TY  - JOUR
AU  - Kovács, Kitti Bernadett
AU  - Bencs, Viktor
AU  - Hudák, Lilla
AU  - Oláh, László
AU  - Csiba, László
TI  - Hemorrhagic Transformation of Ischemic Strokes
JF  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
J2  - INT J MOL SCI
VL  - 24
PY  - 2023
IS  - 18
PG  - 20
SN  - 1661-6596
DO  - 10.3390/ijms241814067
UR  - https://m2.mtmt.hu/api/publication/34238940
ID  - 34238940
AB  - Ischemic stroke, resulting from insufficient blood supply to the brain, is among the leading causes of death and disability worldwide. A potentially severe complication of the disease itself or its treatment aiming to restore optimal blood flow is hemorrhagic transformation (HT) increasing morbidity and mortality. Detailed summaries can be found in the literature on the pathophysiological background of hemorrhagic transformation, the potential clinical risk factors increasing its chance, and the different biomarkers expected to help in its prediction and clinical outcome. Clinicopathological studies also contribute to the improvement in our knowledge of hemorrhagic transformation. We summarized the clinical risk factors of the hemorrhagic transformation of ischemic strokes in terms of risk reduction and collected the most promising biomarkers in the field. Also, auxiliary treatment options in reperfusion therapies have been reviewed and collected. We highlighted that the optimal timing of revascularization treatment for carefully selected patients and the individualized management of underlying diseases and comorbidities are pivotal. Another important conclusion is that a more intense clinical follow-up including serial cranial CTs for selected patients can be recommended, as clinicopathological investigations have shown HT to be much more common than clinically suspected.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Árokszállási, Tamás
AU  - Héja, Máté
AU  - Bagoly, Zsuzsa
AU  - Kovács, Kitti Bernadett
AU  - Orbán-Kálmándi, Rita Angéla
AU  - Sarkady, Ferenc
AU  - Tóth, Judit
AU  - Fekete, Klára
AU  - Fekete, István
AU  - Csiba, László
TI  - Prognostic value of various hemostasis parameters and neurophysiological examinations in spontaneous intracerebral hemorrhage: the IRONHEART study protocol
JF  - FRONTIERS IN NEUROLOGY
J2  - FRONT NEUR
VL  - 12
PY  - 2021
PG  - 6
SN  - 1664-2295
DO  - 10.3389/fneur.2021.615177
UR  - https://m2.mtmt.hu/api/publication/31997174
ID  - 31997174
AB  - Rationale: Stroke is the leading cause of death in all developed countries. In Hungary, more than 10000 patients die annually due to cerebrovascular diseases according to the WHO Mortality Database. 10-15 % of these patients suffer non-traumatic intracerebral hemorrhage (ICH). ICH results in a higher rate of mortality as compared to ischemic stroke and outcomes are difficult to predict. In the GINOP IRONHEART study, we aim to test various hemostasis parameters and clinical neurophysiological examinations in evaluating outcome in intracerebral haemorrhage. Methods: In this prospective, observational study, we plan to enroll consecutive patients with non-traumatic spontaneous intracerebral hemorrhage admitted to a single Stroke Center (Department of Neurology, University of Debrecen, Hungary). The protocol of the GINOP IRONHEART study includes the investigation of detailed clinical, laboratory investigations, and various neurophysiological examiniations. Stroke severity is quantified based on the National Institutes of Health Stroke Scale (NIHSS) on admisson and day 7, 14, 90 after the onset of stroke. Cranial CT is performed on admission, day 14, and 90 to estimate the ICH volume. Modified Rankin Score (mRS) is used for evaluating the long-term outcome (90 days post-event). Blood is drawn immediately on admission for specific hemostasis tests. Digital and quantitative EEG techniques and motor evoked potential (MEP) are performed to