@article{MTMT:34126717,
	title = {Therapeutic Aspects of Prunus cerasus Extract in a Rabbit Model of Atherosclerosis-Associated Diastolic Dysfunction},
	url = {https://m2.mtmt.hu/api/publication/34126717},
	author = {Szekeres, Réka Mária and Priksz, Dániel and Kiss, Rita and Romanescu, Dana Diana and Bombicz, Mariann and Varga, Balázs and Gesztelyi, Rudolf and Szilágyi, Anna and Takács, Barbara and Tarjányi, Vera and Pelles-Tasko, Beata and Forgács, Ildikó Noémi and Gálné Remenyik, Judit and Szilvássy, Zoltán and Juhász, Béla},
	doi = {10.3390/ijms241713253},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34126717},
	issn = {1661-6596},
	abstract = {This study evaluates the potential therapeutic effects of anthocyanin-rich Prunus cerasus (sour cherry) extract (PCE) on atherosclerosis-associated cardiac dysfunction, described by the impairment of the NO-PKG (nitric oxide–protein kinase G) pathway and the antioxidant capacity. Initially, a rabbit model of atherosclerotic cardiovascular disease was established by administering a cholesterol-rich diet, enabling the examination of the impact of 9 g/kg PCE on the pre-existing compromised cardiovascular condition. After that, the animals were divided into four groups for 12 weeks: the (1) untreated control group; (2) PCE-administered healthy rabbits; (3) hypercholesterolemic (HC) group kept on an atherogenic diet; and (4) PCE-treated HC group. Dyslipidemia, impaired endothelial function, and signs of diastolic dysfunction were evident in hypercholesterolemic rabbits, accompanied by a reduced cardiac expression of eNOS (endothelial nitric oxide synthase), PKG, and SERCA2a (sarco/endoplasmic reticulum calcium ATPase 2a). Subsequent PCE treatment improved the lipid profile and the cardiac function. Additionally, PCE administration was associated with elevated myocardial levels of eNOS, PKG, and SERCA2a, while no significant changes in the vascular status were observed. Western blot analysis further revealed hypercholesterolemia-induced increase and PCE-associated reduction in heme oxygenase-1 expression. The observed effects of anthocyanins indicate their potential as a valuable addition to the treatment regimen for atherosclerosis-associated cardiac dysfunction.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Kiss, Rita/0000-0003-1208-366X; Romanescu, Dana Diana/0000-0002-6002-8975; Gesztelyi, Rudolf/0000-0001-7911-055X}
}

@article{MTMT:33703433,
	title = {Drug Candidate BGP-15 Prevents Isoproterenol-Induced Arrhythmias and Alters Heart Rate Variability (HRV) in Telemetry-Implanted Rats},
	url = {https://m2.mtmt.hu/api/publication/33703433},
	author = {Bernát, Brigitta Renáta and Erdelyi, Rita and Fazekas, László Ádám and Garami, Greta and Szekeres, Réka Mária and Takács, Barbara and Bombicz, Mariann and Varga, Balázs and Sárkány, Fruzsina and Ráduly, Arnold and Romanescu, Dana Diana and Papp, Zoltán and Tóth, Attila and Szilvássy, Zoltán and Juhász, Béla and Priksz, Dániel},
	doi = {10.3390/ph16030359},
	journal-iso = {PHARMACEUTICALS-BASE},
	journal = {PHARMACEUTICALS},
	volume = {16},
	unique-id = {33703433},
	abstract = {Multi-target drug candidate BGP-15 has shown cardioprotective and antiarrhythmic actions in diseased models. Here, we investigated the effects of BGP-15 on ECG and echocardiographic parameters, heart rate variability (HRV), and arrhythmia incidence in telemetry-implanted rats, under beta-adrenergic stimulation by isoproterenol (ISO). In total, 40 rats were implanted with radiotelemetry transmitters. First, dose escalation studies (40–160 mg/kg BGP-15), ECG parameters, and 24 h HRV parameters were assessed. After, rats were divided into Control, Control+BGP-15, ISO, and ISO+BGP-15 subgroups for 2 weeks. ECG recordings were obtained from conscious rats, arrhythmias and HRV parameters were assessed, and echocardiography was carried out. ISO-BGP-15 interaction was also evaluated on an isolated canine cardiomyocyte model. BGP-15 had no observable effects on the ECG waveforms; however, it decreased heart rate. HRV monitoring showed that BGP-15 increased RMSSD, SD1, and HF% parameters. BGP-15 failed to counteract 1 mg/kg ISO-induced tachycardia, but diminished the ECG of ischemia and suppressed ventricular arrhythmia incidence. Under echocardiography, after low-dose ISO injection, BGP-15 administration lowered HR and atrial velocities, and increased end-diastolic volume and ventricle relaxation, but did not counteract the positive inotropic effects of ISO. Two weeks of BGP-15 treatment also improved diastolic function in ISO-treated rats. In isolated cardiomyocytes, BGP-15 prevented 100 nM ISO-induced aftercontractions. Here, we show that BGP-15 increases vagally mediated HRV, reduces arrhythmogenesis, enhances left ventricle relaxation, and suppresses the aftercontractions of cardiomyocytes. As the drug is well tolerated, it may have a clinical value in preventing fatal arrhythmias.},
	keywords = {Echocardiography; Arrhythmia; telemetry; BGP-15; heart rate variability (HRV); isoproterenol (ISO)},
	year = {2023},
	eissn = {1424-8247},
	orcid-numbers = {Bernát, Brigitta Renáta/0000-0001-6090-1001; Romanescu, Dana Diana/0000-0002-6002-8975}
}

