TY - JOUR AU - Bogner, Péter AU - Chadaide, Zoltán AU - Lenzsér, Gábor AU - Kondákor, István AU - Tárkányi, Gábor AU - Szukits, Sándor AU - Juhász, Eszter AU - Sebestyén, Andor AU - Janszky, József Vladimír AU - Büki, András AU - Dóczi, Tamás Péter AU - Szapáry, László TI - Stroke-ellátást támogató teleradiológiai hálózat a Nyugat- és Dél-Dunántúlon = Teleradiology-based stroke network in Western and Southern Transdanubia in Hungary JF - ORVOSI HETILAP J2 - ORV HETIL VL - 162 PY - 2021 IS - 17 SP - 668 EP - 675 PG - 8 SN - 0030-6002 DO - 10.1556/650.2021.32097 UR - https://m2.mtmt.hu/api/publication/31960205 ID - 31960205 AB - Összefoglaló. Bevezetés: A stroke kezelésének lehetőségei az utóbbi években jelentősen megváltoztak: a thrombolysis után bevezetésre került a mechanikus thrombectomia, és a terápiás időablak is jelentősen kitágult az utóbbi évek nagy multicentrikus tanulmányai alapján. Ezek a lehetőségek új igényeket fogalmaztak meg a képalkotó diagnosztikával szemben: az ischaemia okozta morfológiai elváltozások mellett az artériás és a kollaterális rendszer állapotát, valamint bizonyos esetekben az agy szöveti perfúzióját is szükséges meghatározni. Ezeket a komplex kiértékelési feladatokat ma már mesterségesintelligencia-algoritmusok támogathatják, melyek a kiértékelést pár perc alatt elvégezve segítenek a terápiás döntés kialakításában. Célkitűzés: A Dél- és a Nyugat-dunántúli régióban hat intézmény részvételével egy dedikált stroke teleradiológiai hálózat kialakítása. Módszer: A stroke-CT-kiértékelő szoftver és a képkommunikáció integrációja, a vizsgálati protokollok technikai paramétereinek egységesítése, a kiértékelési eredmények teleradiológiai megjelenítése valósult meg a hálózat kialakítása során. Eredmények: A hálózat egységesítette nemcsak a stroke-CT-protokollok beállításait, de beutalási és értékelési szempontjait is. A stroke-CT-kiértékelések és a mechanikus thrombectomiák száma is emelkedett az elmúlt egy évben. Következtetés: A dedikált teleradiológiai stroke-hálózat segítségével optimalizálni kívánjuk a régió stroke-ellátását: egyrészt lehetőleg ne maradjanak ellátatlanul a thrombectomiából valószínűleg profitáló betegek, másrészt ne terheljük az ellátórendszert olyan esetekkel, melyekről a teljes dokumentáció ismeretében derül ki, hogy nem javasolt a beavatkozás. Orv Hetil. 2021; 162(17): 668-675.The possibilities of cerebral stroke management have changed substantially during the last few years. Following a few multicentric studies, mechanical thrombectomy became an established method besides thrombolysis. In addition, the therapeutic window for both methods is much wider now than before. These changes described above demanded more information of CT morphological changes due to ischemia, but the condition and functionality of the arterial and collateral system, and occasionally tissue perfusion performance should also be characterized. Recently, evaluation of different computer tomographic (CT) measurements can be done using artificial intelligence based methods, which perform data analysis in a few minutes.To establish a dedicated stroke teleradiology network with artificial intelligence based image analysis in Western and Southern Transdanubia in Hungary that involves six partner institutes.Integration of automated image analysis with teleradiology software was established, and the technical parameters of examination protocols were unified. Results of stroke CT image analysis became accessible through the teleradiology network.The daily use of integrated