@article{MTMT:34824919,
	title = {Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model},
	url = {https://m2.mtmt.hu/api/publication/34824919},
	author = {Horváth, Ádám and Steib, Anita and Nehr-Majoros, Andrea Kinga and Kántás, Boglárka and Király, Ágnes and Racskó, Márk and Tóth, Balázs István and Szánti-Pintér, Eszter and Kudová, Eva and Skodáné Földes, Rita and Helyes, Zsuzsanna and Szőke, Éva},
	doi = {10.3390/ijms25094637},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34824919},
	issn = {1661-6596},
	abstract = {The thermo- and pain-sensitive Transient Receptor Potential Melastatin 3 and 8 (TRPM3 and TRPM8) ion channels are functionally associated in the lipid rafts of the plasma membrane. We have already described that cholesterol and sphingomyelin depletion, or inhibition of sphingolipid biosynthesis decreased the TRPM8 but not the TRPM3 channel opening on cultured sensory neurons. We aimed to test the effects of lipid raft disruptors on channel activation on TRPM3- and TRPM8-expressing HEK293T cells in vitro, as well as their potential analgesic actions in TRPM3 and TRPM8 channel activation involving acute pain models in mice. CHO cell viability was examined after lipid raft disruptor treatments and their effects on channel activation on channel expressing HEK293T cells by measurement of cytoplasmic Ca2+ concentration were monitored. The effects of treatments were investigated in Pregnenolone-Sulphate-CIM-0216-evoked and icilin-induced acute nocifensive pain models in mice. Cholesterol depletion decreased CHO cell viability. Sphingomyelinase and methyl-beta-cyclodextrin reduced the duration of icilin-evoked nocifensive behavior, while lipid raft disruptors did not inhibit the activity of recombinant TRPM3 and TRPM8. We conclude that depletion of sphingomyelin or cholesterol from rafts can modulate the function of native TRPM8 receptors. Furthermore, sphingolipid cleavage provided superiority over cholesterol depletion, and this method can open novel possibilities in the management of different pain conditions.},
	keywords = {PAIN; cholesterol; Sphingomyelinase; lipid raft; methyl-beta-cyclodextrin; transient receptor potential},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Szánti-Pintér, Eszter/0000-0001-8263-9884; Skodáné Földes, Rita/0000-0002-9810-1509}
}

@article{MTMT:32263040,
	title = {Neurosteroids and steroid hormones are allosteric modulators of muscarinic receptors},
	url = {https://m2.mtmt.hu/api/publication/32263040},
	author = {Dolejší, Eva and Szánti-Pintér, Eszter and Chetverikov, Nikolai and Nelic, Dominik and Randáková, Alena and Doležal, Vladimír and Kudová, Eva and Jakubík, Jan},
	doi = {10.1016/j.neuropharm.2021.108798},
	journal-iso = {NEUROPHARMACOLOGY},
	journal = {NEUROPHARMACOLOGY},
	volume = {199},
	unique-id = {32263040},
	issn = {0028-3908},
	year = {2021},
	eissn = {1873-7064},
	orcid-numbers = {Szánti-Pintér, Eszter/0000-0001-8263-9884; Chetverikov, Nikolai/0000-0003-4462-0319}
}

@article{MTMT:32263006,
	title = {Neuroactive steroids, WIN-compounds and cholesterol share a common binding site on muscarinic acetylcholine receptors},
	url = {https://m2.mtmt.hu/api/publication/32263006},
	author = {Dolejší, Eva and Chetverikov, Nikolai and Szánti-Pintér, Eszter and Nelic, Dominik and Randáková, Alena and Doležal, Vladimír and El-Fakahany, Esam E. and Kudová, Eva and Jakubík, Jan},
	doi = {10.1016/j.bcp.2021.114699},
	journal-iso = {BIOCHEMIC PHARMACOL},
	journal = {BIOCHEMICAL PHARMACOLOGY},
	volume = {192},
	unique-id = {32263006},
	issn = {0006-2952},
	year = {2021},
	eissn = {1873-2968},
	orcid-numbers = {Szánti-Pintér, Eszter/0000-0001-8263-9884}
}

