TY - JOUR AU - Pikó, Péter AU - Kósa, Zsigmond AU - Sándor, János AU - Kovács, Nóra AU - Seres, Ildikó AU - Paragh, György AU - Ádány, Róza TI - Association of HDL subfraction profile with the progression of insulin resistance JF - EUROPEAN JOURNAL OF PUBLIC HEALTH J2 - EUR J PUBLIC HEALTH VL - 33 PY - 2023 IS - Supplement_2 PG - 2 SN - 1101-1262 UR - https://m2.mtmt.hu/api/publication/34693667 ID - 34693667 LA - English DB - MTMT ER - TY - JOUR AU - Pikó, Péter AU - Kósa, Zsigmond AU - Sándor, János AU - Seres, Ildikó AU - Paragh, György AU - Ádány, Róza TI - Association of HDL-C subfraction profile with the progression of insulin resistance JF - ATHEROSCLEROSIS J2 - ATHEROSCLEROSIS VL - 379 PY - 2023 IS - S1 SP - S60 EP - S61 SN - 0021-9150 DO - 10.1016/j.atherosclerosis.2023.06.244 UR - https://m2.mtmt.hu/api/publication/34323884 ID - 34323884 LA - English DB - MTMT ER - TY - JOUR AU - Pikó, Péter AU - Jenei, Tibor AU - Kósa, Zsigmond AU - Sándor, János AU - Kovács, Nóra AU - Seres, Ildikó AU - Paragh, György AU - Ádány, Róza TI - Association of HDL Subfraction Profile with the Progression of Insulin Resistance JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 17 PG - 13 SN - 1661-6596 DO - 10.3390/ijms241713563 UR - https://m2.mtmt.hu/api/publication/34138623 ID - 34138623 AB - Type 2 diabetes mellitus (T2DM) is a major global public health problem, as it is associated with increased morbidity, mortality, and healthcare costs. Insulin resistance (IR) is a condition characterized by disturbances in carbohydrate and lipid metabolism that precedes T2DM. The aim of the present study was to investigate the association between HDL and its subfraction profile and the progression of IR, as assessed by the Homeostatic Model Assessment for IR (HOMA-IR) index, and to define cut-off values to identify an increased risk of IR. Individuals with a HOMA-IR greater than 3.63 were considered to have IR. The HDL subfractions were separated using the Lipoprint system, which identifies ten subfractions (HDL-1-10) in three subclasses as large (HDL-L), intermediate (HDL-I) and small (HDL-S). Analyses were performed on samples from 240 individuals without IR and 137 with IR from the Hungarian general and Roma populations. The HDL-1 to -6 subfractions and the HDL-L and -I classes showed a significant negative association with the progression and existence of IR. Among them, HDL-2 (B = −40.37, p = 2.08 × 10−11) and HDL-L (B = −14.85, p = 9.52 × 10−10) showed the strongest correlation. The optimal threshold was found to be 0.264 mmol/L for HDL-L and 0.102 mmol/L and above for HDL-2. Individuals with HDL-L levels below the reference value had a 5.1-fold higher risk of IR (p = 2.2 × 10−7), while those with HDL-2 levels had a 4.2-fold higher risk (p = 3.0 × 10−6). This study demonstrates that the HDL subfraction profile (especially the decrease in HDL-2 and -L) may be a useful marker for the early detection and intervention of atherogenic dyslipidemia in subjects with impaired glucose and insulin metabolism. LA - English DB - MTMT ER - TY - JOUR AU - Pikó, Péter AU - Jenei, Tibor AU - Kósa, Zsigmond AU - Sándor, János AU - Kovács, Nóra AU - Seres, Ildikó AU - Paragh, György AU - Ádány, Róza TI - Association of CETP Gene Polymorphisms and Haplotypes with Cardiovascular Risk JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 12 PG - 16 SN - 1661-6596 DO - 10.3390/ijms241210281 UR - https://m2.mtmt.hu/api/publication/34027446 ID - 34027446 AB - Cholesteryl ester transfer protein (CETP) is known to influence HDL-C levels, potentially altering the profile of HDL subfractions and consequently cardiovascular risk (CVR). This study aimed to