central image analysis and image communication had a positive impact on referrals and therapeutic evaluation of stroke cases. The number of image processing and mechanical thrombectomy increased during the last year.With the help of the dedicated teleradiology stroke network, we want to optimize the stroke care in the region: on the one hand, patients who are likely to benefit from thrombectomy should not be left unattended, on the other, the health care system should not be burdened with cases, when intervention is not recommended having the complete clinical data accessed. Orv Hetil. 2021; 162(17): 668-675. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tóth, Márton AU - Kondákor, István AU - Faludi, Béla TI - Differences of brain electrical activity between moderate and severe obstructive sleep apneic patients: a LORETA study. JF - JOURNAL OF SLEEP RESEARCH J2 - J SLEEP RES VL - 25 PY - 2016 IS - 5 SP - 596 EP - 604 PG - 9 SN - 0962-1105 DO - 10.1111/jsr.12403 UR - https://m2.mtmt.hu/api/publication/3072018 ID - 3072018 LA - English DB - MTMT ER - TY - JOUR AU - Clemens, Béla AU - Puskás, Szilvia AU - Bessenyei, Mónika AU - Kondákor, István AU - Ohmachtné Hollódy, Katalin AU - Fogarasi, András AU - Bense, Katalin AU - Emri, Miklós AU - Opposits, Gábor AU - Kovács, Noémi AU - Fekete, István TI - Egyedi LORETA-abnormalitások vizsgálata idiopathiás generalizált epilepsziákban JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 69 PY - 2016 IS - 3-4 SP - 107 EP - 121 PG - 15 SN - 0019-1442 DO - 10.18071/isz.69.0107 UR - https://m2.mtmt.hu/api/publication/3061798 ID - 3061798 N1 - TT: [Individual evaluation of loreta abnormalities in idiopathic generalized epilepsy] LA - Hungarian DB - MTMT ER - TY - JOUR AU - Rosenow, F AU - Kelemen, Anna AU - Ben-Menachem, E AU - McShea, C AU - Isojarvi, J AU - Doty, P ED - Berkovic, S / Collaborator ED - Kiley, M / Collaborator ED - O'Brien, T / Collaborator ED - Reutens, DC / Collaborator ED - Seneviratne, WU / Collaborator ED - Robinson, MK / Collaborator ED - Schapel, GJ / Collaborator ED - Somerville, ER / Collaborator ED - Babic, T / Collaborator ED - Poljakovic, Z / Collaborator ED - Demarin, V / Collaborator ED - Hajnsek, S / Collaborator ED - Bar, M / Collaborator ED - Buresova, J / Collaborator ED - Hojdikova, H / Collaborator ED - Kralove, H / Collaborator ED - Marusic, P / Collaborator ED - Nespor, E / Collaborator ED - Rektor, I / Collaborator ED - Vacovska, H / Collaborator ED - Zarubova, J / Collaborator ED - Kälviäinen, RK / Collaborator ED - Keränen, T / Collaborator ED - Korpelainen, JT / Collaborator ED - Lamusuo, SL / Collaborator ED - Nylund, T / Collaborator ED - Crespel, A / Collaborator ED - Derambure, P / Collaborator ED - Ryvlin, P / Collaborator ED - Semah, F / Collaborator ED - Tibergé, M / Collaborator ED - Valton, L / Collaborator ED - Arnold, S / Collaborator ED - Siebold, C / Collaborator ED - Holtkamp, M / Collaborator ED - Schmitz, B / Collaborator ED - Lerche, H / Collaborator ED - Meencke, HJ / Collaborator ED - Nitsche, M / Collaborator ED - Tergau, F / Collaborator ED - Stefan, H / Collaborator ED - Balogh, A / Collaborator ED - Halász, P / Collaborator ED - Horvath, A / Collaborator ED - Komoly, Sámuel / Collaborator ED - Kondákor, István / Collaborator ED - Sólyom, A / Collaborator ED - Vécsei, László / Collaborator ED - Endziniene, M / Collaborator ED - Liesiene, V / Collaborator ED - Mameniskiene, R / Collaborator ED - Skaringa, AA / Collaborator ED - Czlonkowska, A / Collaborator ED - Fryze, W / Collaborator