TY - JOUR AU - Matusovits, Danica AU - Murlasits, Zsolt AU - Kupai, Krisztina AU - Baráth, Zoltán Lajos AU - Hsu, Linkang AU - Osváth, Péter AU - Szűcs, Miklós AU - Priksz, Dániel AU - Juhász, Béla AU - Radák, Zsolt AU - Várkonyi, Tamás AU - Pávó, Imre AU - Pósa, Anikó TI - Paclitaxel Protects against Isoproterenol-Induced Damage in Rat Myocardium: Its Heme-Oxygenase Mediated Role in Cardiovascular Research JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 12 PY - 2023 IS - 5 PG - 13 SN - 2076-3921 DO - 10.3390/antiox12051129 UR - https://m2.mtmt.hu/api/publication/33856409 ID - 33856409 N1 - Megosztott első szerzőség AB - (1) Background: In cardiovascular applications, paclitaxel inhibits smooth muscle cell proliferation and migration and significantly reduces the occurrence of restenosis and target lesion revascularization. However, the cellular effects of paclitaxel in the myocardium are not well understood; (2) Methods: Wistar rats were divided into four groups: control (CTRL), isoproterenol (ISO) treated (1 mg/kg) and two groups treated with paclitaxel (PAC), which was administrated (10 mg/kg/day) for 5 days by gavage/per os alone or in combination (ISO + PAC) 3 weeks after ISO treatment. Ventricular tissue was harvested 24 h later for measurements of heme oxygenase (HO-1), reduced glutathione (GSH), oxidized glutathione (GSSG), superoxide dismutase (SOD), NF-κB, TNF-α and myeloperoxidase (MPO); (3) Results: HO-1 protein concentration, HO-1 activity, SOD protein concentration and total glutathione significantly decreased in response to ISO treatment. When PAC was administered in conjunction with ISO, HO-1, SOD concentration and total glutathione were not different from control levels. MPO activity, NF-κB concentration and TNF-α protein concentration were significantly increased in the ISO-only group, while the levels of these molecules were restored when PAC was co-administered; (4) Conclusions: Oral administration of PAC can maintain the expression of important antioxidants, anti-inflammatory molecules, HO-1, SOD and GSH, and suppress the production of TNF-α, MPO and NF-κB, which are involved in myocardial damage. The principal component of this cellular defense seems to be the expression of HO-1. LA - English DB - MTMT ER - TY - JOUR AU - Park, J.-S. AU - Murlasits, Zsolt AU - Kim, S. TI - The Effect of Aerobic Exercise on Variation of Oxidative Stress, hs-CRP and Cortisol Induced by Sleep Deficiency JF - HEALTHCARE J2 - HEALTHCARE-BASEL VL - 11 PY - 2023 IS - 8 PG - 15 SN - 2227-9032 DO - 10.3390/healthcare11081201 UR - https://m2.mtmt.hu/api/publication/33824973 ID - 33824973 LA - English DB - MTMT ER - TY - JOUR AU - Murlasits, Zsolt AU - László, Szilárd AU - Prókai, Judit AU - Sebesi, Balázs AU - Scherer, J. AU - Tóvári, Ferenc AU - Atlasz, Tamás AU - Tovari, A. AU - Katona, Máté AU - Cselkó, Alexandra AU - Petrovics, Péter AU - Balázs, Bence AU - Váczi, Márk TI - Physiological responses to an incremental swim test with different breathing frequencies in competitive male youth swimmers JF - JOURNAL OF PHYSICAL EDUCATION AND SPORT J2 - J PHYS EDUCATION SPORT VL - 23 PY - 2023 IS - 3 SP - 697 EP - 703 PG - 7 SN - 2247-8051 DO - 10.7752/jpes.2023.03086 UR - https://m2.mtmt.hu/api/publication/33802696 ID - 33802696 LA - English DB - MTMT ER - TY - JOUR AU - Prókai, Judit AU - Murlasits, Zsolt AU - Bánhidi, Miklós AU - Csóka, László AU - Gréci, Viktória AU - Atlasz, Tamás AU - Váczi, Márk TI - The Effects of a 12-Week-Long Sand Exercise Training Program on Neuromechanical and Functional Parameters in Type II Diabetic Patients with Neuropathy JF - INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH J2 - INT J ENV RES PUB HE VL - 20 PY - 2023 IS - 7 PG - 12 SN - 1661-7827 DO - 10.3390/ijerph20075413 UR - https://m2.mtmt.hu/api/publication/33754869 ID - 33754869 N1 - * Megosztott szerzőség AB - Studies have proven the effectiveness of different weight-bearing exercise interventions for diabetic patients with neuropathy; however, several adverse effects were reported using solid surfaces. Thus, in