@article{MTMT:31960205, title = {Stroke-ellátást támogató teleradiológiai hálózat a Nyugat- és Dél-Dunántúlon = Teleradiology-based stroke network in Western and Southern Transdanubia in Hungary}, url = {https://m2.mtmt.hu/api/publication/31960205}, author = {Bogner, Péter and Chadaide, Zoltán and Lenzsér, Gábor and Kondákor, István and Tárkányi, Gábor and Szukits, Sándor and Juhász, Eszter and Sebestyén, Andor and Janszky, József Vladimír and Büki, András and Dóczi, Tamás Péter and Szapáry, László}, doi = {10.1556/650.2021.32097}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {162}, unique-id = {31960205}, issn = {0030-6002}, abstract = {Összefoglaló. Bevezetés: A stroke kezelésének lehetőségei az utóbbi években jelentősen megváltoztak: a thrombolysis után bevezetésre került a mechanikus thrombectomia, és a terápiás időablak is jelentősen kitágult az utóbbi évek nagy multicentrikus tanulmányai alapján. Ezek a lehetőségek új igényeket fogalmaztak meg a képalkotó diagnosztikával szemben: az ischaemia okozta morfológiai elváltozások mellett az artériás és a kollaterális rendszer állapotát, valamint bizonyos esetekben az agy szöveti perfúzióját is szükséges meghatározni. Ezeket a komplex kiértékelési feladatokat ma már mesterségesintelligencia-algoritmusok támogathatják, melyek a kiértékelést pár perc alatt elvégezve segítenek a terápiás döntés kialakításában. Célkitűzés: A Dél- és a Nyugat-dunántúli régióban hat intézmény részvételével egy dedikált stroke teleradiológiai hálózat kialakítása. Módszer: A stroke-CT-kiértékelő szoftver és a képkommunikáció integrációja, a vizsgálati protokollok technikai paramétereinek egységesítése, a kiértékelési eredmények teleradiológiai megjelenítése valósult meg a hálózat kialakítása során. Eredmények: A hálózat egységesítette nemcsak a stroke-CT-protokollok beállításait, de beutalási és értékelési szempontjait is. A stroke-CT-kiértékelések és a mechanikus thrombectomiák száma is emelkedett az elmúlt egy évben. Következtetés: A dedikált teleradiológiai stroke-hálózat segítségével optimalizálni kívánjuk a régió stroke-ellátását: egyrészt lehetőleg ne maradjanak ellátatlanul a thrombectomiából valószínűleg profitáló betegek, másrészt ne terheljük az ellátórendszert olyan esetekkel, melyekről a teljes dokumentáció ismeretében derül ki, hogy nem javasolt a beavatkozás. Orv Hetil. 2021; 162(17): 668-675.The possibilities of cerebral stroke management have changed substantially during the last few years. Following a few multicentric studies, mechanical thrombectomy became an established method besides thrombolysis. In addition, the therapeutic window for both methods is much wider now than before. These changes described above demanded more information of CT morphological changes due to ischemia, but the condition and functionality of the arterial and collateral system, and occasionally tissue perfusion performance should also be characterized. Recently, evaluation of different computer tomographic (CT) measurements can be done using artificial intelligence based methods, which perform data analysis in a few minutes.To establish a dedicated stroke teleradiology network with artificial intelligence based image analysis in Western and Southern Transdanubia in Hungary that involves six partner institutes.Integration of automated image analysis with teleradiology software was established, and the technical parameters of examination protocols were unified. Results of stroke CT image analysis became accessible through the teleradiology network.The daily use of integrated central image analysis and image communication had a positive impact on referrals and therapeutic evaluation of stroke cases. The number of image processing and mechanical thrombectomy increased during the last year.With the help of the dedicated teleradiology stroke network, we want to optimize the stroke care in the region: on the one hand, patients who are likely to benefit from thrombectomy should not be left unattended, on the other, the health care system should not be burdened with cases, when intervention is not recommended having the complete clinical data accessed. Orv Hetil. 