@article{MTMT:34238940, title = {Hemorrhagic Transformation of Ischemic Strokes}, url = {https://m2.mtmt.hu/api/publication/34238940}, author = {Kovács, Kitti Bernadett and Bencs, Viktor and Hudák, Lilla and Oláh, László and Csiba, László}, doi = {10.3390/ijms241814067}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34238940}, issn = {1661-6596}, abstract = {Ischemic stroke, resulting from insufficient blood supply to the brain, is among the leading causes of death and disability worldwide. A potentially severe complication of the disease itself or its treatment aiming to restore optimal blood flow is hemorrhagic transformation (HT) increasing morbidity and mortality. Detailed summaries can be found in the literature on the pathophysiological background of hemorrhagic transformation, the potential clinical risk factors increasing its chance, and the different biomarkers expected to help in its prediction and clinical outcome. Clinicopathological studies also contribute to the improvement in our knowledge of hemorrhagic transformation. We summarized the clinical risk factors of the hemorrhagic transformation of ischemic strokes in terms of risk reduction and collected the most promising biomarkers in the field. Also, auxiliary treatment options in reperfusion therapies have been reviewed and collected. We highlighted that the optimal timing of revascularization treatment for carefully selected patients and the individualized management of underlying diseases and comorbidities are pivotal. Another important conclusion is that a more intense clinical follow-up including serial cranial CTs for selected patients can be recommended, as clinicopathological investigations have shown HT to be much more common than clinically suspected.}, keywords = {PATHOPHYSIOLOGY; Biomarkers; ischemic stroke; HEMORRHAGIC TRANSFORMATION; antithrombotic treatment; Clinical risk factors; clinicopathological studies}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Kovács, Kitti Bernadett/0000-0003-1781-2390} } @article{MTMT:31997174, title = {Prognostic value of various hemostasis parameters and neurophysiological examinations in spontaneous intracerebral hemorrhage: the IRONHEART study protocol}, url = {https://m2.mtmt.hu/api/publication/31997174}, author = {Árokszállási, Tamás and Héja, Máté and Bagoly, Zsuzsa and Kovács, Kitti Bernadett and Orbán-Kálmándi, Rita Angéla and Sarkady, Ferenc and Tóth, Judit and Fekete, Klára and Fekete, István and Csiba, László}, doi = {10.3389/fneur.2021.615177}, journal-iso = {FRONT NEUR}, journal = {FRONTIERS IN NEUROLOGY}, volume = {12}, unique-id = {31997174}, issn = {1664-2295}, abstract = {Rationale: Stroke is the leading cause of death in all developed countries. In Hungary, more than 10000 patients die annually due to cerebrovascular diseases according to the WHO Mortality Database. 10-15 % of these patients suffer non-traumatic intracerebral hemorrhage (ICH). ICH results in a higher rate of mortality as compared to ischemic stroke and outcomes are difficult to predict. In the GINOP IRONHEART study, we aim to test various hemostasis parameters and clinical neurophysiological examinations in evaluating outcome in intracerebral haemorrhage. Methods: In this prospective, observational study, we plan to enroll consecutive patients with non-traumatic spontaneous intracerebral hemorrhage admitted to a single Stroke Center (Department of Neurology, University of Debrecen, Hungary). The protocol of the GINOP IRONHEART study includes the investigation of detailed clinical, laboratory investigations, and various neurophysiological examiniations. Stroke severity is quantified based on the National Institutes of Health Stroke Scale (NIHSS) on admisson and day 7, 14, 90 after the onset of stroke. Cranial CT is performed on admission, day 14, and 90 to estimate the ICH volume. Modified Rankin Score (mRS) is used for evaluating the long-term outcome (90 days post-event). Blood is drawn immediately on admission for specific hemostasis tests. Digital and quantitative EEG techniques and motor evoked potential (MEP) are performed to evaluate the prognosis of cerebral hemorrhage on admission (within 24-28h), immediately before discharge (??10?14 days later), and 3 months after the event. Outcomes: The following outcomes are investigated: 1/ Mortality by day 14 and day 90 2/ Long-term outcome at 90 days post-event: mRS 0-1 is defined as favorable long-term outcome. Discussion: If associations between outcomes and the investigated parameters (hemostasis and neurophysiological examinations) are confirmed, results might aid prognosis assessment in this subtype of stroke with particularly high mortality. Improving clinical grading systems on ICH severity and outcomes by including the investigated parameters could help to better guide the management of these patients in the future.