@article{MTMT:32068433,
	title = {AIM2-driven inflammasome activation in heart failure},
	url = {https://m2.mtmt.hu/api/publication/32068433},
	author = {Onódi, Zsófia and Ruppert, Mihály and Kucsera, Dániel and Sayour, Alex Ali and Tóth, Viktória and Koncsos, Gábor and Novák, Julianna and Brenner, Gábor and Makkos, András and Baranyai, Tamás and Giricz, Zoltán and Görbe, Anikó and Leszek, Przemyslaw and Gyöngyösi, Mariann and Horváth, Iván and Schulz, Rainer and Merkely, Béla Péter and Ferdinandy, Péter and Radovits, Tamás and Varga, Zoltán},
	doi = {10.1093/cvr/cvab202},
	journal-iso = {CARDIOVASC RES},
	journal = {CARDIOVASCULAR RESEARCH},
	volume = {117},
	unique-id = {32068433},
	issn = {0008-6363},
	year = {2021},
	eissn = {1755-3245},
	pages = {2639-2651},
	orcid-numbers = {Onódi, Zsófia/0000-0002-3746-8016; Kucsera, Dániel/0000-0001-9446-847X; Sayour, Alex Ali/0000-0001-7728-4775; Tóth, Viktória/0000-0002-0426-2425; Koncsos, Gábor/0000-0001-5451-8719; Brenner, Gábor/0000-0001-7886-2960; Makkos, András/0000-0002-0309-4909; Baranyai, Tamás/0000-0002-9378-8938; Giricz, Zoltán/0000-0003-2036-8665; Görbe, Anikó/0000-0003-4908-1094; Merkely, Béla Péter/0000-0001-6514-0723; Ferdinandy, Péter/0000-0002-6424-6806; Varga, Zoltán/0000-0002-2758-0784}
}

@article{MTMT:31264379,
	title = {Cardiac miRNA Expression and their mRNA Targets in a Rat Model of Prediabetes},
	url = {https://m2.mtmt.hu/api/publication/31264379},
	author = {Sághy, Éva and Vörös, Imre and Ágg, Bence and Kiss, Bernadett and Koncsos, Gábor and Varga, Zoltán and Görbe, Anikó and Giricz, Zoltán and Schulz, Rainer and Ferdinandy, Péter},
	doi = {10.3390/ijms21062128},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {21},
	unique-id = {31264379},
	issn = {1661-6596},
	year = {2020},
	eissn = {1422-0067},
	orcid-numbers = {Sághy, Éva/0000-0002-4031-3461; Vörös, Imre/0000-0001-5922-6109; Ágg, Bence/0000-0002-6492-0426; Kiss, Bernadett/0000-0001-7631-4418; Koncsos, Gábor/0000-0001-5451-8719; Varga, Zoltán/0000-0002-2758-0784; Görbe, Anikó/0000-0003-4908-1094; Giricz, Zoltán/0000-0003-2036-8665; Ferdinandy, Péter/0000-0002-6424-6806}
}

@misc{MTMT:31278823,
	title = {Sex differences in morphological and functional characterization of athlete’s heart in a rat model},
	url = {https://m2.mtmt.hu/api/publication/31278823},
	author = {Kellermayer, Dalma Lucia and Oláh, Attila and Mátyás, Csaba and Ruppert, Mihály and Barta, Bálint András and Sayour, Alex Ali and Török, M and Koncsos, Gábor and Giricz, Zoltán and Ferdinandy, Péter and Merkely, Béla Péter and Radovits, Tamás},
	unique-id = {31278823},
	year = {2019},
	orcid-numbers = {Kellermayer, Dalma Lucia/0000-0003-0398-0801; Mátyás, Csaba/0000-0001-6095-7611; Sayour, Alex Ali/0000-0001-7728-4775; Koncsos, Gábor/0000-0001-5451-8719; Giricz, Zoltán/0000-0003-2036-8665; Ferdinandy, Péter/0000-0002-6424-6806; Merkely, Béla Péter/0000-0001-6514-0723}
}

