TY - BOOK AU - Fodor, Mariann AU - Takács, Lili AU - Kettesy, Andrea Beáta AU - Kolozsvári, Bence Lajos AU - Nagy, Annamária AU - Steiber, Zita AU - Pásztor, Dorottya AU - Surányi, Éva AU - Széll, Noémi AU - Beáta, Bajdik AU - Balla, Szabolcs AU - Aranyosi, János AU - Mátyás, Hankovszky AU - Sára, Makhoul AU - Dorottya, Lilla Nagy AU - Orsolya, Pásztor AU - Anett, Porempovics AU - Ujhelyi, Bernadett TI - Ophthalmogy Practice Notes PB - Debreceni Egyetem CY - Debrecen PY - 2023 UR - https://m2.mtmt.hu/api/publication/34323209 ID - 34323209 LA - English DB - MTMT ER - TY - JOUR AU - Galgóczi, Erika AU - Katkó, Mónika AU - Papp, Fruzsina Réka AU - Csiki, Róbert AU - Bak-Csiha, Sára AU - Erdei, Annamária AU - Bodor, Miklós AU - Ujhelyi, Bernadett AU - Steiber, Zita AU - Győry, Ferenc AU - Nagy, Endre TI - Glucocorticoids Directly Affect Hyaluronan Production of Orbital Fibroblasts; A Potential Pleiotropic Effect in Graves’ Orbitopathy JF - MOLECULES J2 - MOLECULES VL - 28 PY - 2023 IS - 1 SN - 1420-3049 DO - 10.3390/molecules28010015 UR - https://m2.mtmt.hu/api/publication/33578444 ID - 33578444 AB - Orbital connective tissue expansion is a hallmark of Graves’ orbitopathy (GO). In moderate-to-severe active GO, glucocorticoids (GC) are the first line of treatment. Here we show that hydrocortisone (HC), prednisolone (P), methylprednisolone (MP), and dexamethasone (DEX) inhibit the hyaluronan (HA) production of orbital (OF) and dermal (DF) fibroblasts. HA production of GO OFs (n = 4), NON-GO OFs (n = 4) and DFs (n = 4) was measured by ELISA. mRNA expression of enzymes of HA metabolism and fibroblast proliferation was examined by RT-PCR and BrdU incorporation, respectively. After 24 h of GC treatment (1µM) HA production decreased by an average of 67.9 ± 3.11% (p < 0.0001) in all cell cultures. HAS2, HAS3 and HYAL1 expression in OFs also decreased (p = 0.009, p = 0.0005 and p = 0.015, respectively). Ten ng/mL PDGF-BB increased HA production and fibroblast proliferation in all cell lines (p < 0.0001); GC treatment remained effective and reduced HA production under PDGF-BB-stimulated conditions (p < 0.0001). MP and DEX reduced (p < 0.001, p = 0.002, respectively) PDGF-BB-induced HAS2 expression in OFs. MP and DEX treatment decreased PDGF-BB stimulated HAS3 expression (p = 0.035 and p = 0.029, respectively). None of the GCs tested reduced the PDGF-BB stimulated proliferation rate. Our results confirm that GCs directly reduce the HA production of OFs, which may contribute to the beneficial effect of GCs in GO. LA - English DB - MTMT ER - TY - JOUR AU - Galgóczi, Erika AU - Katko, Monika AU - Erdei, Annamária AU - Bodor, Miklós AU - Ujhelyi, Bernadett AU - Steiber, Zita AU - Győry, Ferenc AU - Nagy, Endre TI - The effect of glucocorticoids on hyaluronan production of orbital fibroblasts JF - ENDOCRINE ABSTRACTS J2 - ENDOCR ABSTR VL - 84 PY - 2022 SN - 1470-3947 DO - 10.1530/endoabs.84.PS2-07-64 UR - https://m2.mtmt.hu/api/publication/33211389 ID - 33211389 LA - English DB - MTMT ER - TY - JOUR AU - Erdei, Annamária AU - Gazdag, Annamária AU - Ujhelyi, Bernadett AU - Nagy, Edit B AU - Berényi, Ervin László AU - Berta, Eszter AU - Steiber, Zita AU - Barna, Sándor Kristóf AU - Mezősi, Emese AU - Bodor, Miklós AU - Nagy, Endre TI - Non-surgical orbital decompression using diuresis in dysthyroid optic neuropathy: a case report JF - EUROPEAN THYROID JOURNAL J2 - EUR THYROID J VL - 11 PY - 2022 IS - 5 PG - 5 SN - 2235-0640 DO - 10.1530/ETJ-22-0078 UR - https://m2.mtmt.hu/api/publication/33032320 ID - 33032320 AB - Dysthyroid optic neuropathy (DON) is a rare, severe form of thyroid eye disease, in which decreased visual acuity is accompanied by characteristic MRI findings. The treatment of DON has always been a challenge.In a patient in whom visual acuity deteriorated on the left eye, mannitol 20% 200 ml followed by furosemide 40 mg 6 hours later, administered daily, were initiated on the day of admission. Visual function by ophthalmology methods, and orbital compartment volumes and water content by MRI were followed. Intravenous diuretics resulted in immediate therapeutic response. Visual acuity improved from 20/50 to 20/25 after two days of treatment. MRI revealed decreasing water content of both the muscle and connective tissue compartments without any volume changes. Subsequently, corticosteroids and orbital irradiation were started. Orbital decompression surgery was not required.Edematous swelling of orbital tissues is an established contributor of local pressure increase in thyroid eye disease. Diuretics reduce orbital pressure and, if confirmed by