@article{MTMT:34486303,
	title = {Sarco/endoplasmic reticulum calcium ATPase 3 (SERCA3) expression in gastrointestinal stromal tumours.},
	url = {https://m2.mtmt.hu/api/publication/34486303},
	author = {Adle-Biassette, Homa and Ricci, Riccardo and Martin, Antoine and Martini, Maurizio and Ravegnini, Gloria and Kaci, Rachid and Gélébart, Pascal and Poirot, Brigitte and Sándor, Zsuzsa and Lehman-Che, Jacqueline and Tóth, Erika and Papp, Bela},
	doi = {10.1016/j.pathol.2023.10.012},
	journal-iso = {PATHOLOGY},
	journal = {PATHOLOGY},
	volume = {56},
	unique-id = {34486303},
	issn = {0031-3025},
	abstract = {Accurate characterisation of gastrointestinal stromal tumours (GIST) is important for prognosis and the choice of targeted therapies. Histologically the diagnosis relies on positive immunostaining of tumours for KIT (CD117) and DOG1. Here we report that GISTs also abundantly express the type 3 Sarco/Endoplasmic Reticulum Calcium ATPase (SERCA3). SERCA enzymes transport calcium ions from the cytosol into the endoplasmic reticulum and play an important role in regulating the intensity and the periodicity of calcium-induced cell activation. GISTs from various localisations, histological and molecular subtypes or risk categories were intensely immunopositive for SERCA3 with the exception of PDGFRA-mutated cases where expression was high or moderate. Strong SERCA3 expression was observed also in normal and hyperplastic interstitial cells of Cajal. Decreased SERCA3 expression in GIST was exceptionally observed in a zonal pattern, where CD117 staining was similarly decreased, reflecting clonal heterogeneity. In contrast to GIST, SERCA3 immunostaining of spindle cell tumours and other gastrointestinal tumours resembling GIST was negative or weak. In conclusion, SERCA3 immunohistochemistry may be useful for the diagnosis of GIST with high confidence, when used as a third marker in parallel with KIT and DOG1. Moreover, SERCA3 immunopositivity may be particularly helpful in cases with negative or weak KIT or DOG1 staining, a situation that may be encountered de novo, or during the spontaneous or therapy-induced clonal evolution of GIST.},
	keywords = {calcium; MARKER; immunohistochemistry; endoplasmic reticulum; Gastrointestinal stromal tumour; Interstitial cells of Cajal; sarco/endoplasmic reticulum calcium ATPase},
	year = {2024},
	eissn = {1465-3931},
	pages = {343-356},
	orcid-numbers = {Tóth, Erika/0000-0003-2054-8447}
}

