TY - JOUR AU - Fekete, Klára AU - Héja, Máté AU - Márton, Sándor József AU - Tóth, Judit AU - Horváth, László AU - Harman, Aletta Andrea AU - Fekete, István TI - Predictors and long-term outcome of intracranial hemorrhage after thrombolytic therapy for acute ischemic stroke : A prospective single center study JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 14 PY - 2023 IS - 1 SN - 1664-2295 DO - 10.3389/fneur.2023.1080046 UR - https://m2.mtmt.hu/api/publication/33577682 ID - 33577682 AB - Introduction: Acute ischemic stroke (AIS) is a potentially devastating disease with high disability and mortality. Recombinant tissue plasminogen activator (rt-PA) is an effective treatment with a 2–8% possible risk for symptomatic intracranial hemorrhage (sICH). Our aim was to investigate the risk factors and long-term clinical outcomes of ICH in patients after rt-PA treatment. Methods: Consecutive patients with AIS, thrombolysed at the Department of Neurology, University of Debrecen, between 1 January 2004 and 31 August 2016 were enrolled prospectively. Risk factors, stroke severity based on the National Institute of Health Stroke Scale (NIHSS), functional outcome using the modified Rankin scale, and mortality at 1 year were compared in patients with and without ICH following rt-PA treatment. We evaluated clinical characteristics and prognosis by hemorrhage type based on the Heidelberg Bleeding Classification. Descriptive statistics, the chi-square test, the Mann–Whitney U-test, ANOVA, the Kruskal–Wallis test, a survival analysis, and logistic regression were performed as appropriate. Results: Out of 1,252 patients with thrombolysis, ICH developed in 138 patients, with 37 (2.95%) being symptomatic. Mean ages in the ICH and non-ICH groups differed significantly (p = 0.041). On admission, the 24-h NIHSS after thrombolysis was higher in patients with ICH (p < 0.0001). Large vessel occlusion was more prevalent in patients with ICH (p = 0.0095). The ICH risk was lower after intravenous thrombolysis than intra-arterial or combined thrombolysis (p < 0.0001). Both at 3 months and 1 year, the outcome was worse in patients with ICH compared to patients without ICH group (p < 0.0001). Mortality and poor outcome were more prevalent in all hemorrhage types with a tendency for massive bleeding associated with unfavorable prognosis. At 3 months with the logistic regression model, the worse outcome was detected in patients with ICH after thrombolysis, at 1 year in patients with ICH after thrombolysis and smoking. Discussion: Older age, higher NIHSS, large vessel occlusion, and intra-arterial thrombolysis may correlate with ICH. The unfavorable outcome is more common in patients with ICH. Precise scoring of post-thrombolysis bleeding might be a useful tool in the evaluation of the patient's prognosis. Our findings may help to identify predictors and estimate the prognosis of ICH in patients with AIS treated with rt-PA. Copyright © 2023 LA - English DB - MTMT ER - TY - CHAP AU - Bencze, Zsuzsa AU - Kovalecz, Gabriella AU - Márton, Sándor József AU - Gáll, Tibor AU - Nour, Mahrouseha AU - Varga, Orsolya TI - A gyermekkori fogszuvasodás prevenciója az Európai Unióban - a finanszírozás tagállami sajátosságai T2 - XXII. Debreceni Fogászati Napok PB - Debreceni Egyetem CY - Debrecen SN - 9789634904250 PY - 2022 SP - 37 UR - https://m2.mtmt.hu/api/publication/33340608 ID - 33340608 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Girgis, Michael Magdy Fahmy AU - Fekete, Klára AU - Homoródi, Nóra AU - Márton, Sándor József AU - Fekete, István AU - Horváth, László TI - Use of Complementary and Alternative Medicine Among Patients With Epilepsy and Diabetes Mellitus, Focusing on the Outcome of Treatment JF - FRONTIERS IN NEUROSCIENCE J2 - FRONT NEUROSCI-SWITZ VL - 15 PY - 2022 SN - 1662-4548 DO - 10.3389/fnins.2021.787512 UR - https://m2.mtmt.hu/api/publication/32593397 ID - 32593397 AB - Introduction: Millions all over the world live with epilepsy, and they may require long-term drug treatment. The use and interest in complementary and alternative medicine (CAM) have grown over the previous years. Coadministration of herbal products with medicines may result in adverse drug reactions (ADRs) and/or unfavorable interactions. The aims of this study were to determine the prevalence of CAM use among patients with epilepsy, to compare the results to those of the patients with diabetes mellitus (DM), to reveal factors that may drive the use of CAM, and to