TY - JOUR AU - Lőrincz, Csanád Endre AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Varga, Csaba AU - Szabó, Renáta TI - Mechanisms and Target Parameters in Relation to Polycystic Ovary Syndrome and Physical Exercise: Focus on the Master Triad of Hormonal Changes, Oxidative Stress, and Inflammation JF - BIOMEDICINES J2 - BIOMEDICINES VL - 12 PY - 2024 IS - 3 SP - 560 SN - 2227-9059 DO - 10.3390/biomedicines12030560 UR - https://m2.mtmt.hu/api/publication/34742326 ID - 34742326 AB - Polycystic ovary syndrome (PCOS) is a common endocrine disorder among females of reproductive age with heterogeneous prevalence. It is well known that female reproductive competence depends on the dynamic regulation of the hypothalamic–pituitary–gonadal (HPG) axis; therefore, disruption of this highly regulated system leads to fertility problems. Among disruptors, both oxidative stress and inflammation contribute to an increased LH-FSH ratio and a consequent hyperandrogenism. Shifts in this bidirectional interplay between the neuroendocrine system and oxidative/inflammatory homeostasis result in the accumulation of reactive oxygen/nitrogen species and inflammatory markers as well as alterations in antioxidant defense mechanisms. Evidence shows that lifestyle changes, including regular physical exercise, are recognized as the most effective first-line management to reduce the severity of PCOS symptoms. The aim of our narrative review is to provide insights into the mechanisms and target factors of PCOS-related hormonal changes, oxidative/antioxidant homeostasis, and inflammation, and to discuss the effects of exercise, which takes into account various factors, in relation to PCOS. A better understanding of the PCOS-associated hormonal changes, oxidative and inflammatory circuits, as well as exercise-induced mechanisms of action on those targets may improve the quality of life of women with PCOS. LA - English DB - MTMT ER - TY - JOUR AU - Börzsei, Denise AU - Kiss, Viktória AU - Nagy, András AU - Hoffmann, Alexandra AU - Török, Szilvia AU - Almási, Nikoletta AU - Veszelka, Médea AU - Varga, Csaba AU - Szabó, Renáta TI - Moderate-Intensity Swimming Alleviates Oxidative Injury in Ischemic Heart JF - APPLIED SCIENCES-BASEL J2 - APPL SCI-BASEL VL - 14 PY - 2024 IS - 5 SP - 2073 SN - 2076-3417 DO - 10.3390/app14052073 UR - https://m2.mtmt.hu/api/publication/34724100 ID - 34724100 AB - The global burden of cardiovascular diseases is indisputable, as it claims nearly 18 million lives a year. In this current study, we aimed to prove that exercise, a cornerstone in cardiovascular disease management, emerges as a powerful tool in the pathology of myocardial ischemia. Male rats were divided into three groups: pre-swimming training + isoproterenol (ISO) treated, isoproterenol-treated, and control-sedentary. Myocardial infarction was induced by the subcutaneous injection of 1.0 mg/kg ISO. After the subsequent rest period, the animals swam for 3 weeks, every day for 25 min. At the end of the experiment, the serum levels of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), as well as the cardiac concentrations of reactive oxygen species (ROS), catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) were determined. Our results indicate that both cardiac injury biomarkers (ANP, BNP) and ROS levels were significantly lower in swimming rats compared to the sedentary animals. Moreover, the level of enzymatic components of the intracellular antioxidant system, CAT, SOD, and GPx were increased in swimming animals after ISO-induced myocardial infarction. Our findings support the fact that moderate-intensity swimming training can be efficiently used to prevent myocardial infarction-induced ischemic injury, by inhibiting ROS production and strengthening intracellular antioxidant defense. LA - English DB - MTMT ER - TY - CHAP AU - Kiss, Viktória