TY - JOUR AU - Bényei, Erik AU - Laki, András Miklós AU - Kiss, Gergely AU - Varga, Zsolt AU - Tőke, Judit AU - Tóth, Miklós TI - A phaeochromocytoma peritonealis implantálódása – phaeochromocytomatosis JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 78 PY - 2025 IS - 2 SP - 118 EP - 121 PG - 4 SN - 0133-5464 DO - 10.59063/mba.2025.78.2.9 UR - https://m2.mtmt.hu/api/publication/36169287 ID - 36169287 AB - A phaeochromocytomatosis – a phaeochromocytoma peritoneumon való egy-, vagy többgócú implantálódása a tumor sebészeti eltávolítása során kialakuló ritka szövődmény. Esetbemutatásunkban egy sebészeti szempontból irreszekábilis, két ciklus I131-MIBG kezelés mellett progrediáló phaeochromocytomatosisos beteg 14 éves kórtörténetét ismertetjük. A tüneti alfa-, és béta-blokkoló kezelés elégtelensége miatt a beteg szisztémás tirozinkináz-gátló kezelését tervezzük. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bényei, Erik AU - Laki, András Miklós AU - Kiss, Gergely AU - Varga, Zsolt AU - Tóth, Miklós AU - Tőke, Judit TI - Peritoneal implantation of pheochromocytoma – pheochromocytomatosis: a case report and mini review JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 16 PY - 2025 PG - 8 SN - 1664-2392 DO - 10.3389/fendo.2025.1679629 UR - https://m2.mtmt.hu/api/publication/36425658 ID - 36425658 AB - IntroductionPheochromocytomatosis, defined as the implantation of pheochromocytoma cells to the intraoperatively opened surfaces during surgical manipulation, is an infrequent complication of surgical intervention of pheochromocytomas. Only a handful of pheochromocytomatosis cases have been reported since the first case was described in 2001.Case reportIn 2011, a 33-year-old male patient presented with episodic palpitations and hypertensive surges triggered by physical activity. Imaging revealed a left adrenal tumor, which showed intense radiopharmaceutical uptake on 131I-metaiodobenzylguanidine ([131I]MIBG) scintigraphy. Urinary analysis of metanephrines confirmed pheochromocytoma, and laparoscopic left-sided adrenalectomy was performed. Owing to the large tumor size, intraoperative fragmentation was necessary for removal. The patient remained asymptomatic for five years. In 2016, recurrent paroxysmal symptoms prompted imaging, revealing a lesion at the left renal hilum. During the reoperation in 2017, multiple peritoneal tumor deposits were observed and later confirmed histologically. Over the following years, the patient received conservative, symptomatic treatment with tolerable paroxysmal symptoms. In 2023, worsening symptoms led to the decision to commence three cycles of ([131I]MIBG) therapy, followed by alleviation of symptoms, and a decrease in biochemical parameters.DiscussionAn extensive literature search for publications from the past 25 years identified 22 pheochromocytomatosis cases whose details were also summarized and analyzed. This condition appears to have a longer recurrence-free survival compared to patients’ cohorts with metastatic pheochromocytomas. Pheochromocytomatosis is usually characterized by a prolonged asymptomatic postsurgical interval, emphasizing the need for long-term follow-up with close biochemical and radiological surveillance. Treatment strategies parallel those used for advanced/metastatic pheochromocytomas. LA - English DB - MTMT ER - TY - JOUR AU - Réti, Zsuzsanna AU - Tabák, Ádám AU - Garami, Miklós AU - Kalina, Ildikó AU - Kiss, Gergely AU - Sápi, Zoltán AU - Tóth, Miklós AU - Tőke, Judit TI - Spontaneous and Treatment-Related Changes of Serum Calcitonin in Medullary Thyroid Cancer: Long-Term Experience in a Patient With Multiple Endocrine Neoplasia Type 2B JF - JCO PRECISION ONCOLOGY J2 - JCO PRECIS ONCOL VL - 8 PY - 2024 PG - 7 SN - 2473-4284 DO - 10.1200/PO.23.00675 UR - https://m2.mtmt.hu/api/publication/34844873 ID - 34844873 N1 - Z.R. and A.G.T. contributed equally to this work. LA - English DB - MTMT ER - TY - JOUR AU - Bényei, Erik AU - Tőke, Judit AU - Huszty, Gergely AU - Borka, Katalin AU - Sápi, Zoltán AU - Jakab, Zsuzsanna AU - Kiss, Gergely AU - Kalina, Ildikó AU - Reismann, Péter AU - Uhlyarik, Andrea AU - Igaz, Péter AU - Tóth, Miklós TI - Clinical utility of S-GRAS prognostic system in adrenocortical carcinomas: confirmatory results from a single-centre institutional registry JF - ENDOCRINE ABSTRACTS J2 - ENDOCR ABSTR VL - 99 PY - 2024 SN - 1470-3947 DO - 10.1530/endoabs.99.EP254 UR - https://m2.mtmt.hu/api/publication/34863484 ID - 34863484 LA - English DB - MTMT ER - TY - JOUR AU - Kövesdi, Annamária AU - Tőke, Judit AU - Eitler, Katalin AU - Kiss, Gergely AU - Nyilas, Nóra Luca AU - Scheich, Bálint AU - Tóth, Miklós TI - A peculiar case of ectopic ACTH-syndrome - multiple challenges during diagnostic and therapeutic workup JF - ENDOCRINE ABSTRACTS