}, year = {2021}, eissn = {1664-2295}, orcid-numbers = {Bagoly, Zsuzsa/0000-0001-5314-5607; Kovács, Kitti Bernadett/0000-0003-1781-2390; Orbán-Kálmándi, Rita Angéla/0000-0002-2155-8279} } @article{MTMT:31610168, title = {Uninterrupted Dabigatran Administration Provides Greater Inhibition against Intracardiac Activation of Hemostasis as Compared to Vitamin K Antagonists during Cryoballoon Catheter Ablation of Atrial Fibrillation}, url = {https://m2.mtmt.hu/api/publication/31610168}, author = {Bagoly, Zsuzsa and Hajas, Orsolya and Urbancsek, Réka and Kiss, Alexandra and Fiak, Edit and Sarkady, Ferenc and Tóth, Noémi Klára and Orbán-Kálmándi, Rita Angéla and Kovács, Kitti Bernadett and Nagy, László Tibor and Nagy, Attila Csaba and Kappelmayer, János and Csiba, László and Csanádi, Zoltán}, doi = {10.3390/jcm9093050}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {9}, unique-id = {31610168}, year = {2020}, eissn = {2077-0383}, orcid-numbers = {Bagoly, Zsuzsa/0000-0001-5314-5607; Orbán-Kálmándi, Rita Angéla/0000-0002-2155-8279; Kovács, Kitti Bernadett/0000-0003-1781-2390; Nagy, Attila Csaba/0000-0002-0554-7350} } @article{MTMT:31143304, title = {Intracardiac Fibrinolysis and Endothelium Activation Related to Atrial Fibrillation Ablation with Different Techniques}, url = {https://m2.mtmt.hu/api/publication/31143304}, author = {Hajas, Orsolya and Bagoly, Zsuzsa and Tóth, Noémi Klára and Urbancsek, Réka and Kiss, Alexandra and Kovács, Kitti Bernadett and Sarkady, Ferenc and Nagy, Attila Csaba and Vargáné Oláh, Anna and Nagy, László Tibor and Clemens, Marcell and Csiba, László and Csanádi, Zoltán}, doi = {10.1155/2020/1570483}, journal-iso = {CARDIOL RES PRAC}, journal = {CARDIOLOGY RESEARCH AND PRACTICE}, volume = {2020}, unique-id = {31143304}, issn = {2090-0597}, year = {2020}, eissn = {2090-8016}, orcid-numbers = {Bagoly, Zsuzsa/0000-0001-5314-5607; Kovács, Kitti Bernadett/0000-0003-1781-2390; Nagy, Attila Csaba/0000-0002-0554-7350} } @article{MTMT:3321701, title = {Antithrombin Debrecen (p.Leu205Pro) - Clinical and molecular characterization of a novel mutation associated with severe thrombotic tendency}, url = {https://m2.mtmt.hu/api/publication/3321701}, author = {Selmeczi, Anna and Gindele, Réka and Ilonczai, Péter and Fekete, Attila and Komáromi, István and Schlammadinger, Ágota and Rázsó, Katalin and Kovács, Kitti Bernadett and Bárdos, Helga and Ádány, Róza and Muszbek, László and Bereczky, Zsuzsanna and Boda, Zoltán and Oláh, Zsolt}, doi = {10.1016/j.thromres.2017.07.023}, journal-iso = {THROMB RES}, journal = {THROMBOSIS RESEARCH}, volume = {158}, unique-id = {3321701}, issn = {0049-3848}, year = {2017}, eissn = {1879-2472}, pages = {1-7}, orcid-numbers = {Gindele, Réka/0000-0002-4145-3335; Kovács, Kitti Bernadett/0000-0003-1781-2390; Muszbek, László/0000-0002-3798-9962; Bereczky, Zsuzsanna/0000-0002-1483-3703} } @article{MTMT:3227929, title = {Intracardiac hemostasis and fibrinolysis parameters in patients with atrial fibrillation}, url = {https://m2.mtmt.hu/api/publication/3227929}, author = {Tóth, Noémi Klára and Csanádi, Zoltán and Hajas, Orsolya and Kiss, Alexandra and Nagy-Baló, Edina and Kovács, Kitti Bernadett and Sarkady, Ferenc and Muszbek, László and Bereczky, Zsuzsanna and Csiba, László and Bagoly, Zsuzsa}, doi = {10.1155/2017/3678017}, journal-iso = {BIOMED RES INT}, journal = {BIOMED RESEARCH INTERNATIONAL}, volume = {2017}, unique-id = {3227929}, issn = {2314-6133}, year = {2017}, eissn = {2314-6141}, orcid-numbers = {Kovács, Kitti Bernadett/0000-0003-1781-2390; Muszbek, László/0000-0002-3798-9962; Bereczky, Zsuzsanna/0000-0002-1483-3703; Bagoly, Zsuzsa/0000-0001-5314-5607} } @mastersthesis{MTMT:2974160, title = {Ritka öröklött hemosztázis rendellenességek molekuláris genetikai és fehérje biokémiai vizsgálata}, url = {https://m2.mtmt.hu/api/publication/2974160}, author = {Kovács, Kitti Bernadett}, unique-id = {2974160}, year = {2015}, orcid-numbers = {Kovács, Kitti Bernadett/0000-0003-1781-2390} } @article{MTMT:2816945, title = {Molecular characterization of p.Asp77Gly and the novel p.Ala163Val and p.Ala163Glu mutations causing protein C deficiency}, url = {https://m2.mtmt.hu/api/publication/2816945}, author = {Kovács, Kitti Bernadett and Pataki, István and Bárdos, Helga and Fekete, Attila and Pfliegler, György and Haramura, Gizella and Gindele, Réka and Komáromi, István and Balla, György and Ádány, Róza and Muszbek, László and Bereczky, Zsuzsanna}, doi = {10.1016/j.thromres.2015.01.011}, journal-iso = {THROMB RES}, journal = {THROMBOSIS RESEARCH}, volume = {135}, unique-id = {2816945}, issn = {0049-3848}, year = {2015}, eissn = {1879-2472}, pages = {718-726}, orcid-numbers = {Kovács, Kitti Bernadett/0000-0003-1781-2390; Gindele, Réka/0000-0002-4145-3335; Muszbek, László/0000-0002-3798-9962; Bereczky, Zsuzsanna/0000-0002-1483-3703} } @article{MTMT:2515572, title = {Factor XIII deficiency: complete phenotypic characterization of two cases with novel causative mutations}, url = {https://m2.mtmt.hu/api/publication/2515572}, author = {Katona, Éva and Muszbek, László and Devreese, K and Kovács, Kitti Bernadett and Bereczky, Zsuzsanna and Jonkers, M and Shemirani, Amir Houshang and Mondelaers, V and Ermens, AAM}, doi = {10.1111/hae.12267}, journal-iso = {HAEMOPHILIA}, journal = {HAEMOPHILIA}, volume = {20}, unique-id = {2515572}, issn = {1351-8216}, abstract = {Coagulation factor XIII (FXIII) exists as heterotetramer (FXIII-A(2)B(2)) in the plasma and as dimer (FXIII-A(2)) in cells. Activated FXIII mechanically stabilizes fibrin and protects it from fibrinolysis by cross-linking fibrin chains and (2)-plasmin inhibitor to fibrin. FXIII is essential to maintaining haemostasis, and its deficiency causes severe bleeding diathesis. Due to improper laboratory practices, FXIII deficiency is considered the most under-diagnosed bleeding disorder. The aim of this study was to demonstrate in two cases how FXIII deficiency is properly diagnosed and classified, and to compare results of laboratory analysis and clinical symptoms. FXIII activity from plasma and platelets was measured by a modified ammonia release assay, while FXIII-A(2)B(2), FXIII-A and FXIII-B antigens were determined by ELISA. The exon-intron boundaries and the promoter region of F13A1 gene were amplified by PCR and the amplified products were analysed by direct fluorescent sequencing. FXIII-A mRNA in platelets was determined by RT-qPCR. Two children with severe bleeding symptoms were investigated. In both cases FXIII activity and FXIII-A antigen were undetectable in the plasma and platelet lysate. In the plasma no FXIII-A(2)B(2) antigen was found, while FXIII-B antigen was >30% in both cases. Proband1 was a compound heterozygote possessing a known missense mutation (c.980G>A, p.Arg326Gln) and a novel splice-site mutation (c.1112+2T>C). Proband2 was homozygote for a novel single nucleotide deletion (c.212delA) leading to early stop codon. The discovered mutations explain the severity of clinical symptoms and the laboratory data. Methods precise in the low activity/antigen range are required to draw valid conclusion on phenotype-genotype relationship.}, keywords = {EXPRESSION; ASSAY; PLASMA; FIBRIN; A-SUBUNIT; Factor XIII; COAGULATION-FACTOR; splice-site mutation; single nucleotide deletion; rare bleeding disorder; factor XIII-A deficiency; factor XIII determination}, year = {2014}, eissn = {1365-2516}, pages = {114-120}, orcid-numbers = {Katona, Éva/0000-0003-3476-794X; Muszbek, László/0000-0002-3798-9962; Kovács, Kitti Bernadett/0000-0003-1781-2390; Bereczky, Zsuzsanna/0000-0002-1483-3703} } @article{MTMT:1450128, title = {Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game}, url = {https://m2.mtmt.hu/api/publication/1450128}, author = {Bereczky, Zsuzsanna and Kovács, Kitti Bernadett and Muszbek, László}, doi = {10.1515/CCLM.2010.369}, journal-iso = {CLIN CHEM LAB MED}, journal = {CLINICAL CHEMISTRY AND LABORATORY MEDICINE}, volume = {48}, unique-id = {1450128}, issn = {1434-6621}, year = {2010}, eissn = {1437-4331}, pages = {S53-S66}, orcid-numbers = {Bereczky, Zsuzsanna/0000-0002-1483-3703; Kovács, Kitti Bernadett/0000-0003-1781-2390; Muszbek, László/0000-0002-3798-9962} }