@article{MTMT:33560204,
	title = {Examination of Preferences for COVID-19 Vaccines in Hungary Based on Their Properties—Examining the Impact of Pandemic Awareness with a Hybrid Choice Approach},
	url = {https://m2.mtmt.hu/api/publication/33560204},
	author = {Blaga, Zsanett and Czine, Péter and Takács, Barbara and Szilagyi, Anna and Szekeres, Réka Mária and Juhászné Wachal, Zita Eszter and Hegedus, Csaba and Buchholcz, Gyula and Varga, Balázs and Priksz, Dániel and Bombicz, Mariann and Vargáné Szabó, Adrienn Mónika and Kiss, Rita and Gesztelyi, Rudolf and Romanescu, Dana Diana and Szabó, Zoltán and Szűcs, Miklós and Balogh, Péter and Szilvássy, Zoltán and Juhász, Béla},
	doi = {10.3390/ijerph20021270},
	journal-iso = {INT J ENV RES PUB HE},
	journal = {INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH},
	volume = {20},
	unique-id = {33560204},
	issn = {1661-7827},
	abstract = {The COVID-19 pandemic has posed a huge challenge to the world in recent years. The development of vaccines that are as effective as possible and accessible to society offers a promising alternative for addressing the problems caused by this situation as soon as possible and to restore the pre-epidemic system. The present study investigated the preferences of residents in Hungary’s second-largest city (Debrecen) for the COVID-19 vaccine. To achieve this aim, a discrete choice experiment was conducted with 1011 participants, and the vaccine characteristics included in the design of the experiment were determined by qualitative methods and a pilot survey: (1) country of origin; (2) efficiency; (3) side effect; and (4) duration of protection. During the data collection at three vaccination sites, respondents were asked to choose between three vaccine alternatives and one “no choice” option in eight decision situations. Discrete choice model estimations were performed using a random parameter logit (RPL) specification with the final model extended to include a latent variable measuring pandemic awareness. The results showed that the vaccine with a Chinese country of origin is the least preferred among the respondents, while the Hungarian and the European vaccines are the most preferred. Furthermore, the increase in the vaccine efficiency level increased the respondents’ sense of utility for the vaccine; the short-term side effect was preferred to the long-term one; and the increase in the duration of protection provided by the vaccine increased the respondents’ sense of utility for the vaccine. Based on the parameter estimated for the latent variable, it can be concluded that as the level of pandemic awareness (which is more positive among people with chronic diseases and less important among health workers) increases, the choice of a vaccine option becomes more preferred among respondents compared to the “no choice“. The results of our investigation could contribute towards increasing compliance in the case of the vaccination-rejecting population, not only for COVID-19, but for any kind of vaccination procedure.},
	year = {2023},
	eissn = {1660-4601},
	orcid-numbers = {Kiss, Rita/0000-0003-1208-366X; Gesztelyi, Rudolf/0000-0001-7911-055X; Romanescu, Dana Diana/0000-0002-6002-8975; Szűcs, Miklós/0000-0002-8606-996X; Balogh, Péter/0000-0002-8611-0221}
}

