TY  - GEN
AU  - Nehr-Majoros, Andrea Kinga
AU  - Bencze, Noémi
AU  - Payrits, Maja
AU  - Kemény, Ágnes
AU  - György, Sétáló Jr.
AU  - Helyes, Zsuzsanna
AU  - Szőke, Éva
TI  - Analgesic effects of cyclodextrin derivatives via modulation of Transient Receptor Potential Ankyrin 1 ion channel function
PY  - 2024
UR  - https://m2.mtmt.hu/api/publication/34577002
ID  - 34577002
LA  - English
DB  - MTMT
ER  - 

TY  - GEN
AU  - Payrits, Maja
AU  - Csekő, Kata
AU  - Pohóczky, Krisztina
AU  - Dávid, Ernszt
AU  - Klaudia, Barabás
AU  - Nehr-Majoros, Andrea Kinga
AU  - Bencze, Noémi
AU  - Nemes, Balázs
AU  - Helyes, Zsuzsanna
AU  - Szőke, Éva
TI  - Effect of estradiol on the Transient Receptor Potential Vanilloid 1 and Ankyrin 1 receptors regulated pain responses
PY  - 2024
UR  - https://m2.mtmt.hu/api/publication/34576980
ID  - 34576980
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Horváth, Ádám István
AU  - Szentes, Nikolett
AU  - Tékus, Valéria
AU  - Payrits, Maja
AU  - Szőke, Éva
AU  - Pótóné Oláh, Emőke
AU  - Garami, András
AU  - Fliszár-Nyúl, Eszter
AU  - Poór, Miklós
AU  - Pápayné Sár, Cecília
AU  - Kálai, Tamás
AU  - Pál, Szilárd
AU  - Percze, Krisztina
AU  - Nagyné Scholz, Éva
AU  - Mészáros, Tamás
AU  - Tóth, Blanka
AU  - Mátyus, Péter
AU  - Helyes, Zsuzsanna
TI  - Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain
JF  - BIOMEDICINES
J2  - BIOMEDICINES
VL  - 9
PY  - 2021
IS  - 7
PG  - 18
SN  - 2227-9059
DO  - 10.3390/biomedicines9070749
UR  - https://m2.mtmt.hu/api/publication/32084429
ID  - 32084429
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Horváth, Ádám
AU  - Payrits, Maja
AU  - Steib, Anita
AU  - Kántás, Boglárka
AU  - Biró-Sütő, Tünde
AU  - Erostyák, János
AU  - Makkai, Géza
AU  - Sághy, Éva
AU  - Helyes, Zsuzsanna
AU  - Szőke, Éva
TI  - Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation
JF  - FRONTIERS IN PHARMACOLOGY
J2  - FRONT PHARMACOL
VL  - 11
PY  - 2021
PG  - 11
SN  - 1663-9812
DO  - 10.3389/fphar.2020.593319
UR  - https://m2.mtmt.hu/api/publication/31848850
ID  - 31848850
N1  - Funding Agency and Grant Number: National Brain Research Program [2017-1.2.1-NKP -2017-00002]; Hungarian Government [GINOP-2.3.2-15-2016-00050, EFOP-3.6.2-16-2017-00006, EFOP-3.6.2-16-2017-00008]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; University of Pecs [17886-4/23018/FEKUTSTRAT]; New National Excellence Program of the Ministry of Human Capacities [UNKP-18-4]; Gedeon Richter's Talentum Foundation; New National Excellence Program of the Ministry for Innovation and Technology [UNKP-19-4]
            Funding text: This work was supported by the National Brain Research Program 2017-1.2.1-NKP -2017-00002 (NAP-2; Chronic Pain Research Group). We acknowledge the grant of the Hungarian Government (GINOP-2.3.2-15-2016-00050, EFOP-3.6.2-16-2017-00006 and EFOP-3.6.2-16-2017-00008). ESz and ESa were supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. The University of Pecs is acknowledged for a support by the 17886-4/23018/FEKUTSTRAT excellence grant. MP was supported by the New National Excellence Program of the Ministry of Human Capacities UNKP-18-4. ESz and ESa were supported by the New National Excellence Program of the Ministry of Human Capacities UNKP-18-4 and New National Excellence Program of the Ministry for Innovation and TechnologyUNKP-19-4 grant. AHwas supported by the Gedeon Richter's Talentum Foundation.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Horváth, Györgyi
AU  - Csikós, Eszter
AU  - Andres, Eichertné Violetta
AU  - Bencsik, Tímea
AU  - Takátsy, Anikó
AU  - Gulyás, Gergely
AU  - Turcsi, Erika Margit
AU  - Deli, József
AU  - Szőke, Éva
AU  - Kemény, Ágnes
AU  - Payrits, Maja
AU  - Szente, Lajos
