TY - JOUR AU - Paragh, György AU - Zilahi, Péter AU - Szentimrei, Réka AU - Lőrincz, Hajnalka AU - Kolozsvári, László AU - Harangi, Mariann TI - Milyen kezelési lehetőségeink vannak a magas lipoprotein(a) csökkentésére? JF - METABOLIZMUS J2 - METABOLIZMUS VL - 22 PY - 2024 IS - 1 SP - 16 EP - 22 PG - 7 SN - 1589-7311 UR - https://m2.mtmt.hu/api/publication/34817183 ID - 34817183 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ratku, Balázs AU - Lőrincz, Hajnalka AU - Bak-Csiha, Sára AU - Sebestyén, Veronika AU - Berta, Eszter AU - Bodor, Miklós AU - Nagy, Endre AU - Szabó, Zoltán AU - Harangi, Mariann AU - Somodi, Sándor TI - Serum afamin and its implications in adult growth hormone deficiency: a prospective GH-withdrawal study JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 15 PY - 2024 SN - 1664-2392 DO - 10.3389/fendo.2024.1348046 UR - https://m2.mtmt.hu/api/publication/34564621 ID - 34564621 LA - English DB - MTMT ER - TY - JOUR AU - Juhász, Lilla AU - Lőrincz, Hajnalka AU - Szentpéteri, Anita AU - Nádró, Bíborka AU - Varga, E. AU - Paragh, György AU - Harangi, M. TI - ELEVATED SPHINGOSINE 1-PHOSPHATE LEVEL IN FAMILIAL HYPERCHOLESTEROLEMIC PATIENTS JF - ATHEROSCLEROSIS J2 - ATHEROSCLEROSIS VL - 379 PY - 2023 IS - S1 SP - S118 EP - S118 SN - 0021-9150 UR - https://m2.mtmt.hu/api/publication/34738471 ID - 34738471 LA - English DB - MTMT ER - TY - JOUR AU - Diószegi, Ágnes AU - Lőrincz, Hajnalka AU - Kaali, E. AU - Harangi, Mariann AU - Tarr, Tünde TI - INVESTIGATION OF FLOW-MEDIATED DILATATION, CAROTID ARTERY INTIMA- MEDIA THICKNESS AND ARTERIAL STIFFNESS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS JF - ATHEROSCLEROSIS J2 - ATHEROSCLEROSIS VL - 379 PY - 2023 IS - S1 SP - S152 EP - S152 SN - 0021-9150 UR - https://m2.mtmt.hu/api/publication/34738136 ID - 34738136 LA - English DB - MTMT ER - TY - JOUR AU - Lőrincz, Hajnalka AU - Ratku, Balázs AU - Ötvös, T. AU - Szentpéteri, Anita AU - Seres, Ildikó AU - Paragh, György AU - Harangi, Mariann AU - Somodi, Sándor TI - CORRELATIONS BETWEEN SERUM AFAMIN AND LIPID PARAMETERS IN OBESE TYPE 2 DIABETIC PATIENTS JF - ATHEROSCLEROSIS J2 - ATHEROSCLEROSIS VL - 379 PY - 2023 IS - S1 SP - S104 EP - S104 SN - 0021-9150 UR - https://m2.mtmt.hu/api/publication/34732660 ID - 34732660 LA - English DB - MTMT ER - TY - JOUR AU - Szentimrei, R. AU - Lőrincz, Hajnalka AU - Szentpéteri, Anita AU - Varga, V.E. AU - Harangi, Mariann AU - Seres, I. AU - P. Szabó, Réka AU - Nemes, Balázs AU - Paragh, György TI - Increased serum PEDF levels and altered lipid profile after renal transplantation in patients with end-stage renal disease JF - ATHEROSCLEROSIS J2 - ATHEROSCLEROSIS VL - 379 PY - 2023 SP - S157 EP - S157 PG - 1 SN - 0021-9150 DO - 10.1016/j.atherosclerosis.2023.06.534 UR - https://m2.mtmt.hu/api/publication/34729478 ID - 34729478 LA - English DB - MTMT ER - TY - JOUR AU - Paragh, György AU - Szentimrei, Réka AU - Juhász, Imre Zoltán AU - Lőrincz, Hajnalka AU - Harangi, Mariann TI - A CoQ10 szerepe a kardiológiai betegségek megelőzésében és progressziójának csökkenésében JF - METABOLIZMUS J2 - METABOLIZMUS VL - 21 PY - 2023 IS - 4 SP - 175 EP - 182 PG - 8 SN - 1589-7311 UR - https://m2.mtmt.hu/api/publication/34495932 ID - 34495932 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Lőrincz, Hajnalka AU - Bak-Csiha, Sára AU - Ratku, Balázs AU - Somodi, Sándor AU - Sztanek, Ferenc AU - Seres, Ildikó AU - Paragh, György AU - Harangi, Mariann TI - Gender-Dependent Associations between Serum Betatrophin Levels and Lipoprotein Subfractions in Diabetic and Nondiabetic Obese Patients JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 22 SN - 1661-6596 DO - 10.3390/ijms242216504 UR - https://m2.mtmt.hu/api/publication/34483385 ID - 34483385 AB - Betatrophin, also known as angiopoietin-like protein 8 (ANGPTL8), mainly plays a role in lipid metabolism. To date, associations between betatrophin and lipoprotein subfractions are poorly