ED - Kochanowicz, J / Collaborator ED - Mazurkiewicz-Beldzinska, M / Collaborator ED - Motyl, R / Collaborator ED - Fedin, A / Collaborator ED - Guekht, A / Collaborator ED - Guzeva, V / Collaborator ED - Karlov, V / Collaborator ED - Kotov, S / Collaborator ED - Petrukhin, A / Collaborator ED - Skoromets, A / Collaborator ED - Gil-Nagel, A / Collaborator ED - Llerda, JA / Collaborator ED - Moro, MM / Collaborator ED - Molins, A / Collaborator ED - Sanchez, JC / Collaborator ED - Serratosa, M / Collaborator ED - Lindström, P / Collaborator ED - Söderfeldt, B / Collaborator ED - Brodie, J / Collaborator ED - Cockerell, OC / Collaborator ED - Cooper, PN / Collaborator ED - Roberts, RC / Collaborator ED - Sawhney, IM / Collaborator ED - Smith, E / Collaborator TI - Long-term adjunctive lacosamide treatment in patients with partial-onset seizures JF - ACTA NEUROLOGICA SCANDINAVICA J2 - ACTA NEUROL SCAND VL - 133 PY - 2016 IS - 2 SP - 136 EP - 144 PG - 9 SN - 0001-6314 DO - 10.1111/ane.12451 UR - https://m2.mtmt.hu/api/publication/2962723 ID - 2962723 AB - OBJECTIVE: To evaluate long-term (up to 5.5 years) safety, seizure reduction, and maintenance of efficacy of the antiepileptic drug (AED) lacosamide as adjunctive treatment in an open-label extension trial (SP774; ClinicalTrials.gov: NCT00515619). METHODS: Three hundred and seventy-six adults with partial-onset seizures taking 1-3 AEDs enrolled following completion of a double-blind trial of adjunctive lacosamide. During open-label treatment, dosage of lacosamide (100-800 mg/day) and/or concomitant AEDs could be adjusted to optimize tolerability and seizure control. RESULTS: Kaplan-Meier estimates of patient retention were 74.5% at 12 months, 52.9% at 36 months, and 40.6% at 60 months; median open-label treatment duration was 1183 days (~3.2 years). The most frequently reported treatment-emergent adverse events were dizziness (24.2%), headache (14.4%), diplopia (13.8%), and nasopharyngitis (13.8%); 9.0% of patients discontinued due to adverse events, most commonly dizziness (1.3%). Median percent reduction in 28-day seizure frequency from baseline of the double-blind trial was 49.9% overall, 55.4% for 1-year completers, and 62.3% for 3-year completers. Overall, 50.0% of patients were considered >/=50% responders (achieved >/=50% reduction in 28-day seizure frequency); 55.9% of 1-year completers and 63.0% of 3-year completers were >/=50% responders. CONCLUSION: In eligible patients who entered the open-label extension trial, lacosamide was generally well tolerated. For most patients within each yearly completer cohort, seizure reduction was maintained over time. LA - English DB - MTMT ER - TY - JOUR AU - Clemens, Béla AU - Puskás, Szilvia AU - Besenyei, M AU - Kovács, N Z AU - Spisák, Tamás AU - Kis, Sándor Attila AU - Emri, Miklós AU - Ohmachtné Hollódy, Katalin AU - Fogarasi, András AU - Kondákor, István AU - Fekete, István TI - Valproate treatment normalizes EEG functional connectivity in successfully treated idiopathic generalized epilepsy patients. JF - EPILEPSY RESEARCH J2 - EPILEPSY RES VL - 108 PY - 2014 IS - 10 SP - 1896 EP - 1903 PG - 8 SN - 0920-1211 DO - 10.1016/j.eplepsyres.2014.09.032 UR - https://m2.mtmt.hu/api/publication/2779667 ID - 2779667 N1 - Kenézy Gyula County Hospital, Department of Neurology, Debrecen, Hungary University of Debrecen, Medical Center, Department of Neurology, Debrecen, Hungary University of Debrecen, Medical Center, Department of Pediatrics, Debrecen, Hungary University of Debrecen, Department of