J2 - ENDOCR ABSTR VL - 99 PY - 2024 SN - 1470-3947 DO - 10.1530/endoabs.99.P529 UR - https://m2.mtmt.hu/api/publication/35596764 ID - 35596764 LA - English DB - MTMT ER - TY - JOUR AU - Papp, Zsombor Mátyás AU - Szakács, László AU - Hajivandi, Shayan-Salehi AU - Kalina, Ildikó AU - Varga, Edit AU - Kiss, Gergely AU - Solymos, Ferenc AU - Takács, István AU - Dank, Magdolna AU - Dudás, Ibolyka AU - Szanka, Tímea AU - Dózsa, Csaba AU - Rékassy, Balázs AU - Merkely, Béla Péter AU - Maurovich-Horvat, Pál TI - Impact of a Targeted Project for Shortening of Imaging Diagnostic Waiting Time in Patients with Suspected Oncological Diseases in Hungary JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 59 PY - 2023 IS - 1 PG - 10 SN - 1010-660X DO - 10.3390/medicina59010153 UR - https://m2.mtmt.hu/api/publication/33559989 ID - 33559989 N1 - Funding Agency and Grant Number: Budapest Municipality; Semmelweis University, Budapest, Hungary Funding text: This research was funded by the Healthy Budapest Program (HBP), specifically based on an agreement between the Budapest Municipality and Semmelweis University, Budapest, Hungary, signed on 20 October 2020. AB - Background and Objectives: Medical imaging is a key element in the clinical workup of patients with suspected oncological disease. In Hungary, due to the high number of patients, waiting lists for Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) were created some years ago. The Municipality of Budapest and Semmelweis University signed a cooperation agreement with an extra budget in 2020 (HBP: Healthy Budapest Program) to reduce the waiting lists for these patients. The aim of our study was to analyze the impact of the first experiences with the HBP. Material and Methods: The study database included all the CT/MRI examinations conducted at Semmelweis University with a referral diagnosis of suspected oncological disease within the first 13 months of the HBP (6804 cases). In our retrospective, two-armed, comparative clinical study, different components of the waiting times in the oncology diagnostics pathway were analyzed. Using propensity score matching, we compared the data of the HBP-funded patients (n = 450) to those of the patients with regular care provided by the National Health Insurance Fund (NHIF) (n = 450). Results: In the HBP-funded vs. the NHIF-funded patients, the time interval from the first suspicion of oncological disease to the request for imaging examinations was on average 15.2 days shorter (16.1 vs. 31.3 days), and the mean waiting time for the CT/MRI examination was reduced by 13.0 days (4.2 vs. 17.2 days, respectively). In addition, the imaging medical records were prepared on average 1.7 days faster for the HBP-funded patients than for the NHIF-funded patients (3.4 vs. 5.1 days, respectively). No further shortening of the different time intervals during the subsequent oncology diagnostic pathway (histological investigation and multidisciplinary team decision) or in the starting of specific oncological therapy (surgery, irradiation, and chemotherapy) was observed in the HBP-funded vs. the NHIF-funded patients. We identified a moderately strong negative correlation (r = −0.5736, p = 0.0350) between the CT/MR scans requested and the active COVID-19 case rates during the pandemic waves. Conclusion: The waiting lists for diagnostic CT/MR imaging can be effectively shortened with a targeted project, but a more comprehensive intervention is needed to shorten the time from the radiological diagnosis, through the decisions of the oncoteam, to the start of the oncological treatment. LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Gergely AU - Székely, Bálint AU - Farkas, Ádám Zoltán AU - Lénárd, Zsuzsanna Mária AU - Takács, Szabolcs AU - Kiss, Réka AU - Remport, Ádám AU - Végső, Gyula TI - Oncological Screening of Kidney Tumors After Renal Transplantation JF - TRANSPLANTATION PROCEEDINGS J2 - TRANSPLANT PROC VL - 54 PY - 2022 IS - 9 SP - 2589 EP - 2592 PG - 4 SN - 0041-1345 DO - 10.1016/j.transproceed.2022.10.047 UR - https://m2.mtmt.hu/api/publication/33257644 ID - 33257644 AB - Among renal transplant recipients, renal cell carcinoma in the native kidneys represents the most common solid tumor. At the Department of Surgery, Transplantation and Gastroenterology of Semmelweis University annual control abdominal ultrasound examination is recommended for transplant patients. Our goal was to evaluate the effectiveness of the ultrasound screening program at our institute and to learn about the characteristics of shrunken kidney tumors.Retrospectively, we processed the results of abdominal and pelvic ultrasound examinations of 1687 kidney transplant patients, which were performed at our institute between January 1, 2012 and December 31, 2016.A total of 26 