@article{MTMT:33211172,
	title = {A cytotoxic survey on 2-amino-1H-imidazol based synthetic marine sponge alkaloid analogues},
	url = {https://m2.mtmt.hu/api/publication/33211172},
	author = {Gémes, Nikolett and Makra, Zsófia and Neuperger, Patricia and Szabó, Enikő and Balog, József Ágoston and Flink, Lili Borbála and Kari, Beáta and Hackler, László and Puskás, László and Kanizsai, Iván and Szebeni, Gábor},
	doi = {10.1002/ddr.22006},
	journal-iso = {DRUG DEVELOP RES},
	journal = {DRUG DEVELOPMENT RESEARCH},
	volume = {83},
	unique-id = {33211172},
	issn = {0272-4391},
	abstract = {Here, we describe the synthesis and biologic activity evaluation of 20 novel synthetic marine sponge alkaloid analogues with 2-amino-1H-imidazol (2-AI) core. Cytotoxicity was tested on murine 4T1 breast cancer, A549 human lung cancer, and HL-60 human myeloid leukemia cells by the resazurin assay. A total of 18 of 20 compounds showed cytotoxic effect on the cancer cell lines with different potential. Viability of healthy human fibroblasts and peripheral blood mononuclear cells upon treatment was less hampered compared to cancer cell lines supporting tumor cell specific cytotoxicity of our compounds. The most cytotoxic compounds resulted the following IC50 values 28: 2.91 µM on HL-60 cells, and 29: 3.1 µM on 4T1 cells. The A549 cells were less sensitive to the treatments with IC50 15 µM for both 28 and 29. Flow cytometry demonstrated the apoptotic effect of the most active seven compounds inducing phosphatidylserine exposure and sub-G1 fragmentation of nuclear DNA. Cell cycle arrest was also observed. Four compounds caused depolarization of the mitochondrial membrane potential as an early event of apoptosis. Two lead compounds inhibited tumor growth in vivo in the 4T1 triple negative breast cancer and A549 human lung adenocarcinoma xenograft models. Novel marine sponge alkaloid analogues are demonstrated as potential anticancer agents for further development.},
	keywords = {Mannich; 2-amino-(1H)-imidazole; 4T1 breast cancer; A549 lung cancer; HL-60 myeloid leukemia},
	year = {2022},
	eissn = {1098-2299},
	pages = {1906-1922},
	orcid-numbers = {Szebeni, Gábor/0000-0002-6998-5632}
}

@article{MTMT:32129515,
	title = {PMDTA-catalyzed multicomponent synthesis and biological activity of 2-amino-4 H -chromenes containing a phosphonate or phosphine oxide moiety},
	url = {https://m2.mtmt.hu/api/publication/32129515},
	author = {Tajti, Ádám and Szabó, Kármen and Popovics-Tóth, Nóra and Iskanderov, Javad and Perdih, Franc and Hackler, László and Kari, Beáta and Puskás, László and Bálint, Erika},
	doi = {10.1039/D1OB01204E},
	journal-iso = {ORG BIOMOL CHEM},
	journal = {ORGANIC & BIOMOLECULAR CHEMISTRY},
	volume = {19},
	unique-id = {32129515},
	issn = {1477-0520},
	year = {2021},
	eissn = {1477-0539},
	pages = {6883-6891},
	orcid-numbers = {Popovics-Tóth, Nóra/0000-0003-4134-0514; Perdih, Franc/0000-0002-8416-7291; Kari, Beáta/0000-0002-4377-6824; Puskás, László/0000-0003-0271-3517; Bálint, Erika/0000-0002-5107-7089}
}

@article{MTMT:31940120,
	title = {Immunoprofiling of Drosophila Hemocytes by Single-cell Mass Cytometry},
	url = {https://m2.mtmt.hu/api/publication/31940120},
	author = {Balog, József Ágoston and Honti, Viktor and Kurucz, Judit Éva and Kari, Beáta and Puskás, László and Andó, István and Szebeni, Gábor},
	doi = {10.1016/j.gpb.2020.06.022},
	journal-iso = {GENOM PROTEOM BIOINF},
	journal = {GENOMICS PROTEOMICS & BIOINFORMATICS},
	volume = {19},
	unique-id = {31940120},
	issn = {1672-0229},
	year = {2021},
	eissn = {2210-3244},
	pages = {243-252},
	orcid-numbers = {Andó, István/0000-0002-4648-9396; Szebeni, Gábor/0000-0002-6998-5632}
}