AU  - Kocsis, Marianna
AU  - Molnár, Péter
AU  - Helyes, Zsuzsanna
TI  - Analyzing the Carotenoid Composition of Melilot (Melilotus officinalis (L.) Pall.) Extracts and the Effects of Isolated (All-E)-lutein-5,6-epoxide on Primary Sensory Neurons and Macrophages
JF  - MOLECULES
J2  - MOLECULES
VL  - 26
PY  - 2021
IS  - 2
PG  - 13
SN  - 1420-3049
DO  - 10.3390/molecules26020503
UR  - https://m2.mtmt.hu/api/publication/31823277
ID  - 31823277
N1  - Funding Agency and Grant Number: NKFI [K 128253]; National Brain Research Program-2 [20017-1.2.1-NKP -2017-00002, GINOP-2.3.2-15-2016-00048, EFOP-362-16-2017-00006]; Janos Bolyai fellowship of the Hungarian Academy of Sciences; New National Excellence Program of the Ministry for Innovation and Technology [UNKP-18-4, UNKP-19-4]; University of Pecs [17886-4/23018]
            Funding text: J. Deli was supported by NKFI K 128253 grants. This work was sponsored by National Brain Research Program-2 20017-1.2.1-NKP -2017-00002. (NAP-2; Chronic Pain Research Group), GINOP-2.3.2-15-2016-00048, and EFOP-362-16-2017-00006. E. Sz <spacing diaeresis>oke and A. Kemeny were supported by Janos Bolyai fellowship of the Hungarian Academy of Sciences and the New National Excellence Program of the Ministry for Innovation and Technology UNKP-18-4 an UNKP-19-4. The University of Pecs is acknowledged for a support by the 17886-4/23018/FEKUTSTRAT excellence grant.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Borbély, Éva
AU  - Hunyady, Ágnes
AU  - Pohóczky, Krisztina
AU  - Payrits, Maja
AU  - Botz, Bálint
AU  - Mócsai, Attila
AU  - Berger, Alexandra
AU  - Szőke, Éva
AU  - Helyes, Zsuzsanna
TI  - Hemokinin-1 as a Mediator of Arthritis-Related Pain via Direct Activation of Primary Sensory Neurons
JF  - FRONTIERS IN PHARMACOLOGY
J2  - FRONT PHARMACOL
VL  - 11
PY  - 2021
PG  - 14
SN  - 1663-9812
DO  - 10.3389/fphar.2020.594479
UR  - https://m2.mtmt.hu/api/publication/31818502
ID  - 31818502
N1  - * Megosztott szerzőség
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Payrits, Maja
AU  - Ádám, Horváth
AU  - Biró-Sütő, Tünde
AU  - János, Erostyák
AU  - Géza, Makkai
AU  - Sághy, Éva
AU  - Pohóczky, Krisztina
AU  - Kecskés, Angéla
AU  - Kecskés, Miklós
AU  - Szolcsányi, János
AU  - Helyes, Zsuzsanna
AU  - Szőke, Éva
ED  - Rakonczay, Zoltán
ED  - Kiss, Lóránd
TI  - Resolvin D1 and D2 inhibit Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Ion Channel activation on sensory neurons via lipid raft modification
T2  - Proceedings of the EFOP-3.6.2-16-2017-00006 (LIVE LONGER) project
PB  - University of Szeged
CY  - Szeged
SN  - 9789633067642
PY  - 2020
SP  - 59
EP  - 59
PG  - 1
UR  - https://m2.mtmt.hu/api/publication/31684068
ID  - 31684068
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Szőke, Éva
AU  - Horvath, Adam
AU  - Biró-Sütő, Tünde
AU  - Sághy, Éva
AU  - Payrits, Maja
AU  - Erostyák, János
AU  - Makkai, Géza
AU  - Szolcsányi, János
AU  - Helyes, Zsuzsanna
TI  - In vitro and in vivo evidence for the role of lipid rafts in Ca2+-gating of the Transient Receptor Potential channels in sensory neurons
JF  - FASEB JOURNAL
J2  - FASEB J
VL  - 34
PY  - 2020
IS  - S1
PG  - 2
SN  - 0892-6638
DO  - 10.1096/fasebj.2020.34.s1.05167
UR  - https://m2.mtmt.hu/api/publication/31625361
ID  - 31625361
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Horváth, Ádám
AU  - Biró-Sütő, Tünde
AU  - Kántás, Boglárka
AU  - Payrits, Maja
AU  - Skodáné Földes, Rita
AU  - Szánti-Pintér, Eszter
AU  - Helyes, Zsuzsanna
AU  - Szőke, Éva
TI  - Antinociceptive Effects of Lipid Raft Disruptors, a Novel Carboxamido-Steroid and Methyl β-Cyclodextrin, in Mice by Inhibiting Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Channel Activation