@article{MTMT:30789521,
	title = {Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats},
	url = {https://m2.mtmt.hu/api/publication/30789521},
	author = {Bukosza, Éva Nóra and Kaucsár, Tamás and Godó, Mária and Lajtár, Enikő and Tod, Pál and Koncsos, Gábor and Varga, Zoltán and Baranyai, Tamás and Nguyen, Minh Tu and Schachner, Helga and Sőti, Csaba and Ferdinandy, Péter and Giricz, Zoltán and Szénási, Gábor and Hamar, Péter},
	doi = {10.3390/ijms20174266},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {20},
	unique-id = {30789521},
	issn = {1661-6596},
	abstract = {Feeding rats with high-fat diet (HFD) with a single streptozotocin (STZ) injection induced obesity, slightly elevated fasting blood glucose and impaired glucose and insulin tolerance, and caused cardiac hypertrophy and mild diastolic dysfunction as published before by Koncsos et al. in 2016. Here we aimed to explore the renal consequences in the same groups of rats. Male Long-Evans rats were fed normal chow (CON; n = 9) or HFD containing 40% lard and were administered STZ at 20 mg/kg (i.p.) at week four (prediabetic rats, PRED, n = 9). At week 21 blood and urine samples were taken and kidney and liver samples were collected for histology, immunohistochemistry and for analysis of gene expression. HFD and STZ increased body weight and visceral adiposity and plasma leptin concentration. Despite hyperleptinemia, plasma C-reactive protein concentration decreased in PRED rats. Immunohistochemistry revealed elevated collagen IV protein expression in the glomeruli, and Lcn2 mRNA expression increased, while Il-1β mRNA expression decreased in both the renal cortex and medulla in PRED vs. CON rats. Kidney histology, urinary protein excretion, plasma creatinine, glomerular Feret diameter, desmin protein expression, and cortical and medullary mRNA expression of TGF-β1, Nrf2, and PPARγ were similar in CON and PRED rats. Reduced AMPKα phosphorylation of the autophagy regulator Akt was the first sign of liver damage, while plasma lipid and liver enzyme concentrations were similar. In conclusion, glomerular collagen deposition and increased lipocalin-2 expression were the early signs of kidney injury, while most biomarkers of inflammation, oxidative stress and fibrosis were negative in the kidneys of obese, prediabetic rats with mild heart and liver injury.},
	keywords = {Inflammation; OBESITY; Collagen Type IV; Lipocalin-2; Renal Injury},
	year = {2019},
	eissn = {1422-0067},
	orcid-numbers = {Kaucsár, Tamás/0000-0003-4460-1265; Tod, Pál/0000-0001-9163-7071; Koncsos, Gábor/0000-0001-5451-8719; Varga, Zoltán/0000-0002-2758-0784; Baranyai, Tamás/0000-0002-9378-8938; Nguyen, Minh Tu/0000-0003-1653-8377; Sőti, Csaba/0000-0002-4057-7678; Ferdinandy, Péter/0000-0002-6424-6806; Giricz, Zoltán/0000-0003-2036-8665; Szénási, Gábor/0000-0002-7350-6091; Hamar, Péter/0000-0002-1095-3564}
}

@mastersthesis{MTMT:30765040,
	title = {Cardiac consequences of metabolic derangements: role of mitochondrial oxidative stress and autophagy},
	url = {https://m2.mtmt.hu/api/publication/30765040},
	author = {Koncsos, Gábor},
	doi = {10.14753/SE.2019.2200},
	unique-id = {30765040},
	year = {2019},
	orcid-numbers = {Koncsos, Gábor/0000-0001-5451-8719}
}