the present study, we investigated the effects of a novel sand exercise training intervention on biomechanical and functional parameters in seven diabetic patients (age = 62.7 ± 9.7 years) with neuropathy. Patients underwent a 12-week sand exercise training program, using strengthening, stretching, balance, and gait exercises. They were tested for ankle plantar- and dorsiflexion peak torque, active range of motion (ROM), timed up and go (TUG), and bilateral static balance. EMG activity of tibialis anterior (TA), gastrocnemius medialis (GM), and lateralis (GL) muscles were measured during unilateral isometric contraction in plantar- and dorsiflexion. In the intervention period, plantarflexion peak torque improved significantly (p = 0.033), while dorsiflexion torque remained unchanged. Plantar- and dorsiflexion ROM increased (p = 0.032) and (p = 0.021), respectively. EMG activity of GM (p = 0.005) and GL (p = 0.002) measured during dorsiflexion and postural sway in the balance test, as well as time to complete the TUG test, decreased significantly (p = 0.021) and (p = 0.002), respectively. No adverse effect was reported during the intervention period. We concluded that sand exercise training can be a safe and effective method to improve plantarflexion strength, ankle flexibility, and balance, which is reflected in better gait function in patients with diabetic peripheral neuropathy (DPN). LA - English DB - MTMT ER - TY - JOUR AU - Vadász, Kitty AU - Varga, Mátyás AU - Sebesi, Balázs AU - Hortobágyi, Tibor AU - Murlasits, Zsolt AU - Atlasz, Tamás AU - Fésüs, Ádám AU - Váczi, Márk TI - Frontal Plane Neurokinematic Mechanisms Stabilizing the Knee and the Pelvis during Unilateral Countermovement Jump in Young Trained Males JF - INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH J2 - INT J ENV RES PUB HE VL - 20 PY - 2023 IS - 1 SN - 1661-7827 DO - 10.3390/ijerph20010220 UR - https://m2.mtmt.hu/api/publication/33567314 ID - 33567314 AB - (1) The unilateral countermovement jump is commonly used to examine frontal plane kinetics during unilateral loading and to identify athletes with an increased risk of lower limb injuries. In the present study, we examined the biomechanical mechanisms of knee and pelvis stabilization during unilateral vertical jumps. (2) Healthy males performed jumps on a force plate with the dominant leg. Activity of the dominant-side gluteus medius and the contralateral-side quadratus lumborum and erector spinae muscles was recorded with surface EMG. The EMG data were normalized to the EMG activity recorded during maximal voluntary isometric hip abduction and lateral trunk flexion contractions. During jumps, the propulsive impulse was measured, and the pelvis and thigh segmental orientation angles in the frontal plane were recorded and synchronized with the EMG data. (3) The magnitude of knee valgus during the jump did not correlate with hip abduction force, but negatively correlated with gluteus medius activity. This correlation became stronger when gluteus medius activity was normalized to hip abduction force. Propulsive impulse did not correlate with any neuromechanical measurement. (4) We conclude that hip abduction force itself does not regulate the magnitude of knee valgus during unilateral jumps; rather, the gluteus medius should be highly activated to increase frontal-plane knee joint stability. LA - English DB - MTMT ER - TY - JOUR AU - Murlasits, Zsolt AU - Kupai, Krisztina AU - Kneffel, Zsuzsanna TI - Role of physical activity and cardiorespiratory fitness in metabolically healthy obesity: a narrative review JF - BMJ OPEN SPORT & EXCERCISE MEDICINE J2 - BMJ OPEN SPORT EXCERC MED VL - 8 PY - 2022 IS - 4 PG - 7 SN - 2055-7647 DO - 10.1136/bmjsem-2022-001458 UR - https://m2.mtmt.hu/api/publication/33316600 ID - 33316600 N1 - Accepted November 23, 2022 First published December 5, 2022. Online issue publication December 05, 2022 AB - Obesity has been associated with a multitude of metabolic disorders, often clustering with risk factors of cardiovascular disease and type 