@article{MTMT:33927937,
	title = {Prevention of Chronic Morbidities in Extremely Premature Newborns with LISA-nCPAP Respiratory Therapy and Adjuvant Perinatal Strategies},
	url = {https://m2.mtmt.hu/api/publication/33927937},
	author = {Balázs, Gergely and Balajthy, András and Seri, István and Hegyi, Thomas and Ertl, Tibor and Szabó, Tamás and Röszer, Tamás and Papp, Ágnes and Balla, József and Gáll, Tamás and Balla, György},
	doi = {10.3390/antiox12061149},
	journal-iso = {ANTIOXIDANTS-BASEL},
	journal = {ANTIOXIDANTS},
	volume = {12},
	unique-id = {33927937},
	year = {2023},
	eissn = {2076-3921},
	orcid-numbers = {Seri, István/0000-0001-9568-5513}
}

@article{MTMT:33927792,
	title = {Comparison of flexible nasogastric tube and semi-rigid catheter during less invasive surfactant administration},
	url = {https://m2.mtmt.hu/api/publication/33927792},
	author = {Balázs, Gergely and PECSI, Ivett and FEHER, Csilla and KATONA, Nora and KOTORMAN, Tunde and KOVACS-PASZTHY, Balazs and MARKI, Mariann and Pataki, István and Riszter, Magdolna and ROZSA, Timea and Bélteki, Gusztáv and KOVACS, Tamas and Balla, György and Balajthy, András},
	doi = {10.23736/S2724-5276.23.07210-5},
	journal-iso = {MINERVA PEDIATR},
	journal = {MINERVA PEDIATRICS},
	unique-id = {33927792},
	issn = {2724-5276},
	year = {2023},
	eissn = {2724-5780}
}

@article{MTMT:33805323,
	title = {Multicolored MIS-C, a single-centre cohort study},
	url = {https://m2.mtmt.hu/api/publication/33805323},
	author = {Ispánné Varga, Petra and Balajthy, András and Biró, Erika and Bíró, Bernadett and Reiger, Zsolt and Szikszay, Edit and Mogyorósy, Gábor and Káposzta, Rita Kinga and Szabó, Tamás},
	doi = {10.1186/s12887-023-03997-0},
	journal-iso = {BMC PEDIATR},
	journal = {BMC PEDIATRICS},
	volume = {23},
	unique-id = {33805323},
	issn = {1471-2431},
	year = {2023},
	eissn = {1471-2431}
}

@article{MTMT:33764929,
	title = {A respirációs distressz szindróma kezelésének trendjei a Debreceni Egyetem Klinikai Központjába szállított igen éretlen koraszülöttekben},
	url = {https://m2.mtmt.hu/api/publication/33764929},
	author = {Balajthy, András and Kovács, Panna Eszter and Márki, Mariann and Riszter, Magdolna and Nagy, Andrea and Balázs, Gergely},
	doi = {10.1556/650.2023.32735},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {164},
	unique-id = {33764929},
	issn = {0030-6002},
	abstract = {Bevezetés: Fenyegető koraszülés esetén in utero transzport javasolt, ez azonban nem mindig lehetséges. A postnatalis transzport alatti ellátás jelentősen befolyásolja a szállított betegek kimenetelét. Célkitűzés: Tanulmányunk célja volt a betegek jellemzőinek, ellátásuk és a neonatalis kimenetel trendjeinek vizsgálata a 2008 és 2021 között postnatalis szállítást igénylő koraszülöttekben. Módszer: Retrospektív vizsgálatot végeztünk az írott és az elektronikus betegdokumentáció áttekintésével. A vizsgált trendeket „joinpoint” regressziós analízissel értékeltük, illetve éves százalékos változással (APC) jellemeztük. Eredmények: A vizsgálatba 177 koraszülöttet választottunk be. A szállítások száma nem szignifikáns növekvő trendet mutatott (APC = 6,8%, p = 0,087). A 60 percnél hosszabb helyszíni ellátások aránya szignifikánsan emelkedett (APC = 7,4%, p = 0,016). 2008 és 2010 között a gépi lélegeztetés alkalmazása a szállítások során emelkedett (APC = 36,4%, p = 0,578), majd a vizsgálati időszak hátralévő részében csökkenő tendenciát mutatott (APC = –7,2%, p = 0,068). A 40% feletti oxigénkoncentráció használata szignifikánsan csökkent (APC = –9,5%, p = 0,043). A 150 mg/kg-nál kisebb surfactantdózisok aránya szintén csökkenő tendenciát mutatott (APC = –7,65%, p = 0,162), míg a 180 mg/kg felettiek száma szignifikánsan emelkedett (APC = 8,5%, p = 0,031). Az újszülöttek hosszú távú kimeneti mutatói egyaránt javuló tendenciát mutattak. Megbeszélés: Vizsgálatunk során az ellátás noninvazivitás felé mutató trendjei mellett a szállított koraszülöttek javuló kimenetelét észleltük. Következtetés: Vizsgálatunk felgyorsíthatja a szállítás alatti ellátás folyamatban lévő szemléletváltását, elősegítheti a vonatkozó protokollok, illetve eljárásrendek fejlesztését, melyek együttesen javíthatják a tercier centrumon kívül született koraszülöttek életkilátásait. Orv Hetil. 2023; 164(15): 571–576.},
	year = {2023},
	eissn = {1788-6120},
	pages = {571-576}
}