@article{MTMT:35441001,
	title = {Bones or Stones: How Can We Apply Geophysical Techniques in Bone Research?},
	url = {https://m2.mtmt.hu/api/publication/35441001},
	author = {Szekanecz, Zoltán and Besnyi, Anikó Mária and Kónya, Péter and Füri, Judit Izabella and Király, Edit and Bertalan, Éva and Falus, György and Udvardi, Beatrix and Kovácsné Kis, Viktória and Andrássy, László and Maros, Gyula and Fancsik, Tamás and Pethő, Zsófia and Gomez, Izabella Ilona and Horváth, Ágnes and Gulyás, Katalin and Juhász, Balázs and Hodosi, Katalin and Sándor, Zsuzsa and Bhattoa Harjit, Pál and Kovács, István János},
	doi = {10.3390/ijms251910733},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {35441001},
	issn = {1661-6596},
	abstract = {Some studies have used physical techniques for the assessment of bone structure and composition. However, very few studies applied multiple techniques, such as those described below, at the same time. The aim of our study was to determine the chemical and mineralogical/organic composition of bovine tibial bone samples using geophysical/geochemical reference techniques. X-ray diffraction (XRD), thermogravimetry (TG), Fourier-transform infrared spectrometry with attenuated total reflectance accessory (FTIR-ATR), inductively coupled mass spectrometry (ICP-MS) and inductively coupled optical emission spectrometry (ICP-OES) were applied to measure the organic and inorganic composition of 14 bovine bone samples. In addition, peripheral quantitative CT (QCT) was used to assess BMD in these bones. We were able to define the total composition of the studied bone samples. ICP-OES and ICP-MS techniques were used to determine the major and trace element composition. The X-ray analysis could detect inorganic crystalline compounds of bones, such as bioapatite, and its degree of ordering, indicating whether the bones belong to a younger or older individual. The total volatile content of the samples was calculated using TG and resulted in about 35 weight% (wt%). This, together with the 65 wt% total resulting from the chemical analysis (i.e., inorganic components), yielded a total approaching 100 wt%. As a large portion of the volatile content (H2O, CO2, etc.) was liberated from the organic components and, subordinately, from bioapatite, it could be concluded that the volatile-to-solid ratio of the examined bone samples was ~35:65. The FTIR-ATR analysis revealed that the organic portion consists of collagens containing amide groups, as their typical bands (OH, CH, CO, NC) were clearly identified in the infrared spectra. Numerous parameters of bone composition correlated with BMD as determined by QCT. In conclusion, we performed a complex evaluation of bovine bones to test multiple geophysical/geochemical techniques in bone research in association with QCT bone densitometry. From a medical point of view, the composition of the studied bones could be reliably examined by these methods.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Kovácsné Kis, Viktória/0000-0001-6412-2320; Maros, Gyula/0000-0002-2973-4513; Juhász, Balázs/0000-0003-0704-4017; Bhattoa Harjit, Pál/0000-0002-4909-0065; Kovács, István János/0000-0002-3488-3716}
}

@article{MTMT:31311725,
	title = {A módosított Regnault „B” emlőmegtartó műtét mint II. szintű standard onkoplasztikus emlősebészeti technika},
	url = {https://m2.mtmt.hu/api/publication/31311725},
	author = {Kelemen, Péter Bertalan and Újhelyi, Mihály and Pukancsik, Dávid and Sávolt, Ákos and Kovács, Eszter and Zaka, Z and Sándor, Zsuzsa and Mátrai, Zoltán Tamás},
	doi = {10.1556/650.2020.31738},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {161},
	unique-id = {31311725},
	issn = {0030-6002},
	year = {2020},
	eissn = {1788-6120},
	pages = {1002-1011},
	orcid-numbers = {Újhelyi, Mihály/0000-0001-7164-563X; Sávolt, Ákos/0009-0001-4108-0516}
}

@article{MTMT:1988097,
	title = {Aurora Kinase B Expression in Breast Carcinoma: Cell Kinetic and Genetic Aspects},
	url = {https://m2.mtmt.hu/api/publication/1988097},
	author = {Dull, Katalin and Egervári, Kristóf and Sándor, Zsuzsa and Méhes, Gábor},
	doi = {10.1159/000338082},
	journal-iso = {PATHOBIOLOGY},
	journal = {PATHOBIOLOGY},
	volume = {79},
	unique-id = {1988097},
	issn = {1015-2008},
	year = {2012},
	eissn = {1423-0291},
	pages = {314-322}
}

