@article{MTMT:34745300, title = {Antibiotics and probiotics-induced effects on the total fatty acid composition of feces in a rat model}, url = {https://m2.mtmt.hu/api/publication/34745300}, author = {Marosvölgyi, Tamás and Mintál, Kitti and Borbásné Farkas, Kornélia and Sipos, Zoltán and Makszin, Lilla and Szabó, Éva and Tóth, Attila and Kocsis, Béla and Kovács, Krisztina and Hormay, Edina and Lénárd, László and Karádi, Zoltán György and Bufa, Anita}, doi = {10.1038/s41598-024-57046-6}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34745300}, issn = {2045-2322}, abstract = {Fatty acids (FAs) play important roles as membrane components and signal transduction molecules. Changes in short chain FA (SCFA) composition are associated with gut microbiota modifications. However, the effect of bacteria-driven changes on the detailed FA spectrum has not been explored yet. We investigated the effect of antibiotics (ABx) and/or probiotics, in four treatment groups on rat stool FA composition. Principal component analysis indicated that the chromatogram profiles of the treatment groups differ, which was also observed at different time points. Linear mixed effects models showed that in the parameters compared (sampling times, treatments. and their interactions), both the weight percentage and the concentration of FAs were affected by ABx and probiotic administration. This study found that the gut microbiome defines trans and branched saturated FAs, most saturated FAs, and unsaturated FAs with less carbon atoms. These results are among the first ones to demonstrate the restoring effects of a probiotic mixture on a substantial part of the altered total FA spectrum, and also revealed a previously unknown relationship between gut bacteria and a larger group of FAs. These findings suggest that intestinal bacteria produce not only SCFAs but also other FAs that may affect the host’s physiological processes.}, year = {2024}, eissn = {2045-2322}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513; Mintál, Kitti/0009-0003-4739-2902; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Sipos, Zoltán/0000-0001-7845-8116; Makszin, Lilla/0000-0002-9764-4763; Hormay, Edina/0009-0004-0598-5061} } @article{MTMT:34724787, title = {Trans isomeric fatty acids in human milk and their role in infant health and development}, url = {https://m2.mtmt.hu/api/publication/34724787}, author = {Hatem, Okba and Kaçar, Ömer Furkan and Kaçar, Hüsna Kaya and Szentpéteri, József László (Joe Petersburger) and Marosvölgyi, Tamás and Szabó, Éva}, doi = {10.3389/fnut.2024.1379772}, journal-iso = {FRONT NUTR}, journal = {FRONTIERS IN NUTRITION}, volume = {11}, unique-id = {34724787}, issn = {2296-861X}, abstract = {It is well known that long chain polyunsaturated fatty acids (LCPUFAs) play an important role in neurodevelopment in the perinatal life. The most important source of these fatty acids is the diet, however, they can also be formed in the human body from their shorter chain precursors, the essential fatty acids. Since the WHO recommends exclusive breastfeeding for the first six months after birth, the exclusive source of these fatty acids for breastfed infants is human milk, which can be influenced by the mother’s diet. Unsaturated fatty acids can have either cis or trans configuration double bond in their chain with distinct physiological effects. Cis isomeric unsaturated fatty acids have several beneficial effects, while trans isomers are mostly detrimental, because of their similar structure to saturated fatty acids. Trans fatty acids (TFAs) can be further subdivided into industrial (iTFA) and ruminant-derived trans fatty acids (rTFA). However, the physiological effects of these two TFA subgroups may differ. In adults, dietary intake of iTFA has been linked to atherosclerosis, insulin resistance, obesity, chronic inflammation, and increased development of certain cancers, among other diseases. However, iTFAs can have a negative impact on health not only in adulthood but in childhood too. Results from previous studies have shown that iTFAs have a significant negative effect on LCPUFA levels in the blood of newborns and infants. In addition, iTFAs can affect the growth and development of infants, and animal studies suggest that they might even have lasting negative effects later in life. Since the only source of TFAs in the human body is the diet, the TFA content of breast milk may determine the TFA supply of breastfed infants and thus affect the levels of LCPUFAs important for neurodevelopment and the health of infants. In this review, we aim to provide an overview of the TFA content in human milk available in the literature and their potential effects on infant health and development.