AU - Szabó, Renáta AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Nagy, András Levente AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Varga, Csaba ED - Hagymási, Krisztina ED - Janda, Tibor ED - Pál, Magda ED - Poór, Péter ED - Szalai, Gabriella TI - Effects of lifestyle on adipokine pattern changes in stroke-prone spontaneously hypertensive rat model T2 - A Magyar Szabadgyökkutató Társaság XII. Kongresszusa PB - Agrártudományi Kutatóközpont, Mezőgazdasági Intézet CY - Martonvásár SN - 9786156203021 PY - 2023 SP - 34 EP - 34 PG - 1 UR - https://m2.mtmt.hu/api/publication/34136657 ID - 34136657 LA - English DB - MTMT ER - TY - CHAP AU - Szabó, Renáta AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória AU - Sugár, Anna AU - Nagy, András AU - Toldi, Éva AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Neuperger, Patrícia AU - Szebeni, Gábor AU - Varga, Csaba ED - Hagymási, Krisztina ED - Janda, Tibor ED - Pál, Magda ED - Poór, Péter ED - Szalai, Gabriella TI - Examination of imatinib-induced cardiotoxicity in a rat model T2 - A Magyar Szabadgyökkutató Társaság XII. Kongresszusa PB - Agrártudományi Kutatóközpont, Mezőgazdasági Intézet CY - Martonvásár SN - 9786156203021 PY - 2023 SP - 57 EP - 57 PG - 1 UR - https://m2.mtmt.hu/api/publication/34136645 ID - 34136645 LA - English DB - MTMT ER - TY - CHAP AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória AU - Sugár, Anna AU - Neuperger, Patrícia AU - Szebeni, Gábor AU - Bagyánszki, Mária AU - Barta, Bence Pál AU - Almási, Nikoletta AU - Veszelka, Médea AU - Török, Szilvia AU - Varga, Csaba AU - Szabó, Renáta ED - Hagymási, Krisztina ED - Janda, Tibor ED - Pál, Magda ED - Poór, Péter ED - Szalai, Gabriella TI - A PCOS gyulladásos hátterének vizsgálata és terápiás megközelítése T2 - A Magyar Szabadgyökkutató Társaság XII. Kongresszusa PB - Agrártudományi Kutatóközpont, Mezőgazdasági Intézet CY - Martonvásár SN - 9786156203021 PY - 2023 SP - 16 EP - 16 PG - 1 UR - https://m2.mtmt.hu/api/publication/34136606 ID - 34136606 LA - English DB - MTMT ER - TY - CHAP AU - Török, Szilvia AU - Almási, Nikoletta AU - Veszelka, Médea AU - Börzsei, Denise AU - Szabó, Renáta AU - Varga, Csaba ED - Hagymási, Krisztina ED - Janda, Tibor ED - Pál, Magda ED - Poór, Péter ED - Szalai, Gabriella TI - The effect of H2S treatment on the antioxidant system in a colitis model T2 - A Magyar Szabadgyökkutató Társaság XII. Kongresszusa PB - Agrártudományi Kutatóközpont, Mezőgazdasági Intézet CY - Martonvásár SN - 9786156203021 PY - 2023 SP - 78-615-6203-02-1 UR - https://m2.mtmt.hu/api/publication/34136601 ID - 34136601 LA - English DB - MTMT ER - TY - CONF AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Börzsei, Denise AU - Szabó, Renáta AU - Varga, Csaba TI - Physical activity induced protection in TNBS rat colitis: focus on NETosis PY - 2023 SP - ISBN 978-615-6203-02-1 UR - https://m2.mtmt.hu/api/publication/34136600 ID - 34136600 LA - English DB - MTMT ER - TY - CHAP AU - Veszelka, Médea AU - Almási, Nikoletta AU - Török, Szilvia AU - Bagyánszki, Mária AU - Barta, Bence Pál AU - Bódi, Nikolett AU - Szabó, Renáta AU - Börzsei, Denise AU - Varga, Csaba ED - Hagymási, Krisztina ED - Janda, Tibor ED - Pál, Magda ED - Poór, Péter ED - Szalai, Gabriella TI - Resveratrol hatásának vizsgálata IBD patkánymodellben T2 - A Magyar Szabadgyökkutató Társaság XII. Kongresszusa PB - Agrártudományi Kutatóközpont, Mezőgazdasági Intézet CY - Martonvásár SN - 9786156203021 PY - 2023 SP - 67 EP - 67 PG - 1 UR - https://m2.mtmt.hu/api/publication/34136566 ID - 34136566 LA - English DB - MTMT ER - TY - JOUR AU - Almási, Nikoletta AU - Török, Szilvia AU - Al-Awar, Amin AU - Veszelka, Médea AU - Király, László AU - Börzsei, Denise AU - Szabó, Renáta AU - Varga, Csaba TI - Voluntary Exercise-Mediated Protection in TNBS-Induced Rat Colitis: The Involvement of NETosis and Prdx