mortality. In multiple countries spanning several continents, there are an increasing number of reports referencing the novel coronavirus disease-2019 (COVID-19) spread among nursing homes. These areas are now recognized as potent hotspots regarding the pandemic, which one considers with special regard. Herein, we present currently available data of fatal COVID-19 cases throughout Hungary, along with the analysis of the co-morbidity network. We also report on viral genomic data originating from a nursing home resident. The genomic data was used for viral haplotype network analysis. We emphasize the urgent need for public health authorities to focus on nursing homes and residential service units worldwide, especially in the care of the elderly and infirmed. Our results further emphasize the recent statement released by the World Health Organization (WHO) regarding the vulnerability among seniors and especially the high risk of COVID-19 emergence throughout nursing and social homes. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Péter AU - Joó, József Gábor AU - Tamás, Valentina AU - Molnár, Z. AU - Burik-Hajas, Dóra AU - Bódis, József AU - Kornya, László TI - The role of apoptosis in the complex pathogenesis of the most common obstetrics and gynaecology diseases JF - PHYSIOLOGY INTERNATIONAL J2 - PHYSIOL INT VL - 107 PY - 2020 IS - 1 SP - 106 EP - 119 PG - 14 SN - 2498-602X DO - 10.1556/2060.2020.00014 UR - https://m2.mtmt.hu/api/publication/31304588 ID - 31304588 N1 - Clinical Research Units Hungary, Miskolc, Hungary Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, Pécs, Hungary First Department of Obstetrics and Gynaecology, Semmelweis University, Budapest, Hungary Hungarian Academy of Sciences, University of Pécs (MTA-PTE), Human Reproduction Scientific Research Group, University of Pécs, Pécs, Hungary Central Hospital of Southern Pest, National Institute of Hematology and Infectious Diseases, Budapest, Hungary Cited By :3 Export Date: 16 November 2023 Correspondence Address: Joó, J.G.; Clinical Research Units, H-2132 Th€ok€oly str. 15, Hungary; email: joogabor@hotmail.com Chemicals/CAS: protein bcl 2, 219306-68-0; BAX protein, human; bcl-2-Associated X Protein; BCL2 protein, human; Proto-Oncogene Proteins c-bcl-2 LA - English DB - MTMT ER - TY - JOUR AU - Varga, Péter AU - Berecz, Botond AU - Magyar, Zsófia AU - Pete, Barbara AU - Romicsné Görbe, Éva AU - Dombi, Zsófia Anna AU - Sassi, Lilla AU - Fanczal, Eszter AU - Ács, Nándor AU - Kornya, László AU - Joó, József Gábor AU - Valek, Andrea AU - Harmath, Ágnes AU - Gasparics, Ákos TI - Survival and early complications of preterm infants with birthweight less than 500 grams during a 10‐year period in Hungary JF - PAEDIATRIC AND PERINATAL EPIDEMIOLOGY J2 - PAEDIATR PERINAT EP VL - 34 PY - 2020 IS - 5 SP - 565 EP - 571 PG - 7 SN - 0269-5022 DO - 10.1111/ppe.12598 UR - https://m2.mtmt.hu/api/publication/30910717 ID - 30910717 N1 - Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary Central Hospital of South Pest—National Institute of Hematology and Infectology, Department of Obstetrics-Gynecology and Gynecologic Oncology, Budapest, Hungary Heim Pál Children's Hospital, Budapest, Hungary Cited By :1 Export Date: 16 November 2023 CODEN: PPEPE Correspondence Address: Gasparics, Á.; Department of Obstetrics and Gynecology, Hungary; email: gasparics.akos@med.semmelweis-univ.hu Chemicals/CAS: lung surfactant, 99732-49-7; Glucocorticoids; Pulmonary Surfactants Funding text 1: We thank Zsófia Varga for her help in statistical analysis. We also thank data providers contributing to the NICU database. LA - English DB - MTMT ER - TY - PAT AU - Gödöny, Krisztina AU - Bódis, József AU - Kornya, László TI - Fénytől védett asszisztált reprodukciós laboratóriumi eljárásokhoz használatos eszközcsalád PY - 2018 UR - https://m2.mtmt.hu/api/publication/32507335 ID - 32507335 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kovács, Péter AU - Rab, Attila Zoltán AU - Szentpeteri, I AU - Joó, József Gábor AU - Kornya, László TI - A legjelentősebb angiogeneticus gének méhlepényi expressziójának változásai a méhen belüli növekedési visszamaradás hátterében JF - ORVOSI HETILAP J2 - ORV HETIL VL - 158 PY - 2017 IS - 16 SP - 612 EP - 617 PG - 6 SN - 0030-6002 DO - 10.1556/650.2017.30622 UR - https://m2.mtmt.hu/api/publication/3217276 ID - 3217276 N1 - Export Date: 9 February 2020 CODEN: ORHEA AB - Placental vascular endothelial growth factor A (VEGF-A) gene and endoglin gene are both overexpressed in placental samples obtained from pregnancies with intrauterine growth restriction compared to normal pregnancies. In the background of these changes a mechanism can be supposed, in which the increased endoglin activity in intrauterine growth restriction (IUGR) leads to impaired placental circulation through an antioangiogenetic effect. This results in the development of placental vascular dysfunction and chronic fetal hypoxia. It is chronic hypoxia that turns on VEGF-A as a compensatory mechanism to improve fetal vascular blood supply by promoting placental blood vessel formation. Although the maternal serum placental growth factor (PlGF) level is a potential predictor for both IUGR and praeeclampsia, placental PlGF gene activity may be less of an active in the regulation of placental circulation in IUGR pregnancies during the later stages of gestation. Orv. Hetil., 2017, 158(16), 612-617. LA - Hungarian DB - MTMT ER -