}, year = {2024}, eissn = {2296-861X}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513} } @CONFERENCE{MTMT:34186807, title = {Microfluidic-based protein quantification in plant- based drinks derived from nuts}, url = {https://m2.mtmt.hu/api/publication/34186807}, author = {Balogh-Hartmann, Fruzsina and Páger, Csilla and Bufa, Anita and Madarászné Horváth, Ibolya and Marosvölgyi, Tamás and Makszin, Lilla}, booktitle = {13th Balaton Symposium on High-Performance Separation Methods Book of Abstracts}, unique-id = {34186807}, year = {2023}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513; Makszin, Lilla/0000-0002-9764-4763} } @CONFERENCE{MTMT:34186786, title = {Microfluidic analysis for determination of the protein content in legume-based plant drinks}, url = {https://m2.mtmt.hu/api/publication/34186786}, author = {Balogh-Hartmann, Fruzsina and Páger, Csilla and Bufa, Anita and Madarászné Horváth, Ibolya and Marosvölgyi, Tamás and Makszin, Lilla}, booktitle = {13th Balaton Symposium on High-Performance Separation Methods Book of Abstracts}, unique-id = {34186786}, year = {2023}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513; Makszin, Lilla/0000-0002-9764-4763} } @article{MTMT:34167332, title = {Microfluidic Analysis for the Determination of Protein Content in Different Types of Plant-Based Drinks}, url = {https://m2.mtmt.hu/api/publication/34167332}, author = {Balogh-Hartmann, Fruzsina and Páger, Csilla and Bufa, Anita and Madarászné Horváth, Ibolya and Verzár, Zsófia and Marosvölgyi, Tamás and Makszin, Lilla}, doi = {10.3390/molecules28186684}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {28}, unique-id = {34167332}, issn = {1420-3049}, abstract = {The widespread consumption of plant-based drinks, driven by health and dietary reasons (including cow's milk allergy, lactose intolerance, milk protein intolerance, following a vegetarian or vegan diet) necessitates automated and accurate test methods. Our study demonstrates the simultaneous determination of protein components and total protein concentrations in plant-based milk alternatives using a rapid and reproducible microchip gel electrophoretic method. As expected, the electrophoretic profiles of each plant-based drink differed. Based on our analyses and statistical evaluation, it can be determined that the protein profiles of different plant-based beverages do not differ significantly between different manufacturers or different expiry dates. The measured total protein content was compared with the nominal values, i.e., the values stated on the beverage labels. As the number of consumers of functional and specialized plant-based milk alternatives continues to rise, it is important to prioritize methods that provide qualitative and quantitative information on protein composition and other nutrients.}, keywords = {food allergy; Protein profile; Total protein content; Plant-based milk alternatives; microchip gel electrophoretic method}, year = {2023}, eissn = {1420-3049}, orcid-numbers = {Verzár, Zsófia/0000-0001-5323-0748; Marosvölgyi, Tamás/0000-0002-4244-5513; Makszin, Lilla/0000-0002-9764-4763} } @article{MTMT:34077794, title = {Potential sex differences in human milk fatty acids and their association with atopic dermatitis: Results of the Ulm SPATZ health study}, url = {https://m2.mtmt.hu/api/publication/34077794}, author = {Ordnung, Madeleine and Mank, Marko and Stahl, Bernd and Kurz, Deborah and Marosvölgyi, Tamás and Decsi, Tamás and Rothenbacher, Dietrich and Genuneit, Jon and Siziba, Linda P.}, doi = {10.1111/pai.13992}, journal-iso = {PEDIATR ALLERGY IMMU}, journal = {PEDIATRIC ALLERGY AND IMMUNOLOGY}, volume = {34}, unique-id = {34077794}, issn = {0905-6157}, abstract = {BackgroundPolyunsaturated fatty acids (PUFAs) in human milk are essential in immune system maturation and might play a role in the development of allergic conditions, such as atopic dermatitis (AD) in infants. Immune system responses are modulated by sex, but data on the sex-specific associations with PUFAs are limited. We therefore explored sex-specific differences in human milk PUFAs and their association with AD up to 2 years. MethodsPUFAs were measured in human milk samples from the Ulm SPATZ Health Study at 6 weeks (n = 512) and 6 months (n = 367). Associations with AD up to 2 years were evaluated using crude and multivariable logistic regression. Interactions between infant sex and PUFAs were explored by including the product term. ResultsNo significant associations were observed with 6-week data. At 6 months, the median relative proportion of docosahexaenoic acid (DHA) was significantly higher in milk for female