investigate the effect of five single-nucleotide polymorphisms (SNPs; rs1532624, rs5882, rs708272, rs7499892, and rs9989419) and their haplotypes (H) in the CETP gene on 10-year CVR estimated by the Systematic Coronary Risk Evaluation (SCORE), the Framingham Risk Score for Coronary Heart Disease (FRSCHD) and Cardiovascular Disease (FRSCVD) algorithms. Adjusted linear and logistic regression analyses were used to investigate the association of SNPs and 10 haplotypes (H1–H10) on 368 samples from the Hungarian general and Roma populations. The T allele of rs7499892 showed a significant association with increased CVR estimated by FRS. H5, H7, and H8 showed a significant association with increased CVR based on at least one of the algorithms. The impact of H5 was due to its effect on TG and HDL-C levels, while H7 showed a significant association with FRSCHD and H8 with FRSCVD mediated by a mechanism affecting neither TG nor HDL-C levels. Our results suggest that polymorphisms in the CETP gene may have a significant effect on CVR and that this is not mediated exclusively by their effect on TG and HDL-C levels but also by presently unknown mechanisms. LA - English DB - MTMT ER - TY - JOUR AU - Ali Abbas Mohammad, Kurshed AU - Vincze, Ferenc AU - Pikó, Péter AU - Kósa, Zsigmond AU - Sándor, János AU - Ádány, Róza AU - Diószegi, Judit TI - Taste Preference-Related Genetic Polymorphisms Modify Alcohol Consumption Behavior of the Hungarian General and Roma Populations JF - GENES J2 - GENES-BASEL VL - 14 PY - 2023 IS - 3 PG - 16 SN - 2073-4425 DO - 10.3390/genes14030666 UR - https://m2.mtmt.hu/api/publication/33690497 ID - 33690497 AB - Harmful alcohol consumption has been considered a major public health issue globally, with the amounts of alcohol drunk being highest in the WHO European Region including Hungary. Alcohol consumption behaviors are complex human traits influenced by environmental factors and numerous genes. Beyond alcohol metabolization and neurotransmitter gene polymorphisms, taste preference-related genetic variants may also mediate alcohol consumption behaviors. Applying the Alcohol Use Disorders Identification Test (AUDIT) we aimed to elucidate the underlying genetic determinants of alcohol consumption patterns considering taste preference gene polymorphisms (TAS1R3 rs307355, TAS2R38 rs713598, TAS2R19 rs10772420 and CA6 rs2274333) in the Hungarian general (HG) and Roma (HR) populations. Alcohol consumption assessment was available for 410 HG and 387 HR individuals with 405 HG and 364 HR DNA samples being obtained for genotyping. No significant associations were found between TAS1R3 rs307355, TAS2R19 rs10772420, and CA6 rs2274333 polymorphisms and alcohol consumption phenotypes. Significant associations were identified between TAS2R38 rs713598 and the number of standard drinks consumed in the HG sample (genotype GG negatively correlated with the number of standard drinks; coef: −0.136, p = 0.028) and the prevalence of having six or more drinks among Roma (a negative correlation was identified in the recessive model; genotype GG, coef: −0.170, p = 0.049), although, none of these findings passed the Bonferroni-corrected probability criterion (p > 0.05). Nevertheless, our findings may suggest that alcohol consumption is partially driven by genetically determined taste preferences in our study populations. Further studies are required to strengthen the findings and to understand the drivers of alcohol consumption behavior in more depth. LA - English DB - MTMT ER - TY - JOUR AU - Pikó, Péter AU - Bácsné Bába, Éva AU - Kósa, Zsigmond AU - Sándor, János AU - Kovács, Nóra AU - Bács, Zoltán AU - Ádány, Róza TI - Genetic