@article{MTMT:1121641,
	title = {A betegségprogresszió hatása az egészségi állapotra, életminőségre és költségekre rheumatoid arthritisben Magyarországon. [Impact of disease progression on health status, quality of life and costs in rheumatoid arthritis in Hungary]},
	url = {https://m2.mtmt.hu/api/publication/1121641},
	author = {Péntek, Márta and Szekanecz, Zoltán and Czirják, László and Poór, Gyula and Rojkovich, Bernadette and Polgár, Anna and Genti, G and Kiss, CG and Sándor, Zsuzsa and Májer, I and Brodszky, Valentin and Gulácsi, László},
	doi = {10.1556/OH.2008.28294},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {149},
	unique-id = {1121641},
	issn = {0030-6002},
	abstract = {Rheumatoid arthritis (RA) is a chronic, progressive polyarthritis leading to substantial disability. Standardised data on consequences of discase progression are needed for clinical assessments and also for cost-effectiveness models. Aim: To analyse the impact of disease progression on health status, disease specific quality of life and costs in Hungary. Methods: A cross-sectional survey was performed between April and August, 2004, involving consecutive RA patients of 6 hospital based rheumatology outpatient centres. Self-completed questionnaires were used to assess functional (HAQ) and health status (EQ-5D), quality of life (RAQoL). Disease activity (DAS) and costs were also surveyed, statistical analysis was performed. Results: 255 patients were involved [mean age 55.5 ± 12.3 years; disease duration 9.0 ± 9.3 years; HAQ 1.38 ± 0.76; EQ-5D 0.46 ± 0.33; RAQoL 16.2 ± 8.1; DAS 5.09 ± 1.42; costs 1,043,163 (± 844,750) HUF/patient/year, conversion 1 Euro = 250 HUF]. Correlation was significant between the parameters (p<0.01): EQ-5D index = 1.014-0.25 × HAQ-0.041 × DAS; HAQ = 0.314 + 0.065 × RAQoL. Analysis by disease severity levels (HAQ groups 0.5 difference) revealed that health status worsens (mean EQ-5D: 0.784; 0.576; 0.504; 0.3671 0.211; 0.022) and costs increase (mean 628,280; 888,187; 953,759; 1,291,218; 1,346,112; 1,371,674 HUF/patient/ year) with disease progression. Minimally important worsening of functional ability (0.25 HAQ increase) corresponds to -0.0705 EQ-5D and + 1.884 RAQoL change. Lower health status difference (EQ-5D -0.05725) was calculated in patients with lower disease activity (DAS < 5.1). Conclusions: Correlation between disease progression, health status, quality of life and costs does not differ significantly from international results. The amount of costs is much lower in all disease severity levels than in developed European countries. Our study serves baseline data for health economic analysis in RA in Hungary.},
	keywords = {Aged; Adult; Female; Middle Aged; Male; Humans; DISEASE PROGRESSION; Hungary; Quality of Life; Questionnaires; Health Status; Cross-Sectional Studies; Health Care Costs},
	year = {2008},
	eissn = {1788-6120},
	pages = {733-741},
	orcid-numbers = {Poór, Gyula/0000-0001-9235-3900}
}

