@article{MTMT:3193785,
	title = {Multivalent foldamer-based affinity assay for selective recognition of Aβ oligomers},
	url = {https://m2.mtmt.hu/api/publication/3193785},
	author = {Olajos, Gábor and Bartus, Éva and Schuster, Ildikó and Lautner, Gergely and Gyurcsányi, Ervin Róbert and Szögi, Titanilla and Fülöp, Lívia and Martinek, Tamás},
	doi = {10.1016/j.aca.2017.01.013},
	journal-iso = {ANAL CHIM ACTA},
	journal = {ANALYTICA CHIMICA ACTA},
	volume = {960},
	unique-id = {3193785},
	issn = {0003-2670},
	abstract = {Abstract Mimicking the molecular recognition functionality of antibodies is a great challenge. Foldamers are attractive candidates because of their relatively small size and designable interaction surface. This paper describes a sandwich type enzyme-linked immunoassay with a tetravalent β-peptide foldamer helix array as capture element and enzyme labeled tracer antibodies. The assay was found to be selective to β-amyloid oligomeric species with surface features transiently present in ongoing aggregation. In optimized conditions, with special emphasis on the foldamer immobilization, a detection limit of 5 pM was achieved with a linear range of 10–500 pM. These results suggest that protein mimetic foldamers can be useful tools in biosensors and affinity assays.},
	keywords = {FOLDAMERS; MOLECULAR RECOGNITION; Antibody mimetics; Bioaffinity assay; β-Amyloid oligomers},
	year = {2017},
	eissn = {1873-4324},
	pages = {131-137},
	orcid-numbers = {Olajos, Gábor/0000-0002-2479-4891; Bartus, Éva/0000-0001-9976-6978; Schuster, Ildikó/0000-0001-9997-5729; Gyurcsányi, Ervin Róbert/0000-0002-9929-7865; Szögi, Titanilla/0000-0002-9854-7340; Fülöp, Lívia/0000-0002-8010-0129; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:3113127,
	title = {Nanoparticle displacement assay with electrochemical nanopore-based sensors},
	url = {https://m2.mtmt.hu/api/publication/3113127},
	author = {Lautner, Gergely and Plesz, M and Jágerszki, Gyula and Fürjes, Péter and Gyurcsányi, Ervin Róbert},
	doi = {10.1016/j.elecom.2016.07.012},
	journal-iso = {ELECTROCHEM COMMUN},
	journal = {ELECTROCHEMISTRY COMMUNICATIONS},
	volume = {71},
	unique-id = {3113127},
	issn = {1388-2481},
	abstract = {The proof of concept of a nanoparticle displacement assay that enables the use of large diameter nanopores for the detection of targets of smaller molecular dimensions is presented. We hypothesized that an inherent signal amplification should arise from the selective displacement of nanoparticles preloaded in a nanopore by a much smaller molecular target. The method is demonstrated using peptide nucleic acid (PNA)-functionalized gold nanopore arrays in which short DNA-modified gold nanoparticles are anchored by weak interaction. Complementary microRNAs are detected via the resistance change caused by competitive displacement of nanoparticles from the PNA-functionalized nanopores. © 2016 Elsevier B.V.},
	keywords = {RNA; Nucleic Acids; NANOPARTICLES; nanoparticle; microRNA; GOLD; MICRORNAS; GOLD NANOPARTICLES; Nanopores; PNA; peptide nucleic acid; Displacement assay; SOLID-STATE NANOPORE; Signal amplifications; NASBA; Molecular dimensions; Solid state nanopore},
	year = {2016},
	eissn = {1873-1902},
	pages = {13-17},
	orcid-numbers = {Fürjes, Péter/0000-0002-8022-4367; Gyurcsányi, Ervin Róbert/0000-0002-9929-7865}
}

