@article{MTMT:34757551, title = {Optical Investigation of 2-amino-7-isocyanofluorene, a Novel Blue-Emitting Solvatochromic Dye}, url = {https://m2.mtmt.hu/api/publication/34757551}, author = {Kontra, Bence and Mucsi, Zoltán and Vanyorek, László and Nagy, Miklós}, doi = {10.3390/colorants3020006}, journal-iso = {Colorants}, journal = {COLORANTS}, volume = {3}, unique-id = {34757551}, abstract = {Smart solvatochromic isocyano-aminoarenes (ICAArs) have been gaining attention owing to their unique photophysical, antifungal and anticancer properties. Using a simple dehydration reaction with in situ-generated dichlorocarbene, we prepared 2-amino-7-isocyanofluorene (2,7-ICAF). We studied the effect of the longer polarization axis provided by the fluorene core on the spectral properties and we also compared it to those of the starting diamine. 2,7-ICAF shows a clear solvatochromic behavior close to the blue part (370–420 nm) of the visible spectrum. Quantum chemical calculations show internal charge transfer (ICT) between the donor amino and the electron-withdrawing isocyano groups. 2,7-ICAF has high molar absorptivity (ε = 15–18·103 M−1cm−1) and excellent quantum yield (Φf = 70–95%) in most solvents; however, its fluorescence is completely quenched in water. The high brightness (ε·Φf) and close to zero quantum yield in water may be favorable in biolabeling applications, where background fluorescence should be kept minimal. Overall, 2,7-ICAF shows enhanced photophysical properties compared to its previously investigated relative 4-amino-4′-isocyano-1,1′-biphenyl (4,4′-ICAB).}, year = {2024}, eissn = {2079-6447}, pages = {86-98}, orcid-numbers = {Kontra, Bence/0000-0001-8293-3637; Mucsi, Zoltán/0000-0003-3224-8847; Nagy, Miklós/0000-0002-3484-2244} } @article{MTMT:34748236, title = {A Molecular Hybrid of the GFP Chromophore and 2,2′-Bipyridine: An Accessible Sensor for Zn2+ Detection with Fluorescence Microscopy}, url = {https://m2.mtmt.hu/api/publication/34748236}, author = {Csomos, Attila and Madarász, Miklós and Turczel, Gábor and Cseri, Levente and Katona, Gergely and Rózsa J., Balázs and Kovács, Ervin and Mucsi, Zoltán}, doi = {10.3390/ijms25063504}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {25}, unique-id = {34748236}, issn = {1661-6596}, abstract = {The few commercially available chemosensors and published probes for in vitro Zn2+ detection in two-photon microscopy are compromised by their flawed spectroscopic properties, causing issues in selectivity or challenging multistep syntheses. Herein, we present the development of an effective small molecular GFP chromophore-based fluorescent chemosensor with a 2,2′-bipyridine chelator moiety (GFZnP BIPY) for Zn2+ detection that has straightforward synthesis and uncompromised properties. Detailed experimental characterizations of the free and the zinc-bound compounds within the physiologically relevant pH range are presented. Excellent photophysical characteristics are reported, including a 53-fold fluorescence enhancement with excitation and emission maxima at 422 nm and 492 nm, respectively. A high two-photon cross section of 3.0 GM at 840 nm as well as excellent metal ion selectivity are reported. In vitro experiments on HEK 293 cell culture were carried out using two-photon microscopy to demonstrate the applicability of the novel sensor for zinc bioimaging.