@article{MTMT:1144228,
	title = {Endothelial dysfunction and atherosclerosis in rheumatoid arthritis: a multiparametric analysis using imaging techniques and laboratory markers of inflammation and autoimmunity.},
	url = {https://m2.mtmt.hu/api/publication/1144228},
	author = {Kerekes, György and Szekanecz, Zoltán and Der, H and Sándor, Zsuzsa and Lakos, G and Muszbek, László and Csípő, István and Sipka, Sándor and Seres, Ildikó and Paragh, György and Kappelmayer, János and Szomják, Edit and Veres, Katalin and Szegedi, Gyula and Shoenfeld, Y and Soltész, Pál},
	journal-iso = {J RHEUMATOL},
	journal = {JOURNAL OF RHEUMATOLOGY},
	volume = {35},
	unique-id = {1144228},
	issn = {0315-162X},
	abstract = {OBJECTIVE: Cardiovascular disease is a leading cause of mortality in rheumatoid
		arthritis (RA). Endothelial dysfunction often precedes manifest atherosclerosis. 
		We assessed endothelial dysfunction and atherosclerosis in RA in context with
		laboratory markers. METHODS: Fifty-two patients with RA and 40 matched healthy
		controls were studied. We assessed common carotid intima-media thickness (ccIMT) 
		and flow- (FMD) and nitroglycerine-mediated vasodilation (NMD). We also assayed
		numerous immunological and metabolic laboratory markers. RESULTS: FMD was
		significantly lower in RA (5.32% +/- 4.66%) compared to controls (8.30% +/-
		3.96%) (p = 0.001). NMD was preserved in RA. ccIMT was significantly greater in
		patients with RA (0.63 +/- 0.14 mm) versus controls (0.54 +/- 0.15 mm) (p =
		0.012). In patients with RA, ccIMT correlated with FMD% (R = -0.318, p = 0.022), 
		age (R = 0.831, p < 0.001), and anti-dsDNA levels (R = 0.463, p = 0.006). FMD%
		correlated with serum interferon-gamma (IFN-gamma) levels (R = 0.516, p = 0.014).
		NMD% correlated inversely with the percentage of Th0 lymphocytes (R = -0.636, p =
		0.006), serum immune complex (R = -0.692, p < 0.001), and IgM levels (R = -0.606,
		p = 0.003). Patients with RA were divided as "low" (< 0.65 mm) versus "high" (>
		0.65 mm) ccIMT groups, and into "normal" (> 5%) versus "impaired" (< 5%) FMD%
		subsets. Low and high ccIMT groups differed significantly in age and serum
		interleukin 1 (IL-1) and anti-dsDNA levels. RA patients with normal versus
		impaired FMD% differed significantly in age, disease duration, and serum
		IFN-gamma levels. Lipoprotein(a) [Lp(a)] also correlated with rheumatoid factor
		(RF) and C-reactive protein (CRP); homocysteine (HCy) correlated with CRP and
		correlated inversely with folate and vitamin B12 production. Paraoxonase-1
		(PON-1) activity correlated with serum tumor necrosis factor-alpha(TNF-alpha) and
		IL-6 levels. CONCLUSION: This was a well characterized RA population, where FMD
		and ccIMT were impaired, indicating early endothelial dysfunction and accelerated
		atherosclerosis, respectively. RA-related autoimmune-inflammatory mechanisms and 
		metabolic factors including anti-CCP, RF, CRP, circulating immune complexes, IgM,
		TNF-alpha, IL-6, Th0/Th1 ratio, HCy, folate, vitamin B12, and PON-1 may all be
		involved in the development of vascular disease in RA. Although ccIMT and FMD, as
		well as some laboratory factors, have been assessed by other investigators in
		RA-associated atherosclerosis, our results regarding the possible involvement of 
		anti-CCP, anti-dsDNA, Lp(a), some cytokines, and PON-1 activity are novel. Early 
		determination of FMD% and ccIMT may be useful to assess RA patients with high
		cardiovascular risk.},
	year = {2008},
	eissn = {1499-2752},
	pages = {398-406},
	orcid-numbers = {Muszbek, László/0000-0002-3798-9962}
}

@article{MTMT:1917322,
	title = {Mellkasi lágyrésztumor. rheumatoid csomó?},
	url = {https://m2.mtmt.hu/api/publication/1917322},
	author = {Pethő, Zsófia and Szabó, Zoltán and Brugós, László and Nemes, Zoltán and Szőllősi, Zoltán and Sándor, Zsuzsa and Pápay, Zsuzsanna and Szekanecz, Zoltán},
	journal-iso = {MAGYAR REUMATOL},
	journal = {MAGYAR REUMATOLÓGIA},
	volume = {49},
	unique-id = {1917322},
	issn = {0139-4495},
	year = {2008},
	pages = {172},
	orcid-numbers = {Szőllősi, Zoltán/0000-0002-9794-1602}
}

@article{MTMT:31307762,
	title = {Mellkasi lágyrésztumor: rheumatoid csomó? : esetismertetés},
	url = {https://m2.mtmt.hu/api/publication/31307762},
	author = {Pethő, Zsófia and Szabó, Zoltán and Brugós, László and Nemes, Zoltán and Szöllősi, Zoltán and Sándor, Zsuzsa and Pápay, Zsuzsanna and Szekanecz, Zoltán},
	journal-iso = {MAGYAR REUMATOL},
	journal = {MAGYAR REUMATOLÓGIA},
	volume = {49},
	unique-id = {31307762},
	issn = {0139-4495},
	year = {2008},
	pages = {172-172}
}