@article{MTMT:33719095,
	title = {Synchronized intermittent mandatory ventilation with volume guarantee and pressure support in neonates: Detailed analysis of ventilator parameters},
	url = {https://m2.mtmt.hu/api/publication/33719095},
	author = {Balajthy, András and Balázs, Gergely and Kovacs, Tamas and Bélteki, Gusztáv},
	doi = {10.1002/ppul.26384},
	journal-iso = {PEDIATR PULM},
	journal = {PEDIATRIC PULMONOLOGY},
	volume = {58},
	unique-id = {33719095},
	issn = {8755-6863},
	abstract = {Objective: To analyse the relationship between peak inflating pressure, expired tidal volume, respiratory rate, and inspiratory time of volume-guaranteed ventilator inflations and pressure-supported spontaneous breaths during synchronized intermittent positive pressure mode with volume guarantee and pressure support (SIMV-VG-PS) in neonates. Methods: Ventilator parameters were downloaded every second from 16 babies ventilated with SIMV-VG-PS mode using Dräger Babylog VN500 ventilators over 137 days. Transcutaneous carbon dioxide (tcCO2) data were also collected. Data were computationally analysed using Python. The average of each ventilator parameter was determined during each minute separately for ventilator inflations and for spontaneous breaths. These values were compared and their effect on tcCO2 levels was also analysed. Results: The relationship between the peak inflating pressure of the volume guaranteed inflations (PIPVG) and pressure-supported spontaneous breaths (PIPPS) was highly variable. The PIPPS/PIPVG ratio differed significantly from the value (0.66) targeted by clinicians (group median: 0.80, range: 0.50–1.00). PIPPS frequently exceeded PIPVG. When PIPPS/PIPVG was >0.66, the expired tidal volume and the rate of the pressure-supported spontaneous breaths were also significantly (p < 0.0001) higher, but there was no difference in tcCO2 levels. The flow-cycled spontaneous breaths had significantly shorter inspiratory times than ventilator inflations. Conclusions: During SIMV-VG-PS it is difficult to ensure a pressure support level proportionate to the inflating pressure of ventilator inflations and to achieve the stability of tidal volumes.},
	year = {2023},
	eissn = {1099-0496},
	pages = {1703-1710},
	orcid-numbers = {Balázs, Gergely/0000-0002-9586-6274}
}

@article{MTMT:30588079,
	title = {A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment.},
	url = {https://m2.mtmt.hu/api/publication/30588079},
	author = {Chimote, Ameet A and Balajthy, András and Arnold, Michael J and Newton, Hannah S and Hajdu, Péter Béla and Qualtieri, Julianne and Wise-Draper, Trisha and Conforti, Laura},
	doi = {10.1126/scisignal.aaq1616},
	journal-iso = {SCI SIGNAL},
	journal = {SCIENCE SIGNALING},
	volume = {11},
	unique-id = {30588079},
	issn = {1945-0877},
	abstract = {The limited ability of cytotoxic T cells to infiltrate solid tumors hampers immune surveillance and the efficacy of immunotherapies in cancer. Adenosine accumulates in solid tumors and inhibits tumor-specific T cells. Adenosine inhibits T cell motility through the A2A receptor (A2AR) and suppression of KCa3.1 channels. We conducted three-dimensional chemotaxis experiments to elucidate the effect of adenosine on the migration of peripheral blood CD8+ T cells from head and neck squamous cell carcinoma (HNSCC) patients. The chemotaxis of HNSCC CD8+ T cells was reduced in the presence of adenosine, and the effect was greater on HNSCC CD8+ T cells than on healthy donor (HD) CD8+ T cells. This response correlated with the inability of CD8+ T cells to infiltrate tumors. The effect of adenosine was mimicked by an A2AR agonist and prevented by an A2AR antagonist. We found no differences in A2AR expression, 3',5'-cyclic adenosine monophosphate abundance, or protein kinase A type 1 activity between HNSCC and HD CD8+ T cells. We instead detected a decrease in KCa3.1 channel activity, but not expression, in HNSCC CD8+ T cells. Activation of KCa3.1 channels by 1-EBIO restored the ability of HNSCC CD8+ T cells to chemotax in the presence of adenosine. Our data highlight the mechanism underlying the increased sensitivity of HNSCC CD8+ T cells to adenosine and the potential therapeutic benefit of KCa3.1 channel activators, which could increase infiltration of these T cells into tumors.},
	year = {2018},
	eissn = {1937-9145}
}