2021; 162(17): 668-675.}, keywords = {Artificial intelligence; computer tomography; stroke; Mesterséges intelligencia; teleradiológia; komputertomográfia; ASPECTS; teleradiology}, year = {2021}, eissn = {1788-6120}, pages = {668-675}, orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:3072018, title = {Differences of brain electrical activity between moderate and severe obstructive sleep apneic patients: a LORETA study.}, url = {https://m2.mtmt.hu/api/publication/3072018}, author = {Tóth, Márton and Kondákor, István and Faludi, Béla}, doi = {10.1111/jsr.12403}, journal-iso = {J SLEEP RES}, journal = {JOURNAL OF SLEEP RESEARCH}, volume = {25}, unique-id = {3072018}, issn = {0962-1105}, year = {2016}, eissn = {1365-2869}, pages = {596-604} } @article{MTMT:3061798, title = {Egyedi LORETA-abnormalitások vizsgálata idiopathiás generalizált epilepsziákban}, url = {https://m2.mtmt.hu/api/publication/3061798}, author = {Clemens, Béla and Puskás, Szilvia and Bessenyei, Mónika and Kondákor, István and Ohmachtné Hollódy, Katalin and Fogarasi, András and Bense, Katalin and Emri, Miklós and Opposits, Gábor and Kovács, Noémi and Fekete, István}, doi = {10.18071/isz.69.0107}, journal-iso = {IDEGGYOGY SZEMLE}, journal = {IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE}, volume = {69}, unique-id = {3061798}, issn = {0019-1442}, keywords = {EEG; LORETA; individual diagnosis; idiopathic generalized epilepsies}, year = {2016}, eissn = {2498-6208}, pages = {107-121} } @article{MTMT:2962723, title = {Long-term adjunctive lacosamide treatment in patients with partial-onset seizures}, url = {https://m2.mtmt.hu/api/publication/2962723}, author = {Rosenow, F and Kelemen, Anna and Ben-Menachem, E and McShea, C and Isojarvi, J and Doty, P}, doi = {10.1111/ane.12451}, journal-iso = {ACTA NEUROL SCAND}, journal = {ACTA NEUROLOGICA SCANDINAVICA}, volume = {133}, unique-id = {2962723}, issn = {0001-6314}, abstract = {OBJECTIVE: To evaluate long-term (up to 5.5 years) safety, seizure reduction, and maintenance of efficacy of the antiepileptic drug (AED) lacosamide as adjunctive treatment in an open-label extension trial (SP774; ClinicalTrials.gov: NCT00515619). METHODS: Three hundred and seventy-six adults with partial-onset seizures taking 1-3 AEDs enrolled following completion of a double-blind trial of adjunctive lacosamide. During open-label treatment, dosage of lacosamide (100-800 mg/day) and/or concomitant AEDs could be adjusted to optimize tolerability and seizure control. RESULTS: Kaplan-Meier estimates of patient retention were 74.5% at 12 months, 52.9% at 36 months, and 40.6% at 60 months; median open-label treatment duration was 1183 days (~3.2 years). The most frequently reported treatment-emergent adverse events were dizziness (24.2%), headache (14.4%), diplopia (13.8%), and nasopharyngitis (13.8%); 9.0% of patients discontinued due to adverse events, most commonly dizziness (1.3%). Median percent reduction in 28-day seizure frequency from baseline of the double-blind trial was 49.9% overall, 55.4% for 1-year completers, and 62.3% for 3-year completers. Overall, 50.0% of patients were considered >/=50% responders (achieved >/=50% reduction in 28-day seizure frequency); 55.9% of 1-year completers and 63.0% of 3-year completers were >/=50% responders. CONCLUSION: In eligible patients who entered the open-label extension trial, lacosamide was generally well tolerated. For most patients within each yearly completer cohort, seizure reduction was maintained over time.