@article{MTMT:32718790,
	title = {Population snapshot of the extended-spectrum beta-lactamase-producing Escherichia coli invasive strains isolated from a Hungarian hospital},
	url = {https://m2.mtmt.hu/api/publication/32718790},
	author = {Tóth, Kinga and Tóth, Ákos and Kamotsay, Katalin and Nemeth, Viktoria and Szabó, Dóra},
	doi = {10.1186/s12941-022-00493-8},
	journal-iso = {ANN CLIN MICROB ANTI},
	journal = {ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS},
	volume = {21},
	unique-id = {32718790},
	abstract = {Background: This study was carried out to determine the prevalence and the genetic background of extended-spectrum beta-lactamase-producing Escherichia coli invasive isolates obtained from a tertiary-care hospital in Budapest, Hungary. Methods: Between October-November 2018, all invasive ESBL-producing E. coli isolates were collected from Central Hospital of Southern Pest. The antimicrobial susceptibility testing was performed according to the EUCAST guidelines. The possible clonal relationships were investigated by core genome (cg)MLST (SeqSphere +) using whole-genome sequencing (WGS) data of isolates obtained from Illumina 251-bp paired-end sequencing. From WGS data acquired antimicrobial resistance genes, virulence genes and replicon types were retrieved using ResFinder3.1, PlasmidFinder2.1, pMLST-2.0, VirulenceFinder2.0 and Virulence Factors Database online tools. Results: Overall, six E. coli isolates proved to be resistant to third-generation cephalosporins and ESBL-producers in the study period. Full genome sequence analysis showed that five E. coli isolates belonged to the ST131 clone: two to C1-M27 subclade with bla(CTX-M-27) and three to C2/H30Rx subclade with bla(CTX-M-15). One isolate belonged to ST1193 with bla(CTX-M-27). According to cgMLST, all C2/H30Rx isolates formed a cluster (<= 6 allele differences), while the bla(CTX-M-27)-producing C1-M27 isolates differed at least 35 alleles from each other. Both C2/H30Rx and C1-M27 ST131 isolates harbored similar antimicrobial resistance gene sets. However, only C2/H30Rx isolates had the qnrB and aac(3)-IIa. The isolates carried similar extraintestinal virulence gene set but differed in some genes encoding siderophores, protectins and toxins. Moreover, only one C2/H30Rx isolate carried salmochelin siderophore system and showed virotype B. All isolates showed resistance against ceftriaxone, cefotaxime, and ciprofloxacin, and the C2/H30Rx isolates were also resistant to gentamicin, tobramycin, and ceftazidime. Conclusions: Out of six ESBL-producing E. coli, five belonged to the ST131 clone. This study indicates, that the C2/H30Rx and C1-M27 subclades of the ST131 appear to be the dominant clones collected in a Hungarian hospital.},
	keywords = {CLONES; Virulence; Escherichia coli; Infections; TRENDS; Molecular Epidemiology; RESISTANT; ST131; ST131; extended-spectrum beta-lactamase; bla(CTX-M-27); C1-M27},
	year = {2022},
	eissn = {1476-0711},
	orcid-numbers = {Tóth, Kinga/0000-0002-6352-777X; Szabó, Dóra/0000-0002-8601-3923}
}

@article{MTMT:32606927,
	title = {Comparison of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolates From Rooks (Corvus frugilegus) and Contemporary Human-Derived Strains: A One Health Perspective},
	url = {https://m2.mtmt.hu/api/publication/32606927},
	author = {Nagy, József Bálint and Balázs, Bence and BENMAZOUZ, ISMA and Gyüre, Péter and Kövér, László and Kaszab, Eszter and Bali, Krisztina and Lovas-Kiss, Ádám and Damjanova, Ivelina and Majoros, László and Tóth, Ákos and Bányai, Krisztián and Kardos, Gábor},
	doi = {10.3389/fmicb.2021.785411},
	journal-iso = {FRONT MICROBIOL},
	journal = {FRONTIERS IN MICROBIOLOGY},
	volume = {12},
	unique-id = {32606927},
	issn = {1664-302X},
	abstract = {During winter, a large number of rooks gather and defecate at the park of a university clinic. We investigated the prevalence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in these birds and compared recovered isolates with contemporary human isolates. In 2016, fecal samples were collected from 112 trap-captured rooks and investigated for presence of ESBL producers using eosin methylene blue agar supplemented by 2 mg/L cefotaxime; 2,455 contemporary human fecal samples of patients of the clinics sent for routine culturing were tested similarly. In addition, 42 ESBL-producing E. coli isolates collected during the same period from inpatients were also studied. ESBL genes were sought for by PCR and were characterized by sequencing; E. coli ST131 clones were identified. Epidemiological relatedness was determined by pulsed-field gel electrophoresis and confirmed using whole genome sequencing in selected cases. Thirty-seven (33%) of sampled rooks and 42 (1.7%) of human stools yielded ESBL-producing E coli. Dominant genes were bla(CTX-M-55) and bla(CTX-M-27) in corvid, bla(CTX-M-15) and bla(CTX-M-27) in human isolates. ST162 was common among rooks. Two rook-derived E. coli belonged to ST131 C1-M27, which was also predominant (10/42) among human fecal and (15/42) human clinical isolates. Another potential link between rooks and humans was a single ST744 rook isolate grouped with one human fecal and three clinical isolates. Despite possible contact, genotypes shared between rooks and humans were rare. Thus, rooks are important as long-distance vectors and reservoirs of ESBL-producing E. coli rather than direct sources of infections to humans in our setting.},
	year = {2022},
	eissn = {1664-302X}
}