@article{MTMT:33571706,
	title = {Corrigendum: Improved survival and retinal function of aging ZDF rats in long-term, uncontrolled diabetes by BGP-15 treatment, (Front. Pharmacol, (2021), 12, (650207), 10.3389/fphar.2021.650207)},
	url = {https://m2.mtmt.hu/api/publication/33571706},
	author = {Juhászné Wachal, Zita Eszter and Szilágyi, Anna and Takács, Barbara and Vargáné Szabó, Adrienn Mónika and Priksz, Dániel and Bombicz, Mariann and Szilvássy, Judit and Juhász, Béla and Szilvássy, Zoltán and Varga, Balázs},
	doi = {10.3389/fphar.2022.1034389},
	journal-iso = {FRONT PHARMACOL},
	journal = {FRONTIERS IN PHARMACOLOGY},
	volume = {13},
	unique-id = {33571706},
	abstract = {In the published article, there was an error in affiliation 1. Instead of “Department of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary”, it should be “Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary”. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. © 2022 Wachal, Szilágyi, Takács, Szabó, Priksz, Bombicz, Szilvássy, Juhász, Szilvássy and Varga.},
	keywords = {SURVIVAL; Diabetes; erratum; retinopathy; BGP-15; ERG; ZDF},
	year = {2022},
	eissn = {1663-9812}
}

@article{MTMT:32850670,
	title = {Therapeutic Properties of Ayahuasca Components in Ischemia/Reperfusion Injury of the Eye},
	url = {https://m2.mtmt.hu/api/publication/32850670},
	author = {Szilágyi, Anna and Takács, Barbara and Szekeres, Réka Mária and Tarjányi, Vera and Bombicz, Mariann and Priksz, Dániel and Kovács, Attila and Juhász, Béla and Frecska, Ede and Szilvássy, Zoltán and Varga, Balázs},
	doi = {10.3390/biomedicines10050997},
	journal-iso = {BIOMEDICINES},
	journal = {BIOMEDICINES},
	volume = {10},
	unique-id = {32850670},
	abstract = {Ischemic eye diseases are major causes of vision impairment. Thus, potential retinoprotective effects of N'N-dimethyltryptamine (DMT) were investigated. To inhibit its rapid breakdown by monoamine-oxidase A (MAO-A) enzyme, DMT was co-administered with harmaline, a β-carboline in the Amazonian Ayahuasca brew. Using ligation, 60 min of ischemia was provoked in eyes of rats, followed by 7 days of reperfusion whilst animals received harmaline alone, DMT + harmaline, or vehicle treatment. After 1 week of reperfusion, electroretinographical (ERG) measurements, histological analysis, and Western blot were performed. Harmaline alone exhibited retinoprotection in ischemia-reperfusion (I/R) which was, surprisingly, counterbalanced by DMT in case of co-administration. As both MAO-A inhibition and DMT increase serotoninergic tone synergistically, communicated to be anti-ischemic, thus, involvement of other pathways was investigated. Based on our experiments, DMT and harmaline exert opposite effects on important ocular proteins such as PARP1, NFκB, MMP9, or HSP70, each having a critical role in a different mechanism of eye-ischemia-related pathologies, e.g., cell death, inflammation, tissue destruction, and oxidative stress. Since DMT is proclaimed to be a promising drug candidate, its potentially undesirable effect on eye-ischemia should be further investigated. Meanwhile, this experiment revealed the potential therapeutic effect of MAO-A inhibitor harmaline in I/R-related eye diseases.},
	year = {2022},
	eissn = {2227-9059},
	orcid-numbers = {Priksz, Dániel/0000-0002-5818-4557}
}

