TY - JOUR AU - Cinege, Gyöngyi Ilona AU - Magyar, Lilla Brigitta AU - Kovács, Attila Lajos AU - Lerner, Zita AU - Juhász, Gábor AU - Lukacsovich, David AU - Winterer, Jochen AU - Lukacsovich, Tamás AU - Hegedűs, Zoltán AU - Kurucz, Judit Éva AU - Hultmark, Dan AU - Földy, Csaba AU - Andó, István TI - Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids JF - JOURNAL OF INNATE IMMUNITY J2 - J INNATE IMMUN VL - 14 PY - 2022 IS - 4 SP - 335 EP - 354 PG - 20 SN - 1662-811X DO - 10.1159/000520110 UR - https://m2.mtmt.hu/api/publication/32524824 ID - 32524824 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - THES AU - Lerner, Zita TI - Egy új vérsejt típus, a sokmagvú óriássejt szerepe a Drosophila sejt-közvetítette immunválaszában [The role of a novel blood cell type,the Multinucleated Giant Hemocyte in the cell-mediated immune response of Drosophila] PB - Szegedi Tudományegyetem (SZTE) PY - 2021 SP - 94 DO - 10.14232/phd.10682 UR - https://m2.mtmt.hu/api/publication/32849106 ID - 32849106 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Cinege, Gyöngyi Ilona AU - Lerner, Zita AU - Magyar, Lilla Brigitta AU - Soós, Bálint AU - Tóth, Renáta AU - Kristó, Ildikó AU - Vilmos, Péter AU - Juhász, Gábor AU - Kovács, Attila Lajos AU - Hegedűs, Zoltán AU - Sensen, Christoph W. AU - Kurucz, Judit Éva AU - Andó, István TI - Cellular Immune Response Involving Multinucleated Giant Hemocytes with Two-Step Genome Amplification in the Drosophilid Zaprionus indianus JF - JOURNAL OF INNATE IMMUNITY J2 - J INNATE IMMUN VL - 12 PY - 2020 IS - 3 SP - 257 EP - 272 PG - 16 SN - 1662-811X DO - 10.1159/000502646 UR - https://m2.mtmt.hu/api/publication/30819399 ID - 30819399 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Magyar, Lilla Brigitta AU - Lukacsovich, D AU - Cinege, Gyöngyi Ilona AU - Lerner, Zita AU - Kovacs, A AU - Juhasz, G AU - Lukacsovich, T AU - Winterer, J AU - Hegedus, Z AU - Kurucz, Judit Éva AU - Foldy, C AU - Andó, István TI - A Novel Cell Type in Innate Immunity, the Multinucleated Giant Hemocyte JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 11 PY - 2019 IS - 3 SP - 33 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/30864567 ID - 30864567 LA - English DB - MTMT ER - TY - JOUR AU - Cinege, Gyöngyi Ilona AU - Lerner, Zita AU - Magyar, Lilla Brigitta AU - Soos, B AU - Kurucz, Judit Éva AU - Toth, R AU - Kristo, I AU - Vilmos, P AU - Kovacs, AL AU - Juhasz, G AU - Hegedus, Z AU - Andó, István TI - Highly Efficient Cellular Immune Response Involving Multinucleated Giant Hemocytes with Two-Step Genome Amplification JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 11 PY - 2019 IS - 3 SP - 9 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/30864516 ID - 30864516 LA - English DB - MTMT ER - TY - JOUR AU - Lerner, Zita AU - Cinege, Gyöngyi Ilona AU - Kovacs, AL AU - Juhasz, G AU - Kurucz, Judit Éva AU - Andó, István TI - Comparative analysis of the multinucleated giant hemocytes in two Drosophila species JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 10 PY - 2018 IS - 3 SP - 40 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/30313671 ID - 30313671 LA - English DB - MTMT ER - TY - JOUR AU - Cinege, Gyöngyi Ilona AU - Lerner, Zita AU - Soos, B AU - Kristo, I AU - Kovacs, AL AU - Toth, R AU - Juhasz, G AU - Hegedus, Z AU - Kurucz, Judit Éva AU - Andó, István TI - A highly efficient immune response in the invasive Zaprionus indianus JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 10 PY - 2018 IS - 3 SP - 28 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/30313369 ID - 30313369 LA - English DB - MTMT ER - TY - JOUR AU - Cinege, Gyöngyi Ilona AU - Kurucz, Judit Éva AU - Lerner, Zita AU - Juhasz, G AU - Kovacs, AL AU - Toth, R AU - Soos, B AU - Andó, István TI - The Cellular Immune Responses in Phylogenetically Distant Drosophila Species JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 9 PY - 2017 IS - 3 SP - 9 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/31891558 ID - 31891558 LA - English DB - MTMT ER - TY - JOUR AU - Lerner, Zita AU - Markus, R AU - Honti, Viktor AU - Cinege, Gyöngyi Ilona AU - Kurucz, Judit Éva AU - Ando, I TI - Functional analysis of the multinucleated giant hemocytes JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 9 PY - 2017 IS - 3 SP - 38 PG - 1 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/3421277 ID - 3421277 LA - English DB - MTMT ER - TY - JOUR AU - Márkus, Róbert AU - Lerner, Zita AU - Honti, Viktor AU - Csordás, Gábor AU - Zsámboki, János AU - Cinege, Gyöngyi Ilona AU - Párducz, Árpád AU - Lukacsovich, Tamás AU - Kurucz, Judit Éva AU - Andó, István TI - Multinucleated Giant Hemocytes Are Effector Cells in Cell-Mediated Immune Responses of Drosophila JF - JOURNAL OF INNATE IMMUNITY J2 - J INNATE IMMUN VL - 7 PY - 2015 IS - 4 SP - 340 EP - 353 PG - 14 SN - 1662-811X DO - 10.1159/000369618 UR - https://m2.mtmt.hu/api/publication/2853634 ID - 2853634 N1 - Megjegyzés-25258522 Hiányzó Jelleg: 'JOUR\n\nArticle' Admin megjegyzés-25258522 tblcategory: (Category) ('JOUR\n\nArticle') #Jelleg AB - We identified and characterized a so far unrecognized cell type, dubbed the multinucleated giant hemocyte (MGH), in the ananassae subgroup of Drosophilidae. Here, we describe the functional and ultrastructural characteristics of this novel blood cell type as well as its characterization with a set of discriminative immunological markers. MGHs are encapsulating cells that isolate and kill the parasite without melanization. They share some properties with but differ considerably from lamellocytes, the encapsulating cells of Drosophila melanogaster, the broadly used model organism in studies of innate immunity. MGHs are nonproliferative effector cells that are derived from phagocytic cells of the sessile tissue and the circulation, but do not exhibit phagocytic activity. In contrast to lamellocytes, MGHs are gigantic cells with filamentous projections and contain many nuclei, which are the result of the fusion of several cells. Although the structure of lamellocytes and MGHs differ remarkably, their function in the elimination of parasites is similar, which is potentially the result of the convergent evolution of interactions between hosts and parasites in different geographic regions. MGHs are highly motile and share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during granulomatous inflammation. © 2015 S. Karger AG, Basel LA - English DB - MTMT ER -