Antioxidants JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 12 PY - 2023 IS - 8 PG - 11 SN - 2076-3921 DO - 10.3390/antiox12081531 UR - https://m2.mtmt.hu/api/publication/34081631 ID - 34081631 N1 - Funding Agency and Grant Number: This research was supported by GINOP PLUSZ-2.1.1-21-2022-00189.; GINOP; [PLUSZ-2.1.1-21-2022-00189] Funding text: This research was supported by GINOP PLUSZ-2.1.1-21-2022-00189. AB - Inflammatory bowel diseases (IBDs) are autoimmune disorders of the gut. It is increasingly clear that voluntary exercise (VE) may exert protection against IBDs, but the exact background mechanism needs to be elucidated. In the present study, we aimed to investigate the possible role of NETosis and the antioxidant peroxiredoxin (Prdx) enzyme family in VE-induced protection. Wistar Han rats were randomly divided into two groups: sedentary (SED) and VE. After the 6-week voluntary wheel running, animals were treated with 2,4,6-trinitrobenzene sulphonic acid (TNBS) as a model of colitis. Here, we found that VE significantly decreased inflammation and ulceration of the colon in the VE TNBS group compared with SED TNBS. We also found that VE significantly decreased the expression of protein arginine deiminase 4 (PAD4) and myeloperoxidase (MPO), and markedly reduced citrullinated histone H3 (citH3) compared with SED TNBS. Furthermore, VE caused a significant increase in the levels of Prdx6 in the control and TNBS groups. Taken together, we found that a prior 6-week VE effectively reduces inflammation in TNBS-induced colitis, and we suggest that the protective effect of VE may be mediated via the inhibition of NETosis and upregulation of Prdx6 antioxidant. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Renáta AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória AU - Nagy, András Levente AU - Török, Szilvia AU - Veszelka, Médea AU - Almási, Nikoletta AU - Varga, Csaba TI - The Interplay of Lifestyle and Adipokines in the Non-Obese Stroke-Prone Spontaneously Hypertensive Rats JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 12 PY - 2023 IS - 7 PG - 13 SN - 2076-3921 DO - 10.3390/antiox12071450 UR - https://m2.mtmt.hu/api/publication/34071290 ID - 34071290 N1 - Funding Agency and Grant Number: [2019-1.1.1-PIACI-KFI-2019-00226]; [GINOP-PLUSZ-2.3.1-21-2022-00083] Funding text: The study was supported by the 2019-1.1.1-PIACI-KFI-2019-00226 grant and GINOP-PLUSZ-2.3.1-21-2022-00083. AB - Although the morphological features and functions of adipose tissue are well-described in obesity-prone animal models, less information is available on animals such as the stroke-prone spontaneously hypertensive (SHRSP) strain with cardiovascular abnormalities, which is not characterized by excessive adiposity. Our aim was to focus on lifestyle-induced (type of diet and physical exercise) effects on adipokine profile and lipid peroxidation in SHRSP rats. In our study, male Wistar-kyoto (control) and SHRSP rats were used. SHRSP rats were fed either standard chow or a high-fat diet with 40% fat content (HFD). One group of the animals was placed into cages fitted with a running-wheel; thus, the dietary and training period started at the same time and lasted for 12 weeks. At the end of the experimental period, adiponectin, leptin, omentin, and chemerin concentrations were determined from adipose tissue and serum. Besides adipokines, malondialdehyde (MDA) levels were also measured. Twelve weeks of HFD significantly decreased adiponectin and omentin concentrations of both adipose tissue and serum, which were ameliorated by physical exercise. Serum leptin, chemerin, and MDA values were elevated in HFD groups; however, physical exercise was able to mitigate these adverse changes. Our results underpin the crosstalk between lifestyle changes and dysfunctional adipose tissue in SHRSP rats. LA - English DB - MTMT ER -