@article{MTMT:3360579,
	title = {The C-terminal HRET sequence of Kv1.3 regulates gating rather than targeting of Kv1.3 to the plasma membrane},
	url = {https://m2.mtmt.hu/api/publication/3360579},
	author = {Vörös, Orsolya and Szilágyi, Orsolya and Balajthy, András and Somodi, Sándor and Panyi, György and Hajdu, Péter Béla},
	doi = {10.1038/s41598-018-24159-8},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {8},
	unique-id = {3360579},
	issn = {2045-2322},
	abstract = {Kv1.3 channels are expressed in several cell types including immune cells, such as T lymphocytes. The targeting of Kv1.3 to the plasma membrane is essential for T cell clonal expansion and assumed to be guided by the C-terminus of the channel. Using two point mutants of Kv1.3 with remarkably different features compared to the wild-type Kv1.3 (A413V and H399K having fast inactivation kinetics and tetraethylammonium-insensitivity, respectively) we showed that both Kv1.3 channel variants target to the membrane when the C-terminus was truncated right after the conserved HRET sequence and produce currents identical to those with a full-length C-terminus. The truncation before the HRET sequence (NOHRET channels) resulted in reduced membrane-targeting but non-functional phenotypes. NOHRET channels did not display gating currents, and coexpression with wild-type Kv1.3 did not rescue the NOHRET-A413V phenotype, no heteromeric current was observed. Interestingly, mutants of wild-type Kv1.3 lacking HRET(E) (deletion) or substituted with five alanines for the HRET(E) motif expressed current indistinguishable from the wild-type. These results demonstrate that the C-terminal region of Kv1.3 immediately proximal to the S6 helix is required for the activation gating and conduction, whereas the presence of the distal region of the C-terminus is not exclusively required for trafficking of Kv1.3 to the plasma membrane.},
	year = {2018},
	eissn = {2045-2322},
	orcid-numbers = {Somodi, Sándor/0000-0002-3615-2300; Panyi, György/0000-0001-6227-3301}
}

@article{MTMT:3272305,
	title = {Sterol Regulation of Voltage-Gated K+ Channels},
	url = {https://m2.mtmt.hu/api/publication/3272305},
	author = {Balajthy, András and Hajdu, Péter Béla and Panyi, György and Varga, Zoltán},
	doi = {10.1016/bs.ctm.2017.05.006},
	journal-iso = {CURR TOP MEMBR},
	journal = {CURRENT TOPICS IN MEMBRANES},
	volume = {80},
	unique-id = {3272305},
	issn = {1063-5823},
	year = {2017},
	pages = {255-292},
	orcid-numbers = {Panyi, György/0000-0001-6227-3301}
}

@mastersthesis{MTMT:3142546,
	title = {A Kv1.3 ioncsatornák szterolok általi szabályozásának vizsgálata in vitro és ex vivo rendszerekben},
	url = {https://m2.mtmt.hu/api/publication/3142546},
	author = {Balajthy, András},
	unique-id = {3142546},
	year = {2016}
}

@article{MTMT:3099238,
	title = {7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome},
	url = {https://m2.mtmt.hu/api/publication/3099238},
	author = {Balajthy, András and Somodi, Sándor and Pethő, Z and Péter, Mária and Varga, Zoltán and P. Szabó, Gabriella and Paragh, György and Vigh, László and Panyi, György and Hajdu, Péter Béla},
	doi = {10.1007/s00424-016-1851-4},
	journal-iso = {PFLUG ARCH EUR J PHY},
	journal = {PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY},
	volume = {468},
	unique-id = {3099238},
	issn = {0031-6768},
	abstract = {In vitro manipulation of membrane sterol level affects the regulation of ion channels and consequently certain cellular functions; however, a comprehensive study that confirms the pathophysiological significance of these results is missing. The malfunction of 7-dehydrocholesterol (7DHC) reductase in Smith-Lemli-Opitz syndrome (SLOS) leads to the elevation of the 7-dehydrocholesterol level in the plasma membrane. T lymphocytes were isolated from SLOS patients to assess the effect of the in vivo altered membrane sterol composition on the operation of the voltage-gated Kv1.3 channel and the ion channel-dependent mitogenic responses. We found that the kinetic and equilibrium parameters of Kv1.3 activation changed in SLOS cells. Identical changes in Kv1.3 operation were observed when control/healthy T cells were loaded with 7DHC. Removal of the putative sterol binding sites on Kv1.3 resulted in a phenotype that was not influenced by the elevation in membrane sterol level. Functional assays exhibited impaired activation and proliferation rate of T cells probably partially due to the modified Kv1.3 operation. We concluded that the altered membrane sterol composition hindered the operation of Kv1.3 as well as the ion channel-controlled T cell functions. © 2016, Springer-Verlag Berlin Heidelberg.},
	keywords = {cholesterol; Kv1.3; 7-Dehydrocholesterol; Smith-Lemli-Opitz syndrome; Voltage-gated ion channel},
	year = {2016},
	eissn = {1432-2013},
	pages = {1403-1418},
	orcid-numbers = {Somodi, Sándor/0000-0002-3615-2300; Panyi, György/0000-0001-6227-3301}
}