than male infants (p = .001). Female infants whose milk was lower in quintile proportions of alpha-linolenic acid (ALA) at 6 months had lower odds of AD compared to males [first vs. fifth quintile OR (95% confidence interval): 0.13 (0.02, 0.66), p = .02]. This interaction was not significant when correcting for multiple testing (& alpha; threshold: p = .004). No other statistically significant associations were observed. ConclusionIndividual quintile PUFA proportions in human milk were not associated with AD, overall and in a sex-specific manner. More comprehensive and statistically powered longitudinal studies are needed to determine whether potential sex differences in human milk, if any, could be of clinical relevance for infants including the investigation of mediating factors.}, keywords = {immunology; Allergy; Atopic dermatitis; human milk; BREAST-MILK; UMBILICAL-CORD; infant sex}, year = {2023}, eissn = {1399-3038}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513} } @article{MTMT:33998677, title = {Docosahexaenoic Acid in Formulas for Term Infants: The Way from Pioneer Idea to Mandatory Dietary Recommendation}, url = {https://m2.mtmt.hu/api/publication/33998677}, author = {Decsi, Tamás and Marosvölgyi, Tamás and Szabó, Éva}, doi = {10.3390/life13061326}, journal-iso = {LIFE-BASEL}, journal = {LIFE-BASEL}, volume = {13}, unique-id = {33998677}, year = {2023}, eissn = {2075-1729}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513} } @article{MTMT:33832899, title = {Higher Availability of Long-Chain Monounsaturated Fatty Acids in Preterm than in Full-Term Human Milk}, url = {https://m2.mtmt.hu/api/publication/33832899}, author = {Marosvölgyi, Tamás and Dergez, Tímea and Szentpéteri, József László (Joe Petersburger) and Szabó, Éva and Decsi, Tamás}, doi = {10.3390/life13051205}, journal-iso = {LIFE-BASEL}, journal = {LIFE-BASEL}, volume = {13}, unique-id = {33832899}, abstract = {While the role of n-3 and n-6 long-chain polyunsaturated fatty acids (LCPUFAs) in the maturation of the infantile nervous system is extensively studied and relatively well-characterized, data on the potential developmental importance of the n-9 long-chain monounsaturated fatty acid (LCMUFA), nervonic acid (NA, C24:1n-9) are scarce and ambiguous. Therefore, the aim of the present study was to reanalyze our available data on the contribution of NA and its LCMUFA precursors, gondoic acid (C20:1n-9) and erucic acid (EA, C22:1n-9) to the fatty acid composition of human milk (HM) during the first month of lactation in mothers of both preterm (PT) and full-term (FT) infants. HM samples were obtained daily during the first week of lactation, and then on the 14th, 21st, and 28th days. Values of the LCMUFAs, C20:1n-9, EA, and NA were significantly higher in colostrum than in transient and mature HM. Consequently, there were highly significant inverse associations between LCMUFA values and the duration of lactation. Moreover, C20:1n-9, EA, and NA values were monotonously, considerably, and at many timepoints significantly higher in PT than in FT HM samples. By the 28th day of lactation, summarized LCMUFA values in PT HM samples declined to the level measured in FT HM samples on the first day of lactation; however, EA and NA values were still significantly higher in PT than in FT HM on the 28th day. Significantly higher availability of LCMUFAs in PT than in FT HM underpins the potential biological role of this hitherto somewhat neglected group of fatty acids.}, year = {2023}, eissn = {2075-1729}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513; Szentpéteri, József László (Joe Petersburger)/0000-0001-8685-5189} } @article{MTMT:34533833, title = {A metabolikus szindróma összefüggése a zsírban oldódó tápanyagokkal való ellátottsággal}, url = {https://m2.mtmt.hu/api/publication/34533833}, author = {Decsi, Tamás and Marosvölgyi, Tamás and Szabó, Éva}, journal-iso = {GYERMEKORVOS TOVÁBBKÉPZÉS}, journal = {GYERMEKORVOS TOVÁBBKÉPZÉS}, volume = {21}, unique-id = {34533833}, issn = {1589-0309}, year = {2022}, pages = {315-319}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513} } @CONFERENCE{MTMT:34186831, title = {Modern microfluidic analysis for determination of the protein content in different type of plant-based drinks}, url = {https://m2.mtmt.hu/api/publication/34186831}, author = {Balogh-Hartmann, Fruzsina and Madarászné Horváth, Ibolya and Marosvölgyi, Tamás and Zsófia, Verzár and Makszin, Lilla}, booktitle = {20th INTERNATIONAL SYMPOSIUM AND SUMMER SCHOOL ON BIOANALYSIS Book of Abstracts}, unique-id = {34186831}, year = {2022}, orcid-numbers = {Marosvölgyi, Tamás/0000-0002-4244-5513; Makszin, Lilla/0000-0002-9764-4763} }