@article{MTMT:3028280,
	title = {Biodegradable poly(lactic-co-glycolic acid) microspheres loaded with S-nitroso-N-acetyl-D-penicillamine for controlled nitric oxide delivery},
	url = {https://m2.mtmt.hu/api/publication/3028280},
	author = {Lautner, Gergely and Meyerhoff, Mark E and Schwendeman, Steven P},
	doi = {10.1016/j.jconrel.2015.12.056},
	journal-iso = {J CONTROL RELEASE},
	journal = {JOURNAL OF CONTROLLED RELEASE},
	volume = {225},
	unique-id = {3028280},
	issn = {0168-3659},
	abstract = {Abstract Nitric oxide (NO) is a fascinating and important endogenous free-radical gas with potent antimicrobial, vasodilating, smooth muscle relaxant, and growth factor stimulating effects. However, its wider biomedical applicability is hindered by its cumbersome administration, since NO is unstable especially in biological environments. In this work, to ultimately develop site-specific controlled release vehicles for NO, the NO donor S-nitroso-N-acetyl-D-penicillamine (SNAP) was encapsulated within poly(lactic-co-glycolic acid) 50:50 (PLGA) microspheres by using a solid-in-oil-in-water emulsion solvent evaporation method. The highest payload was 0.56(± 0.01) μmol SNAP/mg microspheres. The in vitro release kinetics of the donor were controlled by the bioerosion of the PLGA microspheres. By using an uncapped PLGA (Mw = 24,000–38,000) SNAP was slowly released for over 10 days, whereas by using the ester capped PLGA (Mw = 38,000–54,000) the release lasted for over 4 weeks. The presence of copper ions and/or ascorbate in solution was necessary to efficiently decompose the released NO donor and obtain sustained NO release. It was also demonstrated that light can be used to induce rapid NO release from the microspheres over several hours. SNAP exhibited excellent storage stability when encapsulated in the PLGA microspheres. These new microsphere formulations may be useful for site-specific administration and treatment of pathologies associated with dysfunction in endogenous NO production, e.g. treatment of diabetic wounds, or in diseases involving other biological functions of NO including vasodilation, antimicrobial, anticancer, and neurotransmission.},
	keywords = {controlled release; nitric oxide; Biodegradable polymers; Poly(lactic-co-glycolic acid); Snitroso-N-acetyl-D-penicillamine},
	year = {2016},
	eissn = {1873-4995},
	pages = {133-139}
}

@article{MTMT:2926219,
	title = {Reliable microspotting methodology for peptide-nucleic acid layers with high hybridization efficiency on gold SPR imaging chips},
	url = {https://m2.mtmt.hu/api/publication/2926219},
	author = {Simon, László Ferenc and Lautner, Gergely and Gyurcsányi, Ervin Róbert},
	doi = {10.1039/c5ay01239b},
	journal-iso = {ANAL METHOD},
	journal = {ANALYTICAL METHODS: ADVANCING METHODS AND APPLICATIONS},
	volume = {7},
	unique-id = {2926219},
	issn = {1759-9660},
	abstract = {One-step direct immobilization of peptide-nucleic acid (PNA) probes onto gold surfaces through Au-S chemistry is critical in terms of generating self-assembled monolayers with high hybridization efficiency. We found that this problem is more severe if the immobilization is performed by contact microspotting to generate PNA arrays. Therefore, here we propose a novel microspotting-based immobilization method to generate PNA arrays with high hybridization efficiency on bare gold surface plasmon resonance imaging (SPRi) chips. The essence of the approach is to spot thiol labelled PNA strands prehybridized with a short complementary DNA strand instead of conventionally used single stranded PNA (ssPNA) probes. After immobilization the complementary DNA strands could be easily removed to activate the surface confined PNA probes. The incubation time and the type of spotting needle also have a marked influence on the hybridization efficiency of the PNA layers. However, we show that if all other conditions remain the same, PNA layers from prehybridized PNA probes exhibit superior hybridization efficiency than those from ssPNA probes. This journal is © The Royal Society of Chemistry 2015.},
	keywords = {PEPTIDES; EFFICIENCY; Nucleic Acids; surface plasmon resonance; PROBES; GOLD; incubation time; Gold surfaces; peptide nucleic acid; Self assembled monolayers; DNA strands; Gold metallurgy; SPR imaging; Microspotting; Immobilization method; Hybridization efficiency},
	year = {2015},
	eissn = {1759-9679},
	pages = {6077-6082},
	orcid-numbers = {Gyurcsányi, Ervin Róbert/0000-0002-9929-7865}
}

@article{MTMT:2906358,
	title = {Microelectrospotting as a new method for electrosynthesis of surface-imprinted polymer microarrays for protein recognition},
	url = {https://m2.mtmt.hu/api/publication/2906358},
	author = {Bosserdt, M and Bognár, Júlia and Lautner, Gergely and Witt, J and Köhler, K and Gajovich-Eichelmann, N and Yarman, A and Wittstock, G and Scheller, FW and Gyurcsányi, Ervin Róbert},
	doi = {10.1016/j.bios.2015.05.049},
	journal-iso = {BIOSENS BIOELECTRON},
	journal = {BIOSENSORS & BIOELECTRONICS},
	volume = {73},
	unique-id = {2906358},
	issn = {0956-5663},
	keywords = {FERRITIN; molecularly imprinted polymers; electropolymerization; scopoletin; surface imprinting; Electrospotting},
	year = {2015},
	eissn = {1873-4235},
	pages = {123-129},
	orcid-numbers = {Gyurcsányi, Ervin Róbert/0000-0002-9929-7865}
}