Determinants of Leisure-Time Physical Activity in the Hungarian General and Roma Populations JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 5 PG - 14 SN - 1661-6596 DO - 10.3390/ijms24054566 UR - https://m2.mtmt.hu/api/publication/33679402 ID - 33679402 AB - Leisure-time physical activity (LTPA) is one of the modifiable lifestyle factors that play an important role in the prevention of non-communicable (especially cardiovascular) diseases. Certain genetic factors predisposing to LTPA have been previously described, but their effects and applicability on different ethnicities are unknown. Our present study aims to investigate the genetic background of LTPA using seven single nucleotide polymorphisms (SNPs) in a sample of 330 individuals from the Hungarian general (HG) and 314 from the Roma population. The LTPA in general and three intensity categories of it (vigorous, moderate, and walking) were examined as binary outcome variables. Allele frequencies were determined, individual correlations of SNPs to LTPA, in general, were determined, and an optimized polygenetic score (oPGS) was created. Our results showed that the allele frequencies of four SNPs differed significantly between the two study groups. The C allele of rs10887741 showed a significant positive correlation with LTPA in general (OR = 1.48, 95% CI: 1.12–1.97; p = 0.006). Three SNPs (rs10887741, rs6022999, and rs7023003) were identified by the process of PGS optimization, whose cumulative effect shows a strong significant positive association with LTPA in general (OR = 1.40, 95% CI: 1.16–1.70; p < 0.001). The oPGS showed a significantly lower value in the Roma population compared with the HG population (oPGSRoma: 2.19 ± SD: 0.99 vs. oPGSHG: 2.70 ± SD: 1.06; p < 0.001). In conclusion, the coexistence of genetic factors that encourage leisure-time physical activity shows a more unfavorable picture among Roma, which may indirectly contribute to their poor health status. LA - English DB - MTMT ER - TY - JOUR AU - Ali Abbas Mohammad, Kurshed AU - Vincze, Ferenc AU - Pikó, Péter AU - Kósa, Zsigmond AU - Sándor, János AU - Ádány, Róza AU - Diószegi, Judit TI - Alcohol consumption patterns of the Hungarian general and Roma populations JF - FRONTIERS IN PUBLIC HEALTH J2 - FRONT PUBLIC HEALTH VL - 10 PY - 2023 PG - 14 SN - 2296-2565 DO - 10.3389/fpubh.2022.1003129 UR - https://m2.mtmt.hu/api/publication/33560424 ID - 33560424 LA - English DB - MTMT ER - TY - CHAP AU - Törő, Viktória AU - Kósa, Zsigmond AU - Takács, Péter AU - Radó, Sándor Istvánné AU - Szelesné Árokszállási, Andrea AU - Sárváry, Attila ED - Rusinné Fedor, Anita ED - Tóth, Dalma ED - Zakor-Broda, Rita TI - A cukorbeteg-ellátás minőségének regionális szintű vizsgálata a beteg szempontjából Magyarországon T2 - XIV. Nemzetközi Nyíregyházi Doktorandusz és Posztdoktori Konferencia PB - Debreceni Egyetem Egészségtudományi Kar CY - Nyíregyháza SN - 9789634904755 PY - 2022 SP - 52 UR - https://m2.mtmt.hu/api/publication/33575077 ID - 33575077 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gyulai, Anikó AU - Takács, Péter AU - Sárváry, Andrea Gabriella AU - Moravcsik-Kornyicki, Ágota AU - Árváné Egri, Csilla AU - Csire, Tamás Béla AU - Kósa, Zsigmond TI - A népegészségügyi célú méhnyakszűrésben résztvevő védőnők szakmai attitűdjének vizsgálata JF - ARANYPAJZS : A CSALÁD VÉDELMÉNEK TUDOMÁNYA / GOLDEN SHIELD : THE SCIENCE OF PROTECTING FAMILIES J2 - ARANYPAJZS / GOLDEN SHIELD VL - 1 PY - 2022 IS - 2 SP - 6 EP - 23 PG - 18 SN - 2939-5704 DO - 10.56077/AP.2022.2.1 UR - https://m2.mtmt.hu/api/publication/33260974 ID - 33260974 AB - A közelmúltban a védőnők nővédelmi feladatai a népegészségügyi célú méhnyakszűréssel