evaluate the prognosis of cerebral hemorrhage on admission (within 24-28h), immediately before discharge (??10?14 days later), and 3 months after the event. Outcomes: The following outcomes are investigated: 1/ Mortality by day 14 and day 90 2/ Long-term outcome at 90 days post-event: mRS 0-1 is defined as favorable long-term outcome. Discussion: If associations between outcomes and the investigated parameters (hemostasis and neurophysiological examinations) are confirmed, results might aid prognosis assessment in this subtype of stroke with particularly high mortality. Improving clinical grading systems on ICH severity and outcomes by including the investigated parameters could help to better guide the management of these patients in the future.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bagoly, Zsuzsa
AU  - Hajas, Orsolya
AU  - Urbancsek, Réka
AU  - Kiss, Alexandra
AU  - Fiak, Edit
AU  - Sarkady, Ferenc
AU  - Tóth, Noémi Klára
AU  - Orbán-Kálmándi, Rita Angéla
AU  - Kovács, Kitti Bernadett
AU  - Nagy, László Tibor
AU  - Nagy, Attila Csaba
AU  - Kappelmayer, János
AU  - Csiba, László
AU  - Csanádi, Zoltán
TI  - Uninterrupted Dabigatran Administration Provides Greater Inhibition against Intracardiac Activation of Hemostasis as Compared to Vitamin K Antagonists during Cryoballoon Catheter Ablation of Atrial Fibrillation
JF  - JOURNAL OF CLINICAL MEDICINE
J2  - J CLIN MED
VL  - 9
PY  - 2020
IS  - 9
PG  - 13
SN  - 2077-0383
DO  - 10.3390/jcm9093050
UR  - https://m2.mtmt.hu/api/publication/31610168
ID  - 31610168
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hajas, Orsolya
AU  - Bagoly, Zsuzsa
AU  - Tóth, Noémi Klára
AU  - Urbancsek, Réka
AU  - Kiss, Alexandra
AU  - Kovács, Kitti Bernadett
AU  - Sarkady, Ferenc
AU  - Nagy, Attila Csaba
AU  - Vargáné Oláh, Anna
AU  - Nagy, László Tibor
AU  - Clemens, Marcell
AU  - Csiba, László
AU  - Csanádi, Zoltán
TI  - Intracardiac Fibrinolysis and Endothelium Activation Related to Atrial Fibrillation Ablation with Different Techniques
JF  - CARDIOLOGY RESEARCH AND PRACTICE
J2  - CARDIOL RES PRAC
VL  - 2020
PY  - 2020
PG  - 8
SN  - 2090-0597
DO  - 10.1155/2020/1570483
UR  - https://m2.mtmt.hu/api/publication/31143304
ID  - 31143304
N1  - 281437
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Selmeczi, Anna
AU  - Gindele, Réka
AU  - Ilonczai, Péter
AU  - Fekete, Attila
AU  - Komáromi, István
AU  - Schlammadinger, Ágota
AU  - Rázsó, Katalin
AU  - Kovács, Kitti Bernadett
AU  - Bárdos, Helga
AU  - Ádány, Róza
AU  - Muszbek, László
AU  - Bereczky, Zsuzsanna
AU  - Boda, Zoltán
AU  - Oláh, Zsolt
TI  - Antithrombin Debrecen (p.Leu205Pro) - Clinical and molecular characterization of a novel mutation associated with severe thrombotic tendency
JF  - THROMBOSIS RESEARCH
J2  - THROMB RES
VL  - 158
PY  - 2017
SP  - 1
EP  - 7
PG  - 7
SN  - 0049-3848
DO  - 10.1016/j.thromres.2017.07.023
UR  - https://m2.mtmt.hu/api/publication/3321701
ID  - 3321701
N1  - 116228, OTKA, Országos Tudományos Kutatási Alapprogramok
OTKA K-106294, OTKA, Országos Tudományos Kutatási Alapprogramok
PD101120, OTKA, Országos Tudományos Kutatási Alapprogramok
ÚNKP-16, Emberi Eroforrások Minisztériuma
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tóth, Noémi Klára
AU  - Csanádi, Zoltán
AU  - Hajas, Orsolya
AU  - Kiss, Alexandra
AU  - Nagy-Baló, Edina
AU  - Kovács, Kitti Bernadett
AU  - Sarkady, Ferenc
AU  - Muszbek, László
AU  - Bereczky, Zsuzsanna
AU  - Csiba, László
AU  - Bagoly, Zsuzsa
TI  - Intracardiac hemostasis and fibrinolysis parameters in patients with atrial fibrillation
JF  - BIOMED RESEARCH INTERNATIONAL
J2  - BIOMED RES INT
VL  - 2017
PY  - 2017
PG  - 10
SN  - 2314-6133
DO  - 10.1155/2017/3678017
UR  - https://m2.mtmt.hu/api/publication/3227929
ID  - 3227929
LA  - English
DB  - MTMT
ER  - 

TY  - THES
AU  - Kovács, Kitti Bernadett
TI  - Ritka öröklött hemosztázis rendellenességek molekuláris genetikai és fehérje biokémiai vizsgálata