}, year = {2024}, eissn = {1422-0067}, orcid-numbers = {Madarász, Miklós/0000-0001-7057-303X; Katona, Gergely/0000-0002-4173-0355; Kovács, Ervin/0000-0002-3939-6925; Mucsi, Zoltán/0000-0003-3224-8847} } @article{MTMT:34724516, title = {A GFP inspired 8-methoxyquinoline-derived fluorescent molecular sensor for the detection of Zn2+ by two-photon microscopy}, url = {https://m2.mtmt.hu/api/publication/34724516}, author = {Csomos, Attila and Madarász, Miklós and Turczel, Gábor and Cseri, Levente and Bodor, Andrea and Anett, Matuscsák and Katona, Gergely and Kovács, Ervin and Rózsa J., Balázs and Mucsi, Zoltán}, doi = {10.1002/chem.202400009}, journal-iso = {CHEM-EUR J}, journal = {CHEMISTRY-A EUROPEAN JOURNAL}, unique-id = {34724516}, issn = {0947-6539}, abstract = {An effective, GFP-inspired fluorescent Zn2+ sensor is developed for two-photon microscopy and related biological application that featured an 8-methoxyquinoline moiety. Excellent photophysical characteristics including a 37-fold fluorescence enhancement with excitation and emission maxima at 440 nm and 505 nm, respectively, as well as a high two-photon cross-section of 73 GM at 880 nm are reported. Based on the experimental data, the relationship between the structure and properties was elucidated and explained backed up by DFT calculations, particularly to the observed PeT phenomenon for the turn-on process. Biological validation and detailed experimental and theoretical characterization of the free and the zinc-bound compounds are presented.}, year = {2024}, eissn = {1521-3765}, orcid-numbers = {Madarász, Miklós/0000-0001-7057-303X; Bodor, Andrea/0000-0002-7422-298X; Katona, Gergely/0000-0002-4173-0355; Kovács, Ervin/0000-0002-3939-6925; Mucsi, Zoltán/0000-0003-3224-8847} } @{MTMT:34561430, title = {Glikomikai alkalmazásra fejlesztett permanens töltéssel rendelkező fluoreszcens jelölővegyületek}, url = {https://m2.mtmt.hu/api/publication/34561430}, author = {Csomos, Attila and Kovács, Ervin and Barkai, Gyöngy and Váradi, Csaba and Mucsi, Zoltán and Viskolcz, Béla and Rózsa J., Balázs and Cseri, Levente and Dojcsák, Dalma}, unique-id = {34561430}, abstract = {A bejelentés új, glikoproteinek elemzésére alkalmazható új jelölővegyületekre és kimutatási eljárásokra vonatkozik. Az új vegyületek N-hidroxi-szukcinimidil-karbamáttal származékolt xanténvázas rodamin- vagy pironin-származékok, amelyek N-glikánok folyadék-kromatográfiás elválasztást követő fluoreszcens és tömegspektrometriás detektálására használhatók fel.}, year = {2024}, orcid-numbers = {Kovács, Ervin/0000-0002-3939-6925; Váradi, Csaba/0000-0002-2672-095X; Mucsi, Zoltán/0000-0003-3224-8847} } @{MTMT:34561278, title = {Piránvázas fluoreszcens jelzővegyületek DNS kimutatására}, url = {https://m2.mtmt.hu/api/publication/34561278}, author = {Domahidy, Farkas László and Kovács, Ervin and Mucsi, Zoltán and Cseri, Levente and Rózsa J., Balázs}, unique-id = {34561278}, abstract = {Találmányunk tárgyát képezik új piránvázas fluoreszcens jelzővegyületek, amely töltéssel rendelkező pirángyűrűn 2 és 6 helyzetben kapcsolódó fenil csoportokhoz amino csoportok kapcsolódnak, amelyek nitrogénjei olyan 2-3 szénatomos lánccal vannak szubsztituálva, amelyek szekunder vagy tercier aminocsoportot tartalmaznak. Ezen szekunder amino csoportok hatására a találmányunk szerinti színezék a korábban ismertnél előnyösebb, jobb vízoldhatóságú, a DNS-hez jól kötődő és DNS jelenlétében meglepően jobb fluoreszcencia-kvantumhatásfokú színezékek.