others, may be useful additions to the standard of care in sight threatening DON. LA - English DB - MTMT ER - TY - JOUR AU - Aranyosi, János AU - Galgóczi, Erika AU - Erdei, Annamária AU - Katkó, Mónika AU - Fodor, Mariann AU - Ujhelyi, Zoltán AU - Bácskay, Ildikó AU - Nagy, Endre AU - Ujhelyi, Bernadett TI - Different Effects of Cigarette Smoke, Heated Tobacco Product and E-Cigarette Vapour on Orbital Fibroblasts in Graves’ Orbitopathy; a Study by Real Time Cell Electronic Sensing JF - MOLECULES J2 - MOLECULES VL - 27 PY - 2022 IS - 9 SN - 1420-3049 DO - 10.3390/molecules27093001 UR - https://m2.mtmt.hu/api/publication/32866680 ID - 32866680 LA - English DB - MTMT ER - TY - JOUR AU - Katkó, Mónika AU - Galgóczi, Erika AU - Erdei, Annamária AU - Gazdag, Annamária AU - Berta, Eszter AU - Bodor, Miklós AU - Seres, Ildiko AU - Hircsu, Ildiko AU - Badics, Arpad AU - Ujhelyi, Bernadett AU - Sira, Livia AU - Bhattoa Harjit, Pál AU - Nagy, Endre TI - The 4G/5G Polymorphism of Plasminogen Activator Inhibitor Type 1 is a Predictor of Moderate-to-Severe Thyroid Eye Disease JF - JOURNAL OF INFLAMMATION RESEARCH J2 - J INFLAMM RES VL - 14 PY - 2021 SP - 1883 EP - 1890 PG - 8 SN - 1178-7031 DO - 10.2147/JIR.S307046 UR - https://m2.mtmt.hu/api/publication/32035348 ID - 32035348 N1 - 310134 LA - English DB - MTMT ER - TY - JOUR AU - Balla, Szabolcs AU - Zöld, Eszter AU - Potor, László AU - Lukucz, Balazs AU - Vajas, Attila AU - Ujhelyi, Bernadett AU - Nagy, Valéria TI - Analysis of intravitreal bevacizumab treatment for macular oedema due to retinal vein occlusion JF - EUROPEAN JOURNAL OF OPHTHALMOLOGY J2 - EUR J OPHTHALMOL VL - 31 PY - 2021 IS - 5 SP - 2528 EP - 2534 PG - 7 SN - 1120-6721 DO - 10.1177/1120672120962051 UR - https://m2.mtmt.hu/api/publication/31746464 ID - 31746464 AB - Purpose: Our aim was to analyse the clinical effect of intravitreal bevacizumab treatment for macular oedema due to central/branch retinal vein occlusion (CRVO/BRVO). The end points were final best-corrected visual acuity (BCVA), BCVA improvement, final central 1-mm macular subfield thickness (CST) and change in CST. Methods: Our study included 34 CRVO and 25 BRVO patients. Patients received intravitreal bevacizumab (IVB) treatment at our department. Our control group consisted of 50 CRVO and 30 BRVO patients, who had not received this treatment because their disease developed before the anti-VEGF treatment became available. For statistical analysis, two-samplet-test, Pearson's correlation, and ANOVA were used. The level of significance was defined atp < 0.05. Results: With the two-sample t-test we found significant improvement of BCVA in the IVB-treated group (CRVO: 0.171 +/- 0.270, p1 = 3.25x10-4; BRVO: 0.215 +/- 0.282, p2 = 5.52x10-4). The difference in BCVA improvement was also significant compared to the control group (CRVO: p1 = 3.46x10-4; BRVO: p2 = 0.003). Significant decrease was observed in the CST in the treated group (CRVO: -345.114 +/- 280.577, p1 = 6.94x10-9; BRVO: -151.875 +/- 174.341, p2 = 1.67x10-4). In case of BRVO patients the final BCVA was significantly better in the treated group (0.617 +/- 0.334) compared to the control group (0.406 +/- 0.357),p = 0.016. Conclusion: IVB treatment results in significantly better final visual acuity and leads to significantly increased BCVA improvement compared to patients with RVO-induced macular oedema receiving no treatment. LA - English DB - MTMT ER - TY - JOUR AU - Aranyosi, Janos K. AU - Deli, Tamás AU - Erdei, Annamária AU - Toth, Geza AU - Jakab, Attila AU - Fodor, Mariann AU - Nagy, Endre AU - Ujhelyi, Bernadett TI - Unusual onset of thyroid associated orbitopathy during pregnancy: case report and review of literature JF - BMC ENDOCRINE DISORDERS J2 - BMC ENDOCR DISORD VL - 20 PY - 2020 IS - 1 SN - 1472-6823 DO - 10.1186/s12902-020-00663-9 UR - https://m2.mtmt.hu/api/publication/32020498 ID - 32020498 LA - English DB - MTMT ER - TY - JOUR AU - Steiber, Zita AU - Erdei, Annamária AU - Nagy, Endre AU - Ujhelyi, Bernadett TI - Az endokrin orbitopathia korszerű kezelése JF - SZEMÉSZET J2 - SZEMÉSZET VL - 157 PY - 2020 IS - 2 SP - 19 EP - 23 PG - 5 SN - 0039-8101 UR - https://m2.mtmt.hu/api/publication/31805981 ID - 31805981 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ujhelyi, Bernadett AU - Aranyosi, János AU - Módis, László TI - A szemfelszín betegségeinek sebészi kezelése amnionmembrán-transzplantációval JF - SZEMÉSZET J2 - SZEMÉSZET VL - 157 PY - 2020 IS - 2 SP - 82 EP - 88 PG - 7 SN - 0039-8101 UR - https://m2.mtmt.hu/api/publication/31805965 ID - 31805965 N1 - 293843 LA - Hungarian DB - MTMT ER -