@article{MTMT:32607988,
	title = {Cardioprotective Role of BGP-15 in Ageing Zucker Diabetic Fatty Rat (ZDF) Model: Extended Mitochondrial Longevity},
	url = {https://m2.mtmt.hu/api/publication/32607988},
	author = {Kozma, Mate and Bombicz, Mariann and Varga, Balázs and Priksz, Dániel and Gesztelyi, Rudolf and Tarjányi, Vera and Kiss, Rita and Szekeres, Réka Mária and Takács, Barbara and Menes, Akos and Balla, József and Balla, György and Szilvássy, Judit and Szilvássy, Zoltán and Juhász, Béla},
	doi = {10.3390/pharmaceutics14020226},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {14},
	unique-id = {32607988},
	issn = {1999-4923},
	year = {2022},
	eissn = {1999-4923},
	orcid-numbers = {Priksz, Dániel/0000-0002-5818-4557; Gesztelyi, Rudolf/0000-0001-7911-055X; Kiss, Rita/0000-0003-1208-366X}
}

@article{MTMT:32555207,
	title = {Nicotinic-acid derivative BGP-15 improves diastolic function in a rabbit model of atherosclerotic cardiomyopathy},
	url = {https://m2.mtmt.hu/api/publication/32555207},
	author = {Priksz, Dániel and Lampé, Nóra and Kovács, Árpád and Herwig, Melissa and Bombicz, Mariann and Varga, Balázs and Wilisicz, Tician and Szilvássy, Judit and Pósa, Anikó and Kiss, Rita and Gesztelyi, Rudolf and Ráduly, Arnold and Szekeres, Réka Mária and Sieme, Marcel and Papp, Zoltán and Tóth, Attila and Hamdani, Nazha and Szilvássy, Zoltán and Juhász, Béla},
	doi = {10.1111/bph.15749},
	journal-iso = {BR J PHARMACOL},
	journal = {BRITISH JOURNAL OF PHARMACOLOGY},
	volume = {179},
	unique-id = {32555207},
	issn = {0007-1188},
	abstract = {Background and purpose: Small molecule BGP-15 has been reported to alleviate signs of heart failure and improve muscle function in murine models. Here, we investigated the acute and chronic effects of BGP-15 in a rabbit model of atherosclerotic cardiomyopathy. Experimental approach: Rabbits were maintained on standard chow (Control) or atherogenic diet (HC) for 16 weeks. BGP-15 was administered intravenously (once) or orally (for 16 weeks), to assess acute and chronic effects. Cardiac function was evaluated by echocardiography, endothelium-dependent vasorelaxation was assessed, and key molecules of the protein kinase G (PKG) axis were examined by ELISA and Western blot. Passive force generation was investigated in skinned cardiomyocytes. Key results: Both acute and chronic BGP-15 treatment improved the diastolic performance of the diseased heart, however, vasorelaxation and serum lipid markers were unaffected. Myocardial cGMP levels were elevated in the BGP-15-treated group, along with preserved PKG activity and increased phospholamban Ser16-phosphorylation. PDE5 expression decreased in the BGP-15-treated group, and the substance inhibited PDE1 enzyme. Cardiomyocyte passive tension reduced in BGP-15-treated rabbits, the ratio of titin N2BA/N2B isoforms increased, and PKG-dependent N2B-titin phosphorylation elevated in the BGP-15-treated group. Conclusions and implications: Here we report that BGP-15-treatment improves diastolic function, reduces cardiomyocyte stiffness, and restores titin compliance in a rabbit model of atherosclerotic cardiomyopathy by increasing the activity of the cGMP-PKG axis. As BGP-15 is proven to be safe, it may have clinical value in the treatment of diastolic dysfunction.},
	keywords = {TITIN; hypercholesterolemia; diastolic dysfunction; BGP-15; Protein kinase G},
	year = {2022},
	eissn = {1476-5381},
	pages = {2240-2258},
	orcid-numbers = {Pósa, Anikó/0000-0003-2167-2888; Kiss, Rita/0000-0003-1208-366X; Gesztelyi, Rudolf/0000-0001-7911-055X}
}