measure outcomes and adherence. It was also our intent to have state-of-the-art information on CAM use in our region among patients with the two diseases above.Materials and Methods: We conducted a non-interventional study using a self-developed questionnaire. It was distributed among adult patients with either epilepsy or DM who also suffered from cardiovascular consequences. A database was compiled from the anonymous questionnaires filled in voluntarily by the patients. Basic statistics were used to analyze this database.Results: A total of 227 questionnaires were filled in by 127 patients (55.9%) with epilepsy and 100 patients (44.1%) with DM. Mean age was 54.54 +/- 17.33 years. Of the patients, 50.2% were male. Average body weight was 80.3 +/- 17.3 kg. Of the patients, 22 (9.7%) used CAM because they believed in CAM. Two of them reported ADRs. Among the patients with epilepsy, the ratio was only 7.9% compared to 12% among those with DM. While the number of CAM users was higher among younger patients with epilepsy, it was the elderly patients with DM who tended to use CAM.Conclusion: Attention should be paid to reliance on CAM during the follow-up. Our finding that health-conscious patients tend to use CAM more often (than the general population) may indicate it is necessary to discuss CAM usage sincerely. CAMs modulating cytochrome P450 (CYP) enzymes were the most common, leading to interactions with medication used and resulting in ADRs. This shows the importance of educating patients and treating team including clinical pharmacists in this field. LA - English DB - MTMT ER - TY - JOUR AU - Fekete, Klára AU - Tóth, Judit AU - Horváth, László AU - Márton, Sándor József AU - Héja, Máté AU - Csiba, László AU - Árokszállási, Tamás AU - Bagoly, Zsuzsa AU - Sulina, Dóra AU - Fekete, István TI - Neurophysiological examinations as adjunctive tool to imaging techniques in spontaneous intracerebral hemorrhage: IRONHEART study JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 12 PY - 2021 PG - 15 SN - 1664-2295 DO - 10.3389/fneur.2021.757078 UR - https://m2.mtmt.hu/api/publication/32246000 ID - 32246000 N1 - 321942 LA - English DB - MTMT ER - TY - JOUR AU - Héja, Máté AU - Fekete, István AU - Horváth, László AU - Márton, Sándor József AU - Fekete, Klára TI - Experiences With Intravenous Thrombolysis in Acute Ischemic Stroke by Elderly Patients–A “Real World Scenario” JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 12 PY - 2021 SN - 1664-2295 DO - 10.3389/fneur.2021.721337 UR - https://m2.mtmt.hu/api/publication/32196282 ID - 32196282 AB - Objectives: This retrospective single-center study aimed to investigate the risk factors, outcomes and complication rates in patients older vs. younger than 80 years treated with intravenous alteplase. Methods: Data of 1,253 thrombolysed patients were analyzed between January 1, 2004 and August 31, 2016. Vascular risk factors, stroke severity based on the NIHSS score, functional outcome using modified Rankin Scale (mRS), mortality and symptomatic intracerebral hemorrhage (SICH) were compared between two subgroups (<80 and >= 80 years). Results: 1,125 patients were included, 199 (17.6%) among them were aged over 80 years, majority (63.3%) were female (p < 0.00001). Mean age was 68.2 +/- 12.4 years, i.e., 64.7 +/- 10.8 years and 84.3 +/- 3.4 years in the younger and the older groups, respectively (p < 0.001). Atrial fibrillation and pre-stroke anticoagulation among patients over 80 years was more likely (p < 0.0005 and p = 0.02, respectively). NIHSS scores on admission and at 24 h were higher in elderly patients (p < 0.0001). ASPECT score at 24 h was less favorable in elderly patients (p = 0.007) and was associated with worse outcome. At 3 months, 59.8% of the patients from the older group had an unfavorable outcome (p < 0.0001), however 34.7% had independent outcome. The one-year- survival was significantly worse in the older group (p < 0.0001). The incidence of SICH was lower among older patients. In a logistic regression model, atrial fibrillation, heart failure, diabetes mellitus and smoking were proven as a significant independent risk factors for worse outcome. Conclusion: Although, the outcomes were less favorable in patients over 80 years of age, our results support the feasibility of using intravenous thrombolysis among patients over 80 years of age. LA - English DB - MTMT ER - TY - JOUR AU - Bencze, Zsuzsa AU - Kovalecz, Gabriella AU - Márton, Sándor József AU - Gáll, Tibor AU - Mahrouseh, Nour AU - Varga, Orsolya TI - Childhood caries management in the European Union: a cross-sectional study JF - HELIYON J2 - HELIYON VL - 7 PY - 2021 IS - 2 PG - 10 SN - 2405-8440 DO - 10.1016/j.heliyon.2021.e06198 UR - https://m2.mtmt.hu/api/publication/31890938 ID - 31890938 N1 - 302204 LA - English DB - MTMT ER - TY - CONF AU - Csoba, Judit AU - Márton, Sándor József AU - Murányi, István ED - Magyar, Szociológiai Társaság TI - Társadalmi tudatosság és identitásreprezentációk a 15-25 év közötti fiatalok körében T2 - Meghatározottságaink PB - Magyar Szociológiai Társaság C1 - Budapest PY - 2020 SP - 15 EP - 16 PG - 2 UR - https://m2.mtmt.hu/api/publication/31795067 ID - 31795067 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Horváth, László AU - Fekete, István AU - Márton, Sándor József AU - Fekete, Klára TI - The choice of antiepileptic drug treatment after status epilepticus JF - EUROPEAN JOURNAL OF HOSPITAL PHARMACY-SCIENCE AND PRACTICE J2 - EUR J HOSP PHARM SCI PRACT VL - 26 PY - 2019 IS - Suppl.1. SP - A149 SN - 2047-9956 DO - 10.1136/ejhpharm-2019-eahpconf.320 UR - https://m2.mtmt.hu/api/publication/31176835 ID - 31176835 N1 - 271398 LA - English DB - MTMT ER - TY - JOUR AU - Horváth, László AU - Fekete, István AU - Molnar, Mark AU - Válóczy, Réka AU - Márton, Sándor József AU - Fekete, Klára TI - The Outcome of Status Epilepticus and Long-Term Follow-Up JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 10 PY - 2019 PG - 8 SN - 1664-2295 DO - 10.3389/fneur.2019.00427 UR - https://m2.mtmt.hu/api/publication/30992532 ID - 30992532 AB - Objective: This study was to investigate the outcome of status epilepticus (SE) associated with antiepileptic therapy during SE and in follow-up period, risk factors including age, co-morbidities, pre-existing epilepsy, and etiology in the East-Hungarian region.Methods: A prospective cross-sectional database was compiled from outpatient files between 2013 and 2017. Follow-up ended on 30.06.2018.Results: One hundred and thirty five episodes (male: 68, 50.4%) were evaluated, mean age and follow-up time being 64.1 +/- 13.9 years and 39.9 +/- 14.2 months, respectively. Of the 89 patients with pre-existing epilepsy, 34 failed to visit the outpatient unit regularly. Case fatality rate was 25.2% and 31 patients (30.7%) died after discharge due to co-morbidities; their mean survival time was 10.44 +/- 8 months. Focal, generalized and combined type epilepsies were diagnosed in 67 patients (49.6%), 47 patients (34.8%), and 21 patients (15.6%) of SE, respectively. Nine patients had non-convulsive SE (NCSE). Mean seizure-free period was 6.8 +/- 6.9 months. Patients taking carbamazepine (20.9%; OR: 0.37, 95% CI: 0.16-0.82; p = 0.018), levetiracetam (27.5%; OR: 0.51, 95% CI: 0.27-0.97; p = 0.041), or valproate (11.1%; OR: 0.18, 95% CI: 0.05-0.61; p = 0.0043) were expected to achieve seizure freedom after SE. The worst outcome was linked to advanced age, etiology, new onset status epilepticus, NCSE, and focal status epilepsy.Conclusion: This study highlights the importance of regular care and patient follow-up. LA - English DB - MTMT ER - TY - JOUR AU - Márkus, Edina AU - Teperics, Károly AU - Márton, Sándor József TI - A tanuló közösségek vizsgálata - módszertani háttér JF - KULTÚRA ÉS KÖZÖSSÉG J2 - KULTÚRA ÉS KÖZÖSSÉG VL - 10 PY - 2019 IS - 1 SP - 21 EP - 26 PG - 6 SN - 0133-2597 DO - 10.35402/kek.2019.1.3 UR - https://m2.mtmt.hu/api/publication/30706525 ID - 30706525 AB - Tanulmányunkban arra vállalkozunk, hogy a Közösségi tanulás és társadalmi innováció kutatásunk módszertani hátterét bemutassuk. A kutatás keretében azt vizsgáljuk, hogy milyen szerepe van a tanulásnak, a felnőttek tanulásának, a közösségi tanulásnak a hátrányok leküzdésében. A közösség a hátrányos helyzetből milyen utakon, módokon keresheti a kitörést? A tanulás hogyan járul hozzá egy településrész, település, térség fejlesztéséhez, felzárkóztatásához; kisebb-nagyobb közösség átalakulásához, hogyan jelenik meg benne az egymástól tanulás, tudásátadás (tanuló közösségek)? Hogyan jelenik meg valamilyen közösségi alapú, együttműködésen alapuló újdonság, társadalmi újítás? Társadalmi újítás alatt Bradford (2004), Ferguson (2017), Kozma (2018) megközelítéséhez hasonlóan olyan új társadalmi tevékenységet értünk, amely egy probléma megoldását célozza, miközben új társadalmi magatartásokat, attitűdöket alakít ki. A tanulmányban a vizsgálat módszereit, vizsgálati szempontjait mutatjuk be. LA - Hungarian DB - MTMT ER -