@article{MTMT:31346366,
	title = {Synthesis and In Vitro Cytotoxicity and Antibacterial Activity of Novel 1,2,3-Triazol-5-yl-Phosphonates},
	url = {https://m2.mtmt.hu/api/publication/31346366},
	author = {Tripolszky, Anna and Tóth, Emese and Szabó, Pál Tamás and Hackler, László and Kari, Beáta and Puskás, László and Bálint, Erika},
	doi = {10.3390/molecules25112643},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {25},
	unique-id = {31346366},
	issn = {1420-3049},
	year = {2020},
	eissn = {1420-3049},
	orcid-numbers = {Szabó, Pál Tamás/0000-0003-2260-4641; Bálint, Erika/0000-0002-5107-7089}
}

@article{MTMT:30644621,
	title = {The Anti-Inflammatory Role of Mannich Curcuminoids; Special Focus on Colitis},
	url = {https://m2.mtmt.hu/api/publication/30644621},
	author = {Szebeni, Gábor and Nagy, Lajos I. and Magyariné, Berkó Anikó and Nagyné Hoffmann, Alexandra and Fehér, Liliána Z. and Bagyánszki, Mária and Kari, Beáta and Balog, József Ágoston and Hackler, László and Kanizsai, Iván and Pósa, Anikó and Varga, Csaba and Puskás, László},
	doi = {10.3390/molecules24081546},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {24},
	unique-id = {30644621},
	issn = {1420-3049},
	abstract = {The incidence of inflammatory bowel disease (IBD) increases gradually in Western countries with high need for novel therapeutic interventions. Mannich curcuminoids, C142 or C150 synthetized in our laboratory, have been tested for anti-inflammatory activity in a rat model of TNBS (2,4,6-trinitrobenzenesulphonic acid) induced colitis. Treatment with C142 or C150 reduced leukocyte infiltration to the submucosa and muscular propria of the inflamed gut. C142 or C150 rescued the loss of body weight and C150 decreased the weight of standard colon preparations proportional with 20% less tissue oedema. Both C142 and C150 curcumin analogues caused 25% decrease in the severity of colonic inflammation and haemorrhagic lesion size. Colonic MPO (myeloperoxidase) enzyme activity as an indicator of intense neutrophil infiltration was 50% decreased either by C142 or C150 Mannich curcuminoids. Lipopolysaccharide (LPS) co-treatment with Mannich curcuminoids inhibited NF-B (nuclear factor kappa B) activity on a concentration-dependent manner in an NF-B-driven luciferase expressing reporter cell line. Co-treatment with LPS and curcuminoids, C142 or C150, resulted in NF-B inhibition with 3.57 M or 1.6 M half maximal effective concentration (EC50) values, respectively. C150 exerted a profound inhibition of the expression of inflammatory cytokines, tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and interleukin-4 (IL-4) in human PBMCs (peripheral blood mononuclear cells) upon LPS stimulus. Mannich curcuminoids reported herein possess a powerful anti-inflammatory activity.},
	year = {2019},
	eissn = {1420-3049},
	orcid-numbers = {Szebeni, Gábor/0000-0002-6998-5632; Magyariné, Berkó Anikó/0000-0002-1237-5745; Bagyánszki, Mária/0000-0003-3533-9461; Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X}
}

@mastersthesis{MTMT:3196422,
	title = {A veleszületett immunitás vizsgálata Drosophila melanogasterben},
	url = {https://m2.mtmt.hu/api/publication/3196422},
	author = {Kari, Beáta},
	doi = {10.14232/phd.3110},
	publisher = {SZTE},
	unique-id = {3196422},
	year = {2016}
}

@article{MTMT:3071742,
	title = {The actin-binding ERM protein Moesin directly regulates spindle assembly and function during mitosis},
	url = {https://m2.mtmt.hu/api/publication/3071742},
	author = {Vilmos, Péter and Kristó, Ildikó and Szikora, Szilárd and Jankovics, Ferenc and Lukácsovich, T and Kari, Beáta and Erdélyi, Miklós},
	doi = {10.1002/cbin.10607},
	journal-iso = {CELL BIOL INT},
	journal = {CELL BIOLOGY INTERNATIONAL},
	volume = {40},
	unique-id = {3071742},
	issn = {1065-6995},
	abstract = {Ezrin-Radixin-Moesin proteins are highly conserved, actin-binding cytoskeletal proteins that play an essential role in microvilli formation, T-cell activation, and tumor metastasis by linking actin filaments to the plasma membrane. Recent studies demonstrated that the only Ezrin-Radixin-Moesin protein of Drosophila melanogaster, Moesin, is involved in mitotic spindle function through stabilizing cell shape and microtubules at the cell cortex. We previously observed that Moesin localizes to the mitotic spindle; hence, we tested for the biological significance of this surprising localization and investigated whether it plays a direct role in spindle function. To separate the cortical and spindle functions of Moesin during mitosis we combined cell biological and genetic methods. We used early Drosophila embryos, in which mitosis occurs in the absence of a cell cortex, and found in vivo evidence for the direct requirement of Moesin in mitotic spindle assembly and function. We also found that the accumulation of Moesin precedes the construction of the microtubule spindle, and the fusiform structure formed by Moesin persists even after the microtubules have disassembled. © 2016 International Federation for Cell Biology.},
	keywords = {DROSOPHILA; ACTIN; Mitosis; SPINDLE; moesin; ERM},
	year = {2016},
	eissn = {1095-8355},
	pages = {696-707}
}