investigated. For this study, 50 obese patients with type 2 diabetes (T2D) and 70 nondiabetic obese (NDO) subjects matched in gender, age, and body mass index (BMI) as well as 49 gender- and age-matched healthy, normal-weight controls were enrolled. Serum betatrophin levels were measured with ELISA, and lipoprotein subfractions were analyzed using Lipoprint gel electrophoresis. Betatrophin concentrations were found to be significantly higher in the T2D and NDO groups compared to the controls in all subjects and in females, but not in males. We found significant positive correlations between triglyceride, very low density lipoprotein (VLDL), large LDL (low density lipoprotein), small LDL, high density lipoprotein (HDL) -6-10 subfractions, and betatrophin, while negative correlations were detected between betatrophin and IDL, mean LDL size, and HDL-1-5. Proportion of small HDL was the best predictor of betatrophin in all subjects. Small LDL and large HDL subfractions were found to be the best predictors in females, while in males, VLDL was found to be the best predictor of betatrophin. Our results underline the significance of serum betatrophin measurement in the cardiovascular risk assessment of obese patients with and without T2D, but gender differences might be taken into consideration. LA - English DB - MTMT ER - TY - JOUR AU - Juhász, Lilla AU - Lőrincz, Hajnalka AU - Szentpéteri, Anita AU - Tóth, Nóra AU - Varga, Éva AU - Paragh, György AU - Harangi, Mariann TI - Decreased Serum Stromal Cell-Derived Factor-1 in Patients with Familial Hypercholesterolemia and Its Strong Correlation with Lipoprotein Subfractions JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 20 PG - 14 SN - 1661-6596 DO - 10.3390/ijms242015308 UR - https://m2.mtmt.hu/api/publication/34215397 ID - 34215397 AB - Stromal cell-derived factor-1 (SDF-1) is a chemokine that exerts multifaceted roles in atherosclerosis. However, its association with hyperlipidemia is contradictory. To date, serum SDF-1 and its correlations with lipid fractions and subfractions in heterozygous familial hypercholesterolemia (HeFH) have not been investigated. Eighty-one untreated patients with HeFH and 32 healthy control subjects were enrolled in the study. Serum SDF-1, oxidized LDL (oxLDL) and myeloperoxidase (MPO) were determined by ELISA. Lipoprotein subfractions were detected by Lipoprint. We diagnosed FH using the Dutch Lipid Clinic Network criteria. Significantly lower serum SDF-1 was found in HeFH patients compared to healthy controls. Significant negative correlations were detected between serum total cholesterol, triglycerides, LDL-cholesterol (LDL-C), apolipoprotein B100 (ApoB100) and SDF-1. Furthermore, serum SDF-1 negatively correlated with VLDL and IDL, as well as large LDL and large and intermediate HDL subfractions, while there was a positive correlation between mean LDL-size, small HDL and SDF-1. SDF-1 negatively correlated with oxLDL and MPO. A backward stepwise multiple regression analysis showed that the best predictors of serum SDF-1 were VLDL and oxLDL. The strong correlation of SDF-1 with lipid fractions and subfractions highlights the potential common pathways of SDF-1 and lipoprotein metabolism, which supports the role of SDF-1 in atherogenesis. LA - English DB - MTMT ER - TY - JOUR AU - Szentimrei, R. AU - Lőrincz, Hajnalka AU - Szentpéteri, Anita AU - Varga, V.E. AU - Seres, Ildikó AU - Varga, Éva AU - Nemes, Balázs AU - Harangi, Mariann AU - Paragh, György TI - Assessment of amino-terminal C-type natriuretic peptide serum level and its correlation with high-density lipoprotein structure and function in patients with end stage renal disease before and after kidney transplantation JF - CHEMICO-BIOLOGICAL INTERACTIONS J2 - CHEM-BIOL INTERACT VL - 385 PY - 2023 IS - 1 PG - 8 SN - 0009-2797 DO - 10.1016/j.cbi.2023.110749 UR - https://m2.mtmt.hu/api/publication/34214638 ID - 34214638 LA - English DB - MTMT ER -