@article{MTMT:1091732,
	title = {Accelerated Atherosclerosis in Rheumatoid Arthritis.},
	url = {https://m2.mtmt.hu/api/publication/1091732},
	author = {Szekanecz, Zoltán and Kerekes, György and Der, H and Sándor, Zsuzsa and Szabo, Z and Vegvari, A and Simkovics, E and Soos, L and Szentpetery, A and Besenyei, Tímea and Szűcs, Gabriella and Szántó, Sándor Zoltán and Tamasi, L and Szegedi, Gyula and Shoenfeld, Y and Soltész, Pál},
	doi = {10.1196/annals.1422.036},
	journal-iso = {ANN NY ACAD SCI},
	journal = {ANNALS OF THE NEW YORK ACADEMY OF SCIENCES},
	volume = {1108},
	unique-id = {1091732},
	issn = {0077-8923},
	abstract = {Cardiovascular disease is a leading cause of mortality in rheumatoid arthritis (RA). Endothelial dysfunction often precedes manifest atherosclerosis. Both traditional, Framingham risk factors and inflammation-associated factors are involved in RA-associated atherosclerosis. Among imaging techniques, the early determination of common carotid intima-media thickness (ccIMT), flow-mediated vasodilation (FMD), and nitroglycerine-mediated vasodilation (NMD) may be useful to determine atherosclerosis and endothelial dysfunction. We and others found increased ccIMT and impaired FMD in RA patients. Among immunological and metabolic laboratory markers, anticyclic citrullinated peptide (anti-CCP) antibodies, IgM rheumatoid factor, circulating immune complexes, pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), Th0/Th1 T cells, homocysteine, dyslipidemia, decreased folate and vitamin B12 production, and impaired paraoxonase activity may all be involved in the development of vascular disease in RA. The early diagnosis of endothelial dysfunction and atherosclerosis, active immunosuppressive treatment, the use of drugs that control atherosclerosis, changes in sedentary lifestyle, and the close follow-up of RA patients may help to minimize cardiovascular risk in these individuals.},
	keywords = {Inflammation; Humans; ATHEROSCLEROSIS; VASODILATATION; MORTALITY; tumor necrosis factor alpha; cytokine; human; Risk Factors; risk factor; disease association; conference paper; laboratory test; disease marker; enzyme activity; Immunoglobulin M; Folic acid; biological marker; Diagnostic Imaging; cardiovascular diseases; corticosteroid; dyslipidemia; vascular disease; triacylglycerol blood level; endothelial dysfunction; cardiovascular disease; interleukin 6; side effect; T lymphocyte; chloroquine; acetylsalicylic acid; METHOTREXATE; glyceryl trinitrate; Th1 cell; autoantibody; carotid artery; rheumatoid arthritis; follow up; ATORVASTATIN; antithrombocytic agent; immunosuppressive treatment; hydroxychloroquine; homocysteine; Endothelium, Vascular; hydroxymethylglutaryl coenzyme A reductase inhibitor; Cardiovascular risk; laboratory diagnosis; antigen antibody complex; protein antibody; artery media; artery intima; antimalarial agent; Arthritis, Rheumatoid; rheumatoid factor; imaging system; artery diameter; sitting; lifestyle; selective estrogen receptor modulator; raloxifene; aryldialkylphosphatase; cyclic citrullinated peptide antibody; cyanocobalamin},
	year = {2007},
	eissn = {1749-6632},
	pages = {349-358},
	orcid-numbers = {Besenyei, Tímea/0000-0001-6514-9779; Szántó, Sándor Zoltán/0000-0001-5030-6292}
}

@article{MTMT:1282700,
	title = {Catastrophic antiphospholipid syndrome (Asherson's syndrome) associated with cytokeratin 7-positive endometrial cancer},
	url = {https://m2.mtmt.hu/api/publication/1282700},
	author = {Soltész, Pál and Veres, Katalin and Szomjḱ, E and Kerekes, György and Dér, H and Sándor, Zsuzsa and Dezső, Balázs and Dévényi, K and Szekanecz, Zoltán},
	journal-iso = {ISRAEL MED ASSOC J},
	journal = {ISRAEL MEDICAL ASSOCIATION JOURNAL},
	volume = {9},
	unique-id = {1282700},
	issn = {1565-1088},
	year = {2007},
	eissn = {1565-1088},
	pages = {891-893}
}