@misc{MTMT:32829192,
	title = {Investigation of carbapenemase-producing Enterobacterales in black-headed gulls (Chroicocephalus ridibundus) and the River Danube},
	url = {https://m2.mtmt.hu/api/publication/32829192},
	author = {Nagy, József Bálint and Balázs, KOLESZÁR and Bence, BALÁZS and Róka, Eszter and Khayer, Bernadett and Tóth, Ákos and Erika, UNGVÁRI and Gábor, KARDOS},
	unique-id = {32829192},
	year = {2021},
	orcid-numbers = {Khayer, Bernadett/0000-0003-3484-9232}
}

@article{MTMT:31921035,
	title = {The influence of antibiotics on transitory resistome during gut colonization with CTX-M-15 and OXA-162 producing Klebsiella pneumoniae ST15},
	url = {https://m2.mtmt.hu/api/publication/31921035},
	author = {Stercz, Balázs and Farkas, Ferenc Balázs and Tóth, Ákos and Gajdács, Márió and Domokos, Judit and Horváth, Viola and Ostorházi, Eszter and Makra, Nóra and Kocsis, Béla and Juhász, János and Ligeti, Balázs and Pongor, Sándor and Szabó, Dóra},
	doi = {10.1038/s41598-021-85766-6},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {11},
	unique-id = {31921035},
	issn = {2045-2322},
	year = {2021},
	eissn = {2045-2322},
	orcid-numbers = {Stercz, Balázs/0000-0002-9585-8397; Gajdács, Márió/0000-0003-1270-0365; Domokos, Judit/0000-0002-0238-105X; Horváth, Viola/0000-0003-1014-7930; Ostorházi, Eszter/0000-0002-9459-7316; Kocsis, Béla/0000-0002-7067-7055; Szabó, Dóra/0000-0002-8601-3923}
}

@article{MTMT:31903338,
	title = {Colonization Dynamics of Multidrug-Resistant Klebsiella pneumoniae Are Dictated by Microbiota-Cluster Group Behavior over Individual Antibiotic Susceptibility: A Metataxonomic Analysis},
	url = {https://m2.mtmt.hu/api/publication/31903338},
	author = {Juhász, János and Ligeti, Balázs and Gajdács, Márió and Makra, Nóra and Ostorházi, Eszter and Farkas, Ferenc Balázs and Stercz, Balázs and Tóth, Ákos and Domokos, Judit and Pongor, Sándor and Szabó, Dóra},
	doi = {10.3390/antibiotics10030268},
	journal-iso = {ANTIBIOTICS-BASEL},
	journal = {ANTIBIOTICS},
	volume = {10},
	unique-id = {31903338},
	year = {2021},
	eissn = {2079-6382},
	orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Ostorházi, Eszter/0000-0002-9459-7316; Stercz, Balázs/0000-0002-9585-8397; Domokos, Judit/0000-0002-0238-105X; Szabó, Dóra/0000-0002-8601-3923}
}