@article{MTMT:31608849,
	title = {Antinociceptive Effects of Lipid Raft Disruptors, a Novel Carboxamido-Steroid and Methyl β-Cyclodextrin, in Mice by Inhibiting Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Channel Activation},
	url = {https://m2.mtmt.hu/api/publication/31608849},
	author = {Horváth, Ádám and Biró-Sütő, Tünde and Kántás, Boglárka and Payrits, Maja and Skodáné Földes, Rita and Szánti-Pintér, Eszter and Helyes, Zsuzsanna and Szőke, Éva},
	doi = {10.3389/fphys.2020.559109},
	journal-iso = {FRONT PHYSIOL},
	journal = {FRONTIERS IN PHYSIOLOGY},
	volume = {11},
	unique-id = {31608849},
	year = {2020},
	eissn = {1664-042X},
	orcid-numbers = {Skodáné Földes, Rita/0000-0002-9810-1509; Szánti-Pintér, Eszter/0000-0001-8263-9884}
}

@article{MTMT:31365295,
	title = {Steroidal ferrocenes as potential enzyme inhibitors of the estrogen biosynthesis},
	url = {https://m2.mtmt.hu/api/publication/31365295},
	author = {Herman, Bianka Edina and Gardi, János and Julesz, János and Tömböly, Csaba and Szánti-Pintér, Eszter and Fehér, Klaudia and Skodáné Földes, Rita and Szécsi, Mihály},
	doi = {10.1007/s42977-020-00023-7},
	journal-iso = {BIOL FUTURA},
	journal = {BIOLOGIA FUTURA},
	volume = {71},
	unique-id = {31365295},
	issn = {2676-8615},
	year = {2020},
	eissn = {2676-8607},
	pages = {249-264},
	orcid-numbers = {Szánti-Pintér, Eszter/0000-0001-8263-9884; Skodáné Földes, Rita/0000-0002-9810-1509; Szécsi, Mihály/0000-0002-4272-1362}
}

@article{MTMT:31628662,
	title = {Application of Ionic Liquids in Synthetic Procedures Leading to Pharmaceutically Active Organic Compounds},
	url = {https://m2.mtmt.hu/api/publication/31628662},
	author = {Szánti-Pintér, Eszter and Skodáné Földes, Rita},
	doi = {10.2174/2213346105666180220121503},
	journal-iso = {CURR GREEN CHEM},
	journal = {CURRENT GREEN CHEMISTRY},
	volume = {5},
	unique-id = {31628662},
	issn = {2213-3461},
	abstract = {Due to an increasing pressure on the chemical society to consider environmental aspects of chemical production, the development of sustainable methodologies has been in the focus of research for years. Ionic Liquids (ILs) have numerous favorable properties: outstanding chemical, thermal and electrochemical stability, non-flammability, negligible volatility, excellent solvation ability and great variability of cation-anion pairs and structure that render them useful materials in green reactions. In pharmaceutics, they may find wide application in the synthesis, extraction and purification of bioactive compounds or may serve as pharmaceutical ingredients themselves. The review focusses on the use of ILs in the synthesis of pharmaceutically active compounds as reaction media, catalyst or catalyst support. ILs can be the efficient solvents as they are known to stabilize reactive intermediates, besides, they facilitate catalyst reuse in e.g. transition metal-catalyzed reactions. Acidic or basic ILs may serve as recyclable catalysts themselves. Other representatives may contain functional groups enabling their application as organocatalysts. Immobilization of catalytically active species on a Supported Ionic Liquid Phase (SILP) as solid material may further enhance catalytic efficiency. The review shows examples for the application of the methodologies mentioned above in the synthesis of biologically active molecules.},
	year = {2018},
	eissn = {2213-347X},
	pages = {4-21},
	orcid-numbers = {Szánti-Pintér, Eszter/0000-0001-8263-9884; Skodáné Földes, Rita/0000-0002-9810-1509}
}

@misc{MTMT:31396002,
	title = {Application of ionic liquids in the synthesis of steroid derivatives},
	url = {https://m2.mtmt.hu/api/publication/31396002},
	author = {Szánti-Pintér, Eszter and Ispán, Dávid and Maksó, Lilla and Skodáné Földes, Rita},
	unique-id = {31396002},
	year = {2018},
	orcid-numbers = {Szánti-Pintér, Eszter/0000-0001-8263-9884; Ispán, Dávid/0000-0002-6698-0078; Maksó, Lilla/0000-0002-2023-8222; Skodáné Földes, Rita/0000-0002-9810-1509}
}