@article{MTMT:3045263,
	title = {The raspberry Gene Is Involved in the Regulation of the Cellular Immune Response in Drosophila melanogaster},
	url = {https://m2.mtmt.hu/api/publication/3045263},
	author = {Kari, Beáta and Csordás, Gábor and Honti, Viktor and Cinege, Gyöngyi Ilona and Williams, MJ and Andó, István and Kurucz, Judit Éva},
	doi = {10.1371/journal.pone.0150910},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {11},
	unique-id = {3045263},
	issn = {1932-6203},
	abstract = {Drosophila is an extremely useful model organism for understanding how innate immune mechanisms defend against microbes and parasitoids. Large foreign objects trigger a potent cellular immune response in Drosophila larva. In the case of endoparasitoid wasp eggs, this response includes hemocyte proliferation, lamellocyte differentiation and eventual encapsulation of the egg. The encapsulation reaction involves the attachment and spreading of hemocytes around the egg, which requires cytoskeletal rearrangements, changes in adhesion properties and cell shape, as well as melanization of the capsule. Guanine nucleotide metabolism has an essential role in the regulation of pathways necessary for this encapsulation response. Here, we show that the Drosophila inosine 5'-monophosphate dehydrogenase (IMPDH), encoded by raspberry (ras), is centrally important for a proper cellular immune response against eggs from the parasitoid wasp Leptopilina boulardi. Notably, hemocyte attachment to the egg and subsequent melanization of the capsule are deficient in hypomorphic ras mutant larvae, which results in a compromised cellular immune response and increased survival of the parasitoid.},
	keywords = {PHAGOCYTOSIS; INHIBITORS; ACTIVATION; SCREEN; RHO; Hematopoiesis; INOSINE MONOPHOSPHATE DEHYDROGENASE; Parasitoids; SMALL GTPASES; LEPTOPILINA-BOULARDI},
	year = {2016},
	eissn = {1932-6203},
	orcid-numbers = {Csordás, Gábor/0000-0001-6871-6839; Andó, István/0000-0002-4648-9396}
}

@inproceedings{MTMT:2519814,
	title = {A SZEPTIKUS SÉRÜLÉST KÖVETŐ IMMUNVÁLASZT SZABÁLYOZÓ GENETIKAI FAKTOROK AZONOSÍTÁSÁNAK MÓDSZEREI DROSOPHILÁBAN},
	url = {https://m2.mtmt.hu/api/publication/2519814},
	author = {Kari, Beáta and Zsámboki, János and Honti, Viktor and Csordás, Gábor and Márkus, Róbert and Andó, István and Kurucz, Judit Éva},
	booktitle = {Tudomány a vidék mindennapjaiban},
	unique-id = {2519814},
	year = {2013},
	pages = {43-47},
	orcid-numbers = {Csordás, Gábor/0000-0001-6871-6839; Andó, István/0000-0002-4648-9396}
}

@article{MTMT:2463198,
	title = {A novel method for the identification of factors involved in host-pathogen interactions in Drosophila melanogaster.},
	url = {https://m2.mtmt.hu/api/publication/2463198},
	author = {Kari, Beáta and Zsámboki, János and Honti, Viktor and Csordás, Gábor and Márkus, Róbert and Andó, István and Kurucz, Judit Éva},
	doi = {10.1016/j.jim.2013.09.011},
	journal-iso = {J IMMUNOL METHODS},
	journal = {JOURNAL OF IMMUNOLOGICAL METHODS},
	volume = {398-399},
	unique-id = {2463198},
	issn = {0022-1759},
	abstract = {A new method was established, standardized and validated for screening factors involved in the response to septic injury in Drosophila melanogaster. The method, based on inducing lesion by removing the tarsal segments of the first pair of legs of Drosophila adults and exposing them to different bacteria, imitates injury that often occurs in the natural habitat. The method is easy to perform, highly reproducible and suitable for large-scale genetic screens with the aim of identifying factors involved in host-pathogen interactions. The technique was validated by using mutant variations of different components of the immune response, blood clotting as well as the involvement of a number of genes known to be instrumental in the humoral and cell-mediated immune responses of Drosophila was confirmed. Moreover, the combination of the present method with antibiotic treatment allows the screening of potential antimicrobial drugs in vivo.},
	year = {2013},
	eissn = {1872-7905},
	pages = {76-82},
	orcid-numbers = {Csordás, Gábor/0000-0001-6871-6839; Andó, István/0000-0002-4648-9396}
}