@article{MTMT:30746785,
	title = {Sex Differences in Morphological and Functional Aspects of Exercise-Induced Cardiac Hypertrophy in a Rat Model},
	url = {https://m2.mtmt.hu/api/publication/30746785},
	author = {Oláh, Attila and Mátyás, Csaba and Kellermayer, Dalma Lucia and Ruppert, Mihály and Barta, Bálint András and Sayour, Alex Ali and Török, Marianna and Koncsos, Gábor and Giricz, Zoltán and Ferdinandy, Péter and Merkely, Béla Péter and Radovits, Tamás},
	doi = {10.3389/fphys.2019.00889},
	journal-iso = {FRONT PHYSIOL},
	journal = {FRONTIERS IN PHYSIOLOGY},
	volume = {10},
	unique-id = {30746785},
	abstract = {Background: Recent evidences suggest that sex hormones may be involved in the regulation of exercise-induced left ventricular (LV) hypertrophy. However, the sex-specific functional consequences of exercise-induced myocardial hypertrophy is still not investigated in detail. We aimed at understanding the sex-specific functional and morphological alterations in the LV and the underlying molecular changes in a rat model of athlete's heart.Methods: We divided our young, adult male and female rats into control and exercised groups. Athlete's heart was induced by a 12-week long swim training. Following the training period, we assessed LV hypertrophy with echocardiography, while pressure-volume analysis was performed to investigate in vivo LV function. After in vivo experiments, molecular biological studies and histological investigations were performed.Results: Echocardiography and post-mortem measured heart weight data indicated LV hypertrophy in both genders, nevertheless it was more pronounced in females. Despite the more significant relative hypertrophy in females, characteristic functional parameters did not show notable differences between the genders. LV pressure-volume analysis showed increased stroke volume, improved contractility and stroke work and unaltered LV stiffness in both male and female exercised rats, while active relaxation was ameliorated solely in male animals. The induction of Akt signaling was more significant in females compared to males. There was also a characteristic difference in the mitogen-activated protein kinase pathway as suppressed phosphorylation of p44/42 MAPK (Erk) and mTOR was observed in female exercised rats, but not in male ones. Myosin heavy chain alpha (MHC)/beta-MHC ratio did not differ in males, but increased markedly in females.Conclusion: Our results confirm that there is a more pronounced exercise-induced LV hypertrophy in females as compared to the males, however, there are only minor differences regarding LV function. There are characteristic molecular differences between male and female animals, that can explain different degrees of LV hypertrophy.},
	keywords = {athlete's heart; sex differences; Left ventricular function; pressure-volume analysis; exercise-induced hypertrophy},
	year = {2019},
	eissn = {1664-042X},
	orcid-numbers = {Mátyás, Csaba/0000-0001-6095-7611; Kellermayer, Dalma Lucia/0000-0003-0398-0801; Sayour, Alex Ali/0000-0001-7728-4775; Török, Marianna/0000-0002-2832-0626; Koncsos, Gábor/0000-0001-5451-8719; Giricz, Zoltán/0000-0003-2036-8665; Ferdinandy, Péter/0000-0002-6424-6806; Merkely, Béla Péter/0000-0001-6514-0723}
}

@article{MTMT:30724853,
	title = {THE KIDNEY IS RELATIVELY RESISTANT TO OBESITY-RELATED COMORBIDITY IN PREDIABETIC LONG EVANS RATS FED A HIGH FAT DIET},
	url = {https://m2.mtmt.hu/api/publication/30724853},
	author = {Bukosza, Éva Nóra and Kaucsár, Tamás and Godó, Mária and Lajtár, Enikő and Tod, Pál and Koncsos, Gábor and Varga, Zoltán and Nguyen, Minhtu and Schachner, Helga and Sőti, Csaba and Giricz, Zoltán and Szénási, Gábor and Hamar, Péter},
	doi = {10.1093/ndt/gfz106.FP059},
	journal-iso = {NEPHROL DIAL TRANSPL},
	journal = {NEPHROLOGY DIALYSIS TRANSPLANTATION},
	volume = {34},
	unique-id = {30724853},
	issn = {0931-0509},
	abstract = {INTRODUCTION: We have shown previously that rats fed high fat diet with a single STZ injection developed obesity, prediabetes, cardiac hypertrophy, diastolic dysfunction and mild liver damage (Koncsos et al., 2016, Am J Physiol Heart Circ Physiol 311(4):H927-H943). The current study aimed to explore the renal consequences in the same groups of rats.METHODS: Male Long-Evans rats were fed normal chow (control; CON; n=9) or high-fat diet containing 40% lard and were administered streptozotocin (20 mg/kg, i.p.) at week four (prediabetic rats; PRED, n=9). At week 21 cardiac function was examined and blood and urine samples were collected for measuring urinary protein concentration, and serum urea, creatinine and leptin concentrations. Kidney samples were collected for histology, immunohistochemistry and mRNA expression.},
	year = {2019},
	eissn = {1460-2385},
	orcid-numbers = {Kaucsár, Tamás/0000-0003-4460-1265; Tod, Pál/0000-0001-9163-7071; Koncsos, Gábor/0000-0001-5451-8719; Varga, Zoltán/0000-0002-2758-0784; Sőti, Csaba/0000-0002-4057-7678; Giricz, Zoltán/0000-0003-2036-8665; Szénási, Gábor/0000-0002-7350-6091; Hamar, Péter/0000-0002-1095-3564}
}