@article{MTMT:32870919,
	title = {Vaginal elasticity is significantly decreased in vaginal atrophy: a strain elastography study},
	url = {https://m2.mtmt.hu/api/publication/32870919},
	author = {Kozma, Bence and Damjanovich, Péter Gábor and Pákozdy, Krisztina Lili and Sipos, Attila Gergely and Bombicz, Mariann and Takács, Péter},
	doi = {10.1007/s00192-020-04555-3},
	journal-iso = {INT UROGYNECOL J},
	journal = {INTERNATIONAL UROGYNECOLOGY JOURNAL},
	volume = {31},
	unique-id = {32870919},
	issn = {0937-3462},
	year = {2021},
	eissn = {1433-3023},
	pages = {S33-S34}
}

@article{MTMT:32193722,
	title = {A Body of Circumstantial Evidence for the Irreversible Ectonucleotidase Inhibitory Action of FSCPX, an Agent Known as a Selective Irreversible A1 Adenosine Receptor Antagonist So Far},
	url = {https://m2.mtmt.hu/api/publication/32193722},
	author = {Viczján, Gábor and Erdei, Tamás Dániel and Óvári, Ignác and Lampé, Nóra and Szekeres, Réka Mária and Bombicz, Mariann and Takács, Barbara and Szilágyi, Anna and Zsuga, Judit and Szilvássy, Zoltán and Juhász, Béla and Gesztelyi, Rudolf},
	doi = {10.3390/ijms22189831},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {22},
	unique-id = {32193722},
	issn = {1661-6596},
	abstract = {In previous studies using isolated, paced guinea pig left atria, we observed that FSCPX, known as a selective A(1) adenosine receptor antagonist, paradoxically increased the direct negative inotropic response to A(1) adenosine receptor agonists (determined using concentration/effect (E/c) curves) if NBTI, a nucleoside transport inhibitor, was present. Based on mathematical modeling, we hypothesized that FSCPX blunted the cardiac interstitial adenosine accumulation in response to nucleoside transport blockade, probably by inhibiting CD39 and/or CD73, which are the two main enzymes of the interstitial adenosine production in the heart. The goal of the present study was to test this hypothesis. In vitro CD39 and CD73 inhibitor assays were carried out; furthermore, E/c curves were constructed in isolated, paced rat and guinea pig left atria using adenosine, CHA and CPA (two A(1) adenosine receptor agonists), FSCPX, NBTI and NBMPR (two nucleoside transport inhibitors), and PSB-12379 (a CD73 inhibitor), measuring the contractile force. We found that FSCPX did not show any inhibitory effect during the in vitro enzyme assays. However, we successfully reproduced the paradox effect of FSCPX in the rat model, mimicked the "paradox" effect of FSCPX with PSB-12379, and demonstrated the lipophilia of FSCPX, which could explain the negative outcome of inhibitor assays with CD39 and CD73 dissolved in a water-based solution. Taken together, these three pieces of indirect evidence are strong enough to indicate that FSCPX possesses an additional action besides the A(1) adenosine receptor antagonism, which action may be the inhibition of an ectonucleotidase. Incidentally, we found that POM-1 inhibited CD73, in addition to CD39.},
	keywords = {HEART; Guinea pig; atrium; A(1) adenosine receptor; ectonucleotidase; FSCPX; rat; NBTI; extracellular adenosine; POM-1; PSB-12379; NBMPR},
	year = {2021},
	eissn = {1422-0067},
	orcid-numbers = {Zsuga, Judit/0000-0002-5350-8188; Gesztelyi, Rudolf/0000-0001-7911-055X}
}

@article{MTMT:32033226,
	title = {Changes of Hematological and Hemorheological Parameters in Rabbits with Hypercholesterolemia},
	url = {https://m2.mtmt.hu/api/publication/32033226},
	author = {Tánczos, Bence and Somogyi, Viktória and Bombicz, Mariann and Juhász, Béla and Németh, Norbert and Deák, Ádám},
	doi = {10.3390/metabo11040249},
	journal-iso = {METABOLITES},
	journal = {METABOLITES},
	volume = {11},
	unique-id = {32033226},
	issn = {2218-1989},
	year = {2021},
	eissn = {2218-1989},
	orcid-numbers = {Németh, Norbert/0000-0002-1162-3778}
}