PY  - 2015
UR  - https://m2.mtmt.hu/api/publication/2974160
ID  - 2974160
N1  - Tudományág: klinikai orvostudományok
Témavezető: Bereczky Zsuzsanna
Beadás éve: 2015
A védés időpontja: 2015-05-26 13:00
A fokozat odaítélésének dátuma: 2015-06-15

Debreceni Egyetem, Laki Kálmán Doktori Iskola
Debrecen, Magyarország
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kovács, Kitti Bernadett
AU  - Pataki, István
AU  - Bárdos, Helga
AU  - Fekete, Attila
AU  - Pfliegler, György
AU  - Haramura, Gizella
AU  - Gindele, Réka
AU  - Komáromi, István
AU  - Balla, György
AU  - Ádány, Róza
AU  - Muszbek, László
AU  - Bereczky, Zsuzsanna
TI  - Molecular characterization of p.Asp77Gly and the novel p.Ala163Val and p.Ala163Glu mutations causing protein C deficiency
JF  - THROMBOSIS RESEARCH
J2  - THROMB RES
VL  - 135
PY  - 2015
IS  - 4
SP  - 718
EP  - 726
PG  - 9
SN  - 0049-3848
DO  - 10.1016/j.thromres.2015.01.011
UR  - https://m2.mtmt.hu/api/publication/2816945
ID  - 2816945
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Katona, Éva
AU  - Muszbek, László
AU  - Devreese, K
AU  - Kovács, Kitti Bernadett
AU  - Bereczky, Zsuzsanna
AU  - Jonkers, M
AU  - Shemirani, Amir Houshang
AU  - Mondelaers, V
AU  - Ermens, AAM
TI  - Factor XIII deficiency: complete phenotypic characterization of two cases with novel causative mutations
JF  - HAEMOPHILIA
J2  - HAEMOPHILIA
VL  - 20
PY  - 2014
IS  - 1
SP  - 114
EP  - 120
PG  - 7
SN  - 1351-8216
DO  - 10.1111/hae.12267
UR  - https://m2.mtmt.hu/api/publication/2515572
ID  - 2515572
N1  - Megjegyzés-23700690
N1 Molecular Sequence Numbers: GENBANK: NG_008107;
AB  - Coagulation factor XIII (FXIII) exists as heterotetramer (FXIII-A(2)B(2)) in the plasma and as dimer (FXIII-A(2)) in cells. Activated FXIII mechanically stabilizes fibrin and protects it from fibrinolysis by cross-linking fibrin chains and (2)-plasmin inhibitor to fibrin. FXIII is essential to maintaining haemostasis, and its deficiency causes severe bleeding diathesis. Due to improper laboratory practices, FXIII deficiency is considered the most under-diagnosed bleeding disorder. The aim of this study was to demonstrate in two cases how FXIII deficiency is properly diagnosed and classified, and to compare results of laboratory analysis and clinical symptoms. FXIII activity from plasma and platelets was measured by a modified ammonia release assay, while FXIII-A(2)B(2), FXIII-A and FXIII-B antigens were determined by ELISA. The exon-intron boundaries and the promoter region of F13A1 gene were amplified by PCR and the amplified products were analysed by direct fluorescent sequencing. FXIII-A mRNA in platelets was determined by RT-qPCR. Two children with severe bleeding symptoms were investigated. In both cases FXIII activity and FXIII-A antigen were undetectable in the plasma and platelet lysate. In the plasma no FXIII-A(2)B(2) antigen was found, while FXIII-B antigen was >30% in both cases. Proband1 was a compound heterozygote possessing a known missense mutation (c.980G>A, p.Arg326Gln) and a novel splice-site mutation (c.1112+2T>C). Proband2 was homozygote for a novel single nucleotide deletion (c.212delA) leading to early stop codon. The discovered mutations explain the severity of clinical symptoms and the laboratory data. Methods precise in the low activity/antigen range are required to draw valid conclusion on phenotype-genotype relationship.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bereczky, Zsuzsanna
AU  - Kovács, Kitti Bernadett
AU  - Muszbek, László
TI  - Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game
JF  - CLINICAL CHEMISTRY AND LABORATORY MEDICINE
J2  - CLIN CHEM LAB MED
VL  - 48
PY  - 2010
IS  - S1
SP  - S53
EP  - S66
SN  - 1434-6621
DO  - 10.1515/CCLM.2010.369
UR  - https://m2.mtmt.hu/api/publication/1450128
ID  - 1450128
LA  - English
DB  - MTMT
ER  -