@article{MTMT:3402940,
	title = {Carboxamido steroids inhibit the opening properties of Transient Receptor Potential ion channels by lipid raft modulation.},
	url = {https://m2.mtmt.hu/api/publication/3402940},
	author = {Sághy, Éva and Payrits, Maja and Biro-Suto, T and Skodáné Földes, Rita and Szánti-Pintér, Eszter and Erostyák, János and Makkai, Géza and Sétáló, György (ifj.) and Kollár, László and Kőszegi, Tamás and Jakabfi-Csepregi, Rita and Szolcsányi, János and Helyes, Zsuzsanna and Szőke, Éva},
	doi = {10.1194/jlr.M084723},
	journal-iso = {J LIPID RES},
	journal = {JOURNAL OF LIPID RESEARCH},
	volume = {59},
	unique-id = {3402940},
	issn = {0022-2275},
	abstract = {Transient Receptor Potential (TRP) cation channels, like the TRP Vanilloid 1 and TRP Ankyrin 1 (TRPV1 and TRPA1) are expressed on primary sensory neurons. These thermosensor channels play role in pain processing. We provided evidence that lipid raft disruption influenced the TRP channel activation and a carboxamido-steroid compound (C1) inhibited TRPV1 activation. Therefore, our aim was to investigate whether this compound exerts its effect through lipid raft disruption and the steroid backbone (C3) or altered position of the carboxamido group (C2) influence the inhibitory action by measuring Ca2+-transients on isolated neurons and calcium-uptake on receptor-expressing CHO cells. Membrane cholesterol content was measured by filipin staining and membrane polarisation by fluorescence spectroscopy. Both the percentage of responsive cells and the magnitude of the intracellular Ca2+-enhancement evoked by the TRPV1 agonist capsaicin were significantly inhibited after C1 and C2 incubation, but not after C3 administration. C1 was able to reduce other TRP channel activation as well. The compounds induced cholesterol depletion in CHO cells, but only C1 induced changes in membrane polarisation. The inhibitory action of the compounds on TRP channel activation develops by lipid raft disruption, and the presence and the position of the carboxamido group is essential.},
	keywords = {CELL-LINE; ACTIVATION; NICOTINIC ACETYLCHOLINE-RECEPTOR; ROOT GANGLION NEURONS; LIPID RAFTS; steroid; transient receptor potential channel; TRPV1 receptor; sensory neuron; Cation channels; nerve terminal; TRIGEMINAL SENSORY NEURONS; ALPHA-SPINASTEROL; SCREEN REVEALS},
	year = {2018},
	eissn = {1539-7262},
	pages = {1851-1863},
	orcid-numbers = {Sághy, Éva/0000-0002-4031-3461; Skodáné Földes, Rita/0000-0002-9810-1509; Szánti-Pintér, Eszter/0000-0001-8263-9884}
}

@article{MTMT:3365577,
	title = {The use of switchable polarity solvents for the synthesis of 16-arylidene steroids via Claisen-Schmidt condensation},
	url = {https://m2.mtmt.hu/api/publication/3365577},
	author = {Ispán, Dávid and Szánti-Pintér, Eszter and Papp, Máté and J, Wouters and N, Tumanov and Zsirka, Balázs and Gömöry, Ágnes and Kollár, László and Skodáné Földes, Rita},
	doi = {10.1002/ejoc.201800356},
	journal-iso = {EUR J ORG CHEM},
	journal = {EUROPEAN JOURNAL OF ORGANIC CHEMISTRY},
	volume = {2018},
	unique-id = {3365577},
	issn = {1434-193X},
	year = {2018},
	eissn = {1099-0690},
	pages = {3236-3244},
	orcid-numbers = {Ispán, Dávid/0000-0002-6698-0078; Szánti-Pintér, Eszter/0000-0001-8263-9884; Zsirka, Balázs/0000-0001-9788-484X; Gömöry, Ágnes/0000-0001-5216-0135; Skodáné Földes, Rita/0000-0002-9810-1509}
}

@article{MTMT:3227244,
	title = {Synthesis of 16α-amino-pregnenolone derivatives via ionic liquid-catalyzed aza-Michael addition and their evaluation as C17,20-lyase inhibitors},
	url = {https://m2.mtmt.hu/api/publication/3227244},
	author = {Szánti-Pintér, Eszter and L, Maksó and Gömöry, Ágnes and J, Wouters and Herman, Bianka Edina and Szécsi, Mihály and Mikle, Gábor and Kollár, László and Skodáné Földes, Rita},
	doi = {10.1016/j.steroids.2017.05.006},
	journal-iso = {STEROIDS},
	journal = {STEROIDS},
	volume = {123},
	unique-id = {3227244},
	issn = {0039-128X},
	year = {2017},
	eissn = {1878-5867},
	pages = {61-66},
	orcid-numbers = {Szánti-Pintér, Eszter/0000-0001-8263-9884; Gömöry, Ágnes/0000-0001-5216-0135; Szécsi, Mihály/0000-0002-4272-1362; Skodáné Földes, Rita/0000-0002-9810-1509}
}