}, keywords = {Adult; Female; Male; SAFETY; ARTICLE; human; major clinical study; valproic acid; topiramate; lamotrigine; carbamazepine; TREMOR; fatigue; long term care; drug tolerability; dizziness; drug withdrawal; drug efficacy; double blind procedure; vomiting; headache; open study; seizure; backache; phase 3 clinical trial; Tolerability; morning dosage; somnolence; etiracetam; convulsion; treatment duration; vertigo; oxcarbazepine; evening dosage; diplopia; rhinopharyngitis; Partial-onset seizures; harkoseride; Responders; Open label; Lacosamide}, year = {2016}, eissn = {1600-0404}, pages = {136-144}, orcid-numbers = {Kelemen, Anna/0000-0003-3942-3409; Vécsei, László/0000-0001-8037-3672} } @article{MTMT:2779667, title = {Valproate treatment normalizes EEG functional connectivity in successfully treated idiopathic generalized epilepsy patients.}, url = {https://m2.mtmt.hu/api/publication/2779667}, author = {Clemens, Béla and Puskás, Szilvia and Besenyei, M and Kovács, N Z and Spisák, Tamás and Kis, Sándor Attila and Emri, Miklós and Ohmachtné Hollódy, Katalin and Fogarasi, András and Kondákor, István and Fekete, István}, doi = {10.1016/j.eplepsyres.2014.09.032}, journal-iso = {EPILEPSY RES}, journal = {EPILEPSY RESEARCH}, volume = {108}, unique-id = {2779667}, issn = {0920-1211}, year = {2014}, eissn = {1872-6844}, pages = {1896-1903} } @article{MTMT:2082623, title = {Effects of CPAP-Therapy on Brain Electrical Activity in Obstructive Sleep Apneic Patients: A Combined EEG Study Using LORETA and Omega Complexity}, url = {https://m2.mtmt.hu/api/publication/2082623}, author = {Tóth, Márton and Faludi, Béla and Kondákor, István}, doi = {10.1007/s10548-012-0243-0}, journal-iso = {BRAIN TOPOGR}, journal = {BRAIN TOPOGRAPHY}, volume = {25}, unique-id = {2082623}, issn = {0896-0267}, keywords = {Electrophysiology; SPECTRAL-ANALYSIS; event-related potentials; COGNITIVE IMPAIRMENT; SPATIAL-RESOLUTION; MEASUREMENT NOISE; ELECTRODE DENSITY; DIURNAL-VARIATIONS; SOURCE-LOCALIZATION; POSITIVE AIRWAY PRESSURE; RESOLUTION ELECTROMAGNETIC TOMOGRAPHY; qEEG; Omega complexity; OSAS; LORETA; CPAP-therapy}, year = {2012}, eissn = {1573-6792}, pages = {450-460} } @article{MTMT:1961059, title = {EEG-LORETA endophenotypes of the common idiopathic generalized epilepsy syndromes}, url = {https://m2.mtmt.hu/api/publication/1961059}, author = {Clemens, Béla and Puskás, Szilvia and Besenyei, M and Emri, Miklós and Opposits, Gábor and Kis, Sándor Attila and Ohmachtné Hollódy, Katalin and Fogarasi, András and Kondákor, István and Füle, K and Bense, K and Fekete, István}, doi = {10.1016/j.eplepsyres.2011.12.008}, journal-iso = {EPILEPSY RES}, journal = {EPILEPSY RESEARCH}, volume = {99}, unique-id = {1961059}, issn = {0920-1211}, keywords = {Adolescent; Female; Male; Humans; Young Adult; Electroencephalography/*methods; *Electromagnetic Phenomena; *Endophenotypes; Tomography/*methods; Epilepsy, Generalized/*diagnosis/*physiopathology}, year = {2012}, eissn = {1872-6844}, pages = {281-292} } @article{MTMT:1707119, title = {EEG functional connectivity of the intrahemispheric cortico-cortical network of idiopathic generalized epilepsy}, url = {https://m2.mtmt.hu/api/publication/1707119}, author = {Clemens, Béla and Puskás, Szilvia and Bessenyei, M and Emri, Miklós and Spisák, Tamás and Koselak, M and Ohmachtné Hollódy, Katalin and Fogarasi, András and Kondákor, István and Fule, K and Bense, K and Fekete, István}, doi = {10.1016/j.eplepsyres.2011.04.011}, journal-iso = {EPILEPSY RES}, journal = {EPILEPSY RESEARCH}, volume = {96}, unique-id = {1707119}, issn = {0920-1211}, abstract = {AIMS: Intrahemispheric, cortico-cortical EEG functional connectivity (fC) was investigated in untreated patients with idiopathic generalized epilepsy (IGE) in this explorative study. PATIENTS AND METHODS: Group comparison was carried out between 19, drug-naive IGE patients and 19, matched healthy persons. 