Nuclear Medicine, Debrecen, Hungary University of Pécs, Department of Pediatrics, Pécs, Hungary Epilepsy Center, Bethesda Children's Hospital, Budapest, Hungary Balassa János Hospital, Department of Neurology, Szekszárd, Hungary Cited By :13 Export Date: 15 May 2019 CODEN: EPIRE Correspondence Address: Puskás, S.; University of Debrecen, Medical Center, Department of Neurology, Móricz Zsigmond krt. 22, Hungary Export Date: 16 July 2020 CODEN: EPIRE LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Márton AU - Faludi, Béla AU - Kondákor, István TI - Effects of CPAP-Therapy on Brain Electrical Activity in Obstructive Sleep Apneic Patients: A Combined EEG Study Using LORETA and Omega Complexity JF - BRAIN TOPOGRAPHY J2 - BRAIN TOPOGR VL - 25 PY - 2012 IS - 4 SP - 450 EP - 460 PG - 11 SN - 0896-0267 DO - 10.1007/s10548-012-0243-0 UR - https://m2.mtmt.hu/api/publication/2082623 ID - 2082623 LA - English DB - MTMT ER - TY - JOUR AU - Clemens, Béla AU - Puskás, Szilvia AU - Besenyei, M AU - Emri, Miklós AU - Opposits, Gábor AU - Kis, Sándor Attila AU - Ohmachtné Hollódy, Katalin AU - Fogarasi, András AU - Kondákor, István AU - Füle, K AU - Bense, K AU - Fekete, István TI - EEG-LORETA endophenotypes of the common idiopathic generalized epilepsy syndromes JF - EPILEPSY RESEARCH J2 - EPILEPSY RES VL - 99 PY - 2012 IS - 3 SP - 281 EP - 292 PG - 12 SN - 0920-1211 DO - 10.1016/j.eplepsyres.2011.12.008 UR - https://m2.mtmt.hu/api/publication/1961059 ID - 1961059 N1 - Kenézy Hospital Ltd., Department of Neurology, Debrecen, Hungary University of Debrecen, Medical and Health Science Center, Department of Neurology, Debrecen, Hungary University of Debrecen, Institute of Nuclear Medicine, Debrecen, Hungary University of Pécs, Department of Pediatrics, Pécs, Hungary Epilepsy Center, Bethesda Children's Hospital, Budapest, Hungary Teaching County Hospital of Bács-Kiskun, Department of Neurology, Kecskemét, Hungary Teaching County Hospital of Bács-Kiskun, Department of Child Neurology, Kecskemét, Hungary Cited By :7 Export Date: 15 May 2019 CODEN: EPIRE Correspondence Address: Clemens, B.; Kenézy Kórház Ltd., Department of Neurology, Bartók Béla út 3, 4031, Debrecen, Hungary; email: bela.clemens@yahoo.com Export Date: 16 July 2020 CODEN: EPIRE LA - English DB - MTMT ER - TY - JOUR AU - Clemens, Béla AU - Puskás, Szilvia AU - Bessenyei, M AU - Emri, Miklós AU - Spisák, Tamás AU - Koselak, M AU - Ohmachtné Hollódy, Katalin AU - Fogarasi, András AU - Kondákor, István AU - Fule, K AU - Bense, K AU - Fekete, István TI - EEG functional connectivity of the intrahemispheric cortico-cortical network of idiopathic generalized epilepsy JF - EPILEPSY RESEARCH J2 - EPILEPSY RES VL - 96 PY - 2011 IS - 1-2 SP - 11 EP - 23 PG - 13 SN - 0920-1211 DO - 10.1016/j.eplepsyres.2011.04.011 UR - https://m2.mtmt.hu/api/publication/1707119 ID - 1707119 N1 - Megjegyzés-25680495 Megjegyzés-21709604 : FN Thomson Reuters Web of Knowledge Kenézy Hospital Ltd., Department of Neurology, Bartók Béla út 3., 4031 Debrecen, Hungary University of Debrecen, Medical and Health Science Center, Department of Neurology, Debrecen, Hungary University of Debrecen, Institute of Nuclear Medicine, Debrecen, Hungary University of Pécs, Department of Pediatrics, Pécs, Hungary Epilepsy Center, Bethesda Children's Hospital, Budapest, Hungary Teaching County Hospital of Bács-Kiskun, Department of Neurology, Kecskemét, Hungary Teaching County Hospital of Bács-Kiskun, Department of Child Neurology, Kecskemét, Hungary Cited By :11 Export Date: 15 May 2019 