TY - JOUR AU - Koech, Peter Kiplang'at AU - Jócsák, Gergely AU - Boldizsár, Imre AU - Moldován, Kinga Réka AU - Borbély, Sándor AU - Világi, Ildikó AU - Dobolyi, Árpád AU - Varró, Petra TI - Anti-glutamatergic effects of three lignan compounds: arctigenin, matairesinol and trachelogenin - An ex vivo study on rat brain slices JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 89 PY - 2022 IS - 09 SP - 879 EP - 889 PG - 11 SN - 0032-0943 DO - 10.1055/a-2005-5497 UR - https://m2.mtmt.hu/api/publication/33615942 ID - 33615942 N1 - Department of Physiology and Neurobiology, Institute of Biology, Eötvös Loránd University, Budapest, Hungary Department of Physiology and Biochemistry, University of Veterinary Medicine, Budapest, Hungary Department of Plant Anatomy, Institute of Biology, Eötvös Loránd University, Budapest, Hungary Department of Pharmacognosy, Semmelweis University, Budapest, Hungary Neuronal Network and Behavior Research Group, Institute of Experimental Medicine, ELKH, Budapest, Hungary MTA-ELTE Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology, Eötvös Loránd University, The Hungarian Academy of Sciences, Budapest, Hungary Cited By :1 Export Date: 17 October 2023 CODEN: PLMEA Correspondence Address: Varró, P.; Department of Physiology and Neurobiology, Pázmány Péter sétány 1/C +, Hungary; email: varro.petra@ttk.elte.hu AB - Arctigenin is a bioactive dibenzylbutyrolactone-type lignan exhibiting various pharmacological activities. The neuroprotective effects of arctigenin were demonstrated to be mediated via inhibition of AMPA and KA type glutamate receptors in the somatosensory cortex of the rat brain. The aim of this study was to compare the effects of arctigenin with matairesinol and trachelogenin on synaptic activity in ex vivo rat brain slices. Arctigenin, matairesinol and trachelogenin were isolated from Arctium lappa, Centaurea scabiosa and Cirsium arvense, respectively, and applied on brain slices via perfusion medium at the concentration range of 0.5-40 µM. The effects of the lignans were examined in the CA1 hippocampus and the somatosensory cortex by recording electrically evoked field potentials. Arctigenin and trachelogenin caused a significant dose-dependent decrease in the amplitude of hippocampal population spikes (POPS) and the slope of excitatory postsynaptic potentials (EPSPs), whereas matairesinol (1 µM and 10 µM) decreased EPSP slope but had no effect on POPS amplitude. Trachelogenin effect (0.5 µM, 10 µM, 20 µM) was comparable to arctigenin (1 µM, 20 µM, 40 µM) (p ˃ 0.05). In the neocortex, arctigenin (10 µM, 20 µM) and trachelogenin (10 µM) significantly decreased the amplitude of evoked potential early component, while matairesinol (1 µM and 10 µM) had no significant effect (p>0.05). The results suggest that trachelogenin and arctigenin act via inhibition of AMPA and KA receptors in the brain and trachelogenin has a higher potency than arctigenin. Thus, trachelogenin and arctigenin could serve as lead compounds in the development of neuroprotective drugs. LA - English DB - MTMT ER - TY - JOUR AU - Bárány, Zoltán Balázs AU - Tóth, István AU - Jócsák, Gergely AU - Frenyó V., László AU - Bartha, Tibor AU - Sterczer, Ágnes AU - Kiss, Dávid Sándor TI - Differential production of interleukin‐6 and tumor necrosis factor‐α in primary rat astrocyte cultures using two distinct methods of microglia elimination JF - CLINICAL AND EXPERIMENTAL NEUROIMMUNOLOGY J2 - CLIN EXP NEUROIMMUNOLOGY VL - 12 PY - 2021 IS - 3 SP - 192 EP - 201 PG - 10 SN - 1759-1961 DO - 10.1111/cen3.12650 UR - https://m2.mtmt.hu/api/publication/32475357 ID - 32475357 LA - English DB - MTMT ER - TY - JOUR AU - Kerek, Ádám AU - Bárány, Zoltán Balázs AU - Sterczer, Ágnes AU - Jócsák, Gergely TI - A neuroinflammáció kórfolyamata és egyes terápiás vonatkozásai : Irodalmi összefoglaló JF - MAGYAR ÁLLATORVOSOK LAPJA J2 - MAGY ALLATORVOSOK VL - 142 PY - 2020 IS - 12 SP - 755 EP - 767 PG - 13 SN - 0025-004X UR - https://m2.mtmt.hu/api/publication/31801333 ID - 31801333 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kiss, Dávid Sándor AU - Tóth, István AU - Jócsák, Gergely AU - Bárány, Zoltán Balázs AU - Bartha, Tibor AU - Frenyó V., László AU - Horvath, Tamas L. AU - Zsarnovszky, Attila TI - Functional Aspects of Hypothalamic Asymmetry JF - BRAIN SCIENCES J2 - BRAIN SCI VL - 10 PY - 2020 IS - 6 PG - 14 SN - 2076-3425 DO - 10.3390/brainsci10060389 UR - https://m2.mtmt.hu/api/publication/31399182 ID - 31399182 AB - Anatomically, the