90x2s of 19 channels waking, interictal background EEG signal (without epileptiform potentials) were processed to the LORETA (low resolution electromagnetic tomography) software to compute current source density for 2394 voxels representing parcels of the cerebral cortex for 25 very narrow bands of 1Hz bandwidth (VNBs) from 1 to 25Hz. EEG fC was investigated among the already localized sources. Pearson correlation coefficients (R) were computed among the 33 regions of interest (ROI) within the left and within the right hemisphere, separately. Group differences were computed by means of t-statistics. Corrected p<0.05 differences were accepted as statistically significant. MAIN RESULTS: (1) The anatomical patterns of the fC differences showed great frequency-dependency. (2) Hemispheric asymmetry was prominent within most VNBs. (3) Decreased fC in the IGE group was found across all VNBs in the 1-6Hz frequency range as compared to mixed patterns comprising both increased and decreased fC at >6Hz frequencies. (4) In the 5-25Hz range, decreased fC dominated in the anterior, increased fC in the posterior parts of the cortex. (5) The results delineated an anterior and a posterior network. DISCUSSION: (1) Decreased fC in the 1-6Hz band might indicate some relationship to yet hidden structure network abnormalities. (2) The anatomical patterns of fC indicate frequency-dependent, pathological coupling and decoupling processes in the interictal state. (3) The two networks might help to understand seizure liability and seizure precipitation in IGE. SIGNIFICANCE: This is the first study to explore EEG fC in the interictal condition of IGE patients. The importance of EEG frequencies in evaluating fC in IGE was demonstrated and starting points for further research were given.}, keywords = {Adult; Adolescent; Female; Male; Humans; Child; Brain Mapping; Case-Control Studies; Young Adult; Dominance, Cerebral/*physiology; *Electroencephalography; Neural Pathways/physiopathology; Epilepsy, Generalized/*pathology/*physiopathology; Cerebral Cortex/*pathology/*physiopathology}, year = {2011}, eissn = {1872-6844}, pages = {11-23} } @article{MTMT:2380567, title = {CORTICAL EFFECT OF ANTIEPILEPTIC THERAPY IN UNVERRICHT-LUNDBORG SYNDROME: A QUANTITATIVE EEG STUDY USING LORETA ANALYSIS}, url = {https://m2.mtmt.hu/api/publication/2380567}, author = {Fule, K and Jobbagy, Z and Kondákor, István}, journal-iso = {EPILEPSIA}, journal = {EPILEPSIA}, volume = {51}, unique-id = {2380567}, issn = {0013-9580}, year = {2010}, eissn = {1528-1167}, pages = {53-54} } @article{MTMT:1681107, title = {Theta EEG source localization using LORETA in partial epilepsy patients with and without medication}, url = {https://m2.mtmt.hu/api/publication/1681107}, author = {Clemens, Béla and Bessenyei, M and Fekete, István and Puskás, Szilvia and Kondákor, István and Tóth, Márton and Ohmachtné Hollódy, Katalin}, doi = {10.1016/j.clinph.2010.01.020}, journal-iso = {CLIN NEUROPHYSIOL}, journal = {CLINICAL NEUROPHYSIOLOGY}, volume = {121}, unique-id = {1681107}, issn = {1388-2457}, keywords = {Adult; Adolescent; Female; Male; Humans; *Theta Rhythm; Image Processing, Computer-Assisted; Electroencephalography; Brain Mapping/*methods; Signal Processing, Computer-Assisted; Cerebral Cortex/*physiopathology; Tomography/methods; Epilepsies, Partial/drug therapy/*physiopathology; Anticonvulsants/therapeutic use}, year = {2010}, eissn = {1872-8952}, pages = {848-858} }