egészültek ki. A vizsgálatunk célja, hogy a méhnyakszűrésre történő felkészítő képzésben részt vett védőnők körében feltárja a szolgáltatással kapcsolatos szakmai attitűdjét, véleményét. Kérdőíves adatfelvétel történt a képzésben részt vett védőnők körében (n=485). A leíró statisztikai elemzéseket követően faktoranalízist végeztünk, két mintás t próba, Mann Whitney próba, lineáris és bináris regressziós modell alkalmazásával. Vizsgáltuk az adatfelvétel idején szűrő (n=98) és a korábban szűrő (n=100) védőnők szakmai attitűdjének különbségeit, valamint a szűréssel kapcsolatos pozitív tapasztalatokat meghatározó tényezőket. Lineáris regressziós modell alkalmazásával vizsgálva azt tapasztaltuk, hogy a motivációs (külső és belső) faktorok (mindkettő: p<0,01) és a szűrésben résztvevő szereplők, mint támogató faktor (p=0,006) pozitívan befolyásolják a védőnők szűréssel kapcsolatos tapasztalatait, míg a szűrési tevékenység alacsony anyagi és erkölcsi megbecsültsége szignifikánsan (p=0,003) csökkenti azt. A védőnők részvétele a szűrésben elengedhetetlen feltétele a program sikeres végrehajtásának, melyhez szükséges az új kompetencia megbecsülésének, elismertségének a növelése. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bárdos, Helga AU - Llanaj, Erand AU - Vincze, Ferenc AU - Diószegi, Judit AU - Pikó, Péter AU - Kósa, Zsigmond AU - Sándor, János AU - Ádány, Róza TI - Diet quality as assessed by Healthy Eating Index-2015 among Hungarian Roma living in settlements of Northeast Hungary JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 11 SN - 2045-2322 DO - 10.1038/s41598-022-23670-3 UR - https://m2.mtmt.hu/api/publication/33229804 ID - 33229804 AB - Inequalities in diet quality are increasingly reported, but such studies among Roma are scarce and challenging. Here we attempt to examine diet quality and adherence to food based dietary guidelines among Hungarian Roma (HR) ethnic minority living in segregated settlements while comparing a sample of Hungarian adults from the general population (HG). Data were obtained from a complex comparative health survey conducted in Northeast Hungary in 2018, including sociodemographic and physical examination data. Dietary data were collected using two non-consecutive 24-h dietary recalls. We assessed diet quality based on using a 13-component Healthy Eating Index-2015 (HEI-2015, range 0–100). Differences in median intakes of food and nutrients and HEI-2015 scores were evaluated by Mann–Whitney test or Kruskal–Wallis test. Quantile regression was used to adjust HEI-2015 scores for socioeconomic factors including age, sex, educational status, and perceived financial status. This analysis included 393 and 415 subjects, aged between 18 to 70 years, of HR and HG populations, respectively. Results showed overall low median HEI-2015 scores for both HR and HG, with significantly lower total score among HR participants (41.6, interquartile range (IQR): 39.5–42.8) compared to HG (47.2, IQR: 45.7–51.1). Scores for individual components, such as intake of fruits, greens and beans, whole grains, seafood, and plant proteins were particularly suboptimal among both groups, but significantly lower among the HR population. Scores for refined grains, sodium, saturated fats and added sugar reflected high intakes of these components but did not differ between study groups. Our findings revealed an unfavorable diet quality among the HR compared to HG and a potentially increased risk for diet-related NCDs. Future health intervention programs are warranted to address dietary disparities of segregated minorities in Hungary while considering ethnic and cultural differences. LA - English DB - MTMT ER -