2 diabetes mellitus, hypertension, dyslipidaemia. Overall, obesity is a worldwide, growing health concern. However, a subgroup of obese individuals with a low burden of metabolic abnormalities have been identified and described as metabolically healthy obese (MHO). Whether the MHO phenotype is protective against obesity-related metabolic disorders in the long-term is presently unclear, and current research examining the potential transition has yielded inconsistent results. In this current narrative review, we aim to provide insights on the role of physical activity (PA) and cardiorespiratory fitness (CRF) in MHO. Lifestyle factors such as PA and CRF may influence the MHO phenotype. Limited studies have characterised energy expenditure and CRF in MHO and metabolically unhealthy obese. However, higher levels of PA, less sedentary behaviour and higher CRF have been observed in MHO individuals. Considering the multiple benefits of PA, it is high time to advocate this lifestyle change beyond its influence on energy balance in a weight loss programme to improve cardiovascular and metabolic risk factors irrespective of body weight and fat mass changes. Improved CRF via increased PA, especially exercise participation, while avoiding weight gain is not only a realistic goal, but should be the primary intervention for MHO populations to prevent the transition to an abnormal metabolic state. LA - English DB - MTMT ER - TY - JOUR AU - Kneffel, Zsuzsanna AU - Murlasits, Zsolt TI - Sztatin-használat és inaktív életmód: csökkenti-e a sztatinok használata a fizikai aktivitási szintet kardiovaszkuláris rizikóval rendelkezőkben? JF - MAGYAR SPORTTUDOMÁNYI SZEMLE J2 - M SPORTTUD SZLE VL - 23 PY - 2022 IS - 2 (96) SP - 57 EP - 57 PG - 1 SN - 1586-5428 UR - https://m2.mtmt.hu/api/publication/32887418 ID - 32887418 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Gáspár, Balázs AU - Fésüs, Ádám AU - Ivusza, Patrik AU - Varga, Mátyás AU - Tar, Sarolta AU - Sebesi, Balázs AU - Murlasits, Zsolt AU - Váczi, Márk ED - Prisztóka, Gyöngyvér ED - Kertai, Bendegúz TI - Ismert és váratlan ellenállás alkalmazásának krónikus hatása a quadriceps femoris izom propriocepciójára és erőkifejtésének szabályozására = The chronic effects of predetermined and random application of resistance on quadriceps femoris proprioception and force control T2 - XX. Szentágothai János Mutidiszciplináris Konferencia és Hallgatói Verseny Absztrakt kötet = XX. János Szentágothai Multidisciplinary Conference and Student Competition PB - PTE TTK Szentágothai János Szakkollégium, Tehetségpont és Egyesület CY - Pécs SN - 9789634299554 PY - 2022 SP - 281 EP - 282 PG - 2 UR - https://m2.mtmt.hu/api/publication/32831817 ID - 32831817 LA - English DB - MTMT ER - TY - CONF AU - Kneffel, Zsuzsanna AU - Murlasits, Zsolt AU - Reedc, Jacob AU - Kriegerd, James TI - The Effects of Resistance Training Frequency on Muscular Strength and Hypertrophy in Elderly T2 - IV. Sport és Innováció Nemzetközi Konferencia, SPORTINNO 2021: Programfüzet absztraktokkal PB - Testnevelési Egyetem C1 - Budapest PY - 2021 SP - 80 EP - 81 PG - 2 UR - https://m2.mtmt.hu/api/publication/32234804 ID - 32234804 LA - English DB - MTMT ER - TY - JOUR AU - Almási, Nikoletta AU - Murlasits, Zsolt AU - Al-Awar, Amin AU - Csonka, Ákos AU - Dvorácskó, Szabolcs AU - Tömböly, Csaba AU - Török, Szilvia AU - Bester, D. AU - Pósa, Anikó AU - Varga, Csaba AU - Kupai, Krisztina TI - Effects of aging on proteasomal-ubiquitin system, oxidative stress balance and calcium homeostasis in middle-aged female rat colon JF - PHYSIOLOGY INTERNATIONAL J2 - PHYSIOL INT VL - 108 PY - 2021 IS - 1 SP - 27 EP - 42 PG - 16 SN - 2498-602X DO - 10.1556/2060.2021.00012 UR - https://m2.mtmt.hu/api/publication/32128211 ID - 32128211 N1 - Funding Agency and Grant Number: Ministry of Human Capacities, Hungarian grant [GINOP2.3.215201600030]; [203913/2018/FEKUSTRAT] Funding text: This research was supported by GINOP2.3.215201600030 and Ministry of Human Capacities, Hungarian grant 203913/2018/FEKUSTRAT. LA - English DB - MTMT ER -