brain is a symmetric structure. However, growing evidence suggests that certain higher brain functions are regulated by only one of the otherwise duplicated (and symmetric) brain halves. Hemispheric specialization correlates with phylogeny supporting intellectual evolution by providing an ergonomic way of brain processing. The more complex the task, the higher are the benefits of the functional lateralization (all higher functions show some degree of lateralized task sharing). Functional asymmetry has been broadly studied in several brain areas with mirrored halves, such as the telencephalon, hippocampus, etc. Despite its paired structure, the hypothalamus has been generally considered as a functionally unpaired unit, nonetheless the regulation of a vast number of strongly interrelated homeostatic processes are attributed to this relatively small brain region. In this review, we collected all available knowledge supporting the hypothesis that a functional lateralization of the hypothalamus exists. We collected and discussed findings from previous studies that have demonstrated lateralized hypothalamic control of the reproductive functions and energy expenditure. Also, sporadic data claims the existence of a partial functional asymmetry in the regulation of the circadian rhythm, body temperature and circulatory functions. This hitherto neglected data highlights the likely high-level ergonomics provided by such functional asymmetry. LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Dávid Sándor AU - Tóth, István AU - Jócsák, Gergely AU - Bartha, Tibor AU - Frenyó V., László AU - Bárány, Zoltán Balázs AU - Horváth, Tamás AU - Zsarnovszky, Attila TI - Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States JF - REPRODUCTIVE SCIENCES J2 - REPROD SCI VL - 27 PY - 2020 IS - 5 SP - 1197 EP - 1205 PG - 9 SN - 1933-7191 DO - 10.1007/s43032-019-00131-3 UR - https://m2.mtmt.hu/api/publication/31260011 ID - 31260011 LA - English DB - MTMT ER - TY - JOUR AU - Jócsák, Gergely AU - Ioja, Enikő AU - Kiss, Dávid Sándor AU - Tóth, István AU - Bárány, Zoltán Balázs AU - Bartha, Tibor AU - Frenyó V., László AU - Zsarnovszky, Attila TI - Endocrine Disruptors Induced Distinct Expression of Thyroid and Estrogen Receptors in Rat versus Mouse Primary Cerebellar Cell Cultures JF - BRAIN SCIENCES J2 - BRAIN SCI VL - 9 PY - 2019 IS - 12 PG - 19 SN - 2076-3425 DO - 10.3390/brainsci9120359 UR - https://m2.mtmt.hu/api/publication/31194217 ID - 31194217 LA - English DB - MTMT ER - TY - CHAP AU - Bárány, Zoltán Balázs AU - Kiss, Dávid Sándor AU - Tóth, István AU - Jócsák, Gergely AU - Frenyó V., László AU - Bartha, Tibor Zsarnovszky Attila AU - Sterczer, Ágnes ED - Sótonyi, Péter ED - Gálfi, Péter ED - Vörös, Károly ED - Magyar, Tibor TI - Az oxidatív stressz és a tumor nekrózis faktor alfa (TNF-alfa) -termelés vizsgálata hepatikus encephalopathiában T2 - Akadémiai beszámolók PB - Állatorvostudományi Egyetem CY - Budapest SN - 9789637149290 T3 - Akadémiai beszámolók PY - 2019 SP - 8 PG - 1 UR - https://m2.mtmt.hu/api/publication/30659394 ID - 30659394 LA - Hungarian DB - MTMT ER - TY - GEN AU - Jócsák, Gergely AU - Kiss, Dávid Sándor AU - Tóth, István AU - Bárány, Zoltán Balázs AU - Frenyó V., László AU - Bartha, Tibor AU - Zsarnovszky, Attila TI - Az endokrin diszruptorkezelés indukálta ösztrogén- és pajzsmirigyhormon receptor expressziós változások összehasonlítása patkány és egér modellben ET - 0 PY - 2019 UR - https://m2.mtmt.hu/api/publication/30412858 ID - 30412858 N1 - Akadémiai beszámoló LA - Hungarian DB - MTMT ER - TY - GEN AU - Bárány, Zoltán Balázs AU - Kiss, Dávid Sándor AU - Tóth, István AU - Jócsák, Gergely AU - Frenyó V., László AU - Bartha, Tibor AU - Zsarnovszky, Attila AU - Sterczer, Ágnes TI - Az oxidatív stressz és a tumor nekrózis faktor alfa (TNF-α)-termelés vizsgálata hepaticus encephalopathiaban ET - 0 PY - 2019 UR - https://m2.mtmt.hu/api/publication/30412856 ID - 30412856 N1 - Akadémiai beszámoló LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bárány, Zoltán Balázs AU - Kiss, Dávid Sándor AU - Tóth, István AU - Jócsák, Gergely AU - Bartha, Tibor AU - Frenyó V., László AU - Zsarnovszky, Attila AU - Sterczer, Ágnes TI - Examination of the oxidative stress and the tumor necrosis factor (tnf)-α-production in hepatic encephalopathy JF - GLIA J2 - GLIA VL - 67 PY - 2019 IS - S1 SP - E549 EP - E550 PG - 2 SN - 0894-1491 UR - https://m2.mtmt.hu/api/publication/30412849 ID - 30412849 LA - English DB - MTMT ER -