}, year = {2024}, orcid-numbers = {Kovács, Ervin/0000-0002-3939-6925; Mucsi, Zoltán/0000-0003-3224-8847} } @article{MTMT:34191513, title = {Two-Photon Fluorescent Chemosensors Based on the GFP-Chromophore for the Detection of Zn2+ in Biological Samples – From Design to Application}, url = {https://m2.mtmt.hu/api/publication/34191513}, author = {Csomos, Attila and Kovács, Ervin and Madarász, Miklós and Fedor, Flóra Zsófia and Fülöp, Anna and Katona, Gergely and Rózsa J., Balázs and Mucsi, Zoltán}, doi = {10.1016/j.snb.2023.134753}, journal-iso = {SENSOR ACTUAT B CHEM}, journal = {SENSORS AND ACTUATORS B-CHEMICAL}, volume = {398}, unique-id = {34191513}, issn = {0925-4005}, keywords = {FLUORESCENCE; chemosensor; two-photon; Zinc); GFP-chromophore}, year = {2024}, eissn = {0925-4005}, orcid-numbers = {Kovács, Ervin/0000-0002-3939-6925; Madarász, Miklós/0000-0001-7057-303X; Fedor, Flóra Zsófia/0000-0003-4085-1419; Katona, Gergely/0000-0002-4173-0355; Mucsi, Zoltán/0000-0003-3224-8847} } @inproceedings{MTMT:34753229, title = {Imaging of dendrites and sparse interneuronal networks with 3D random access microscopy}, url = {https://m2.mtmt.hu/api/publication/34753229}, author = {Rózsa J., Balázs and Szadai, Zoltán and Judák, Linda and Chiovini, Balázs and Juhász, Gábor and Ócsai, Katalin and Pálfi, Dénes and Mezriczky, Zsolt and Szalay, Gergely and Katona, Gergely and Mihály, Anna and Szepesi, Áron and Mucsi, Zoltán and Roska, Botond and Pi, Hyun-Jae and Chevy, Quentin and Albeanu, Florin and Kepecs, Adam}, booktitle = {Optics and the Brain part of Optica Biophotonics Congress: Optics in the Life Sciences, 2023}, doi = {10.1364/BRAIN.2023.BW3B.6}, unique-id = {34753229}, abstract = {Acousto-optical microscopy is a powerful tool to study spare networks and extensive dendritic arborization from the cortex of behaving animals. We used this novel approach for imaging dendrites and somata of sparse interneuron populations in a combination with auditory discrimination and detection tasks. Our results shed light of not yet known subcellular and network mechanisms from multiple brain regions.}, year = {2023}, pages = {2023}, orcid-numbers = {Katona, Gergely/0000-0002-4173-0355; Mucsi, Zoltán/0000-0003-3224-8847} } @{MTMT:34511143, title = {Eljárás higany hatékony eltávolítására vízből aromás izocianidok felhasználásával redukálószerként}, url = {https://m2.mtmt.hu/api/publication/34511143}, author = {Nagy, Miklós and Vanyorek, László and Braun, Mihály and Sóvágó, Dávid and Mucsi, Zoltán and Viskolcz, Béla and Czébely, Andrea}, unique-id = {34511143}, year = {2023}, orcid-numbers = {Nagy, Miklós/0000-0002-3484-2244; Mucsi, Zoltán/0000-0003-3224-8847; Czébely, Andrea/0000-0002-6439-2977} } @article{MTMT:34509253, title = {Excited state iminium form can explain the unexpected solvatochromic behavior of symmetric 1,5- and 1,8-diaminonaphthalenes}, url = {https://m2.mtmt.hu/api/publication/34509253}, author = {Kopcsik, Erika and Mucsi, Zoltán and Kontra, Bence and Vanyorek, László and Gál, R. and Viskolcz, Béla and Nagy, Miklós}, doi = {10.1039/d3cc05643k}, journal-iso = {CHEM COMMUN}, journal = {CHEMICAL COMMUNICATIONS}, volume = {60}, unique-id = {34509253}, issn = {1359-7345}, year = {2023}, eissn = {1364-548X}, pages = {1008-1011}, orcid-numbers = {Mucsi, Zoltán/0000-0003-3224-8847; Kontra, Bence/0000-0001-8293-3637; Nagy, Miklós/0000-0002-3484-2244} } @article{MTMT:34442783, title = {Az 1,5-diizocianonaftalin optikai tulajdonságainak vizsgálata}, url = {https://m2.mtmt.hu/api/publication/34442783}, author = {Kopcsik, Erika and Mucsi, Zoltán and Nagy, Miklós}, journal-iso = {Doktorandusz Almanach}, journal = {Doktorandusz Almanach}, volume = {1}, unique-id = {34442783}, issn = {2939-7294}, year = {2023}, pages = {117-122}, orcid-numbers = {Mucsi, Zoltán/0000-0003-3224-8847; Nagy, Miklós/0000-0002-3484-2244} }