@article{MTMT:31837646,
	title = {The Role of Uniform Meropenem Usage in Acinetobacter baumannii Clone Replacement},
	url = {https://m2.mtmt.hu/api/publication/31837646},
	author = {Balázs, Bence and Tóth, Zoltán and Nagy, Fruzsina and Kovács, Renátó and Tóth, Hajnalka and Nagy, József Bálint and Tóth, Ákos and Szarka, Krisztina Zsuzsanna and Majoros, László and Kardos, Gábor},
	doi = {10.3390/antibiotics10020127},
	journal-iso = {ANTIBIOTICS-BASEL},
	journal = {ANTIBIOTICS},
	volume = {10},
	unique-id = {31837646},
	abstract = {The dominant carbapenem resistant Acinetobacter baumannii harboring bla(OXA-23-like) carbapenemase was replaced by bla(OXA-40-like) carriers in a Hungarian tertiary-care center with high meropenem but relatively low imipenem use. We hypothesized that alterations in antibiotic consumption may have contributed to this switch. Our workgroup previous study examined the relation between resistance spiral and the antibiotic consumption, and the results suggest that the antibiotic usage provoked the increasing resistance in case of A. baumannii. We aimed at measuring the activity of imipenem and meropenem to compare the selection pressure exerted by the different carbapenems in time-kill assays. Strain replacement was confirmed by whole genome sequencing, core-genome multilocus sequence typing (cgMLST), and resistome analysis. Based on results of the time-kill assays, we found a significant difference between two different sequence-types (STs) in case of meropenem, but not in case of imipenem susceptibility. The newly emerged ST636 and ST492 had increased resistance level against meropenem compared to the previously dominant ST2 and ST49. On the other hand, the imipenem and colistin resistance profiles were similar. These results suggest, that the uniform meropenem usage may have contributed to A. baumannii strain replacement in our setting.},
	keywords = {multidrug resistance; Acinetobacter baumannii; clonal dynamics; Strain replacement; changepoint analysis; carbapenem resistant; blaOXA-23-like-carbapenemase; BlaOXA-40-like carbapenemase},
	year = {2021},
	eissn = {2079-6382},
	orcid-numbers = {Kovács, Renátó/0000-0003-3946-2424}
}

@CONFERENCE{MTMT:32006607,
	title = {Comparison of inpatient-care antibiotic consumption patterns in three Hungarian tertiary-care university hospitals},
	url = {https://m2.mtmt.hu/api/publication/32006607},
	author = {Gábor, Kardos and Tóth, Ákos and Benkő, Ria and Kristóf, Katalin and Ivelina, Damjanova and Erika, Ungvári and Judit, Pászti and Bence, Balázs and Nagy, József Bálint and Hajnalka, Tóth and Matuz, Mária},
	booktitle = {European Drug Utilisation Research Group Conference 2020},
	unique-id = {32006607},
	year = {2020},
	pages = {78-78},
	orcid-numbers = {Benkő, Ria/0000-0002-8009-8962; Kristóf, Katalin/0000-0002-5189-4636; Matuz, Mária/0000-0002-7877-2399}
}

@article{MTMT:31679098,
	title = {Detection of VIM, NDM and OXA-48 producing carbapenem resistant Enterobacterales among clinical isolates in Southern Hungary},
	url = {https://m2.mtmt.hu/api/publication/31679098},
	author = {Gajdács, Márió and Pappné Ábrók, Marianna and Lázár, Andrea and Jánvári, Laura and Tóth, Ákos and Terhes, Gabriella and Burián, Katalin},
	doi = {10.1556/030.2020.01181},
	journal-iso = {ACTA MICROBIOL IMMUNOL HUNG},
	journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA},
	volume = {67},
	unique-id = {31679098},
	issn = {1217-8950},
	year = {2020},
	eissn = {1588-2640},
	pages = {209-215},
	orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Pappné Ábrók, Marianna/0000-0002-9812-4778; Terhes, Gabriella/0000-0002-7301-9672; Burián, Katalin/0000-0003-1300-2374}
}

@article{MTMT:31408959,
	title = {Streptococcus suis: An Underestimated Emerging Pathogen in Hungary?},
	url = {https://m2.mtmt.hu/api/publication/31408959},
	author = {Gajdács, Márió and Németh, Anita and Knausz, Márta and Barrak, Ibrahim Ádám and Stájer, Anette and Mestyán, Gyula and Melegh, Szilvia Zsóka and Nyul, Adrienn and Tóth, Ákos and Ágoston, Zsuzsanna and Zsoldiné Urbán, Edit},
	doi = {10.3390/microorganisms8091292},
	journal-iso = {MICROORGANISMS},
	journal = {MICROORGANISMS},
	volume = {8},
	unique-id = {31408959},
	issn = {2076-2607},
	year = {2020},
	eissn = {2076-2607},
	orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Barrak, Ibrahim Ádám/0000-0001-8808-1762; Stájer, Anette/0000-0003-4158-173X; Zsoldiné Urbán, Edit/0000-0002-9602-7552}
}

@article{MTMT:31362524,
	title = {Characterization of a rare blaVIM-4 metallo-β-lactamase-producing Serratia marcescens clinical isolate in Hungary. [case report]},
	url = {https://m2.mtmt.hu/api/publication/31362524},
	author = {Tóth, Ákos and Makai, Attila and Jánvári, Laura and Damjanova, Ivelina and Gajdács, Márió and Zsoldiné Urbán, Edit},
	doi = {10.1016/j.heliyon.2020.e04231},
	journal-iso = {HELIYON},
	journal = {HELIYON},
	volume = {6},
	unique-id = {31362524},
	year = {2020},
	eissn = {2405-8440},
	orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Zsoldiné Urbán, Edit/0000-0002-9602-7552}
}