tumors were detected during the abovementioned period of time, of which 18 were renal cancers. Renal cancer was significantly (P = 0.029) more common in men. Seventeen renal cancers were classified as stage I and one as stage IV disease. The mean time of dialysis was 37.73 ± 24.37 months. The mean time between kidney transplantation and tumor recognition was 7.9 ± 6.29 years. The 5-year survival was 66%; however, it should be noted that only 1 patient lost his life due to his tumor disease. The mean time between the last 2 ultrasound examinations was 27.8 ± 23.89 months. Only 57% of tumors were detected by screening. No significant differences in tumor size, stage, and survival could be detected between screened and nonscreened renal cancer patients.Ultrasound examination at least every 2 years is an effective tool for the early detection of renal cell carcinoma of the shrunken kidneys. LA - English DB - MTMT ER - TY - THES AU - Kiss, Gergely TI - A vesetranszplantált betegek tumoros rizikófaktorainak felmérése, a nem működő, sajátvese-daganatok szűrésének problematikája PY - 2022 DO - 10.14753/SE.2022.2610 UR - https://m2.mtmt.hu/api/publication/33722358 ID - 33722358 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kuzmanovszki, Daniella AU - Kiss, Norbert AU - Tóth, Béla AU - Tóth, Veronika AU - Szakonyi, József AU - Hársing, Judit AU - Imrédi, Eleonóra AU - Lőrincz, Kende Kálmán AU - Kerner, Tünde Zsuzsanna AU - Doros, Attila AU - Offenbächer, Éva AU - Kiss, Gergely AU - Patyánik, Mihály AU - Wikonkál, Norbert AU - Holló, Péter TI - Az onkológiában alkalmazott immunterápiák bőrt érintő mellékhatásai JF - BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE J2 - BVSZ VL - 98 PY - 2022 IS - 5 SP - 264 EP - 274 PG - 11 SN - 0006-7768 DO - 10.7188/bvsz.2022.98.5.4 UR - https://m2.mtmt.hu/api/publication/34047751 ID - 34047751 AB - As the fifth pillar of antitumor treatment, immunotherapies have brought a significant breakthrough in oncology. Immune checkpoint inhibitors have been shown to be the most effective modality among immunotherapies by stimulating the antitumor activity of the patient’s immune system. Monoclonal antibodies such as inhibitors of cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), programmed cell death protein-1 (PD-1), and programmed cell death protein ligand (PD-L1) as immune checkpoint blockers (ICIs) have been approved in many solid tumors. In addition to the introduction of immunotherapies, immunerelated side effects must also be expected. Skin reactions are one of the leading adverse immune-mediated adverse events. Below, we describe the typical immune-mediated adverse reactions affecting the skin during immunotherapy used in oncology. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Farkas, Ádám Zoltán AU - Török, Szilárd AU - Kovács, János Balázs AU - Piros, László AU - Végső, Gyula AU - Kiss, Gergely AU - Korda, Dávid Ádám AU - Bibok, András AU - Hartmann, Erika AU - Deák, Pál Ákos AU - Doros, Attila TI - Diagnosis and Management of a De Novo Urothelial Carcinoma in a Kidney Allograft: A Case Report JF - TRANSPLANTATION PROCEEDINGS J2 - TRANSPLANT PROC VL - 51 PY - 2019 IS - 4 SP - 1281 EP - 1285 PG - 5 SN - 0041-1345 DO - 10.1016/j.transproceed.2019.04.011 UR - https://m2.mtmt.hu/api/publication/30685455 ID - 30685455 AB - Following renal transplantation, the incidence of malignancies is 3-5 times higher than that of healthy individuals. Among other type of cancers, the risk of urological tumors is also elevated. However, only a few cases of de novo transitional cell carcinomas occurring in renal allografts have been reported.A 63-year-old tertiary transplanted male patient was urgently hospitalized for a painless macroscopic hematuria. Ultrasonography revealed pyelectasis and a hematoma in the renal pelvis. A percutaneous nephrostomy tube was inserted. An anterograde pyelography was performed later, where a filling defect was still observable in the location of the previously reported hypoechoic mass. Contrast-enhanced ultrasonography showed enhancement of the lesion. An ultrasound-guided percutaneous biopsy was performed. The histologic evaluation revealed a high-grade transitional cell carcinoma. A whole-body staging computed tomography scan did not show signs of metastatic disease. The renal allograft was surgically removed. No disease progression was observed during the 21-month follow-up period.Painless hematuria and asymptomatic hydronephrosis occurring after kidney transplantation should raise the possibility of urothelial carcinoma in the kidney graft. Contrast-enhanced ultrasound should be considered as a first-line diagnostic modality because it is easily accessible and does not raise concerns about nephrotoxicity or radiation burden. LA - English DB - MTMT ER -