@article{MTMT:32110245,
	title = {Nagarse treatment of cardiac subsarcolemmal and interfibrillar mitochondria accounts for inaccurate quantification of proteins},
	url = {https://m2.mtmt.hu/api/publication/32110245},
	author = {Koncsos, Gábor and Varga, Zoltán and Baranyai, Tamás and Ferdinandy, Péter and Schulz, R. and Giricz, Zoltán and Boengler, K.},
	doi = {10.1016/j.yjmcc.2018.05.029},
	journal-iso = {J MOL CELL CARDIOL},
	journal = {JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY},
	volume = {120},
	unique-id = {32110245},
	issn = {0022-2828},
	keywords = {Cardiac & Cardiovascular Systems},
	year = {2018},
	eissn = {1095-8584},
	pages = {5-6},
	orcid-numbers = {Koncsos, Gábor/0000-0001-5451-8719; Varga, Zoltán/0000-0002-2758-0784; Baranyai, Tamás/0000-0002-9378-8938; Ferdinandy, Péter/0000-0002-6424-6806; Giricz, Zoltán/0000-0003-2036-8665}
}

@article{MTMT:3393405,
	title = {Selegiline reduces adiposity induced by high-fat, high-sucrose diet in male rats},
	url = {https://m2.mtmt.hu/api/publication/3393405},
	author = {Nagy, Csilla Terézia and Koncsos, Gábor and Varga, Zoltán and Baranyai, Tamás and Tuza, Sebestyén and Kassai, Ferenc and Ernyey, Alíz Judit and Gyertyán, István and Király, Kornél P and Oláh, Attila and Radovits, Tamás and Merkely, Béla Péter and Bukosza, Éva Nóra and Szénási, Gábor and Hamar, Péter and Máthé, Domokos and Szigeti, Krisztián and Pelyhe, Csilla and Jelemensky, M and Onódi, Zsófia and Helyes, Zsuzsanna and Schulz, R and Giricz, Zoltán and Ferdinandy, Péter},
	doi = {10.1111/bph.14437},
	journal-iso = {BR J PHARMACOL},
	journal = {BRITISH JOURNAL OF PHARMACOLOGY},
	volume = {175},
	unique-id = {3393405},
	issn = {0007-1188},
	abstract = {BACKGROUND AND PURPOSE: Incidence and severity of obesity is increasing worldwide. To date, efficient and safe pharmacological tools to treat or prevent obesity have not been developed. Certain monoamine-oxidase (MAO) inhibitors have been shown to reduce body weight, although their effect on metabolic parameters have not been investigated. Here we assessed the effect of a widely used, selective MAO-B inhibitor, selegiline, on metabolic parameters in high-fat, high-sucrose diet-induced rat model of obesity. EXPERIMENTAL APPROACH: Male Long-Evans rats were fed with control (CON) or high-fat (20%), high-sucrose (15%) diet (HFS) for 25 weeks. From week 16 groups of animals received subcutaneous injections of 0.25 mg kg(-1) selegiline (CON+S and HFS+S) or vehicle (CON, HFS) once daily. KEY RESULTS: Selegiline decreased whole body fat, subcutaneous and visceral adiposity as measured by computer tomography and epididymal fat weight in the HFS group as compared to HFS placebo animals without influencing body weight. Oral glucose tolerance test and insulin tolerance test results showed impaired glucose homeostasis in HFS and HFS+S groups despite unchanged insulin levels in the blood plasma and pancreas. HFS induced expression of Srebp-1c, Glut1, and Mip1alpha in adipose tissue, which was alleviated by selegiline treatment. CONCLUSION AND IMPLICATIONS: This is the first demonstration that selegiline reduces adiposity, alteration in adipose tissue energy metabolism and adipose inflammation induced by HFS diet without affecting the increase in body weight, impairment of glucose homeostasis, or behaviour. These results suggest the potential benefit of selegiline to mitigate harmful effects of visceral adiposity.},
	year = {2018},
	eissn = {1476-5381},
	pages = {3713-3726},
	orcid-numbers = {Nagy, Csilla Terézia/0000-0002-3774-0243; Koncsos, Gábor/0000-0001-5451-8719; Varga, Zoltán/0000-0002-2758-0784; Baranyai, Tamás/0000-0002-9378-8938; Kassai, Ferenc/0000-0003-4815-3527; Ernyey, Alíz Judit/0000-0003-1957-2239; Gyertyán, István/0000-0002-5727-1974; Király, Kornél P/0000-0002-7252-0422; Merkely, Béla Péter/0000-0001-6514-0723; Szénási, Gábor/0000-0002-7350-6091; Hamar, Péter/0000-0002-1095-3564; Pelyhe, Csilla/0000-0001-6267-4527; Onódi, Zsófia/0000-0002-3746-8016; Giricz, Zoltán/0000-0003-2036-8665; Ferdinandy, Péter/0000-0002-6424-6806}
}