@article{MTMT:2790830,
	title = {Szelektív szintetikus receptorok fejlesztése és alkalmazása fehérjék meghatározására},
	url = {https://m2.mtmt.hu/api/publication/2790830},
	author = {Lautner, Gergely and Gyurcsányi, Ervin Róbert},
	journal-iso = {MAGY KÉM FOLY KÉM KÖZL},
	journal = {MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-)},
	volume = {120},
	unique-id = {2790830},
	issn = {1418-9933},
	year = {2014},
	eissn = {1418-8600},
	pages = {32-37},
	orcid-numbers = {Gyurcsányi, Ervin Róbert/0000-0002-9929-7865}
}

@article{MTMT:2706894,
	title = {Electrochemical Detection of miRNAs},
	url = {https://m2.mtmt.hu/api/publication/2706894},
	author = {Lautner, Gergely and Gyurcsányi, Ervin Róbert},
	doi = {10.1002/elan.201400055},
	journal-iso = {ELECTROANAL},
	journal = {ELECTROANALYSIS},
	volume = {26},
	unique-id = {2706894},
	issn = {1040-0397},
	year = {2014},
	eissn = {1521-4109},
	pages = {1224-1235},
	orcid-numbers = {Gyurcsányi, Ervin Róbert/0000-0002-9929-7865}
}

@article{MTMT:2590382,
	title = {A rational approach for generating cardiac troponin I selective Spiegelmers},
	url = {https://m2.mtmt.hu/api/publication/2590382},
	author = {Szeitner, Zsuzsanna and Lautner, Gergely and Nagy, Szilvia Krisztina and Gyurcsányi, Ervin Róbert and Mészáros, Tamás},
	doi = {10.1039/C4CC00447G},
	journal-iso = {CHEM COMMUN},
	journal = {CHEMICAL COMMUNICATIONS},
	volume = {50},
	unique-id = {2590382},
	issn = {1359-7345},
	abstract = {We report the first protein selective Spiegelmers of diagnostic relevance by rational identification of a target epitope and reverse screening of Spiegelmer candidates following the selection procedure. Application of the presented approach resulted in isolation of cardiac troponin I selective Spiegelmers with low nanomolar dissociation constant and functionality in serum.},
	year = {2014},
	eissn = {1364-548X},
	pages = {6801-6804},
	orcid-numbers = {Szeitner, Zsuzsanna/0000-0001-8862-4915; Nagy, Szilvia Krisztina/0000-0002-5505-1329; Gyurcsányi, Ervin Róbert/0000-0002-9929-7865; Mészáros, Tamás/0000-0002-7396-9678}
}

@mastersthesis{MTMT:2944046,
	title = {Szelektiv szintetikus receptorok fejlesztése és alkalmazása fehérjék meghatározására},
	url = {https://m2.mtmt.hu/api/publication/2944046},
	author = {Lautner, Gergely},
	publisher = {Budapest University of Technology and Economics},
	unique-id = {2944046},
	year = {2013}
}

@article{MTMT:2039581,
	title = {Homogeneous assay for evaluation of aptamer-protein interaction},
	url = {https://m2.mtmt.hu/api/publication/2039581},
	author = {Lautner, Gergely and Balogh, Zsófia and Gyurkovics, A and Gyurcsányi, Ervin Róbert and Mészáros, Tamás},
	doi = {10.1039/c2an35419e},
	journal-iso = {ANALYST},
	journal = {ANALYST},
	volume = {137},
	unique-id = {2039581},
	issn = {0003-2654},
	abstract = {We introduce Amplified Luminescent Proximity Homogenous Assay (ALPHA) to assess the K D value of aptamer-protein complexes as demonstrated through the study of apple stem pitting virus coat protein-specific aptamers. This method can be used as a simple, cost-effective method for screening aptamer-target protein interactions during aptamer selection. © 2012 The Royal Society of Chemistry.},
	keywords = {GENERATION; IMMUNOASSAY; Fluorescence anisotropy; ALPHASCREEN},
	year = {2012},
	eissn = {1364-5528},
	pages = {3929-3931},
	orcid-numbers = {Gyurcsányi, Ervin Róbert/0000-0002-9929-7865; Mészáros, Tamás/0000-0002-7396-9678}
}