@article{MTMT:32524824, title = {Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids}, url = {https://m2.mtmt.hu/api/publication/32524824}, author = {Cinege, Gyöngyi Ilona and Magyar, Lilla Brigitta and Kovács, Attila Lajos and Lerner, Zita and Juhász, Gábor and Lukacsovich, David and Winterer, Jochen and Lukacsovich, Tamás and Hegedűs, Zoltán and Kurucz, Judit Éva and Hultmark, Dan and Földy, Csaba and Andó, István}, doi = {10.1159/000520110}, journal-iso = {J INNATE IMMUN}, journal = {JOURNAL OF INNATE IMMUNITY}, volume = {14}, unique-id = {32524824}, issn = {1662-811X}, year = {2022}, eissn = {1662-8128}, pages = {335-354}, orcid-numbers = {Juhász, Gábor/0000-0001-8548-8874; Winterer, Jochen/0000-0002-6800-6594; Lukacsovich, Tamás/0000-0001-5908-9861; Hultmark, Dan/0000-0002-6506-5855; Andó, István/0000-0002-4648-9396} } @mastersthesis{MTMT:32849106, title = {Egy új vérsejt típus, a sokmagvú óriássejt szerepe a Drosophila sejt-közvetítette immunválaszában [The role of a novel blood cell type,the Multinucleated Giant Hemocyte in the cell-mediated immune response of Drosophila]}, url = {https://m2.mtmt.hu/api/publication/32849106}, author = {Lerner, Zita}, doi = {10.14232/phd.10682}, publisher = {SZTE}, unique-id = {32849106}, year = {2021} } @article{MTMT:30819399, title = {Cellular Immune Response Involving Multinucleated Giant Hemocytes with Two-Step Genome Amplification in the Drosophilid Zaprionus indianus}, url = {https://m2.mtmt.hu/api/publication/30819399}, author = {Cinege, Gyöngyi Ilona and Lerner, Zita and Magyar, Lilla Brigitta and Soós, Bálint and Tóth, Renáta and Kristó, Ildikó and Vilmos, Péter and Juhász, Gábor and Kovács, Attila Lajos and Hegedűs, Zoltán and Sensen, Christoph W. and Kurucz, Judit Éva and Andó, István}, doi = {10.1159/000502646}, journal-iso = {J INNATE IMMUN}, journal = {JOURNAL OF INNATE IMMUNITY}, volume = {12}, unique-id = {30819399}, issn = {1662-811X}, year = {2020}, eissn = {1662-8128}, pages = {257-272}, orcid-numbers = {Juhász, Gábor/0000-0001-8548-8874; Andó, István/0000-0002-4648-9396} } @article{MTMT:30864567, title = {A Novel Cell Type in Innate Immunity, the Multinucleated Giant Hemocyte}, url = {https://m2.mtmt.hu/api/publication/30864567}, author = {Magyar, Lilla Brigitta and Lukacsovich, D and Cinege, Gyöngyi Ilona and Lerner, Zita and Kovacs, A and Juhasz, G and Lukacsovich, T and Winterer, J and Hegedus, Z and Kurucz, Judit Éva and Foldy, C and Andó, István}, journal-iso = {IMMUNOLÓGIAI SZEMLE}, journal = {IMMUNOLÓGIAI SZEMLE}, volume = {11}, unique-id = {30864567}, issn = {2061-0203}, year = {2019}, pages = {33}, orcid-numbers = {Andó, István/0000-0002-4648-9396} } @article{MTMT:30864516, title = {Highly Efficient Cellular Immune Response Involving Multinucleated Giant Hemocytes with Two-Step Genome Amplification}, url = {https://m2.mtmt.hu/api/publication/30864516}, author = {Cinege, Gyöngyi Ilona and Lerner, Zita and Magyar, Lilla Brigitta and Soos, B and Kurucz, Judit Éva and Toth, R and Kristo, I and Vilmos, P and Kovacs, AL and Juhasz, G and Hegedus, Z and Andó, István}, journal-iso = {IMMUNOLÓGIAI SZEMLE}, journal = {IMMUNOLÓGIAI SZEMLE}, volume = {11}, unique-id = {30864516}, issn = {2061-0203}, year = {2019}, pages = {9}, orcid-numbers = {Andó, István/0000-0002-4648-9396} } @article{MTMT:30313671, title = {Comparative analysis of the multinucleated giant hemocytes in two Drosophila species}, url = {https://m2.mtmt.hu/api/publication/30313671}, author = {Lerner, Zita and Cinege, Gyöngyi Ilona and Kovacs, AL and Juhasz, G and Kurucz, Judit Éva and Andó, István}, journal-iso = {IMMUNOLÓGIAI SZEMLE}, journal = {IMMUNOLÓGIAI SZEMLE}, volume = {10}, unique-id = {30313671}, issn = {2061-0203}, year = {2018}, pages = {40}, orcid-numbers = {Andó, István/0000-0002-4648-9396} } @article{MTMT:30313369, title = {A highly efficient immune response in the invasive Zaprionus indianus}, url = {https://m2.mtmt.hu/api/publication/30313369}, author = {Cinege, Gyöngyi Ilona and Lerner, Zita and Soos, B and Kristo, I and Kovacs, AL and Toth, R and Juhasz, G and Hegedus, Z and Kurucz, Judit Éva and Andó, István}, journal-iso = {IMMUNOLÓGIAI SZEMLE}, journal = {IMMUNOLÓGIAI SZEMLE}, volume = {10}, unique-id = {30313369}, issn = {2061-0203}, year = {2018}, pages = {28}, orcid-numbers = {Andó, István/0000-0002-4648-9396} } @article{MTMT:31891558, title = {The Cellular Immune Responses in Phylogenetically Distant Drosophila Species}, url = {https://m2.mtmt.hu/api/publication/31891558}, author = {Cinege, Gyöngyi Ilona and Kurucz, Judit Éva and Lerner, Zita and Juhasz, G and Kovacs, AL and Toth, R and Soos, B and Andó, István}, journal-iso = {IMMUNOLÓGIAI SZEMLE}, journal = {IMMUNOLÓGIAI SZEMLE}, volume = {9}, unique-id = {31891558}, issn = {2061-0203}, year = {2017}, pages = {9}, orcid-numbers = {Andó, István/0000-0002-4648-9396} } @article{MTMT:3421277, title = {Functional analysis of the multinucleated giant hemocytes}, url = {https://m2.mtmt.hu/api/publication/3421277}, author = {Lerner, Zita and Markus, R and Honti, Viktor and Cinege, Gyöngyi Ilona and Kurucz, Judit Éva and Ando, I}, journal-iso = {IMMUNOLÓGIAI SZEMLE}, journal = {IMMUNOLÓGIAI SZEMLE}, volume = {9}, unique-id = {3421277}, issn = {2061-0203}, year = {2017}, pages = {38-39} } @article{MTMT:2853634, title = {Multinucleated Giant Hemocytes Are Effector Cells in Cell-Mediated Immune Responses of Drosophila}, url = {https://m2.mtmt.hu/api/publication/2853634}, author = {Márkus, Róbert and Lerner, Zita and Honti, Viktor and Csordás, Gábor and Zsámboki, János and Cinege, Gyöngyi Ilona and Párducz, Árpád and Lukacsovich, Tamás and Kurucz, Judit Éva and Andó, István}, doi = {10.1159/000369618}, journal-iso = {J INNATE IMMUN}, journal = {JOURNAL OF INNATE IMMUNITY}, volume = {7}, unique-id = {2853634}, issn = {1662-811X}, abstract = {We identified and characterized a so far unrecognized cell type, dubbed the multinucleated giant hemocyte (MGH), in the ananassae subgroup of Drosophilidae. Here, we describe the functional and ultrastructural characteristics of this novel blood cell type as well as its characterization with a set of discriminative immunological markers. MGHs are encapsulating cells that isolate and kill the parasite without melanization. They share some properties with but differ considerably from lamellocytes, the encapsulating cells of Drosophila melanogaster, the broadly used model organism in studies of innate immunity. MGHs are nonproliferative effector cells that are derived from phagocytic cells of the sessile tissue and the circulation, but do not exhibit phagocytic activity. In contrast to lamellocytes, MGHs are gigantic cells with filamentous projections and contain many nuclei, which are the result of the fusion of several cells. Although the structure of lamellocytes and MGHs differ remarkably, their function in the elimination of parasites is similar, which is potentially the result of the convergent evolution of interactions between hosts and parasites in different geographic regions. MGHs are highly motile and share several features with mammalian multinucleated giant cells, a syncytium of macrophages formed during granulomatous inflammation. © 2015 S. Karger AG, Basel}, year = {2015}, eissn = {1662-8128}, pages = {340-353}, orcid-numbers = {Csordás, Gábor/0000-0001-6871-6839; Andó, István/0000-0002-4648-9396} }