CODEN: EPIRE Correspondence Address: Clemens, B.; Kenézy Hospital Ltd., Department of Neurology, Bartók Béla út 3., 4031 Debrecen, Hungary; email: bela.clemens@yahoo.com Funding Agency and Grant Number: Hungarian Ministry of Health [ETT 238/2006] Funding text: Supported by grant from the Hungarian Ministry of Health No. ETT 238/2006 Export Date: 16 July 2020 CODEN: EPIRE AB - AIMS: Intrahemispheric, cortico-cortical EEG functional connectivity (fC) was investigated in untreated patients with idiopathic generalized epilepsy (IGE) in this explorative study. PATIENTS AND METHODS: Group comparison was carried out between 19, drug-naive IGE patients and 19, matched healthy persons. 90x2s of 19 channels waking, interictal background EEG signal (without epileptiform potentials) were processed to the LORETA (low resolution electromagnetic tomography) software to compute current source density for 2394 voxels representing parcels of the cerebral cortex for 25 very narrow bands of 1Hz bandwidth (VNBs) from 1 to 25Hz. EEG fC was investigated among the already localized sources. Pearson correlation coefficients (R) were computed among the 33 regions of interest (ROI) within the left and within the right hemisphere, separately. Group differences were computed by means of t-statistics. Corrected p<0.05 differences were accepted as statistically significant. MAIN RESULTS: (1) The anatomical patterns of the fC differences showed great frequency-dependency. (2) Hemispheric asymmetry was prominent within most VNBs. (3) Decreased fC in the IGE group was found across all VNBs in the 1-6Hz frequency range as compared to mixed patterns comprising both increased and decreased fC at >6Hz frequencies. (4) In the 5-25Hz range, decreased fC dominated in the anterior, increased fC in the posterior parts of the cortex. (5) The results delineated an anterior and a posterior network. DISCUSSION: (1) Decreased fC in the 1-6Hz band might indicate some relationship to yet hidden structure network abnormalities. (2) The anatomical patterns of fC indicate frequency-dependent, pathological coupling and decoupling processes in the interictal state. (3) The two networks might help to understand seizure liability and seizure precipitation in IGE. SIGNIFICANCE: This is the first study to explore EEG fC in the interictal condition of IGE patients. The importance of EEG frequencies in evaluating fC in IGE was demonstrated and starting points for further research were given. LA - English DB - MTMT ER - TY - JOUR AU - Fule, K AU - Jobbagy, Z AU - Kondákor, István TI - CORTICAL EFFECT OF ANTIEPILEPTIC THERAPY IN UNVERRICHT-LUNDBORG SYNDROME: A QUANTITATIVE EEG STUDY USING LORETA ANALYSIS JF - EPILEPSIA J2 - EPILEPSIA VL - 51 PY - 2010 IS - 4 SP - 53 EP - 54 PG - 2 SN - 0013-9580 UR - https://m2.mtmt.hu/api/publication/2380567 ID - 2380567 LA - English DB - MTMT ER - TY - JOUR AU - Clemens, Béla AU - Bessenyei, M AU - Fekete, István AU - Puskás, Szilvia AU - Kondákor, István AU - Tóth, Márton AU - Ohmachtné Hollódy, Katalin TI - Theta EEG source localization using LORETA in partial epilepsy patients with and without medication JF - CLINICAL NEUROPHYSIOLOGY J2 - CLIN NEUROPHYSIOL VL - 121 PY - 2010 IS - 6 SP - 848 EP - 858 PG - 11 SN - 1388-2457 DO - 10.1016/j.clinph.2010.01.020 UR - https://m2.mtmt.hu/api/publication/1681107 ID - 1681107 N1 - Funding Agency and Grant Number: Hungarian Ministry of Health [ETT 238/2006] Funding text: Supported by grant from the Hungarian Ministry of Health No. ETT 238/2006. LA - English DB - MTMT ER -