@article{MTMT:3328031,
	title = {Nagarse treatment of cardiac subsarcolemmal and interfibrillar mitochondria leads to -artefacts in mitochondrial protein quantification},
	url = {https://m2.mtmt.hu/api/publication/3328031},
	author = {Koncsos, Gábor and Varga, Zoltán and Baranyai, Tamás and Ferdinandy, Péter and Schulz, R and Giricz, Zoltán and Boengler, K},
	doi = {10.1016/j.vascn.2018.01.004},
	journal-iso = {J PHARMACOL TOXICOL METH},
	journal = {JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS},
	volume = {91},
	unique-id = {3328031},
	issn = {1056-8719},
	abstract = {INTRODUCTION: In the heart, subsarcolemmal (SSM), interfibrillar (IFM) and perinuclear mitochondria represent three subtypes of mitochondria. The most commonly used protease during IFM isolation is the nagarse, however, its effect on the detection of mitochondrial proteins is still unclear. Therefore, we investigated whether nagarse treatment influences the quantification of mitochondrial proteins. METHODS: SSM and IFM were isolated from hearts of mice and rats. During IFM isolation, nagarse activity was either stopped by centrifugation (common protocol, IFM+N) or inhibited by phenylmethylsulfonyl fluoride (PMSF, IFM+N+I). The amounts of proteins located in different mitochondrial compartments (outer membrane: mitofusin 1 (MFN1) and 2 (MFN2); intermembrane space: p66shc; inner membrane (connexin 43 (Cx43)), and of protein deglycase DJ-1 were determined by Western blot. RESULTS: MFN2 and Cx43 were predominantly in SSM isolated from mouse and rat hearts. MFN1 and p66shc were present in similar amounts in SSM and IFM+N, whereas the level of DJ-1 was higher in IFM+N compared to SSM. In IFM+N+I samples from mice, the amount of MFN2, but not that of Cx43 increased. Nagarse or nagarse inhibition by PMSF had no effect on oxygen consumption of SSM or IFM. DISCUSSION: Whereas the use of the common protocol indicates the localization of MFN2 predominantly in SSM, the inhibition of nagarse by PMSF increases the signal of MFN2 in IFM to that of in SSM, indicating an underestimation of MFN2 in IFM. Therefore, protease sensitivity should be considered when assessing distribution of mitochondrial proteins using nagarse-based isolation.},
	year = {2018},
	eissn = {1873-488X},
	pages = {50-58},
	orcid-numbers = {Koncsos, Gábor/0000-0001-5451-8719; Varga, Zoltán/0000-0002-2758-0784; Baranyai, Tamás/0000-0002-9378-8938; Ferdinandy, Péter/0000-0002-6424-6806; Giricz, Zoltán/0000-0003-2036-8665}
}