JF  - FRONTIERS IN PHYSIOLOGY
J2  - FRONT PHYSIOL
VL  - 11
PY  - 2020
PG  - 9
SN  - 1664-042X
DO  - 10.3389/fphys.2020.559109
UR  - https://m2.mtmt.hu/api/publication/31608849
ID  - 31608849
N1  - * Megosztott szerzőség
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Payrits, Maja
AU  - Horváth, Ádám
AU  - Biró-Sütő, Tünde
AU  - Erostyák, János
AU  - Makkai, Géza
AU  - Sághy, Éva
AU  - Pohóczky, Krisztina
AU  - Kecskés, Angéla
AU  - Kecskés, Miklós
AU  - Szolcsányi, János
AU  - Helyes, Zsuzsanna
AU  - Szőke, Éva
TI  - Resolvin D1 and D2 inhibit transient receptor potential vanilloid 1 and ankyrin 1 ion channel activation on sensory neurons via lipid raft modification
JF  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
J2  - INT J MOL SCI
VL  - 21
PY  - 2020
IS  - 14
PG  - 17
SN  - 1661-6596
DO  - 10.3390/ijms21145019
UR  - https://m2.mtmt.hu/api/publication/31387590
ID  - 31387590
N1  - Funding Agency and Grant Number: National Brain Research Program [2017-1.2.1-NKP-2017-00002]; Hungarian Government [GINOP-2.3.2-15-2016-00050, EFOP-3.6.2-16-2017-00006, EFOP-3.6.2-16-2017-00008]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; University of Pecs [17886-4/23018/FEKUTSTRAT]; New National Excellence Program of the ministry of Human Capacities [UNKP-18-4]; New National Excellence Program of the ministry for Innovation and Technology [UNKP-19-4]
            Funding text: This work was supported by the National Brain Research Program 2017-1.2.1-NKP-2017-00002 (NAP-2; Chronic Pain Research Group). We acknowledge the grant of the Hungarian Government (GINOP-2.3.2-15-2016-00050, EFOP-3.6.2-16-2017-00006 and EFOP-3.6.2-16-2017-00008). E. Szoke A. Kecskes and E. Saghy were supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. The University of Pecs is acknowledged for a support by the 17886-4/23018/FEKUTSTRAT excellence grant. M. Payrits was supported by the New National Excellence Program of the ministry of Human Capacities UNKP-18-4. E. Szoke and E. Saghy were supported by the New National Excellence Program of the ministry of Human Capacities UNKP-18-4 and New National Excellence Program of the ministry for Innovation and Technology UNKP-19-4 grant.
AB  - Transient Receptor Potential Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons and regulate nociceptor and inflammatory functions. Resolvins are endogenous lipid mediators. Resolvin D1 (RvD1) is described as a selective inhibitor of TRPA1-related postoperative and inflammatory pain in mice acting on the G protein-coupled receptor DRV1/GPR32. Resolvin D2 (RvD2) is a very potent TRPV1 and TRPA1 inhibitor in DRG neurons, and decreases inflammatory pain in mice acting on the GPR18 receptor, via TRPV1/TRPA1-independent mechanisms. We provided evidence that resolvins inhibited neuropeptide release from the stimulated sensory nerve terminals by TRPV1 and TRPA1 activators capsaicin (CAPS) and allyl-isothiocyanate (AITC), respectively. We showed that RvD1 and RvD2 in nanomolar concentrations significantly decreased TRPV1 and TRPA1 activation on sensory neurons by fluorescent calcium imaging and inhibited the CAPS-and AITC-evoked45Ca-uptake on TRPV1-and TRPA1-expressing CHO cells. Since CHO cells are unlikely to express resolvin receptors, resolvins are suggested to inhibit channel opening through surrounding lipid raft disruption. Here, we proved the ability of resolvins to alter the membrane polarity related to cholesterol composition by fluorescence spectroscopy. It is concluded that targeting lipid raft integrity can open novel peripheral analgesic opportunities by decreasing the activation of nociceptors. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
LA  - English
DB  - MTMT
ER  -